Development Level

Tbio 3,430 | 10,625
Tchem 730 | 1,890
Tdark 686 | 7,003
Tclin 214 | 602

Collection

Eligible Kinase Proteins 32 | 134
Eligible Ion Channel Proteins 16 | 117
Eligible non-olfactory GPCR Proteins 10 | 145

IMPC Term

preweaning lethality, complete... 230 | 633
preweaning lethality, incomple... 98 | 260
decreased body weight 69 | 174
decreased lean body mass 68 | 195
abnormal behavior 67 | 226
decreased total body fat amoun... 64 | 186
embryonic lethality prior to t... 58 | 187
embryonic lethality prior to o... 55 | 148
increased circulating alkaline... 48 | 119
decreased grip strength 47 | 123
decreased bone mineral content 45 | 157
abnormal embryo size 43 | 112
decreased bone mineral density 42 | 126
increased or absent threshold ... 42 | 128
decreased body length 40 | 108
abnormal bone structure 39 | 131
abnormal retina morphology 38 | 100
increased lean body mass 38 | 107
decreased circulating glucose ... 36 | 121
decreased circulating triglyce... 35 | 83
decreased circulating HDL chol... 34 | 77
decreased circulating choleste... 34 | 85
hyperactivity 31 | 108
hypoactivity 29 | 89
abnormal lens morphology 27 | 73
decreased circulating serum al... 27 | 79
increased mean corpuscular hem... 27 | 93
enlarged heart 24 | 111
increased fasted circulating g... 24 | 68
increased mean corpuscular vol... 24 | 91
increased grip strength 23 | 83
increased bone mineral content 22 | 92
increased circulating sodium l... 22 | 71
abnormal retinal pigmentation 21 | 61
decreased leukocyte cell numbe... 21 | 54
prenatal lethality prior to he... 21 | 64
decreased circulating insulin ... 20 | 75
decreased erythrocyte cell num... 20 | 43
increased blood urea nitrogen ... 20 | 44
increased exploration in new e... 20 | 56
abnormal sleep behavior 19 | 63
decreased fasted circulating g... 19 | 49
increased circulating HDL chol... 19 | 63
increased circulating choleste... 19 | 53
short tibia 19 | 82
abnormal bone mineralization 18 | 55
decreased circulating LDL chol... 18 | 37
impaired glucose tolerance 18 | 52
increased circulating chloride... 18 | 43
male infertility 18 | 62
abnormal coat/hair pigmentatio... 17 | 54
decreased hemoglobin content 17 | 53
increased total body fat amoun... 17 | 57
increased body weight 16 | 42
increased bone mineral density 16 | 52
increased circulating creatini... 16 | 29
decreased circulating alanine ... 15 | 53
decreased circulating free fat... 15 | 39
decreased mean corpuscular vol... 15 | 50
improved glucose tolerance 15 | 56
increased hemoglobin content 15 | 45
abnormal behavioral response t... 14 | 52
abnormal neural tube closure 14 | 37
abnormal seminal vesicle morph... 14 | 47
decreased lumbar vertebrae num... 14 | 62
thrombocytopenia 14 | 46
abnormal tooth morphology 13 | 24
decreased circulating alkaline... 13 | 41
decreased circulating fructosa... 13 | 31
decreased circulating sodium l... 13 | 18
decreased circulating total pr... 13 | 41
decreased heart weight 13 | 44
decreased prepulse inhibition 13 | 52
decreased rib number 13 | 59
decreased startle reflex 13 | 48
increased startle reflex 13 | 38
limb grasping 13 | 35
tremors 13 | 34
cardiovascular system phenotyp... 12 | 35
decreased caudal vertebrae num... 12 | 49
decreased circulating amylase ... 12 | 24
decreased neutrophil cell numb... 12 | 37
increased sacral vertebrae num... 12 | 62
abnormal cornea morphology 11 | 24
abnormal gait 11 | 51
decreased circulating calcium ... 11 | 33
decreased circulating iron lev... 11 | 25
decreased eosinophil cell numb... 11 | 41
decreased mean corpuscular hem... 11 | 34
increased circulating potassiu... 11 | 31
increased circulating total pr... 11 | 20
increased heart weight 11 | 37
increased rib number 11 | 41
small testis 11 | 37
abnormal epididymis morphology 10 | 31
enlarged epididymis 10 | 27
increased circulating calcium ... 10 | 32
increased circulating serum al... 10 | 25
increased erythrocyte cell num... 10 | 26
thrombocytosis 10 | 23

