Development Level

Tbio 6,822 | 11,178
Tdark 1,918 | 6,569
Tchem 1,275 | 1,885
Tclin 399 | 612

Collection

Kinase: IDG Consortium (Target... 63 | 125
Ion Channel: IDG Consortium (T... 34 | 99
GPCR: IDG Consortium (Targets) 32 | 126
Kinase: IDG Consortium (Comple... 25 | 37
GPCR: IDG Consortium (Complete... 10 | 25

IMPC Phenotype

preweaning lethality, complete... 681 | 979
preweaning lethality, incomple... 297 | 499
embryonic lethality prior to t... 187 | 278
abnormal behavior 186 | 298
embryonic lethality prior to o... 170 | 239
abnormal embryo size 142 | 220
decreased total body fat amoun... 132 | 207
abnormal bone structure 119 | 187
decreased vertical activity 119 | 208
enlarged heart 118 | 210
decreased body weight 111 | 161
increased lean body mass 104 | 172
decreased bone mineral content 102 | 151
abnormal heart morphology 93 | 162
hyperactivity 90 | 148
hypoactivity 89 | 132
increased total body fat amoun... 86 | 134
decreased lean body mass 80 | 135
decreased bone mineral density 79 | 126
increased circulating alkaline... 75 | 122
male infertility 72 | 123
decreased circulating glucose ... 71 | 126
increased startle reflex 71 | 112
abnormal seminal vesicle morph... 68 | 114
decreased grip strength 68 | 116
embryonic growth retardation 67 | 106
increased bone mineral content 67 | 108
increased or absent threshold ... 66 | 101
prenatal lethality prior to he... 63 | 87
decreased body length 62 | 101
increased mean corpuscular vol... 61 | 92
increased mean corpuscular hem... 60 | 96
decreased circulating choleste... 56 | 93
short tibia 56 | 97
cataract 54 | 92
improved glucose tolerance 53 | 79
decreased circulating triglyce... 51 | 79
decreased lymphocyte cell numb... 51 | 83
decreased prepulse inhibition 51 | 82
abnormal sleep behavior 50 | 70
decreased circulating serum al... 50 | 82
abnormal lens morphology 49 | 81
decreased mean corpuscular vol... 49 | 79
decreased leukocyte cell numbe... 48 | 73
impaired glucose tolerance 48 | 75
abnormal retina morphology 46 | 71
increased circulating HDL chol... 46 | 80
decreased startle reflex 45 | 75
increased fasted circulating g... 45 | 76
small superior vagus ganglion 45 | 74
increased bone mineral density 44 | 72
decreased erythrocyte cell num... 43 | 62
decreased hemoglobin content 43 | 68
abnormal gait 42 | 69
decreased circulating insulin ... 42 | 76
increased circulating choleste... 42 | 66
abnormal behavioral response t... 41 | 66
decreased circulating HDL chol... 41 | 68
abnormal coat-hair pigmentatio... 40 | 64
abnormal kidney morphology 40 | 65
edema 39 | 59
increased circulating sodium l... 39 | 71
thrombocytopenia 39 | 56
abnormal eye morphology 38 | 68
increased heart weight 38 | 62
decreased fasted circulating g... 36 | 65
increased monocyte cell number 36 | 63
small testis 35 | 58
abnormal spleen morphology 33 | 55
decreased caudal vertebrae num... 33 | 53
decreased circulating alkaline... 33 | 46
decreased circulating total pr... 33 | 49
abnormal skin morphology 32 | 50
hydrometra 32 | 53
increased neutrophil cell numb... 31 | 46
abnormal neural tube closure 30 | 46
cardiovascular system phenotyp... 30 | 36
decreased circulating LDL chol... 30 | 38
decreased circulating alanine ... 30 | 47
female infertility 30 | 60
increased blood urea nitrogen ... 30 | 48
increased leukocyte cell numbe... 30 | 47
increased circulating chloride... 29 | 41
increased erythrocyte cell num... 29 | 39
decreased hematocrit 28 | 46
increased hemoglobin content 28 | 45
increased mean platelet volume 28 | 45
tremors 28 | 39
decreased mean corpuscular hem... 27 | 50
decreased neutrophil cell numb... 27 | 42
enlarged lymph nodes 27 | 37
increased grip strength 27 | 41
decreased blood urea nitrogen ... 26 | 51
decreased red blood cell distr... 26 | 41
enlarged spleen 26 | 41
abnormal cranium morphology 25 | 36
increased hematocrit 25 | 46
prolonged ST segment 25 | 36
increased circulating iron lev... 24 | 30
increased prepulse inhibition 24 | 32

