Development Level

Tbio 9,775 | 11,178
Tdark 4,204 | 6,569
Tchem 1,645 | 1,885
Tclin 556 | 612

Collection

Kinase: IDG Consortium (Target... 106 | 125
GPCR: IDG Consortium (Targets) 88 | 126
Ion Channel: IDG Consortium (T... 79 | 99
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 903 | 979
preweaning lethality, incomple... 459 | 499
abnormal behavior 270 | 298
embryonic lethality prior to t... 259 | 278
embryonic lethality prior to o... 224 | 239
abnormal embryo size 201 | 220
decreased total body fat amoun... 194 | 207
enlarged heart 190 | 210
decreased vertical activity 185 | 208
abnormal bone structure 170 | 187
increased lean body mass 160 | 172
decreased body weight 147 | 161
abnormal heart morphology 146 | 162
decreased bone mineral content 133 | 151
hyperactivity 132 | 148
increased total body fat amoun... 122 | 134
hypoactivity 119 | 132
decreased lean body mass 118 | 135
decreased bone mineral density 116 | 126
increased circulating alkaline... 108 | 122
decreased circulating glucose ... 107 | 126
male infertility 107 | 123
decreased grip strength 106 | 116
abnormal seminal vesicle morph... 103 | 114
increased startle reflex 101 | 112
increased bone mineral content 100 | 108
embryonic growth retardation 96 | 106
increased or absent threshold ... 90 | 101
decreased body length 88 | 101
cataract 87 | 92
decreased circulating choleste... 84 | 93
increased mean corpuscular vol... 84 | 92
short tibia 83 | 97
increased mean corpuscular hem... 81 | 96
prenatal lethality prior to he... 78 | 87
abnormal lens morphology 76 | 81
decreased lymphocyte cell numb... 76 | 83
decreased circulating serum al... 75 | 82
improved glucose tolerance 73 | 79
decreased circulating insulin ... 72 | 76
decreased mean corpuscular vol... 72 | 79
decreased prepulse inhibition 72 | 82
decreased circulating triglyce... 70 | 79
increased circulating HDL chol... 70 | 80
small superior vagus ganglion 70 | 74
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
impaired glucose tolerance 67 | 75
abnormal sleep behavior 66 | 70
decreased leukocyte cell numbe... 66 | 73
decreased hemoglobin content 64 | 68
increased fasted circulating g... 64 | 76
abnormal gait 63 | 69
abnormal eye morphology 61 | 68
abnormal kidney morphology 61 | 65
abnormal retina morphology 60 | 71
decreased circulating HDL chol... 60 | 68
abnormal behavioral response t... 59 | 66
increased circulating choleste... 59 | 66
increased monocyte cell number 59 | 63
abnormal coat-hair pigmentatio... 58 | 64
decreased erythrocyte cell num... 57 | 62
increased circulating sodium l... 57 | 71
decreased fasted circulating g... 55 | 65
edema 55 | 59
increased heart weight 54 | 62
abnormal spleen morphology 51 | 55
small testis 51 | 58
decreased caudal vertebrae num... 50 | 53
female infertility 49 | 60
thrombocytopenia 49 | 56
abnormal skin morphology 47 | 50
hydrometra 47 | 53
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
decreased circulating alanine ... 45 | 47
increased hematocrit 44 | 46
decreased blood urea nitrogen ... 43 | 51
decreased hematocrit 43 | 46
increased hemoglobin content 42 | 45
abnormal neural tube closure 41 | 46
decreased circulating alkaline... 41 | 46
increased neutrophil cell numb... 41 | 46
increased circulating triglyce... 40 | 42
increased leukocyte cell numbe... 40 | 47
increased mean platelet volume 40 | 45
abnormal testis morphology 39 | 43
enlarged spleen 39 | 41
increased blood urea nitrogen ... 39 | 48
limb grasping 39 | 41
increased erythrocyte cell num... 38 | 39
abnormal bone mineralization 37 | 38
abnormal epididymis morphology 37 | 42
decreased red blood cell distr... 37 | 41
increased grip strength 37 | 41
abnormal cranium morphology 36 | 36
decreased circulating LDL chol... 36 | 38
decreased neutrophil cell numb... 36 | 42
increased circulating chloride... 36 | 41
tremors 36 | 39

