Development Level

Tbio 10,867 | 11,178
Tdark 5,350 | 6,569
Tchem 1,857 | 1,885
Tclin 605 | 612

Collection

GPCR: IDG Consortium (Targets) 124 | 126
Kinase: IDG Consortium (Target... 122 | 125
Ion Channel: IDG Consortium (T... 96 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 25 | 25

IMPC Phenotype

preweaning lethality, complete... 968 | 979
preweaning lethality, incomple... 494 | 499
abnormal behavior 295 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 217 | 220
enlarged heart 208 | 210
decreased vertical activity 203 | 208
decreased total body fat amoun... 202 | 207
abnormal bone structure 183 | 187
increased lean body mass 166 | 172
abnormal heart morphology 162 | 162
decreased body weight 158 | 161
decreased bone mineral content 149 | 151
hyperactivity 146 | 148
decreased lean body mass 133 | 135
hypoactivity 131 | 132
increased total body fat amoun... 129 | 134
decreased bone mineral density 125 | 126
decreased circulating glucose ... 125 | 126
male infertility 122 | 123
increased circulating alkaline... 120 | 122
abnormal seminal vesicle morph... 114 | 114
decreased grip strength 114 | 116
embryonic growth retardation 106 | 106
increased startle reflex 106 | 112
increased bone mineral content 105 | 108
decreased body length 100 | 101
increased or absent threshold ... 100 | 101
short tibia 96 | 97
increased mean corpuscular hem... 94 | 96
increased mean corpuscular vol... 92 | 92
decreased circulating choleste... 91 | 93
cataract 90 | 92
prenatal lethality prior to he... 85 | 87
decreased circulating serum al... 82 | 82
decreased lymphocyte cell numb... 82 | 83
decreased prepulse inhibition 81 | 82
abnormal lens morphology 79 | 81
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 78 | 79
improved glucose tolerance 78 | 79
increased circulating HDL chol... 78 | 80
decreased startle reflex 75 | 75
increased fasted circulating g... 75 | 76
decreased circulating insulin ... 74 | 76
decreased leukocyte cell numbe... 73 | 73
impaired glucose tolerance 72 | 75
small superior vagus ganglion 72 | 74
increased bone mineral density 71 | 72
increased circulating sodium l... 71 | 71
abnormal gait 69 | 69
abnormal retina morphology 69 | 71
abnormal sleep behavior 69 | 70
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 67 | 68
decreased hemoglobin content 67 | 68
increased circulating choleste... 66 | 66
abnormal behavioral response t... 65 | 66
abnormal kidney morphology 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
decreased fasted circulating g... 63 | 65
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 61 | 62
female infertility 59 | 60
increased heart weight 58 | 62
edema 57 | 59
small testis 56 | 58
abnormal spleen morphology 54 | 55
thrombocytopenia 53 | 56
decreased caudal vertebrae num... 52 | 53
abnormal skin morphology 50 | 50
hydrometra 50 | 53
decreased blood urea nitrogen ... 49 | 51
decreased mean corpuscular hem... 49 | 50
decreased circulating total pr... 48 | 49
increased blood urea nitrogen ... 47 | 48
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alanine ... 46 | 47
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
decreased hematocrit 45 | 46
decreased circulating alkaline... 44 | 46
increased mean platelet volume 44 | 45
increased hemoglobin content 43 | 45
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
abnormal epididymis morphology 41 | 42
abnormal testis morphology 41 | 43
enlarged spleen 41 | 41
decreased red blood cell distr... 40 | 41
limb grasping 40 | 41
increased circulating chloride... 39 | 41
increased erythrocyte cell num... 39 | 39
increased grip strength 39 | 41
decreased circulating LDL chol... 38 | 38
decreased circulating creatini... 38 | 39
increased circulating creatini... 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 10,938 | 11,192
ovarian cancer 8,159 | 8,297
osteosarcoma 7,587 | 7,766
psoriasis 6,297 | 6,514
medulloblastoma, large-cell 5,990 | 6,086
glioblastoma 5,552 | 5,635
