Development Level

Tbio 6,299 | 11,178
Tdark 2,336 | 6,569
Tchem 1,199 | 1,885
Tclin 421 | 612

Collection

Kinase: IDG Consortium (Target... 76 | 125
Ion Channel: IDG Consortium (T... 62 | 99
GPCR: IDG Consortium (Targets) 50 | 126
Kinase: IDG Consortium (Comple... 21 | 37
GPCR: IDG Consortium (Complete... 13 | 25

IMPC Phenotype

preweaning lethality, complete... 544 | 979
preweaning lethality, incomple... 312 | 499
abnormal behavior 173 | 298
embryonic lethality prior to t... 142 | 278
decreased total body fat amoun... 134 | 207
enlarged heart 130 | 210
abnormal embryo size 127 | 220
abnormal bone structure 125 | 187
decreased vertical activity 117 | 208
embryonic lethality prior to o... 112 | 239
increased lean body mass 110 | 172
decreased body weight 105 | 161
abnormal heart morphology 97 | 162
hypoactivity 90 | 132
hyperactivity 86 | 148
decreased bone mineral content 82 | 151
decreased circulating glucose ... 82 | 126
increased circulating alkaline... 77 | 122
decreased grip strength 75 | 116
increased total body fat amoun... 75 | 134
decreased lean body mass 74 | 135
male infertility 72 | 123
abnormal seminal vesicle morph... 71 | 114
increased startle reflex 71 | 112
decreased bone mineral density 70 | 126
decreased circulating choleste... 66 | 93
increased bone mineral content 65 | 108
increased mean corpuscular hem... 65 | 96
short tibia 64 | 97
cataract 62 | 92
decreased body length 59 | 101
increased mean corpuscular vol... 59 | 92
increased or absent threshold ... 58 | 101
embryonic growth retardation 56 | 106
decreased circulating serum al... 53 | 82
decreased lymphocyte cell numb... 53 | 83
prenatal lethality prior to he... 53 | 87
impaired glucose tolerance 52 | 75
decreased circulating triglyce... 51 | 79
decreased mean corpuscular vol... 51 | 79
improved glucose tolerance 51 | 79
abnormal retina morphology 50 | 71
decreased prepulse inhibition 49 | 82
abnormal lens morphology 48 | 81
abnormal gait 47 | 69
abnormal sleep behavior 47 | 70
decreased circulating HDL chol... 47 | 68
increased fasted circulating g... 47 | 76
increased circulating HDL chol... 46 | 80
small testis 45 | 58
decreased erythrocyte cell num... 44 | 62
decreased leukocyte cell numbe... 44 | 73
increased circulating sodium l... 44 | 71
decreased startle reflex 43 | 75
increased bone mineral density 42 | 72
abnormal coat-hair pigmentatio... 41 | 64
abnormal eye morphology 41 | 68
thrombocytopenia 41 | 56
abnormal behavioral response t... 40 | 66
decreased hemoglobin content 40 | 68
female infertility 40 | 60
decreased circulating insulin ... 39 | 76
decreased fasted circulating g... 39 | 65
increased circulating choleste... 38 | 66
edema 37 | 59
increased heart weight 37 | 62
increased monocyte cell number 37 | 63
small superior vagus ganglion 36 | 74
abnormal kidney morphology 35 | 65
decreased caudal vertebrae num... 35 | 53
abnormal testis morphology 34 | 43
decreased circulating alkaline... 33 | 46
decreased blood urea nitrogen ... 32 | 51
increased leukocyte cell numbe... 32 | 47
increased mean platelet volume 32 | 45
abnormal epididymis morphology 31 | 42
decreased circulating alanine ... 31 | 47
decreased circulating total pr... 31 | 49
abnormal spleen morphology 29 | 55
increased circulating triglyce... 29 | 42
increased hematocrit 29 | 46
increased blood urea nitrogen ... 28 | 48
increased circulating chloride... 28 | 41
increased grip strength 28 | 41
decreased mean corpuscular hem... 27 | 50
increased hemoglobin content 27 | 45
prolonged QT interval 27 | 38
tremors 27 | 39
abnormal bone mineralization 26 | 38
abnormal neural tube closure 26 | 46
abnormal skin morphology 26 | 50
decreased red blood cell distr... 26 | 41
hydrometra 26 | 53
increased neutrophil cell numb... 26 | 46
prolonged ST segment 26 | 36
abnormal cranium morphology 25 | 36
decreased circulating calcium ... 25 | 36
decreased neutrophil cell numb... 25 | 42
decreased circulating aspartat... 24 | 34
increased mean corpuscular hem... 24 | 36

