Development Level

Tbio 11,131 | 11,445
Tdark 5,363 | 6,588
Tchem 1,579 | 1,598
Tclin 606 | 613

Collection

RFA-RM-18-021 319 | 328
GPCR: IDG Consortium (Targets) 124 | 126
Kinase: IDG Consortium (Target... 122 | 125
Ion Channel: IDG Consortium (T... 96 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 25 | 25

IMPC Phenotype

preweaning lethality, complete... 968 | 979
preweaning lethality, incomple... 494 | 499
abnormal behavior 295 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 217 | 220
enlarged heart 208 | 210
decreased vertical activity 203 | 208
decreased total body fat amoun... 202 | 207
abnormal bone structure 183 | 187
increased lean body mass 166 | 172
abnormal heart morphology 162 | 162
decreased body weight 158 | 161
decreased bone mineral content 149 | 151
hyperactivity 146 | 148
decreased lean body mass 133 | 135
hypoactivity 131 | 132
increased total body fat amoun... 129 | 134
decreased bone mineral density 125 | 126
decreased circulating glucose ... 125 | 126
male infertility 122 | 123
increased circulating alkaline... 120 | 122
abnormal seminal vesicle morph... 114 | 114
decreased grip strength 114 | 116
embryonic growth retardation 106 | 106
increased startle reflex 106 | 112
increased bone mineral content 105 | 108
decreased body length 100 | 101
increased or absent threshold ... 100 | 101
short tibia 96 | 97
increased mean corpuscular hem... 94 | 96
increased mean corpuscular vol... 92 | 92
decreased circulating choleste... 91 | 93
cataract 90 | 92
prenatal lethality prior to he... 85 | 87
decreased circulating serum al... 82 | 82
decreased lymphocyte cell numb... 82 | 83
decreased prepulse inhibition 81 | 82
abnormal lens morphology 79 | 81
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 78 | 79
improved glucose tolerance 78 | 79
increased circulating HDL chol... 78 | 80
decreased startle reflex 75 | 75
increased fasted circulating g... 75 | 76
decreased circulating insulin ... 74 | 76
decreased leukocyte cell numbe... 73 | 73
impaired glucose tolerance 72 | 75
small superior vagus ganglion 72 | 74
increased bone mineral density 71 | 72
increased circulating sodium l... 71 | 71
abnormal gait 69 | 69
abnormal retina morphology 69 | 71
abnormal sleep behavior 69 | 70
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 67 | 68
decreased hemoglobin content 67 | 68
increased circulating choleste... 66 | 66
abnormal behavioral response t... 65 | 66
abnormal kidney morphology 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
decreased fasted circulating g... 63 | 65
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 61 | 62
female infertility 59 | 60
increased heart weight 58 | 62
edema 57 | 59
small testis 56 | 58
abnormal spleen morphology 54 | 55
thrombocytopenia 53 | 56
decreased caudal vertebrae num... 52 | 53
abnormal skin morphology 50 | 50
hydrometra 50 | 53
decreased blood urea nitrogen ... 49 | 51
decreased mean corpuscular hem... 49 | 50
decreased circulating total pr... 48 | 49
increased blood urea nitrogen ... 47 | 48
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alanine ... 46 | 47
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
decreased hematocrit 45 | 46
decreased circulating alkaline... 44 | 46
increased mean platelet volume 44 | 45
increased hemoglobin content 43 | 45
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
abnormal epididymis morphology 41 | 42
abnormal testis morphology 41 | 43
enlarged spleen 41 | 41
decreased red blood cell distr... 40 | 41
limb grasping 40 | 41
increased circulating chloride... 39 | 41
increased erythrocyte cell num... 39 | 39
increased grip strength 39 | 41
decreased circulating LDL chol... 38 | 38
decreased circulating creatini... 38 | 39
increased circulating creatini... 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 11,236 | 11,493
ovarian cancer 8,377 | 8,520
osteosarcoma 7,769 | 7,950
psoriasis 6,473 | 6,694
medulloblastoma, large-cell 6,142 | 6,241
glioblastoma 5,704 | 5,792
