Development Level

Tbio 10,082 | 10,625
Tdark 4,991 | 7,003
Tchem 1,812 | 1,890
Tclin 570 | 602

Collection

Eligible Kinase Proteins 127 | 134
Eligible Ion Channel Proteins 101 | 117
Eligible non-olfactory GPCR Proteins 89 | 145

IMPC Term

preweaning lethality, complete... 622 | 633
preweaning lethality, incomple... 255 | 260
abnormal behavior 217 | 226
decreased lean body mass 190 | 195
embryonic lethality prior to t... 185 | 187
decreased total body fat amoun... 179 | 186
decreased body weight 168 | 174
decreased bone mineral content 153 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 125 | 131
increased or absent threshold ... 125 | 128
decreased bone mineral density 122 | 126
decreased circulating glucose ... 119 | 121
decreased grip strength 115 | 123
increased circulating alkaline... 115 | 119
abnormal embryo size 108 | 112
enlarged heart 108 | 111
decreased body length 107 | 108
hyperactivity 102 | 108
increased lean body mass 102 | 107
abnormal retina morphology 99 | 100
increased bone mineral content 90 | 92
increased mean corpuscular hem... 90 | 93
increased mean corpuscular vol... 90 | 91
decreased circulating choleste... 83 | 85
hypoactivity 83 | 89
decreased circulating triglyce... 82 | 83
increased grip strength 81 | 83
short tibia 81 | 82
decreased circulating HDL chol... 76 | 77
decreased circulating serum al... 75 | 79
decreased circulating insulin ... 71 | 75
abnormal lens morphology 70 | 73
increased circulating sodium l... 68 | 71
increased fasted circulating g... 68 | 68
abnormal sleep behavior 62 | 63
increased circulating HDL chol... 62 | 63
prenatal lethality prior to he... 62 | 64
abnormal retinal pigmentation 60 | 61
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 60 | 62
male infertility 58 | 62
decreased rib number 56 | 59
increased exploration in new e... 55 | 56
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 53 | 54
improved glucose tolerance 53 | 56
increased total body fat amoun... 53 | 57
decreased hemoglobin content 52 | 53
increased circulating choleste... 52 | 53
decreased circulating alanine ... 51 | 53
decreased prepulse inhibition 51 | 52
increased bone mineral density 51 | 52
abnormal behavioral response t... 50 | 52
abnormal bone mineralization 50 | 55
decreased mean corpuscular vol... 50 | 50
impaired glucose tolerance 50 | 52
abnormal gait 49 | 51
abnormal heart morphology 49 | 51
decreased caudal vertebrae num... 48 | 49
decreased startle reflex 48 | 48
decreased fasted circulating g... 46 | 49
thrombocytopenia 44 | 46
abnormal seminal vesicle morph... 43 | 47
increased blood urea nitrogen ... 43 | 44
increased hemoglobin content 43 | 45
decreased erythrocyte cell num... 42 | 43
decreased heart weight 42 | 44
increased body weight 42 | 42
increased rib number 41 | 41
decreased circulating total pr... 40 | 41
decreased eosinophil cell numb... 40 | 41
increased circulating chloride... 40 | 43
decreased circulating alkaline... 38 | 41
abnormal eye morphology 37 | 38
decreased circulating LDL chol... 37 | 37
decreased circulating free fat... 37 | 39
decreased neutrophil cell numb... 37 | 37
increased startle reflex 37 | 38
abnormal neural tube closure 36 | 37
increased leukocyte cell numbe... 36 | 37
abnormal spleen morphology 35 | 36
cardiovascular system phenotyp... 35 | 35
increased hematocrit 35 | 36
small testis 35 | 37
limb grasping 34 | 35
decreased mean corpuscular hem... 33 | 34
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
decreased circulating chloride... 32 | 32
tremors 32 | 34
decreased circulating creatini... 31 | 31
increased circulating potassiu... 31 | 31
increased heart weight 31 | 37
decreased T cell number 30 | 31
decreased circulating fructosa... 30 | 31
increased circulating calcium ... 30 | 32
decreased blood urea nitrogen ... 29 | 31
decreased threshold for audito... 29 | 32
increased circulating creatini... 29 | 29

