Development Level

Tbio 10,259 | 10,625
Tdark 5,682 | 7,003
Tchem 1,854 | 1,890
Tclin 587 | 602

Collection

Eligible Kinase Proteins 130 | 134
Eligible non-olfactory GPCR Proteins 128 | 145
Eligible Ion Channel Proteins 112 | 117

IMPC Term

preweaning lethality, complete... 623 | 633
preweaning lethality, incomple... 257 | 260
abnormal behavior 224 | 226
decreased lean body mass 191 | 195
embryonic lethality prior to t... 185 | 187
decreased total body fat amoun... 183 | 186
decreased body weight 170 | 174
decreased bone mineral content 155 | 157
embryonic lethality prior to o... 147 | 148
abnormal bone structure 127 | 131
increased or absent threshold ... 125 | 128
decreased bone mineral density 124 | 126
decreased circulating glucose ... 120 | 121
decreased grip strength 119 | 123
increased circulating alkaline... 114 | 119
abnormal embryo size 110 | 112
enlarged heart 108 | 111
decreased body length 107 | 108
hyperactivity 107 | 108
increased lean body mass 104 | 107
abnormal retina morphology 98 | 100
increased mean corpuscular vol... 91 | 91
increased bone mineral content 90 | 92
increased mean corpuscular hem... 90 | 93
hypoactivity 89 | 89
decreased circulating choleste... 83 | 85
decreased circulating triglyce... 82 | 83
increased grip strength 81 | 83
short tibia 80 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 75 | 77
decreased circulating insulin ... 73 | 75
abnormal lens morphology 71 | 73
increased circulating sodium l... 70 | 71
increased fasted circulating g... 66 | 68
increased circulating HDL chol... 62 | 63
prenatal lethality prior to he... 62 | 64
abnormal sleep behavior 61 | 63
decreased lumbar vertebrae num... 61 | 62
increased sacral vertebrae num... 61 | 62
male infertility 61 | 62
abnormal retinal pigmentation 59 | 61
decreased rib number 58 | 59
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
increased total body fat amoun... 55 | 57
abnormal coat/hair pigmentatio... 53 | 54
decreased leukocyte cell numbe... 53 | 54
abnormal behavioral response t... 52 | 52
decreased hemoglobin content 52 | 53
increased circulating choleste... 52 | 53
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased circulating alanine ... 51 | 53
decreased prepulse inhibition 51 | 52
increased bone mineral density 51 | 52
abnormal bone mineralization 50 | 55
decreased mean corpuscular vol... 50 | 50
impaired glucose tolerance 50 | 52
decreased caudal vertebrae num... 48 | 49
decreased fasted circulating g... 48 | 49
decreased startle reflex 47 | 48
abnormal seminal vesicle morph... 44 | 47
decreased heart weight 44 | 44
increased hemoglobin content 44 | 45
thrombocytopenia 44 | 46
increased blood urea nitrogen ... 43 | 44
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
increased circulating chloride... 42 | 43
decreased eosinophil cell numb... 41 | 41
decreased circulating total pr... 40 | 41
increased rib number 40 | 41
decreased circulating free fat... 39 | 39
decreased circulating LDL chol... 37 | 37
decreased circulating alkaline... 37 | 41
decreased neutrophil cell numb... 37 | 37
increased startle reflex 37 | 38
abnormal eye morphology 36 | 38
abnormal neural tube closure 36 | 37
small testis 36 | 37
abnormal spleen morphology 35 | 36
cardiovascular system phenotyp... 35 | 35
increased hematocrit 35 | 36
increased leukocyte cell numbe... 35 | 37
limb grasping 34 | 35
decreased circulating calcium ... 33 | 33
decreased mean corpuscular hem... 33 | 34
female infertility 33 | 34
increased heart weight 33 | 37
abnormal cranium morphology 32 | 32
tremors 32 | 34
decreased circulating chloride... 31 | 32
decreased circulating fructosa... 31 | 31
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
decreased B cell number 30 | 30
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31
decreased circulating creatini... 30 | 31