Disease

ovarian cancer 2,780 | 8,492
osteosarcoma 2,392 | 7,933
psoriasis 2,056 | 6,685
medulloblastoma, large-cell 1,884 | 6,234
glioblastoma 1,732 | 5,572
lung cancer 1,640 | 4,473
atypical teratoid / rhabdoid tumor 1,306 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,115 | 3,289
Cancer 1,070 | 2,346
malignant mesothelioma 1,063 | 3,163
Breast cancer 1,039 | 3,099
intraductal papillary-mucinous carcinoma (IPMC) 988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 970 | 2,956
non-small cell lung cancer 962 | 2,798
pilocytic astrocytoma 945 | 3,086
invasive ductal carcinoma 940 | 2,950
primitive neuroectodermal tumor 928 | 3,031
lung adenocarcinoma 918 | 2,714
oligodendroglioma 891 | 2,849
lung carcinoma 876 | 2,844
pediatric high grade glioma 850 | 2,712
pancreatic cancer 821 | 2,300
subependymal giant cell astrocytoma 769 | 2,287
ependymoma 765 | 2,514
interstitial cystitis 762 | 2,299
ulcerative colitis 760 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 694 | 1,795
group 3 medulloblastoma 666 | 2,254
astrocytic glioma 659 | 2,241
Carcinoma 632 | 2,147
adult high grade glioma 612 | 2,148
astrocytoma 604 | 1,493
Multiple myeloma 600 | 1,328
diabetes mellitus 593 | 1,663
pituitary cancer 591 | 1,972
Pick disease 585 | 1,893
ductal carcinoma in situ 573 | 1,745
colon cancer 566 | 1,475
breast carcinoma 558 | 1,614
cystic fibrosis 543 | 1,670
tuberculosis 525 | 1,563
group 4 medulloblastoma 520 | 1,875
posterior fossa group A ependymoma 484 | 1,511
medulloblastoma 477 | 1,524
adrenocortical carcinoma 454 | 1,427
sonic hedgehog group medulloblastoma 450 | 1,482
acute quadriplegic myopathy 448 | 1,157
primary pancreatic ductal adenocarcinoma 443 | 1,271
juvenile dermatomyositis 432 | 1,189
posterior fossa group B ependymoma 413 | 1,530
dermatomyositis 411 | 967
Rheumatoid Arthritis 406 | 1,171
nasopharyngeal carcinoma 396 | 1,056
Waldenstrons macroglobulinemia 392 | 765
cutaneous lupus erythematosus 371 | 1,056
atypical teratoid/rhabdoid tumor 356 | 1,095
spina bifida 326 | 1,064
active Crohn's disease 321 | 918
Atopic dermatitis 312 | 944
esophageal adenocarcinoma 306 | 737
non primary Sjogren syndrome sicca 281 | 840
acute myeloid leukemia 278 | 785
gastric carcinoma 278 | 832
primary Sjogren syndrome 264 | 789
Alzheimer's disease 248 | 644
aldosterone-producing adenoma 241 | 664
Down syndrome 231 | 548
Prostatic Neoplasms 224 | 471
Obesity 221 | 616
progressive supranuclear palsy 221 | 674
Duchenne muscular dystrophy 217 | 602
tuberculosis and treatment for 6 months 202 | 686
pancreatic carcinoma 201 | 567
Intellectual disability 200 | 573
Endometriosis 195 | 535
IGA Glomerulonephritis 192 | 454
mucosa-associated lymphoid tissue lymphoma 186 | 480
Mammary Neoplasms 185 | 410
autosomal dominant Emery-Dreifuss muscular dystrophy 184 | 499
Amyotrophic Lateral Sclerosis 182 | 432
Kidney disease 182 | 397
Schizophrenia 171 | 503
fibroadenoma 169 | 557
hepatocellular carcinoma 167 | 550
chronic rhinosinusitis 160 | 512
Neurodegenerative disease 158 | 383
gastric cancer 151 | 436
active ulcerative colitis 146 | 477
Multiple Sclerosis 144 | 498
nephrosclerosis 140 | 329
non-small cell lung carcinoma 140 | 413
Heart disease 138 | 279
Hypertension 138 | 293
Asthma 136 | 349
Parkinson's disease 136 | 364
Stomach Neoplasms 135 | 282
hereditary spastic paraplegia 134 | 313
Epilepsy 127 | 346
sarcoidosis 127 | 368
Atherosclerosis 124 | 275

Tissue

Endocrine System 5,057 | 18,512
Female tissues 5,051 | 18,647
Digestive Tract 5,050 | 18,473
Nervous System 5,050 | 18,561
Urinary Tract 5,040 | 18,444
Male tissues 5,039 | 17,969
Skin and soft tissues 5,037 | 18,115
Liver and Pancreas 5,029 | 18,136
Blood and immune system 5,016 | 17,995
Cardiovascular System 5,005 | 17,958
Respiratory system 4,968 | 17,484

Target Family

Non-IDG 2,955 | 11,969
Enzyme 1,302 | 4,146
Transcription Factor 296 | 1,400
Kinase 182 | 634
Transporter 105 | 473
Epigenetic 92 | 242
Ion Channel 63 | 341
GPCR 40 | 408
Nuclear Receptor 12 | 48
TF/Epigenetic 12 | 38
oGPCR 1 | 421

Data Source

HPA Protein 5,060 | 5,060
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
Serine/threonine-protein kinase RIO1 RIOK1 Tchem Kinase -0.72835 5.14 142
Ubiquitin-associated domain-containing protein 1 UBAC1 Tbio Non-IDG -2.56341 358.4 116
Homeobox protein Nkx-3.1 NKX3-1 Tbio Transcription Factor -2.10264 130.3 456
Small proline-rich protein 4 SPRR4 Tdark Non-IDG -0.32647 2.13 6
Syncollin SYCN Tdark Non-IDG -2.12341 132.9 35