Disease

Carcinoma 9,948 | 11,192
ovarian cancer 8,285 | 8,297
osteosarcoma 7,761 | 7,766
psoriasis 6,454 | 6,514
medulloblastoma, large-cell 6,086 | 6,086
glioblastoma 5,630 | 5,635
atypical teratoid / rhabdoid tumor 4,971 | 4,971
ependymoma 4,558 | 4,559
lung cancer 4,545 | 4,607
group 3 medulloblastoma 4,002 | 4,002
adult high grade glioma 3,701 | 3,701
Breast cancer 3,437 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,204
malignant mesothelioma 3,131 | 3,135
Astrocytoma, Pilocytic 3,006 | 3,006
primitive neuroectodermal tumor 2,957 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,902 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,872
invasive ductal carcinoma 2,867 | 2,867
non-small cell lung cancer 2,796 | 2,799
oligodendroglioma 2,768 | 2,768
lung carcinoma 2,755 | 2,755
lung adenocarcinoma 2,627 | 2,627
astrocytic glioma 2,530 | 2,530
Kidney cancer 2,387 | 2,548
pancreatic cancer 2,308 | 2,322
interstitial cystitis 2,235 | 2,237
subependymal giant cell astrocytoma 2,229 | 2,230
Cancer 2,148 | 2,388
tuberculosis 1,928 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,911
pituitary cancer 1,911 | 1,915
Pick disease 1,856 | 1,856
group 4 medulloblastoma 1,806 | 1,806
ulcerative colitis 1,754 | 1,765
ductal carcinoma in situ 1,686 | 1,686
cystic fibrosis 1,626 | 1,629
breast carcinoma 1,589 | 1,589
diabetes mellitus 1,555 | 1,683
colon cancer 1,428 | 1,428
adrenocortical carcinoma 1,385 | 1,385
Autosomal recessive predisposition 1,325 | 1,407
Multiple myeloma 1,293 | 1,296
juvenile dermatomyositis 1,147 | 1,147
acute quadriplegic myopathy 1,133 | 1,133
astrocytoma 1,113 | 1,113
Rheumatoid arthritis 1,076 | 1,156
primary pancreatic ductal adenocarcinoma 1,071 | 1,071
Schizophrenia 1,048 | 1,136
spina bifida 1,047 | 1,053
pediatric high grade glioma 1,035 | 1,035
nasopharyngeal carcinoma 1,024 | 1,024
cutaneous lupus erythematosus 1,015 | 1,016
Intellectual disability 936 | 998
dermatomyositis 906 | 941
Atopic dermatitis 905 | 915
active Crohn's disease 882 | 882
non primary Sjogren syndrome sicca 861 | 861
gastric carcinoma 781 | 781
acute myeloid leukemia 760 | 760
Waldenstrons macroglobulinemia 742 | 742
active ulcerative colitis 736 | 736
Epilepsy 712 | 775
Liver Cirrhosis, Experimental 711 | 733
primary Sjogren syndrome 710 | 710
medulloblastoma 699 | 702
esophageal adenocarcinoma 696 | 696
progressive supranuclear palsy 654 | 656
aldosterone-producing adenoma 646 | 646
Melanoma 640 | 689
Obesity 606 | 655
Alzheimer's disease 603 | 640
Bipolar Disorder 602 | 646
Dull intelligence 601 | 634
Low intelligence 601 | 634
Mental Retardation 601 | 634
Mental deficiency 601 | 634
Poor school performance 601 | 634
Duchenne muscular dystrophy 585 | 587
Cognitive delay 564 | 596
Global developmental delay 564 | 596
Mental and motor retardation 564 | 596
Liver cancer 559 | 589
pancreatic carcinoma 555 | 555
Seizures 540 | 584
fibroadenoma 538 | 538
Muscle hypotonia 534 | 562
hepatocellular carcinoma 532 | 536
Endometriosis 510 | 521
chronic rhinosinusitis 505 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 492
Short stature 484 | 514
Multiple Sclerosis 474 | 527
mucosa-associated lymphoid tissue lymphoma 473 | 473
Down syndrome 471 | 480
sonic hedgehog group medulloblastoma 459 | 459
posterior fossa group A ependymoma 456 | 456
Prostatic Neoplasms 445 | 472
gastric cancer 445 | 445
Amyotrophic lateral sclerosis 428 | 437

Tissue

Endocrine System 15,452 | 18,159
Female tissues 15,153 | 17,400
Digestive Tract 15,136 | 17,369
Skin and soft tissues 15,065 | 17,230
Male tissues 14,937 | 17,142
Blood and immune system 14,770 | 16,909
Liver and Pancreas 14,715 | 16,750
Urinary Tract 14,685 | 16,678
Nervous System 14,663 | 16,725
Respiratory system 14,450 | 16,393
Cardiovascular System 13,545 | 15,192

Target Family

Non-IDG 9,567 | 12,091
Enzyme 3,418 | 4,145
Transcription Factor 1,133 | 1,400
Kinase 584 | 634
Transporter 432 | 473
GPCR 328 | 408
Ion Channel 294 | 344
Epigenetic 224 | 242
oGPCR 119 | 421
Nuclear Receptor 45 | 48
TF/Epigenetic 36 | 38

Data Source

Expression Atlas 16,180 | 16,180
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93