Development Level

Tbio 3,212 | 10,625
Tdark 1,085 | 7,003
Tchem 640 | 1,890
Tclin 239 | 602

Collection

Eligible Kinase Proteins 44 | 134
Eligible Ion Channel Proteins 39 | 117
Eligible non-olfactory GPCR Proteins 13 | 145

IMPC Term

preweaning lethality, complete... 185 | 633
preweaning lethality, incomple... 96 | 260
abnormal behavior 81 | 226
decreased lean body mass 79 | 195
decreased body weight 66 | 174
decreased bone mineral content 59 | 157
decreased total body fat amoun... 59 | 186
embryonic lethality prior to t... 56 | 187
decreased bone mineral density 55 | 126
decreased grip strength 53 | 123
abnormal bone structure 51 | 131
increased circulating alkaline... 49 | 119
abnormal retina morphology 44 | 100
decreased body length 43 | 108
decreased circulating glucose ... 42 | 121
hypoactivity 41 | 89
increased or absent threshold ... 40 | 128
decreased circulating HDL chol... 39 | 77
increased lean body mass 38 | 107
decreased circulating choleste... 37 | 85
hyperactivity 37 | 108
increased mean corpuscular vol... 36 | 91
abnormal embryo size 35 | 112
decreased circulating serum al... 34 | 79
short tibia 34 | 82
abnormal lens morphology 33 | 73
embryonic lethality prior to o... 33 | 148
increased mean corpuscular hem... 33 | 93
decreased circulating triglyce... 30 | 83
abnormal bone mineralization 29 | 55
increased bone mineral content 29 | 92
enlarged heart 28 | 111
decreased prepulse inhibition 27 | 52
decreased hemoglobin content 25 | 53
increased circulating sodium l... 25 | 71
increased grip strength 25 | 83
abnormal retinal pigmentation 23 | 61
decreased lumbar vertebrae num... 23 | 62
decreased rib number 23 | 59
increased circulating HDL chol... 23 | 63
increased fasted circulating g... 23 | 68
decreased circulating insulin ... 22 | 75
increased startle reflex 22 | 38
male infertility 22 | 62
decreased circulating alanine ... 21 | 53
decreased heart weight 21 | 44
impaired glucose tolerance 21 | 52
increased body weight 21 | 42
increased circulating choleste... 21 | 53
abnormal sleep behavior 20 | 63
decreased mean corpuscular vol... 20 | 50
increased rib number 20 | 41
increased sacral vertebrae num... 20 | 62
prenatal lethality prior to he... 20 | 64
thrombocytopenia 20 | 46
abnormal gait 19 | 51
decreased circulating free fat... 19 | 39
decreased circulating total pr... 19 | 41
increased blood urea nitrogen ... 19 | 44
increased bone mineral density 19 | 52
increased total body fat amoun... 19 | 57
abnormal coat/hair pigmentatio... 18 | 54
improved glucose tolerance 18 | 56
abnormal seminal vesicle morph... 17 | 47
abnormal cranium morphology 16 | 32
decreased circulating LDL chol... 16 | 37
decreased circulating alkaline... 16 | 41
decreased eosinophil cell numb... 16 | 41
decreased erythrocyte cell num... 16 | 43
decreased startle reflex 16 | 48
female infertility 16 | 34
increased exploration in new e... 16 | 56
decreased blood urea nitrogen ... 15 | 31
decreased caudal vertebrae num... 15 | 49
decreased leukocyte cell numbe... 15 | 54
tremors 15 | 34
abnormal heart morphology 14 | 51
cardiovascular system phenotyp... 14 | 35
decreased T cell number 14 | 31
increased leukocyte cell numbe... 14 | 37
small testis 14 | 37
abnormal locomotor activation 13 | 26
abnormal spleen morphology 13 | 36
abnormal testis morphology 13 | 30
decreased circulating aspartat... 13 | 27
decreased fasted circulating g... 13 | 49
decreased mean corpuscular hem... 13 | 34
increased circulating chloride... 13 | 43
increased hemoglobin content 13 | 45
persistence of hyaloid vascula... 13 | 22
abnormal behavioral response t... 12 | 52
abnormal epididymis morphology 12 | 31
abnormal eye morphology 12 | 38
abnormal rib morphology 12 | 28
decreased CD4-positive, CD25-p... 12 | 24
decreased circulating iron lev... 12 | 25
decreased hematocrit 12 | 25
enlarged spleen 12 | 26
increased body length 12 | 20
increased mean corpuscular hem... 12 | 25

