Development Level

Tbio 10,068 | 11,445
Tdark 3,959 | 6,588
Tchem 1,460 | 1,598
Tclin 539 | 613

Collection

RFA-RM-18-021 253 | 328
Kinase: IDG Consortium (Target... 117 | 125
Ion Channel: IDG Consortium (T... 90 | 99
GPCR: IDG Consortium (Targets) 54 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 10 | 25

IMPC Phenotype

preweaning lethality, complete... 927 | 979
preweaning lethality, incomple... 452 | 499
abnormal behavior 266 | 298
embryonic lethality prior to t... 259 | 278
embryonic lethality prior to o... 231 | 239
abnormal embryo size 203 | 220
decreased total body fat amoun... 181 | 207
enlarged heart 176 | 210
abnormal bone structure 166 | 187
decreased vertical activity 162 | 208
increased lean body mass 149 | 172
decreased body weight 143 | 161
abnormal heart morphology 138 | 162
hyperactivity 133 | 148
decreased bone mineral content 130 | 151
decreased lean body mass 121 | 135
hypoactivity 118 | 132
increased total body fat amoun... 117 | 134
increased circulating alkaline... 113 | 122
decreased circulating glucose ... 111 | 126
decreased bone mineral density 108 | 126
male infertility 108 | 123
decreased grip strength 106 | 116
increased startle reflex 103 | 112
abnormal seminal vesicle morph... 100 | 114
embryonic growth retardation 100 | 106
increased bone mineral content 92 | 108
decreased body length 91 | 101
increased mean corpuscular hem... 89 | 96
increased or absent threshold ... 88 | 101
short tibia 88 | 97
decreased circulating choleste... 84 | 93
prenatal lethality prior to he... 84 | 87
cataract 82 | 92
increased mean corpuscular vol... 81 | 92
increased circulating HDL chol... 76 | 80
abnormal lens morphology 75 | 81
decreased circulating serum al... 75 | 82
decreased circulating triglyce... 75 | 79
decreased lymphocyte cell numb... 75 | 83
decreased mean corpuscular vol... 73 | 79
decreased prepulse inhibition 72 | 82
improved glucose tolerance 72 | 79
increased fasted circulating g... 70 | 76
impaired glucose tolerance 68 | 75
abnormal retina morphology 67 | 71
small superior vagus ganglion 67 | 74
decreased startle reflex 66 | 75
abnormal gait 65 | 69
abnormal sleep behavior 64 | 70
decreased leukocyte cell numbe... 64 | 73
abnormal behavioral response t... 63 | 66
decreased circulating insulin ... 63 | 76
increased circulating sodium l... 63 | 71
increased bone mineral density 62 | 72
decreased circulating HDL chol... 61 | 68
increased circulating choleste... 60 | 66
abnormal eye morphology 59 | 68
decreased fasted circulating g... 59 | 65
increased monocyte cell number 58 | 63
abnormal coat-hair pigmentatio... 57 | 64
decreased erythrocyte cell num... 57 | 62
decreased hemoglobin content 56 | 68
increased heart weight 55 | 62
edema 53 | 59
thrombocytopenia 53 | 56
abnormal kidney morphology 52 | 65
decreased caudal vertebrae num... 51 | 53
small testis 51 | 58
abnormal spleen morphology 50 | 55
decreased blood urea nitrogen ... 49 | 51
female infertility 49 | 60
hydrometra 47 | 53
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
abnormal skin morphology 45 | 50
increased hematocrit 45 | 46
increased mean platelet volume 45 | 45
abnormal neural tube closure 43 | 46
increased hemoglobin content 43 | 45
decreased circulating alanine ... 42 | 47
decreased circulating alkaline... 42 | 46
increased blood urea nitrogen ... 42 | 48
increased neutrophil cell numb... 42 | 46
increased circulating triglyce... 41 | 42
increased leukocyte cell numbe... 41 | 47
decreased neutrophil cell numb... 39 | 42
decreased hematocrit 38 | 46
increased circulating creatini... 38 | 38
increased erythrocyte cell num... 38 | 39
decreased red blood cell distr... 37 | 41
increased circulating chloride... 37 | 41
prolonged QT interval 37 | 38
abnormal bone mineralization 36 | 38
enlarged spleen 36 | 41
increased grip strength 36 | 41
abnormal testis morphology 35 | 43
decreased circulating LDL chol... 35 | 38
decreased circulating calcium ... 35 | 36
limb grasping 35 | 41