Disease

Carcinoma 6,713 | 11,192
ovarian cancer 4,819 | 8,297
osteosarcoma 4,546 | 7,766
medulloblastoma, large-cell 3,766 | 6,086
psoriasis 3,740 | 6,514
glioblastoma 3,515 | 5,635
atypical teratoid / rhabdoid tumor 3,108 | 4,971
ependymoma 2,889 | 4,559
lung cancer 2,873 | 4,607
group 3 medulloblastoma 2,424 | 4,002
adult high grade glioma 2,341 | 3,701
Breast cancer 2,201 | 3,469
Astrocytoma, Pilocytic 2,005 | 3,006
intraductal papillary-mucinous neoplasm (IPMN) 1,957 | 3,204
malignant mesothelioma 1,944 | 3,135
intraductal papillary-mucinous adenoma (IPMA) 1,911 | 2,872
lung carcinoma 1,893 | 2,755
primitive neuroectodermal tumor 1,874 | 2,957
Kidney cancer 1,871 | 2,548
intraductal papillary-mucinous carcinoma (IPMC) 1,864 | 2,902
invasive ductal carcinoma 1,840 | 2,867
oligodendroglioma 1,794 | 2,768
non-small cell lung cancer 1,781 | 2,799
lung adenocarcinoma 1,659 | 2,627
astrocytic glioma 1,588 | 2,530
pancreatic cancer 1,515 | 2,322
interstitial cystitis 1,482 | 2,237
Cancer 1,471 | 2,388
subependymal giant cell astrocytoma 1,445 | 2,230
pituitary cancer 1,293 | 1,915
tuberculosis 1,241 | 1,963
Pick disease 1,206 | 1,856
ulcerative colitis 1,195 | 1,765
pancreatic ductal adenocarcinoma liver metastasis 1,145 | 1,911
group 4 medulloblastoma 1,124 | 1,806
ductal carcinoma in situ 1,119 | 1,686
cystic fibrosis 1,113 | 1,629
breast carcinoma 994 | 1,589
colon cancer 893 | 1,428
Autosomal recessive predisposition 885 | 1,407
adrenocortical carcinoma 857 | 1,385
diabetes mellitus 857 | 1,683
Schizophrenia 801 | 1,136
Rheumatoid arthritis 776 | 1,156
juvenile dermatomyositis 719 | 1,147
acute quadriplegic myopathy 705 | 1,133
astrocytoma 681 | 1,113
primary pancreatic ductal adenocarcinoma 664 | 1,071
spina bifida 661 | 1,053
cutaneous lupus erythematosus 652 | 1,016
Multiple myeloma 647 | 1,296
pediatric high grade glioma 643 | 1,035
nasopharyngeal carcinoma 622 | 1,024
Intellectual disability 587 | 998
Atopic dermatitis 575 | 915
active Crohn's disease 562 | 882
dermatomyositis 542 | 941
Melanoma 540 | 689
gastric carcinoma 533 | 781
Liver cancer 487 | 589
active ulcerative colitis 484 | 736
Epilepsy 483 | 775
Bipolar Disorder 481 | 646
non primary Sjogren syndrome sicca 478 | 861
primary Sjogren syndrome 475 | 710
Liver Cirrhosis, Experimental 471 | 733
Obesity 459 | 655
Alzheimer's disease 453 | 640
medulloblastoma 435 | 702
aldosterone-producing adenoma 428 | 646
esophageal adenocarcinoma 428 | 696
acute myeloid leukemia 416 | 760
progressive supranuclear palsy 413 | 656
Waldenstrons macroglobulinemia 412 | 742
Duchenne muscular dystrophy 382 | 587
Skin cancer 379 | 451
Dull intelligence 375 | 634
Low intelligence 375 | 634
Mental Retardation 375 | 634
Mental deficiency 375 | 634
Poor school performance 375 | 634
Seizures 363 | 584
Multiple Sclerosis 361 | 527
pancreatic carcinoma 353 | 555
Cognitive delay 346 | 596
Global developmental delay 346 | 596
Mental and motor retardation 346 | 596
fibroadenoma 343 | 538
autosomal dominant Emery-Dreifuss muscular dystrophy 339 | 492
Endometriosis 338 | 521
chronic rhinosinusitis 334 | 505
Muscle hypotonia 331 | 562
Prostatic Neoplasms 325 | 472
mucosa-associated lymphoid tissue lymphoma 317 | 473
Short stature 316 | 514
hepatocellular carcinoma 313 | 536
Down syndrome 312 | 480
Acquired metabolic disease 307 | 329
Amyotrophic lateral sclerosis 298 | 437
Kidney disease 294 | 411

Tissue

Endocrine System 9,810 | 18,159
Female tissues 9,531 | 17,400
Digestive Tract 9,514 | 17,369
Skin and soft tissues 9,429 | 17,230
Male tissues 9,389 | 17,142
Blood and immune system 9,251 | 16,909
Liver and Pancreas 9,249 | 16,750
Urinary Tract 9,226 | 16,678
Nervous System 9,197 | 16,725
Respiratory system 9,049 | 16,393
Cardiovascular System 8,385 | 15,192

Target Family

Non-IDG 5,744 | 12,091
Enzyme 2,248 | 4,145
Transcription Factor 769 | 1,400
Kinase 421 | 634
Transporter 306 | 473
Ion Channel 230 | 344
GPCR 221 | 408
Epigenetic 152 | 242
oGPCR 99 | 421
Nuclear Receptor 35 | 48
TF/Epigenetic 30 | 38

Data Source

GWAS Catalog 10,255 | 10,255
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Nidogen-2 NID2 Tbio Non-IDG -1.62355 40.1 116
LIM homeobox transcription factor 1-alpha LMX1A Tbio Transcription Factor -1.82498 66.0 175
Cannabinoid receptor 2 CNR2 Tchem GPCR -2.45761 269.7 345
MyoD family inhibitor domain-containing protein MDFIC Tbio Non-IDG -2.90969 749.0 122
Protein RCC2 RCC2 Tbio Non-IDG -1.49831 31.4 148