Development Level

Tbio 7,010 | 11,445
Tdark 1,924 | 6,588
Tchem 1,080 | 1,598
Tclin 400 | 613

Collection

RFA-RM-18-021 128 | 328
Kinase: IDG Consortium (Target... 63 | 125
Ion Channel: IDG Consortium (T... 34 | 99
GPCR: IDG Consortium (Targets) 32 | 126
Kinase: IDG Consortium (Comple... 25 | 37
GPCR: IDG Consortium (Complete... 10 | 25

IMPC Phenotype

preweaning lethality, complete... 681 | 979
preweaning lethality, incomple... 297 | 499
embryonic lethality prior to t... 187 | 278
abnormal behavior 186 | 298
embryonic lethality prior to o... 170 | 239
abnormal embryo size 142 | 220
decreased total body fat amoun... 132 | 207
abnormal bone structure 119 | 187
decreased vertical activity 119 | 208
enlarged heart 118 | 210
decreased body weight 111 | 161
increased lean body mass 104 | 172
decreased bone mineral content 102 | 151
abnormal heart morphology 93 | 162
hyperactivity 90 | 148
hypoactivity 89 | 132
increased total body fat amoun... 86 | 134
decreased lean body mass 80 | 135
decreased bone mineral density 79 | 126
increased circulating alkaline... 75 | 122
male infertility 72 | 123
decreased circulating glucose ... 71 | 126
increased startle reflex 71 | 112
abnormal seminal vesicle morph... 68 | 114
decreased grip strength 68 | 116
embryonic growth retardation 67 | 106
increased bone mineral content 67 | 108
increased or absent threshold ... 66 | 101
prenatal lethality prior to he... 63 | 87
decreased body length 62 | 101
increased mean corpuscular vol... 61 | 92
increased mean corpuscular hem... 60 | 96
decreased circulating choleste... 56 | 93
short tibia 56 | 97
cataract 54 | 92
improved glucose tolerance 53 | 79
decreased circulating triglyce... 51 | 79
decreased lymphocyte cell numb... 51 | 83
decreased prepulse inhibition 51 | 82
abnormal sleep behavior 50 | 70
decreased circulating serum al... 50 | 82
abnormal lens morphology 49 | 81
decreased mean corpuscular vol... 49 | 79
decreased leukocyte cell numbe... 48 | 73
impaired glucose tolerance 48 | 75
abnormal retina morphology 46 | 71
increased circulating HDL chol... 46 | 80
decreased startle reflex 45 | 75
increased fasted circulating g... 45 | 76
small superior vagus ganglion 45 | 74
increased bone mineral density 44 | 72
decreased erythrocyte cell num... 43 | 62
decreased hemoglobin content 43 | 68
abnormal gait 42 | 69
decreased circulating insulin ... 42 | 76
increased circulating choleste... 42 | 66
abnormal behavioral response t... 41 | 66
decreased circulating HDL chol... 41 | 68
abnormal coat-hair pigmentatio... 40 | 64
abnormal kidney morphology 40 | 65
edema 39 | 59
increased circulating sodium l... 39 | 71
thrombocytopenia 39 | 56
abnormal eye morphology 38 | 68
increased heart weight 38 | 62
decreased fasted circulating g... 36 | 65
increased monocyte cell number 36 | 63
small testis 35 | 58
abnormal spleen morphology 33 | 55
decreased caudal vertebrae num... 33 | 53
decreased circulating alkaline... 33 | 46
decreased circulating total pr... 33 | 49
abnormal skin morphology 32 | 50
hydrometra 32 | 53
increased neutrophil cell numb... 31 | 46
abnormal neural tube closure 30 | 46
cardiovascular system phenotyp... 30 | 36
decreased circulating LDL chol... 30 | 38
decreased circulating alanine ... 30 | 47
female infertility 30 | 60
increased blood urea nitrogen ... 30 | 48
increased leukocyte cell numbe... 30 | 47
increased circulating chloride... 29 | 41
increased erythrocyte cell num... 29 | 39
decreased hematocrit 28 | 46
increased hemoglobin content 28 | 45
increased mean platelet volume 28 | 45
tremors 28 | 39
decreased mean corpuscular hem... 27 | 50
decreased neutrophil cell numb... 27 | 42
enlarged lymph nodes 27 | 37
increased grip strength 27 | 41
decreased blood urea nitrogen ... 26 | 51
decreased red blood cell distr... 26 | 41
enlarged spleen 26 | 41
abnormal cranium morphology 25 | 36
increased hematocrit 25 | 46
prolonged ST segment 25 | 36
increased circulating iron lev... 24 | 30
increased prepulse inhibition 24 | 32