atypical teratoid / rhabdoid tumor 4,898 | 4,971
lung cancer 4,519 | 4,607
ependymoma 4,500 | 4,559
group 3 medulloblastoma 3,941 | 4,002
adult high grade glioma 3,644 | 3,701
Breast cancer 3,412 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,149 | 3,204
malignant mesothelioma 3,076 | 3,135
Astrocytoma, Pilocytic 2,967 | 3,006
primitive neuroectodermal tumor 2,917 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,854 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,829 | 2,872
invasive ductal carcinoma 2,828 | 2,867
non-small cell lung cancer 2,760 | 2,799
oligodendroglioma 2,732 | 2,768
lung carcinoma 2,707 | 2,755
lung adenocarcinoma 2,582 | 2,627
Kidney cancer 2,507 | 2,548
astrocytic glioma 2,494 | 2,530
pancreatic cancer 2,289 | 2,322
Cancer 2,243 | 2,388
interstitial cystitis 2,202 | 2,237
subependymal giant cell astrocytoma 2,195 | 2,230
tuberculosis 1,907 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,886 | 1,911
pituitary cancer 1,884 | 1,915
Pick disease 1,836 | 1,856
group 4 medulloblastoma 1,782 | 1,806
ulcerative colitis 1,740 | 1,765
ductal carcinoma in situ 1,667 | 1,686
cystic fibrosis 1,608 | 1,629
breast carcinoma 1,568 | 1,589
diabetes mellitus 1,565 | 1,683
colon cancer 1,404 | 1,428
Autosomal recessive predisposition 1,390 | 1,407
adrenocortical carcinoma 1,371 | 1,385
Multiple myeloma 1,286 | 1,296
juvenile dermatomyositis 1,129 | 1,147
acute quadriplegic myopathy 1,117 | 1,133
Schizophrenia 1,104 | 1,136
astrocytoma 1,095 | 1,113
Rheumatoid arthritis 1,094 | 1,156
primary pancreatic ductal adenocarcinoma 1,068 | 1,071
spina bifida 1,034 | 1,053
pediatric high grade glioma 1,019 | 1,035
nasopharyngeal carcinoma 1,014 | 1,024
cutaneous lupus erythematosus 1,003 | 1,016
Intellectual disability 977 | 998
Atopic dermatitis 905 | 915
dermatomyositis 895 | 941
active Crohn's disease 863 | 882
non primary Sjogren syndrome sicca 844 | 861
gastric carcinoma 769 | 781
Epilepsy 766 | 775
acute myeloid leukemia 752 | 760
Waldenstrons macroglobulinemia 736 | 742
Liver Cirrhosis, Experimental 726 | 733
active ulcerative colitis 721 | 736
primary Sjogren syndrome 698 | 710
esophageal adenocarcinoma 692 | 696
medulloblastoma 687 | 702
Melanoma 678 | 689
progressive supranuclear palsy 646 | 656
aldosterone-producing adenoma 641 | 646
Obesity 638 | 655
Bipolar Disorder 631 | 646
Alzheimer's disease 626 | 640
Dull intelligence 626 | 634
Low intelligence 626 | 634
Mental Retardation 626 | 634
Mental deficiency 626 | 634
Poor school performance 626 | 634
Cognitive delay 593 | 596
Global developmental delay 593 | 596
Mental and motor retardation 593 | 596
Seizures 580 | 584
Duchenne muscular dystrophy 574 | 587
Liver cancer 568 | 589
Muscle hypotonia 557 | 562
pancreatic carcinoma 548 | 555
fibroadenoma 532 | 538
hepatocellular carcinoma 526 | 536
Endometriosis 515 | 521
Short stature 504 | 514
chronic rhinosinusitis 500 | 505
Multiple Sclerosis 488 | 527
autosomal dominant Emery-Dreifuss muscular dystrophy 483 | 492
Down syndrome 468 | 480
mucosa-associated lymphoid tissue lymphoma 462 | 473
Prostatic Neoplasms 461 | 472
posterior fossa group A ependymoma 451 | 456
sonic hedgehog group medulloblastoma 451 | 459
Skin cancer 447 | 451
gastric cancer 435 | 445

Tissue

Endocrine System 17,891 | 18,159
Female tissues 17,185 | 17,400
Digestive Tract 17,142 | 17,369
Skin and soft tissues 17,018 | 17,230
Male tissues 16,933 | 17,142
Blood and immune system 16,698 | 16,909
Liver and Pancreas 16,560 | 16,750
Nervous System 16,536 | 16,725
Urinary Tract 16,495 | 16,678
Respiratory system 16,195 | 16,393
Cardiovascular System 15,044 | 15,192

Target Family

Non-IDG 10,828 | 12,091
Enzyme 3,985 | 4,145
Transcription Factor 1,379 | 1,400
Kinase 623 | 634
Transporter 461 | 473
GPCR 394 | 408
oGPCR 350 | 421
Ion Channel 337 | 344
Epigenetic 237 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 38 | 38

Data Source

GTEx 18,679 | 18,679
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116