Disease

ovarian cancer 8,273 | 8,492
osteosarcoma 7,659 | 7,933
psoriasis 6,224 | 6,685
medulloblastoma, large-cell 6,054 | 6,234
glioblastoma 5,454 | 5,572
lung cancer 4,380 | 4,473
atypical teratoid / rhabdoid tumor 4,271 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,233 | 3,289
malignant mesothelioma 3,095 | 3,163
Breast cancer 3,035 | 3,099
pilocytic astrocytoma 3,021 | 3,086
primitive neuroectodermal tumor 2,979 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,931 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,904 | 2,956
invasive ductal carcinoma 2,902 | 2,950
oligodendroglioma 2,798 | 2,849
lung carcinoma 2,772 | 2,844
non-small cell lung cancer 2,748 | 2,798
pediatric high grade glioma 2,662 | 2,712
lung adenocarcinoma 2,648 | 2,714
ependymoma 2,467 | 2,514
pancreatic cancer 2,261 | 2,300
interstitial cystitis 2,245 | 2,299
subependymal giant cell astrocytoma 2,234 | 2,287
astrocytic glioma 2,200 | 2,241
group 3 medulloblastoma 2,196 | 2,254
Cancer 2,177 | 2,346
adult high grade glioma 2,074 | 2,148
Carcinoma 2,054 | 2,147
ulcerative colitis 2,040 | 2,087
pituitary cancer 1,925 | 1,972
Pick disease 1,867 | 1,893
group 4 medulloblastoma 1,824 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,772 | 1,795
ductal carcinoma in situ 1,718 | 1,745
cystic fibrosis 1,641 | 1,670
breast carcinoma 1,583 | 1,614
tuberculosis 1,524 | 1,563
posterior fossa group B ependymoma 1,501 | 1,530
medulloblastoma 1,491 | 1,524
posterior fossa group A ependymoma 1,478 | 1,511
astrocytoma 1,463 | 1,493
sonic hedgehog group medulloblastoma 1,455 | 1,482
colon cancer 1,440 | 1,475
adrenocortical carcinoma 1,408 | 1,427
diabetes mellitus 1,397 | 1,663
Multiple myeloma 1,308 | 1,328
primary pancreatic ductal adenocarcinoma 1,259 | 1,271
juvenile dermatomyositis 1,166 | 1,189
acute quadriplegic myopathy 1,143 | 1,157
Rheumatoid Arthritis 1,099 | 1,171
atypical teratoid/rhabdoid tumor 1,077 | 1,095
spina bifida 1,044 | 1,064
nasopharyngeal carcinoma 1,036 | 1,056
cutaneous lupus erythematosus 1,035 | 1,056
dermatomyositis 920 | 967
Atopic dermatitis 901 | 944
active Crohn's disease 898 | 918
gastric carcinoma 819 | 832
non primary Sjogren syndrome sicca 807 | 840
acute myeloid leukemia 771 | 785
primary Sjogren syndrome 770 | 789
Waldenstrons macroglobulinemia 756 | 765
esophageal adenocarcinoma 728 | 737
tuberculosis and treatment for 6 months 675 | 686
progressive supranuclear palsy 662 | 674
aldosterone-producing adenoma 658 | 664
Alzheimer's disease 620 | 644
Obesity 592 | 616
Duchenne muscular dystrophy 586 | 602
Intellectual disability 559 | 573
pancreatic carcinoma 557 | 567
fibroadenoma 548 | 557
hepatocellular carcinoma 539 | 550
Down syndrome 536 | 548
Endometriosis 524 | 535
chronic rhinosinusitis 502 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 499
Schizophrenia 473 | 503
mucosa-associated lymphoid tissue lymphoma 465 | 480
active ulcerative colitis 463 | 477
Prostatic Neoplasms 462 | 471
IGA Glomerulonephritis 445 | 454
Multiple Sclerosis 440 | 498
Amyotrophic Lateral Sclerosis 426 | 432
gastric cancer 425 | 436
Mammary Neoplasms 404 | 410
non-small cell lung carcinoma 395 | 413
inflammatory breast cancer 390 | 404
Neurodegenerative disease 374 | 383
Kidney disease 361 | 397
Parkinson's disease 347 | 364
glioblastoma multiforme 344 | 347
sarcoidosis 344 | 368
Epilepsy 333 | 346
Asthma 327 | 349
tuberculosis and treatment for 3 months 324 | 327
nephrosclerosis 323 | 329
Polycystic Ovary Syndrome 320 | 335
hereditary spastic paraplegia 313 | 313

Tissue

Endocrine System 17,424 | 18,512
Female tissues 17,378 | 18,647
Nervous System 17,370 | 18,561
Digestive Tract 17,354 | 18,473
Urinary Tract 17,307 | 18,444
Skin and soft tissues 17,275 | 18,115
Liver and Pancreas 17,204 | 18,136
Male tissues 17,127 | 17,969
Cardiovascular System 17,105 | 17,958
Blood and immune system 17,091 | 17,995
Respiratory system 16,878 | 17,484

Target Family

Non-IDG 10,214 | 11,969
Enzyme 3,915 | 4,146
Transcription Factor 1,293 | 1,400
Kinase 613 | 634
Transporter 454 | 473
Ion Channel 313 | 341
GPCR 312 | 408
Epigenetic 236 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 35 | 38
oGPCR 23 | 421

Data Source

HPA RNA 17,455 | 17,455
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24