Disease

Carcinoma 6,514 | 11,493
ovarian cancer 5,471 | 8,520
osteosarcoma 4,814 | 7,950
psoriasis 3,946 | 6,694
medulloblastoma, large-cell 3,805 | 6,241
glioblastoma 3,618 | 5,792
lung cancer 3,134 | 4,740
atypical teratoid / rhabdoid tumor 3,097 | 5,112
ependymoma 2,865 | 4,679
group 3 medulloblastoma 2,516 | 4,104
Breast cancer 2,299 | 3,578
adult high grade glioma 2,267 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 2,148 | 3,291
malignant mesothelioma 2,083 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,948 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,907 | 2,955
Astrocytoma, Pilocytic 1,882 | 3,081
invasive ductal carcinoma 1,869 | 2,951
non-small cell lung cancer 1,852 | 2,890
primitive neuroectodermal tumor 1,833 | 3,035
oligodendroglioma 1,782 | 2,850
lung carcinoma 1,747 | 2,843
Cancer 1,740 | 2,499
lung adenocarcinoma 1,717 | 2,716
astrocytic glioma 1,610 | 2,597
pancreatic cancer 1,592 | 2,398
Kidney cancer 1,574 | 2,613
subependymal giant cell astrocytoma 1,482 | 2,287
interstitial cystitis 1,430 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,366 | 1,962
tuberculosis 1,252 | 2,010
Pick disease 1,231 | 1,894
pituitary cancer 1,191 | 1,972
ulcerative colitis 1,174 | 1,819
group 4 medulloblastoma 1,119 | 1,855
ductal carcinoma in situ 1,100 | 1,745
breast carcinoma 1,073 | 1,638
diabetes mellitus 1,053 | 1,728
Autosomal recessive predisposition 1,048 | 1,442
cystic fibrosis 1,021 | 1,696
Multiple myeloma 1,004 | 1,332
colon cancer 981 | 1,478
adrenocortical carcinoma 886 | 1,428
astrocytoma 841 | 1,146
juvenile dermatomyositis 832 | 1,187
acute quadriplegic myopathy 807 | 1,158
Rheumatoid arthritis 774 | 1,191
Schizophrenia 755 | 1,160
primary pancreatic ductal adenocarcinoma 743 | 1,109
nasopharyngeal carcinoma 708 | 1,058
Intellectual disability 698 | 1,016
dermatomyositis 688 | 966
spina bifida 683 | 1,074
pediatric high grade glioma 682 | 1,064
cutaneous lupus erythematosus 677 | 1,057
Waldenstrons macroglobulinemia 612 | 765
Atopic dermatitis 591 | 952
active Crohn's disease 582 | 922
Epilepsy 580 | 792
Liver Cirrhosis, Experimental 543 | 769
acute myeloid leukemia 542 | 783
non primary Sjogren syndrome sicca 532 | 891
esophageal adenocarcinoma 531 | 737
gastric carcinoma 523 | 807
primary Sjogren syndrome 498 | 735
active ulcerative colitis 487 | 764
Dull intelligence 460 | 645
Low intelligence 460 | 645
Mental Retardation 460 | 645
Mental deficiency 460 | 645
Poor school performance 460 | 645
Seizures 456 | 596
progressive supranuclear palsy 449 | 676
Alzheimer's disease 448 | 658
Cognitive delay 447 | 608
Global developmental delay 447 | 608
Mental and motor retardation 447 | 608
aldosterone-producing adenoma 443 | 665
Obesity 442 | 678
Muscle hypotonia 432 | 571
medulloblastoma 428 | 720
Bipolar Disorder 422 | 666
Duchenne muscular dystrophy 419 | 601
Melanoma 416 | 711
pancreatic carcinoma 388 | 562
Short stature 377 | 531
Prostatic Neoplasms 364 | 495
Down syndrome 359 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 353 | 510
Liver cancer 351 | 604
Endometriosis 345 | 540
hepatocellular carcinoma 341 | 547
fibroadenoma 334 | 559
Multiple Sclerosis 330 | 540
Amyotrophic lateral sclerosis 328 | 451
mucosa-associated lymphoid tissue lymphoma 319 | 484
Breast Neoplasms 318 | 445
chronic rhinosinusitis 315 | 512
Mammary Neoplasms 306 | 425
Neurodegenerative disease 304 | 414

Tissue

Endocrine System 10,313 | 18,159
Digestive Tract 10,112 | 17,369
Female tissues 10,111 | 17,400
Skin and soft tissues 10,072 | 17,230
Male tissues 10,040 | 17,142
Blood and immune system 9,931 | 16,909
Liver and Pancreas 9,897 | 16,750
Urinary Tract 9,888 | 16,678
Nervous System 9,878 | 16,725
Respiratory system 9,748 | 16,393
Cardiovascular System 9,305 | 15,192

Target Family

Non-IDG 6,099 | 12,091
Enzyme 2,528 | 4,145
Transcription Factor 577 | 1,400
Kinase 431 | 634
Transporter 267 | 473
Epigenetic 160 | 242
Ion Channel 158 | 344
GPCR 151 | 408
Nuclear Receptor 24 | 48
TF/Epigenetic 18 | 38
oGPCR 1 | 421

Data Source

HPA Protein 10,414 | 10,414
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Fibrosin-1-like protein FBRSL1 Tdark Non-IDG 0.48 0.50 58