Development Level

Tbio 6,473 | 11,445
Tdark 2,344 | 6,588
Tchem 1,017 | 1,598
Tclin 421 | 613

Collection

RFA-RM-18-021 183 | 328
Kinase: IDG Consortium (Target... 76 | 125
Ion Channel: IDG Consortium (T... 62 | 99
GPCR: IDG Consortium (Targets) 50 | 126
Kinase: IDG Consortium (Comple... 21 | 37
GPCR: IDG Consortium (Complete... 13 | 25

IMPC Phenotype

preweaning lethality, complete... 544 | 979
preweaning lethality, incomple... 312 | 499
abnormal behavior 173 | 298
embryonic lethality prior to t... 142 | 278
decreased total body fat amoun... 134 | 207
enlarged heart 130 | 210
abnormal embryo size 127 | 220
abnormal bone structure 125 | 187
decreased vertical activity 117 | 208
embryonic lethality prior to o... 112 | 239
increased lean body mass 110 | 172
decreased body weight 105 | 161
abnormal heart morphology 97 | 162
hypoactivity 90 | 132
hyperactivity 86 | 148
decreased bone mineral content 82 | 151
decreased circulating glucose ... 82 | 126
increased circulating alkaline... 77 | 122
decreased grip strength 75 | 116
increased total body fat amoun... 75 | 134
decreased lean body mass 74 | 135
male infertility 72 | 123
abnormal seminal vesicle morph... 71 | 114
increased startle reflex 71 | 112
decreased bone mineral density 70 | 126
decreased circulating choleste... 66 | 93
increased bone mineral content 65 | 108
increased mean corpuscular hem... 65 | 96
short tibia 64 | 97
cataract 62 | 92
decreased body length 59 | 101
increased mean corpuscular vol... 59 | 92
increased or absent threshold ... 58 | 101
embryonic growth retardation 56 | 106
decreased circulating serum al... 53 | 82
decreased lymphocyte cell numb... 53 | 83
prenatal lethality prior to he... 53 | 87
impaired glucose tolerance 52 | 75
decreased circulating triglyce... 51 | 79
decreased mean corpuscular vol... 51 | 79
improved glucose tolerance 51 | 79
abnormal retina morphology 50 | 71
decreased prepulse inhibition 49 | 82
abnormal lens morphology 48 | 81
abnormal gait 47 | 69
abnormal sleep behavior 47 | 70
decreased circulating HDL chol... 47 | 68
increased fasted circulating g... 47 | 76
increased circulating HDL chol... 46 | 80
small testis 45 | 58
decreased erythrocyte cell num... 44 | 62
decreased leukocyte cell numbe... 44 | 73
increased circulating sodium l... 44 | 71
decreased startle reflex 43 | 75
increased bone mineral density 42 | 72
abnormal coat-hair pigmentatio... 41 | 64
abnormal eye morphology 41 | 68
thrombocytopenia 41 | 56
abnormal behavioral response t... 40 | 66
decreased hemoglobin content 40 | 68
female infertility 40 | 60
decreased circulating insulin ... 39 | 76
decreased fasted circulating g... 39 | 65
increased circulating choleste... 38 | 66
edema 37 | 59
increased heart weight 37 | 62
increased monocyte cell number 37 | 63
small superior vagus ganglion 36 | 74
abnormal kidney morphology 35 | 65
decreased caudal vertebrae num... 35 | 53
abnormal testis morphology 34 | 43
decreased circulating alkaline... 33 | 46
decreased blood urea nitrogen ... 32 | 51
increased leukocyte cell numbe... 32 | 47
increased mean platelet volume 32 | 45
abnormal epididymis morphology 31 | 42
decreased circulating alanine ... 31 | 47
decreased circulating total pr... 31 | 49
abnormal spleen morphology 29 | 55
increased circulating triglyce... 29 | 42
increased hematocrit 29 | 46
increased blood urea nitrogen ... 28 | 48
increased circulating chloride... 28 | 41
increased grip strength 28 | 41
decreased mean corpuscular hem... 27 | 50
increased hemoglobin content 27 | 45
prolonged QT interval 27 | 38
tremors 27 | 39
abnormal bone mineralization 26 | 38
abnormal neural tube closure 26 | 46
abnormal skin morphology 26 | 50
decreased red blood cell distr... 26 | 41
hydrometra 26 | 53
increased neutrophil cell numb... 26 | 46
prolonged ST segment 26 | 36
abnormal cranium morphology 25 | 36
decreased circulating calcium ... 25 | 36
decreased neutrophil cell numb... 25 | 42
decreased circulating aspartat... 24 | 34
increased mean corpuscular hem... 24 | 36

