Development Level

Tbio 9,827 | 11,178
Tdark 3,945 | 6,569
Tchem 1,716 | 1,885
Tclin 538 | 612

Collection

Kinase: IDG Consortium (Target... 117 | 125
Ion Channel: IDG Consortium (T... 90 | 99
GPCR: IDG Consortium (Targets) 54 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 10 | 25

IMPC Phenotype

preweaning lethality, complete... 927 | 979
preweaning lethality, incomple... 452 | 499
abnormal behavior 266 | 298
embryonic lethality prior to t... 259 | 278
embryonic lethality prior to o... 231 | 239
abnormal embryo size 203 | 220
decreased total body fat amoun... 181 | 207
enlarged heart 176 | 210
abnormal bone structure 166 | 187
decreased vertical activity 162 | 208
increased lean body mass 149 | 172
decreased body weight 143 | 161
abnormal heart morphology 138 | 162
hyperactivity 133 | 148
decreased bone mineral content 130 | 151
decreased lean body mass 121 | 135
hypoactivity 118 | 132
increased total body fat amoun... 117 | 134
increased circulating alkaline... 113 | 122
decreased circulating glucose ... 111 | 126
decreased bone mineral density 108 | 126
male infertility 108 | 123
decreased grip strength 106 | 116
increased startle reflex 103 | 112
abnormal seminal vesicle morph... 100 | 114
embryonic growth retardation 100 | 106
increased bone mineral content 92 | 108
decreased body length 91 | 101
increased mean corpuscular hem... 89 | 96
increased or absent threshold ... 88 | 101
short tibia 88 | 97
decreased circulating choleste... 84 | 93
prenatal lethality prior to he... 84 | 87
cataract 82 | 92
increased mean corpuscular vol... 81 | 92
increased circulating HDL chol... 76 | 80
abnormal lens morphology 75 | 81
decreased circulating serum al... 75 | 82
decreased circulating triglyce... 75 | 79
decreased lymphocyte cell numb... 75 | 83
decreased mean corpuscular vol... 73 | 79
decreased prepulse inhibition 72 | 82
improved glucose tolerance 72 | 79
increased fasted circulating g... 70 | 76
impaired glucose tolerance 68 | 75
abnormal retina morphology 67 | 71
small superior vagus ganglion 67 | 74
decreased startle reflex 66 | 75
abnormal gait 65 | 69
abnormal sleep behavior 64 | 70
decreased leukocyte cell numbe... 64 | 73
abnormal behavioral response t... 63 | 66
decreased circulating insulin ... 63 | 76
increased circulating sodium l... 63 | 71
increased bone mineral density 62 | 72
decreased circulating HDL chol... 61 | 68
increased circulating choleste... 60 | 66
abnormal eye morphology 59 | 68
decreased fasted circulating g... 59 | 65
increased monocyte cell number 58 | 63
abnormal coat-hair pigmentatio... 57 | 64
decreased erythrocyte cell num... 57 | 62
decreased hemoglobin content 56 | 68
increased heart weight 55 | 62
edema 53 | 59
thrombocytopenia 53 | 56
abnormal kidney morphology 52 | 65
decreased caudal vertebrae num... 51 | 53
small testis 51 | 58
abnormal spleen morphology 50 | 55
decreased blood urea nitrogen ... 49 | 51
female infertility 49 | 60
hydrometra 47 | 53
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
abnormal skin morphology 45 | 50
increased hematocrit 45 | 46
increased mean platelet volume 45 | 45
abnormal neural tube closure 43 | 46
increased hemoglobin content 43 | 45
decreased circulating alanine ... 42 | 47
decreased circulating alkaline... 42 | 46
increased blood urea nitrogen ... 42 | 48
increased neutrophil cell numb... 42 | 46
increased circulating triglyce... 41 | 42
increased leukocyte cell numbe... 41 | 47
decreased neutrophil cell numb... 39 | 42
decreased hematocrit 38 | 46
increased circulating creatini... 38 | 38
increased erythrocyte cell num... 38 | 39
decreased red blood cell distr... 37 | 41
increased circulating chloride... 37 | 41
prolonged QT interval 37 | 38
abnormal bone mineralization 36 | 38
enlarged spleen 36 | 41
increased grip strength 36 | 41
abnormal testis morphology 35 | 43
decreased circulating LDL chol... 35 | 38
decreased circulating calcium ... 35 | 36
limb grasping 35 | 41

