Development Level

Tbio 9,468 | 10,625
Tdark 4,460 | 7,003
Tchem 1,724 | 1,890
Tclin 533 | 602

Collection

Eligible Kinase Proteins 126 | 134
Eligible Ion Channel Proteins 98 | 117
Eligible non-olfactory GPCR Proteins 58 | 145

IMPC Term

preweaning lethality, complete... 597 | 633
preweaning lethality, incomple... 238 | 260
abnormal behavior 214 | 226
decreased lean body mass 185 | 195
embryonic lethality prior to t... 179 | 187
decreased total body fat amoun... 171 | 186
decreased body weight 159 | 174
embryonic lethality prior to o... 145 | 148
decreased bone mineral content 142 | 157
abnormal bone structure 117 | 131
decreased bone mineral density 114 | 126
decreased grip strength 114 | 123
increased or absent threshold ... 114 | 128
increased circulating alkaline... 113 | 119
abnormal embryo size 107 | 112
decreased circulating glucose ... 105 | 121
hyperactivity 105 | 108
decreased body length 103 | 108
increased lean body mass 92 | 107
enlarged heart 91 | 111
abnormal retina morphology 90 | 100
increased mean corpuscular hem... 87 | 93
increased bone mineral content 84 | 92
hypoactivity 83 | 89
increased mean corpuscular vol... 80 | 91
decreased circulating choleste... 78 | 85
short tibia 77 | 82
decreased circulating triglyce... 76 | 83
decreased circulating serum al... 74 | 79
decreased circulating HDL chol... 71 | 77
increased grip strength 69 | 83
abnormal lens morphology 67 | 73
decreased circulating insulin ... 64 | 75
increased circulating sodium l... 63 | 71
increased fasted circulating g... 62 | 68
prenatal lethality prior to he... 61 | 64
decreased lumbar vertebrae num... 58 | 62
increased sacral vertebrae num... 58 | 62
abnormal sleep behavior 57 | 63
increased circulating HDL chol... 56 | 63
male infertility 55 | 62
abnormal retinal pigmentation 53 | 61
decreased rib number 51 | 59
improved glucose tolerance 51 | 56
increased exploration in new e... 51 | 56
abnormal gait 50 | 51
decreased leukocyte cell numbe... 50 | 54
increased total body fat amoun... 50 | 57
abnormal behavioral response t... 49 | 52
abnormal bone mineralization 49 | 55
abnormal coat/hair pigmentatio... 49 | 54
impaired glucose tolerance 49 | 52
decreased mean corpuscular vol... 48 | 50
decreased hemoglobin content 47 | 53
increased circulating choleste... 47 | 53
decreased fasted circulating g... 46 | 49
increased bone mineral density 46 | 52
decreased caudal vertebrae num... 45 | 49
decreased circulating alanine ... 45 | 53
decreased prepulse inhibition 45 | 52
increased hemoglobin content 45 | 45
thrombocytopenia 44 | 46
abnormal heart morphology 41 | 51
decreased startle reflex 40 | 48
decreased circulating total pr... 39 | 41
decreased erythrocyte cell num... 39 | 43
increased blood urea nitrogen ... 39 | 44
increased circulating chloride... 39 | 43
abnormal seminal vesicle morph... 38 | 47
increased body weight 38 | 42
decreased heart weight 37 | 44
abnormal neural tube closure 36 | 37
decreased circulating alkaline... 36 | 41
increased rib number 36 | 41
abnormal eye morphology 35 | 38
decreased circulating LDL chol... 35 | 37
increased hematocrit 35 | 36
decreased circulating free fat... 34 | 39
decreased eosinophil cell numb... 34 | 41
decreased neutrophil cell numb... 34 | 37
increased leukocyte cell numbe... 34 | 37
increased startle reflex 34 | 38
abnormal spleen morphology 33 | 36
cardiovascular system phenotyp... 33 | 35
decreased circulating chloride... 32 | 32
decreased blood urea nitrogen ... 31 | 31
decreased mean corpuscular hem... 31 | 34
small testis 31 | 37
tremors 31 | 34
abnormal cranium morphology 30 | 32
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 30 | 31
increased heart weight 30 | 37
decreased threshold for audito... 29 | 32
increased circulating calcium ... 29 | 32
increased circulating potassiu... 29 | 31
limb grasping 29 | 35
embryonic growth retardation 28 | 28
female infertility 28 | 34
increased circulating creatini... 28 | 29