Disease

Carcinoma 6,905 | 11,493
ovarian cancer 4,959 | 8,520
osteosarcoma 4,668 | 7,950
medulloblastoma, large-cell 3,867 | 6,241
psoriasis 3,853 | 6,694
glioblastoma 3,621 | 5,792
atypical teratoid / rhabdoid tumor 3,207 | 5,112
ependymoma 2,972 | 4,679
lung cancer 2,963 | 4,740
group 3 medulloblastoma 2,492 | 4,104
adult high grade glioma 2,408 | 3,801
Breast cancer 2,276 | 3,578
Astrocytoma, Pilocytic 2,060 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 2,009 | 3,291
malignant mesothelioma 2,009 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 1,962 | 2,955
lung carcinoma 1,960 | 2,843
primitive neuroectodermal tumor 1,934 | 3,035
Kidney cancer 1,922 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 1,915 | 2,989
invasive ductal carcinoma 1,895 | 2,951
oligodendroglioma 1,851 | 2,850
non-small cell lung cancer 1,846 | 2,890
lung adenocarcinoma 1,709 | 2,716
astrocytic glioma 1,630 | 2,597
pancreatic cancer 1,570 | 2,398
Cancer 1,543 | 2,499
interstitial cystitis 1,534 | 2,312
subependymal giant cell astrocytoma 1,484 | 2,287
pituitary cancer 1,330 | 1,972
tuberculosis 1,269 | 2,010
Pick disease 1,234 | 1,894
ulcerative colitis 1,231 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 1,182 | 1,962
cystic fibrosis 1,156 | 1,696
ductal carcinoma in situ 1,155 | 1,745
group 4 medulloblastoma 1,152 | 1,855
breast carcinoma 1,025 | 1,638
colon cancer 925 | 1,478
Autosomal recessive predisposition 914 | 1,442
diabetes mellitus 886 | 1,728
adrenocortical carcinoma 884 | 1,428
Schizophrenia 820 | 1,160
Rheumatoid arthritis 801 | 1,191
juvenile dermatomyositis 742 | 1,187
acute quadriplegic myopathy 720 | 1,158
astrocytoma 707 | 1,146
primary pancreatic ductal adenocarcinoma 692 | 1,109
cutaneous lupus erythematosus 676 | 1,057
spina bifida 674 | 1,074
Multiple myeloma 668 | 1,332
pediatric high grade glioma 664 | 1,064
nasopharyngeal carcinoma 648 | 1,058
Intellectual disability 600 | 1,016
Atopic dermatitis 597 | 952
active Crohn's disease 591 | 922
dermatomyositis 559 | 966
Melanoma 556 | 711
gastric carcinoma 554 | 807
active ulcerative colitis 503 | 764
Liver cancer 500 | 604
Liver Cirrhosis, Experimental 498 | 769
non primary Sjogren syndrome sicca 498 | 891
Bipolar Disorder 496 | 666
Epilepsy 496 | 792
primary Sjogren syndrome 493 | 735
Obesity 477 | 678
Alzheimer's disease 467 | 658
esophageal adenocarcinoma 457 | 737
medulloblastoma 450 | 720
aldosterone-producing adenoma 440 | 665
acute myeloid leukemia 433 | 783
Waldenstrons macroglobulinemia 428 | 765
progressive supranuclear palsy 426 | 676
Skin cancer 393 | 469
Duchenne muscular dystrophy 391 | 601
Dull intelligence 383 | 645
Low intelligence 383 | 645
Mental Retardation 383 | 645
Mental deficiency 383 | 645
Poor school performance 383 | 645
Seizures 372 | 596
Multiple Sclerosis 371 | 540
fibroadenoma 359 | 559
pancreatic carcinoma 359 | 562
Cognitive delay 353 | 608
Global developmental delay 353 | 608
Mental and motor retardation 353 | 608
Endometriosis 350 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 350 | 510
Prostatic Neoplasms 340 | 495
chronic rhinosinusitis 339 | 512
Muscle hypotonia 338 | 571
Short stature 328 | 531
Down syndrome 327 | 499
mucosa-associated lymphoid tissue lymphoma 326 | 484
hepatocellular carcinoma 322 | 547
Acquired metabolic disease 313 | 336
Amyotrophic lateral sclerosis 308 | 451
Kidney disease 308 | 430

Tissue

Endocrine System 9,810 | 18,159
Female tissues 9,531 | 17,400
Digestive Tract 9,514 | 17,369
Skin and soft tissues 9,429 | 17,230
Male tissues 9,389 | 17,142
Blood and immune system 9,251 | 16,909
Liver and Pancreas 9,249 | 16,750
Urinary Tract 9,226 | 16,678
Nervous System 9,197 | 16,725
Respiratory system 9,049 | 16,393
Cardiovascular System 8,385 | 15,192

Target Family

Non-IDG 5,744 | 12,091
Enzyme 2,248 | 4,145
Transcription Factor 769 | 1,400
Kinase 421 | 634
Transporter 306 | 473
Ion Channel 230 | 344
GPCR 221 | 408
Epigenetic 152 | 242
oGPCR 99 | 421
Nuclear Receptor 35 | 48
TF/Epigenetic 30 | 38

Data Source

GWAS Catalog 10,255 | 10,255
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39