Disease

Carcinoma 10,093 | 11,493
ovarian cancer 7,646 | 8,520
osteosarcoma 7,076 | 7,950
psoriasis 5,764 | 6,694
medulloblastoma, large-cell 5,568 | 6,241
glioblastoma 5,233 | 5,792
atypical teratoid / rhabdoid tumor 4,601 | 5,112
lung cancer 4,305 | 4,740
ependymoma 4,200 | 4,679
group 3 medulloblastoma 3,702 | 4,104
adult high grade glioma 3,394 | 3,801
Breast cancer 3,219 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,983 | 3,291
malignant mesothelioma 2,937 | 3,232
Astrocytoma, Pilocytic 2,770 | 3,081
primitive neuroectodermal tumor 2,746 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,725 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,690 | 2,955
invasive ductal carcinoma 2,649 | 2,951
oligodendroglioma 2,602 | 2,850
non-small cell lung cancer 2,565 | 2,890
lung carcinoma 2,547 | 2,843
Kidney cancer 2,440 | 2,613
lung adenocarcinoma 2,376 | 2,716
astrocytic glioma 2,365 | 2,597
pancreatic cancer 2,182 | 2,398
Cancer 2,170 | 2,499
subependymal giant cell astrocytoma 2,076 | 2,287
interstitial cystitis 2,026 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,828 | 1,962
Pick disease 1,767 | 1,894
tuberculosis 1,751 | 2,010
pituitary cancer 1,747 | 1,972
group 4 medulloblastoma 1,677 | 1,855
ulcerative colitis 1,616 | 1,819
ductal carcinoma in situ 1,546 | 1,745
cystic fibrosis 1,531 | 1,696
breast carcinoma 1,459 | 1,638
diabetes mellitus 1,376 | 1,728
Autosomal recessive predisposition 1,349 | 1,442
colon cancer 1,330 | 1,478
adrenocortical carcinoma 1,265 | 1,428
Multiple myeloma 1,235 | 1,332
juvenile dermatomyositis 1,103 | 1,187
acute quadriplegic myopathy 1,083 | 1,158
astrocytoma 1,063 | 1,146
Rheumatoid arthritis 1,054 | 1,191
Schizophrenia 1,043 | 1,160
primary pancreatic ductal adenocarcinoma 1,020 | 1,109
spina bifida 970 | 1,074
Intellectual disability 964 | 1,016
pediatric high grade glioma 964 | 1,064
cutaneous lupus erythematosus 944 | 1,057
nasopharyngeal carcinoma 936 | 1,058
dermatomyositis 887 | 966
Atopic dermatitis 832 | 952
active Crohn's disease 823 | 922
non primary Sjogren syndrome sicca 791 | 891
Epilepsy 746 | 792
gastric carcinoma 725 | 807
Liver Cirrhosis, Experimental 715 | 769
Waldenstrons macroglobulinemia 715 | 765
acute myeloid leukemia 705 | 783
esophageal adenocarcinoma 677 | 737
active ulcerative colitis 674 | 764
primary Sjogren syndrome 672 | 735
Melanoma 653 | 711
medulloblastoma 647 | 720
progressive supranuclear palsy 626 | 676
Dull intelligence 616 | 645
Low intelligence 616 | 645
Mental Retardation 616 | 645
Mental deficiency 616 | 645
Poor school performance 616 | 645
aldosterone-producing adenoma 609 | 665
Obesity 605 | 678
Alzheimer's disease 596 | 658
Bipolar Disorder 589 | 666
Cognitive delay 580 | 608
Global developmental delay 580 | 608
Mental and motor retardation 580 | 608
Duchenne muscular dystrophy 564 | 601
Liver cancer 560 | 604
Seizures 560 | 596
Muscle hypotonia 549 | 571
pancreatic carcinoma 512 | 562
fibroadenoma 494 | 559
hepatocellular carcinoma 492 | 547
Short stature 484 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 480 | 510
Endometriosis 470 | 540
Prostatic Neoplasms 465 | 495
Down syndrome 459 | 499
Multiple Sclerosis 441 | 540
chronic rhinosinusitis 439 | 512
Skin cancer 437 | 469
mucosa-associated lymphoid tissue lymphoma 429 | 484
sonic hedgehog group medulloblastoma 425 | 467
Amyotrophic lateral sclerosis 423 | 451
posterior fossa group A ependymoma 419 | 468

Tissue

Endocrine System 15,550 | 18,159
Female tissues 15,057 | 17,400
Digestive Tract 15,041 | 17,369
Skin and soft tissues 14,947 | 17,230
Male tissues 14,856 | 17,142
Blood and immune system 14,696 | 16,909
Liver and Pancreas 14,603 | 16,750
Nervous System 14,595 | 16,725
Urinary Tract 14,564 | 16,678
Respiratory system 14,314 | 16,393
Cardiovascular System 13,414 | 15,192

Target Family

Non-IDG 9,149 | 12,091
Enzyme 3,669 | 4,145
Transcription Factor 1,257 | 1,400
Kinase 605 | 634
Transporter 420 | 473
Ion Channel 303 | 344
GPCR 217 | 408
Epigenetic 215 | 242
oGPCR 107 | 421
Nuclear Receptor 48 | 48
TF/Epigenetic 36 | 38

Data Source

HPM Gene 16,026 | 16,026
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22