atypical teratoid / rhabdoid tumor 5,036 | 5,112
lung cancer 4,649 | 4,740
ependymoma 4,615 | 4,679
group 3 medulloblastoma 4,040 | 4,104
adult high grade glioma 3,740 | 3,801
Breast cancer 3,516 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,233 | 3,291
malignant mesothelioma 3,173 | 3,232
Astrocytoma, Pilocytic 3,040 | 3,081
primitive neuroectodermal tumor 2,993 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,938 | 2,989
invasive ductal carcinoma 2,909 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,908 | 2,955
non-small cell lung cancer 2,848 | 2,890
oligodendroglioma 2,813 | 2,850
lung carcinoma 2,793 | 2,843
lung adenocarcinoma 2,668 | 2,716
Kidney cancer 2,570 | 2,613
astrocytic glioma 2,559 | 2,597
pancreatic cancer 2,362 | 2,398
Cancer 2,353 | 2,499
interstitial cystitis 2,274 | 2,312
subependymal giant cell astrocytoma 2,250 | 2,287
tuberculosis 1,953 | 2,010
pituitary cancer 1,941 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,936 | 1,962
Pick disease 1,874 | 1,894
group 4 medulloblastoma 1,830 | 1,855
ulcerative colitis 1,792 | 1,819
ductal carcinoma in situ 1,723 | 1,745
cystic fibrosis 1,673 | 1,696
breast carcinoma 1,615 | 1,638
diabetes mellitus 1,609 | 1,728
colon cancer 1,451 | 1,478
Autosomal recessive predisposition 1,425 | 1,442
adrenocortical carcinoma 1,412 | 1,428
Multiple myeloma 1,321 | 1,332
juvenile dermatomyositis 1,169 | 1,187
acute quadriplegic myopathy 1,142 | 1,158
Rheumatoid arthritis 1,128 | 1,191
Schizophrenia 1,128 | 1,160
astrocytoma 1,127 | 1,146
primary pancreatic ductal adenocarcinoma 1,105 | 1,109
spina bifida 1,055 | 1,074
pediatric high grade glioma 1,048 | 1,064
nasopharyngeal carcinoma 1,046 | 1,058
cutaneous lupus erythematosus 1,043 | 1,057
Intellectual disability 995 | 1,016
Atopic dermatitis 939 | 952
dermatomyositis 920 | 966
active Crohn's disease 901 | 922
non primary Sjogren syndrome sicca 873 | 891
gastric carcinoma 795 | 807
Epilepsy 783 | 792
acute myeloid leukemia 775 | 783
Liver Cirrhosis, Experimental 762 | 769
Waldenstrons macroglobulinemia 758 | 765
active ulcerative colitis 747 | 764
esophageal adenocarcinoma 732 | 737
primary Sjogren syndrome 722 | 735
medulloblastoma 705 | 720
Melanoma 699 | 711
progressive supranuclear palsy 665 | 676
Obesity 661 | 678
aldosterone-producing adenoma 659 | 665
Bipolar Disorder 651 | 666
Alzheimer's disease 644 | 658
Dull intelligence 637 | 645
Low intelligence 637 | 645
Mental Retardation 637 | 645
Mental deficiency 637 | 645
Poor school performance 637 | 645
Cognitive delay 605 | 608
Global developmental delay 605 | 608
Mental and motor retardation 605 | 608
Seizures 592 | 596
Duchenne muscular dystrophy 588 | 601
Liver cancer 582 | 604
Muscle hypotonia 566 | 571
pancreatic carcinoma 555 | 562
fibroadenoma 552 | 559
hepatocellular carcinoma 537 | 547
Endometriosis 533 | 540
Short stature 521 | 531
chronic rhinosinusitis 507 | 512
Multiple Sclerosis 501 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 501 | 510
Down syndrome 487 | 499
Prostatic Neoplasms 484 | 495
mucosa-associated lymphoid tissue lymphoma 473 | 484
Skin cancer 464 | 469
posterior fossa group A ependymoma 463 | 468
sonic hedgehog group medulloblastoma 458 | 467
gastric cancer 449 | 459

Tissue

Endocrine System 17,891 | 18,159
Female tissues 17,185 | 17,400
Digestive Tract 17,142 | 17,369
Skin and soft tissues 17,018 | 17,230
Male tissues 16,933 | 17,142
Blood and immune system 16,698 | 16,909
Liver and Pancreas 16,560 | 16,750
Nervous System 16,536 | 16,725
Urinary Tract 16,495 | 16,678
Respiratory system 16,195 | 16,393
Cardiovascular System 15,044 | 15,192

Target Family

Non-IDG 10,828 | 12,091
Enzyme 3,985 | 4,145
Transcription Factor 1,379 | 1,400
Kinase 623 | 634
Transporter 461 | 473
GPCR 394 | 408
oGPCR 350 | 421
Ion Channel 337 | 344
Epigenetic 237 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 38 | 38

Data Source

GTEx 18,679 | 18,679
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93