Disease

ovarian cancer 7,728 | 8,492
osteosarcoma 7,137 | 7,933
psoriasis 5,811 | 6,685
medulloblastoma, large-cell 5,623 | 6,234
glioblastoma 5,084 | 5,572
lung cancer 4,126 | 4,473
atypical teratoid / rhabdoid tumor 3,971 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,013 | 3,289
malignant mesothelioma 2,903 | 3,163
Breast cancer 2,822 | 3,099
pilocytic astrocytoma 2,799 | 3,086
primitive neuroectodermal tumor 2,771 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,748 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,718 | 2,956
invasive ductal carcinoma 2,673 | 2,950
oligodendroglioma 2,620 | 2,849
lung carcinoma 2,564 | 2,844
non-small cell lung cancer 2,507 | 2,798
pediatric high grade glioma 2,471 | 2,712
lung adenocarcinoma 2,399 | 2,714
ependymoma 2,317 | 2,514
pancreatic cancer 2,108 | 2,300
subependymal giant cell astrocytoma 2,094 | 2,287
astrocytic glioma 2,058 | 2,241
Cancer 2,040 | 2,346
interstitial cystitis 2,040 | 2,299
group 3 medulloblastoma 2,030 | 2,254
Carcinoma 2,016 | 2,147
adult high grade glioma 1,924 | 2,148
ulcerative colitis 1,885 | 2,087
Pick disease 1,779 | 1,893
pituitary cancer 1,769 | 1,972
group 4 medulloblastoma 1,731 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,686 | 1,795
ductal carcinoma in situ 1,558 | 1,745
cystic fibrosis 1,517 | 1,670
breast carcinoma 1,455 | 1,614
astrocytoma 1,397 | 1,493
tuberculosis 1,394 | 1,563
medulloblastoma 1,383 | 1,524
posterior fossa group A ependymoma 1,357 | 1,511
sonic hedgehog group medulloblastoma 1,354 | 1,482
colon cancer 1,346 | 1,475
diabetes mellitus 1,332 | 1,663
posterior fossa group B ependymoma 1,313 | 1,530
adrenocortical carcinoma 1,281 | 1,427
Multiple myeloma 1,255 | 1,328
primary pancreatic ductal adenocarcinoma 1,188 | 1,271
juvenile dermatomyositis 1,111 | 1,189
acute quadriplegic myopathy 1,093 | 1,157
Rheumatoid Arthritis 1,040 | 1,171
atypical teratoid/rhabdoid tumor 995 | 1,095
spina bifida 967 | 1,064
cutaneous lupus erythematosus 953 | 1,056
nasopharyngeal carcinoma 943 | 1,056
dermatomyositis 894 | 967
Atopic dermatitis 828 | 944
active Crohn's disease 828 | 918
gastric carcinoma 761 | 832
non primary Sjogren syndrome sicca 747 | 840
Waldenstrons macroglobulinemia 727 | 765
primary Sjogren syndrome 726 | 789
acute myeloid leukemia 716 | 785
esophageal adenocarcinoma 684 | 737
tuberculosis and treatment for 6 months 633 | 686
progressive supranuclear palsy 625 | 674
aldosterone-producing adenoma 612 | 664
Alzheimer's disease 593 | 644
Duchenne muscular dystrophy 569 | 602
Intellectual disability 545 | 573
Obesity 544 | 616
pancreatic carcinoma 522 | 567
Down syndrome 505 | 548
fibroadenoma 499 | 557
hepatocellular carcinoma 498 | 550
autosomal dominant Emery-Dreifuss muscular dystrophy 471 | 499
Endometriosis 466 | 535
chronic rhinosinusitis 446 | 512
Prostatic Neoplasms 443 | 471
Schizophrenia 443 | 503
mucosa-associated lymphoid tissue lymphoma 429 | 480
active ulcerative colitis 424 | 477
IGA Glomerulonephritis 420 | 454
Multiple Sclerosis 408 | 498
Amyotrophic Lateral Sclerosis 407 | 432
gastric cancer 401 | 436
Mammary Neoplasms 373 | 410
Neurodegenerative disease 366 | 383
non-small cell lung carcinoma 363 | 413
inflammatory breast cancer 351 | 404
Kidney disease 340 | 397
Parkinson's disease 330 | 364
Epilepsy 324 | 346
sarcoidosis 323 | 368
glioblastoma multiforme 315 | 347
Polycystic Ovary Syndrome 305 | 335
hereditary spastic paraplegia 302 | 313
nephrosclerosis 299 | 329
tuberculosis and treatment for 3 months 286 | 327
Asthma 285 | 349

Tissue

Female tissues 15,989 | 18,647
Nervous System 15,972 | 18,561
Digestive Tract 15,915 | 18,473
Endocrine System 15,893 | 18,512
Urinary Tract 15,848 | 18,444
Liver and Pancreas 15,787 | 18,136
Male tissues 15,755 | 17,969
Blood and immune system 15,734 | 17,995
Cardiovascular System 15,662 | 17,958
Skin and soft tissues 15,620 | 18,115
Respiratory system 15,319 | 17,484

Target Family

Non-IDG 9,266 | 11,969
Enzyme 3,707 | 4,146
Transcription Factor 1,259 | 1,400
Kinase 605 | 634
Transporter 421 | 473
Ion Channel 301 | 341
Epigenetic 219 | 242
GPCR 216 | 408
oGPCR 107 | 421
Nuclear Receptor 48 | 48
TF/Epigenetic 36 | 38

Data Source

HPM Gene 16,185 | 16,185
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
NACHT, LRR and PYD domains-containing protein 14 NLRP14 Tbio Non-IDG -1.33032 17.6 30
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24