Development Level

Tbio 11,357 | 11,445
Tdark 5,305 | 6,588
Tchem 1,596 | 1,598
Tclin 610 | 613

Collection

RFA-RM-18-021 323 | 328
Kinase: IDG Consortium (Target... 125 | 125
GPCR: IDG Consortium (Targets) 122 | 126
Ion Channel: IDG Consortium (T... 98 | 99
Kinase: IDG Consortium (Comple... 37 | 37
GPCR: IDG Consortium (Complete... 25 | 25

IMPC Phenotype

preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 498 | 499
abnormal behavior 297 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 147 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 80 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 74 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
increased circulating sodium l... 71 | 71
abnormal retina morphology 70 | 71
abnormal gait 69 | 69
abnormal sleep behavior 69 | 70
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
increased circulating choleste... 66 | 66
abnormal behavioral response t... 65 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
edema 59 | 59
female infertility 59 | 60
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hematocrit 45 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
abnormal epididymis morphology 41 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 11,292 | 11,493
ovarian cancer 8,453 | 8,520
osteosarcoma 7,833 | 7,950
psoriasis 6,590 | 6,694
medulloblastoma, large-cell 6,189 | 6,241
glioblastoma 5,763 | 5,792
atypical teratoid / rhabdoid tumor 5,086 | 5,112
lung cancer 4,697 | 4,740
ependymoma 4,659 | 4,679
group 3 medulloblastoma 4,080 | 4,104
adult high grade glioma 3,776 | 3,801
Breast cancer 3,554 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,265 | 3,291
malignant mesothelioma 3,215 | 3,232
Astrocytoma, Pilocytic 3,072 | 3,081
primitive neuroectodermal tumor 3,024 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,968 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,939 | 2,955
invasive ductal carcinoma 2,939 | 2,951
non-small cell lung cancer 2,874 | 2,890
oligodendroglioma 2,840 | 2,850
lung carcinoma 2,816 | 2,843
lung adenocarcinoma 2,686 | 2,716
Kidney cancer 2,596 | 2,613
astrocytic glioma 2,585 | 2,597
Cancer 2,459 | 2,499
pancreatic cancer 2,384 | 2,398
interstitial cystitis 2,281 | 2,312
subependymal giant cell astrocytoma 2,274 | 2,287
tuberculosis 1,988 | 2,010
pituitary cancer 1,962 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,955 | 1,962
Pick disease 1,888 | 1,894
group 4 medulloblastoma 1,847 | 1,855
ulcerative colitis 1,794 | 1,819
ductal carcinoma in situ 1,739 | 1,745
cystic fibrosis 1,686 | 1,696
diabetes mellitus 1,662 | 1,728
breast carcinoma 1,625 | 1,638
colon cancer 1,461 | 1,478
Autosomal recessive predisposition 1,438 | 1,442
adrenocortical carcinoma 1,420 | 1,428
Multiple myeloma 1,319 | 1,332
Rheumatoid arthritis 1,185 | 1,191
juvenile dermatomyositis 1,184 | 1,187
acute quadriplegic myopathy 1,156 | 1,158
Schizophrenia 1,145 | 1,160
astrocytoma 1,142 | 1,146
primary pancreatic ductal adenocarcinoma 1,105 | 1,109
spina bifida 1,070 | 1,074
pediatric high grade glioma 1,059 | 1,064
nasopharyngeal carcinoma 1,052 | 1,058
cutaneous lupus erythematosus 1,046 | 1,057
Intellectual disability 1,015 | 1,016
dermatomyositis 964 | 966
Atopic dermatitis 944 | 952
active Crohn's disease 915 | 922
non primary Sjogren syndrome sicca 881 | 891
gastric carcinoma 799 | 807
Epilepsy 791 | 792
acute myeloid leukemia 782 | 783
Liver Cirrhosis, Experimental 767 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 756 | 764
esophageal adenocarcinoma 734 | 737
primary Sjogren syndrome 727 | 735
medulloblastoma 715 | 720
Melanoma 708 | 711
Obesity 673 | 678
progressive supranuclear palsy 671 | 676
aldosterone-producing adenoma 665 | 665
Bipolar Disorder 661 | 666
Alzheimer's disease 649 | 658
Dull intelligence 644 | 645
Low intelligence 644 | 645
Mental Retardation 644 | 645
Mental deficiency 644 | 645
Poor school performance 644 | 645
Cognitive delay 607 | 608
Global developmental delay 607 | 608
Mental and motor retardation 607 | 608
Liver cancer 599 | 604
Duchenne muscular dystrophy 597 | 601
Seizures 596 | 596
Muscle hypotonia 570 | 571
pancreatic carcinoma 559 | 562
fibroadenoma 556 | 559
hepatocellular carcinoma 544 | 547
Endometriosis 538 | 540
Multiple Sclerosis 534 | 540
Short stature 529 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 508 | 510
chronic rhinosinusitis 508 | 512
Down syndrome 495 | 499
Prostatic Neoplasms 493 | 495
mucosa-associated lymphoid tissue lymphoma 476 | 484
Skin cancer 466 | 469
posterior fossa group A ependymoma 465 | 468
sonic hedgehog group medulloblastoma 464 | 467
gastric cancer 456 | 459

Tissue

Endocrine System 18,067 | 18,159
Female tissues 17,354 | 17,400
Digestive Tract 17,328 | 17,369
Skin and soft tissues 17,191 | 17,230
Male tissues 17,092 | 17,142
Blood and immune system 16,868 | 16,909
Liver and Pancreas 16,717 | 16,750
Nervous System 16,694 | 16,725
Urinary Tract 16,647 | 16,678
Respiratory system 16,358 | 16,393
Cardiovascular System 15,173 | 15,192

Target Family

Non-IDG 11,017 | 12,091
Enzyme 4,041 | 4,145
Transcription Factor 1,394 | 1,400
Kinase 630 | 634
Transporter 466 | 473
GPCR 397 | 408
Ion Channel 340 | 344
oGPCR 255 | 421
Epigenetic 242 | 242
Nuclear Receptor 48 | 48
TF/Epigenetic 38 | 38

Data Source

HCA RNA 18,868 | 18,868
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93