Disease

Carcinoma 9,819 | 11,192
ovarian cancer 7,435 | 8,297
osteosarcoma 6,907 | 7,766
psoriasis 5,603 | 6,514
medulloblastoma, large-cell 5,422 | 6,086
glioblastoma 5,082 | 5,635
atypical teratoid / rhabdoid tumor 4,466 | 4,971
lung cancer 4,176 | 4,607
ependymoma 4,087 | 4,559
group 3 medulloblastoma 3,606 | 4,002
adult high grade glioma 3,299 | 3,701
Breast cancer 3,117 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 2,900 | 3,204
malignant mesothelioma 2,844 | 3,135
Astrocytoma, Pilocytic 2,698 | 3,006
primitive neuroectodermal tumor 2,670 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,643 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,610 | 2,872
invasive ductal carcinoma 2,570 | 2,867
oligodendroglioma 2,525 | 2,768
non-small cell lung cancer 2,478 | 2,799
lung carcinoma 2,463 | 2,755
Kidney cancer 2,378 | 2,548
astrocytic glioma 2,302 | 2,530
lung adenocarcinoma 2,294 | 2,627
pancreatic cancer 2,110 | 2,322
Cancer 2,069 | 2,388
subependymal giant cell astrocytoma 2,020 | 2,230
interstitial cystitis 1,954 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,779 | 1,911
Pick disease 1,729 | 1,856
tuberculosis 1,708 | 1,963
pituitary cancer 1,693 | 1,915
group 4 medulloblastoma 1,630 | 1,806
ulcerative colitis 1,564 | 1,765
ductal carcinoma in situ 1,491 | 1,686
cystic fibrosis 1,467 | 1,629
breast carcinoma 1,415 | 1,589
diabetes mellitus 1,336 | 1,683
Autosomal recessive predisposition 1,315 | 1,407
colon cancer 1,282 | 1,428
adrenocortical carcinoma 1,226 | 1,385
Multiple myeloma 1,199 | 1,296
juvenile dermatomyositis 1,066 | 1,147
acute quadriplegic myopathy 1,060 | 1,133
astrocytoma 1,033 | 1,113
Schizophrenia 1,021 | 1,136
Rheumatoid arthritis 1,019 | 1,156
primary pancreatic ductal adenocarcinoma 984 | 1,071
spina bifida 949 | 1,053
Intellectual disability 947 | 998
pediatric high grade glioma 936 | 1,035
cutaneous lupus erythematosus 905 | 1,016
nasopharyngeal carcinoma 904 | 1,024
dermatomyositis 862 | 941
Atopic dermatitis 800 | 915
active Crohn's disease 785 | 882
non primary Sjogren syndrome sicca 761 | 861
Epilepsy 730 | 775
gastric carcinoma 701 | 781
Waldenstrons macroglobulinemia 692 | 742
acute myeloid leukemia 684 | 760
Liver Cirrhosis, Experimental 679 | 733
active ulcerative colitis 649 | 736
primary Sjogren syndrome 647 | 710
esophageal adenocarcinoma 639 | 696
Melanoma 632 | 689
medulloblastoma 629 | 702
Dull intelligence 606 | 634
Low intelligence 606 | 634
Mental Retardation 606 | 634
Mental deficiency 606 | 634
Poor school performance 606 | 634
progressive supranuclear palsy 606 | 656
aldosterone-producing adenoma 592 | 646
Obesity 582 | 655
Alzheimer's disease 578 | 640
Bipolar Disorder 570 | 646
Cognitive delay 569 | 596
Global developmental delay 569 | 596
Mental and motor retardation 569 | 596
Duchenne muscular dystrophy 550 | 587
Seizures 549 | 584
Liver cancer 545 | 589
Muscle hypotonia 540 | 562
pancreatic carcinoma 505 | 555
hepatocellular carcinoma 481 | 536
fibroadenoma 475 | 538
Short stature 469 | 514
autosomal dominant Emery-Dreifuss muscular dystrophy 463 | 492
Endometriosis 453 | 521
Prostatic Neoplasms 444 | 472
Down syndrome 440 | 480
chronic rhinosinusitis 432 | 505
Multiple Sclerosis 429 | 527
Skin cancer 419 | 451
mucosa-associated lymphoid tissue lymphoma 418 | 473
sonic hedgehog group medulloblastoma 417 | 459
Amyotrophic lateral sclerosis 409 | 437
posterior fossa group A ependymoma 407 | 456

Tissue

Endocrine System 15,550 | 18,159
Female tissues 15,057 | 17,400
Digestive Tract 15,041 | 17,369
Skin and soft tissues 14,947 | 17,230
Male tissues 14,856 | 17,142
Blood and immune system 14,696 | 16,909
Liver and Pancreas 14,603 | 16,750
Nervous System 14,595 | 16,725
Urinary Tract 14,564 | 16,678
Respiratory system 14,314 | 16,393
Cardiovascular System 13,414 | 15,192

Target Family

Non-IDG 9,149 | 12,091
Enzyme 3,669 | 4,145
Transcription Factor 1,257 | 1,400
Kinase 605 | 634
Transporter 420 | 473
Ion Channel 303 | 344
GPCR 217 | 408
Epigenetic 215 | 242
oGPCR 107 | 421
Nuclear Receptor 48 | 48
TF/Epigenetic 36 | 38

Data Source

HPM Gene 16,026 | 16,026
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116