Disease

ovarian cancer 8,305 | 8,492
osteosarcoma 7,702 | 7,933
psoriasis 6,421 | 6,685
medulloblastoma, large-cell 6,104 | 6,234
glioblastoma 5,458 | 5,572
lung cancer 4,380 | 4,473
atypical teratoid / rhabdoid tumor 4,282 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,226 | 3,289
malignant mesothelioma 3,094 | 3,163
Breast cancer 3,034 | 3,099
pilocytic astrocytoma 3,024 | 3,086
primitive neuroectodermal tumor 2,973 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,927 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,899 | 2,956
invasive ductal carcinoma 2,896 | 2,950
oligodendroglioma 2,800 | 2,849
lung carcinoma 2,781 | 2,844
non-small cell lung cancer 2,751 | 2,798
pediatric high grade glioma 2,663 | 2,712
lung adenocarcinoma 2,650 | 2,714
ependymoma 2,469 | 2,514
pancreatic cancer 2,259 | 2,300
interstitial cystitis 2,253 | 2,299
subependymal giant cell astrocytoma 2,239 | 2,287
astrocytic glioma 2,201 | 2,241
group 3 medulloblastoma 2,200 | 2,254
Cancer 2,192 | 2,346
Carcinoma 2,100 | 2,147
adult high grade glioma 2,095 | 2,148
ulcerative colitis 2,048 | 2,087
pituitary cancer 1,927 | 1,972
Pick disease 1,861 | 1,893
group 4 medulloblastoma 1,831 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,761 | 1,795
ductal carcinoma in situ 1,717 | 1,745
cystic fibrosis 1,643 | 1,670
breast carcinoma 1,585 | 1,614
diabetes mellitus 1,535 | 1,663
tuberculosis 1,525 | 1,563
medulloblastoma 1,497 | 1,524
posterior fossa group B ependymoma 1,497 | 1,530
posterior fossa group A ependymoma 1,480 | 1,511
astrocytoma 1,457 | 1,493
sonic hedgehog group medulloblastoma 1,455 | 1,482
colon cancer 1,439 | 1,475
adrenocortical carcinoma 1,409 | 1,427
Multiple myeloma 1,309 | 1,328
primary pancreatic ductal adenocarcinoma 1,261 | 1,271
juvenile dermatomyositis 1,163 | 1,189
acute quadriplegic myopathy 1,139 | 1,157
Rheumatoid Arthritis 1,097 | 1,171
atypical teratoid/rhabdoid tumor 1,071 | 1,095
spina bifida 1,045 | 1,064
nasopharyngeal carcinoma 1,039 | 1,056
cutaneous lupus erythematosus 1,033 | 1,056
Atopic dermatitis 930 | 944
dermatomyositis 916 | 967
active Crohn's disease 896 | 918
gastric carcinoma 820 | 832
non primary Sjogren syndrome sicca 814 | 840
acute myeloid leukemia 771 | 785
primary Sjogren syndrome 771 | 789
Waldenstrons macroglobulinemia 753 | 765
esophageal adenocarcinoma 728 | 737
tuberculosis and treatment for 6 months 669 | 686
progressive supranuclear palsy 660 | 674
aldosterone-producing adenoma 656 | 664
Alzheimer's disease 622 | 644
Obesity 603 | 616
Duchenne muscular dystrophy 584 | 602
Intellectual disability 560 | 573
pancreatic carcinoma 556 | 567
fibroadenoma 548 | 557
Down syndrome 536 | 548
hepatocellular carcinoma 535 | 550
Endometriosis 526 | 535
chronic rhinosinusitis 505 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 488 | 499
Schizophrenia 483 | 503
mucosa-associated lymphoid tissue lymphoma 468 | 480
active ulcerative colitis 465 | 477
Prostatic Neoplasms 459 | 471
Multiple Sclerosis 457 | 498
IGA Glomerulonephritis 443 | 454
Amyotrophic Lateral Sclerosis 427 | 432
gastric cancer 420 | 436
Mammary Neoplasms 405 | 410
non-small cell lung carcinoma 399 | 413
inflammatory breast cancer 390 | 404
Neurodegenerative disease 375 | 383
Kidney disease 366 | 397
Parkinson's disease 358 | 364
sarcoidosis 347 | 368
glioblastoma multiforme 343 | 347
Epilepsy 339 | 346
Asthma 338 | 349
Polycystic Ovary Syndrome 324 | 335
tuberculosis and treatment for 3 months 323 | 327
nephrosclerosis 321 | 329
urothelial carcinoma 312 | 318

Tissue

Female tissues 18,234 | 18,647
Endocrine System 18,177 | 18,512
Nervous System 18,143 | 18,561
Urinary Tract 18,104 | 18,444
Digestive Tract 18,069 | 18,473
Skin and soft tissues 17,953 | 18,115
Liver and Pancreas 17,719 | 18,136
Cardiovascular System 17,599 | 17,958
Blood and immune system 17,549 | 17,995
Male tissues 17,535 | 17,969
Respiratory system 17,204 | 17,484

Target Family

Non-IDG 10,597 | 11,969
Enzyme 3,952 | 4,146
Transcription Factor 1,370 | 1,400
Kinase 616 | 634
Transporter 462 | 473
GPCR 384 | 408
oGPCR 348 | 421
Ion Channel 333 | 341
Epigenetic 235 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 38 | 38

Data Source

GTEx 18,382 | 18,382
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
NACHT, LRR and PYD domains-containing protein 14 NLRP14 Tbio Non-IDG -1.33032 17.6 30
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101