Disease

Carcinoma 6,355 | 11,192
ovarian cancer 5,324 | 8,297
osteosarcoma 4,704 | 7,766
psoriasis 3,850 | 6,514
medulloblastoma, large-cell 3,711 | 6,086
glioblastoma 3,522 | 5,635
lung cancer 3,047 | 4,607
atypical teratoid / rhabdoid tumor 3,008 | 4,971
ependymoma 2,794 | 4,559
group 3 medulloblastoma 2,456 | 4,002
Breast cancer 2,224 | 3,469
adult high grade glioma 2,211 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 2,094 | 3,204
malignant mesothelioma 2,029 | 3,135
intraductal papillary-mucinous carcinoma (IPMC) 1,890 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 1,859 | 2,872
Astrocytoma, Pilocytic 1,836 | 3,006
invasive ductal carcinoma 1,818 | 2,867
non-small cell lung cancer 1,801 | 2,799
primitive neuroectodermal tumor 1,785 | 2,957
oligodendroglioma 1,736 | 2,768
lung carcinoma 1,688 | 2,755
lung adenocarcinoma 1,666 | 2,627
Cancer 1,664 | 2,388
astrocytic glioma 1,572 | 2,530
pancreatic cancer 1,546 | 2,322
Kidney cancer 1,537 | 2,548
subependymal giant cell astrocytoma 1,447 | 2,230
interstitial cystitis 1,388 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,330 | 1,911
tuberculosis 1,223 | 1,963
Pick disease 1,207 | 1,856
pituitary cancer 1,164 | 1,915
ulcerative colitis 1,141 | 1,765
group 4 medulloblastoma 1,092 | 1,806
ductal carcinoma in situ 1,063 | 1,686
breast carcinoma 1,038 | 1,589
Autosomal recessive predisposition 1,026 | 1,407
diabetes mellitus 1,020 | 1,683
cystic fibrosis 987 | 1,629
Multiple myeloma 971 | 1,296
colon cancer 947 | 1,428
adrenocortical carcinoma 863 | 1,385
astrocytoma 822 | 1,113
juvenile dermatomyositis 804 | 1,147
acute quadriplegic myopathy 788 | 1,133
Rheumatoid arthritis 752 | 1,156
Schizophrenia 739 | 1,136
primary pancreatic ductal adenocarcinoma 719 | 1,071
nasopharyngeal carcinoma 687 | 1,024
Intellectual disability 684 | 998
spina bifida 675 | 1,053
dermatomyositis 669 | 941
pediatric high grade glioma 662 | 1,035
cutaneous lupus erythematosus 657 | 1,016
Waldenstrons macroglobulinemia 591 | 742
Atopic dermatitis 571 | 915
Epilepsy 566 | 775
active Crohn's disease 559 | 882
acute myeloid leukemia 526 | 760
Liver Cirrhosis, Experimental 516 | 733
non primary Sjogren syndrome sicca 513 | 861
gastric carcinoma 505 | 781
esophageal adenocarcinoma 504 | 696
primary Sjogren syndrome 480 | 710
active ulcerative colitis 473 | 736
Dull intelligence 451 | 634
Low intelligence 451 | 634
Mental Retardation 451 | 634
Mental deficiency 451 | 634
Poor school performance 451 | 634
Seizures 445 | 584
Cognitive delay 437 | 596
Global developmental delay 437 | 596
Mental and motor retardation 437 | 596
progressive supranuclear palsy 435 | 656
Alzheimer's disease 433 | 640
aldosterone-producing adenoma 429 | 646
Obesity 426 | 655
Muscle hypotonia 423 | 562
medulloblastoma 414 | 702
Bipolar Disorder 413 | 646
Duchenne muscular dystrophy 408 | 587
Melanoma 405 | 689
pancreatic carcinoma 383 | 555
Short stature 365 | 514
Prostatic Neoplasms 349 | 472
Down syndrome 346 | 480
Liver cancer 343 | 589
autosomal dominant Emery-Dreifuss muscular dystrophy 341 | 492
Endometriosis 331 | 521
hepatocellular carcinoma 331 | 536
fibroadenoma 325 | 538
Multiple Sclerosis 319 | 527
Amyotrophic lateral sclerosis 317 | 437
mucosa-associated lymphoid tissue lymphoma 312 | 473
chronic rhinosinusitis 310 | 505
Breast Neoplasms 303 | 423
Neurodegenerative disease 295 | 402
gastric cancer 291 | 445

Tissue

Endocrine System 10,313 | 18,159
Digestive Tract 10,112 | 17,369
Female tissues 10,111 | 17,400
Skin and soft tissues 10,072 | 17,230
Male tissues 10,040 | 17,142
Blood and immune system 9,931 | 16,909
Liver and Pancreas 9,897 | 16,750
Urinary Tract 9,888 | 16,678
Nervous System 9,878 | 16,725
Respiratory system 9,748 | 16,393
Cardiovascular System 9,305 | 15,192

Target Family

Non-IDG 6,099 | 12,091
Enzyme 2,528 | 4,145
Transcription Factor 577 | 1,400
Kinase 431 | 634
Transporter 267 | 473
Epigenetic 160 | 242
Ion Channel 158 | 344
GPCR 151 | 408
Nuclear Receptor 24 | 48
TF/Epigenetic 18 | 38
oGPCR 1 | 421

Data Source

HPA Protein 10,414 | 10,414
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen B1 MAGEB1 Tbio Non-IDG -0.95979 9.05 218
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135