Disease

ovarian cancer 2,625 | 8,492
osteosarcoma 2,529 | 7,933
medulloblastoma, large-cell 2,120 | 6,234
psoriasis 2,026 | 6,685
glioblastoma 1,946 | 5,572
atypical teratoid / rhabdoid tumor 1,576 | 4,369
lung cancer 1,494 | 4,473
pilocytic astrocytoma 1,246 | 3,086
lung carcinoma 1,181 | 2,844
primitive neuroectodermal tumor 1,117 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 1,116 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 1,109 | 3,289
Breast cancer 1,108 | 3,099
malignant mesothelioma 1,102 | 3,163
Carcinoma 1,100 | 2,147
oligodendroglioma 1,076 | 2,849
invasive ductal carcinoma 1,066 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 1,060 | 2,988
pediatric high grade glioma 991 | 2,712
non-small cell lung cancer 942 | 2,798
lung adenocarcinoma 933 | 2,714
ependymoma 875 | 2,514
subependymal giant cell astrocytoma 875 | 2,287
interstitial cystitis 869 | 2,299
astrocytic glioma 822 | 2,241
pancreatic cancer 800 | 2,300
pituitary cancer 794 | 1,972
Cancer 785 | 2,346
ulcerative colitis 754 | 2,087
adult high grade glioma 725 | 2,148
Pick disease 724 | 1,893
group 3 medulloblastoma 719 | 2,254
ductal carcinoma in situ 669 | 1,745
cystic fibrosis 646 | 1,670
group 4 medulloblastoma 636 | 1,875
tuberculosis 588 | 1,563
posterior fossa group A ependymoma 570 | 1,511
posterior fossa group B ependymoma 558 | 1,530
pancreatic ductal adenocarcinoma liver metastasis 554 | 1,795
medulloblastoma 548 | 1,524
breast carcinoma 542 | 1,614
colon cancer 512 | 1,475
sonic hedgehog group medulloblastoma 504 | 1,482
astrocytoma 500 | 1,493
Rheumatoid Arthritis 499 | 1,171
adrenocortical carcinoma 481 | 1,427
diabetes mellitus 480 | 1,663
primary pancreatic ductal adenocarcinoma 437 | 1,271
spina bifida 391 | 1,064
juvenile dermatomyositis 389 | 1,189
acute quadriplegic myopathy 362 | 1,157
atypical teratoid/rhabdoid tumor 361 | 1,095
cutaneous lupus erythematosus 361 | 1,056
nasopharyngeal carcinoma 355 | 1,056
active Crohn's disease 326 | 918
dermatomyositis 325 | 967
gastric carcinoma 321 | 832
Alzheimer's disease 316 | 644
Obesity 312 | 616
Atopic dermatitis 311 | 944
primary Sjogren syndrome 302 | 789
Multiple myeloma 295 | 1,328
Schizophrenia 274 | 503
aldosterone-producing adenoma 262 | 664
progressive supranuclear palsy 252 | 674
non primary Sjogren syndrome sicca 245 | 840
esophageal adenocarcinoma 241 | 737
acute myeloid leukemia 237 | 785
Duchenne muscular dystrophy 223 | 602
Multiple Sclerosis 216 | 498
Waldenstrons macroglobulinemia 214 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 209 | 499
Acquired metabolic disease 206 | 267
fibroadenoma 202 | 557
Intellectual disability 201 | 573
tuberculosis and treatment for 6 months 200 | 686
Crohn's disease 197 | 304
Down syndrome 193 | 548
chronic rhinosinusitis 193 | 512
pancreatic carcinoma 192 | 567
Amyotrophic Lateral Sclerosis 189 | 432
Prostatic Neoplasms 186 | 471
non-small cell lung carcinoma 185 | 413
active ulcerative colitis 182 | 477
Endometriosis 177 | 535
mucosa-associated lymphoid tissue lymphoma 175 | 480
Kidney disease 171 | 397
Autistic Disorder 167 | 320
Parkinson's disease 165 | 364
Asthma 159 | 349
Bipolar Disorder 151 | 266
Mammary Neoplasms 149 | 410
Epilepsy 148 | 346
Cardiovascular system disease 146 | 194
Neurodegenerative disease 146 | 383
IGA Glomerulonephritis 145 | 454
hepatocellular carcinoma 144 | 550
sarcoidosis 141 | 368
Peripheral Neuropathy 135 | 303
Osteoporosis 133 | 259

Tissue

Nervous System 5,038 | 18,561
Female tissues 5,029 | 18,647
Digestive Tract 5,028 | 18,473
Endocrine System 5,025 | 18,512
Urinary Tract 5,020 | 18,444
Liver and Pancreas 5,008 | 18,136
Cardiovascular System 4,997 | 17,958
Blood and immune system 4,978 | 17,995
Male tissues 4,977 | 17,969
Skin and soft tissues 4,965 | 18,115
Respiratory system 4,916 | 17,484

Target Family

Non-IDG 2,890 | 11,969
Enzyme 1,148 | 4,146
Transcription Factor 349 | 1,400
Kinase 244 | 634
Transporter 180 | 473
Ion Channel 140 | 341
GPCR 93 | 408
Epigenetic 86 | 242
Nuclear Receptor 21 | 48
TF/Epigenetic 15 | 38
oGPCR 10 | 421

Data Source

GWAS Catalog 5,176 | 5,176
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
Ubiquitin-conjugating enzyme E2 Q2 UBE2Q2 Tbio Non-IDG -0.88971 8.59 121
Zinc finger protein 334 ZNF334 Tdark Transcription Factor -0.12494 1.43 22
E3 ubiquitin-protein ligase RNF115 RNF115 Tbio Enzyme -1.29757 20.6 76
SH3 domain-binding glutamic acid-rich-like protein 2 SH3BGRL2 Tbio Non-IDG 0.08 0.71 6
NACHT, LRR and PYD domains-containing protein 8 NLRP8 Tdark Non-IDG -0.64290 3.57 30