Development Level

Tbio 10,268 | 11,445
Tdark 4,267 | 6,588
Tchem 1,484 | 1,598
Tclin 566 | 613

Collection

RFA-RM-18-021 268 | 328
Kinase: IDG Consortium (Target... 111 | 125
GPCR: IDG Consortium (Targets) 88 | 126
Ion Channel: IDG Consortium (T... 79 | 99
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 921 | 979
preweaning lethality, incomple... 468 | 499
abnormal behavior 278 | 298
embryonic lethality prior to t... 262 | 278
embryonic lethality prior to o... 225 | 239
abnormal embryo size 208 | 220
decreased total body fat amoun... 198 | 207
enlarged heart 192 | 210
decreased vertical activity 186 | 208
abnormal bone structure 173 | 187
increased lean body mass 162 | 172
decreased body weight 152 | 161
abnormal heart morphology 148 | 162
hyperactivity 137 | 148
decreased bone mineral content 136 | 151
increased total body fat amoun... 126 | 134
decreased lean body mass 125 | 135
hypoactivity 125 | 132
decreased bone mineral density 118 | 126
increased circulating alkaline... 111 | 122
decreased circulating glucose ... 110 | 126
male infertility 109 | 123
decreased grip strength 108 | 116
abnormal seminal vesicle morph... 104 | 114
increased bone mineral content 103 | 108
increased startle reflex 103 | 112
embryonic growth retardation 101 | 106
decreased body length 94 | 101
increased or absent threshold ... 91 | 101
decreased circulating choleste... 88 | 93
cataract 87 | 92
short tibia 87 | 97
increased mean corpuscular hem... 86 | 96
increased mean corpuscular vol... 86 | 92
prenatal lethality prior to he... 81 | 87
decreased lymphocyte cell numb... 78 | 83
abnormal lens morphology 76 | 81
decreased circulating serum al... 75 | 82
decreased circulating triglyce... 75 | 79
decreased prepulse inhibition 75 | 82
decreased circulating insulin ... 73 | 76
decreased mean corpuscular vol... 73 | 79
improved glucose tolerance 73 | 79
increased circulating HDL chol... 72 | 80
decreased startle reflex 71 | 75
increased bone mineral density 70 | 72
small superior vagus ganglion 70 | 74
decreased leukocyte cell numbe... 69 | 73
abnormal sleep behavior 67 | 70
impaired glucose tolerance 67 | 75
abnormal gait 66 | 69
increased fasted circulating g... 66 | 76
abnormal eye morphology 64 | 68
decreased circulating HDL chol... 64 | 68
decreased hemoglobin content 64 | 68
abnormal retina morphology 63 | 71
abnormal kidney morphology 62 | 65
abnormal coat-hair pigmentatio... 61 | 64
increased circulating choleste... 61 | 66
increased circulating sodium l... 60 | 71
abnormal behavioral response t... 59 | 66
decreased erythrocyte cell num... 59 | 62
increased monocyte cell number 59 | 63
decreased fasted circulating g... 58 | 65
edema 56 | 59
increased heart weight 55 | 62
thrombocytopenia 52 | 56
abnormal spleen morphology 51 | 55
female infertility 51 | 60
small testis 51 | 58
decreased caudal vertebrae num... 50 | 53
abnormal skin morphology 49 | 50
decreased mean corpuscular hem... 47 | 50
hydrometra 47 | 53
decreased blood urea nitrogen ... 46 | 51
decreased circulating alanine ... 46 | 47
decreased circulating total pr... 46 | 49
increased hematocrit 45 | 46
decreased hematocrit 43 | 46
abnormal neural tube closure 42 | 46
decreased circulating alkaline... 42 | 46
increased blood urea nitrogen ... 42 | 48
increased hemoglobin content 42 | 45
increased leukocyte cell numbe... 42 | 47
increased mean platelet volume 42 | 45
increased neutrophil cell numb... 42 | 46
increased circulating triglyce... 41 | 42
enlarged spleen 40 | 41
limb grasping 40 | 41
abnormal testis morphology 39 | 43
increased erythrocyte cell num... 39 | 39
abnormal bone mineralization 38 | 38
abnormal epididymis morphology 38 | 42
decreased neutrophil cell numb... 38 | 42
increased circulating chloride... 38 | 41
decreased red blood cell distr... 37 | 41
increased grip strength 37 | 41
tremors 37 | 39
abnormal cranium morphology 36 | 36
decreased circulating LDL chol... 36 | 38

Disease

Carcinoma 10,220 | 11,493
ovarian cancer 8,508 | 8,520
osteosarcoma 7,945 | 7,950
psoriasis 6,633 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,787 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
ependymoma 4,678 | 4,679
lung cancer 4,676 | 4,740
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,545 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,228 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,887 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
astrocytic glioma 2,597 | 2,597
Kidney cancer 2,447 | 2,613
pancreatic cancer 2,383 | 2,398
interstitial cystitis 2,310 | 2,312
subependymal giant cell astrocytoma 2,286 | 2,287
Cancer 2,256 | 2,499
tuberculosis 1,975 | 2,010
pituitary cancer 1,968 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,807 | 1,819
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,691 | 1,696
breast carcinoma 1,638 | 1,638
diabetes mellitus 1,600 | 1,728
colon cancer 1,478 | 1,478
adrenocortical carcinoma 1,428 | 1,428
Autosomal recessive predisposition 1,358 | 1,442
Multiple myeloma 1,328 | 1,332
juvenile dermatomyositis 1,187 | 1,187
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
Rheumatoid arthritis 1,110 | 1,191
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
Schizophrenia 1,071 | 1,160
spina bifida 1,068 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,056 | 1,057
Intellectual disability 953 | 1,016
Atopic dermatitis 942 | 952
dermatomyositis 931 | 966
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
acute myeloid leukemia 783 | 783
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
Liver Cirrhosis, Experimental 746 | 769
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
Epilepsy 728 | 792
medulloblastoma 717 | 720
progressive supranuclear palsy 674 | 676
aldosterone-producing adenoma 665 | 665
Melanoma 660 | 711
Obesity 628 | 678
Bipolar Disorder 622 | 666
Alzheimer's disease 619 | 658
Dull intelligence 611 | 645
Low intelligence 611 | 645
Mental Retardation 611 | 645
Mental deficiency 611 | 645
Poor school performance 611 | 645
Duchenne muscular dystrophy 599 | 601
Cognitive delay 576 | 608
Global developmental delay 576 | 608
Mental and motor retardation 576 | 608
Liver cancer 572 | 604
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
Seizures 551 | 596
hepatocellular carcinoma 543 | 547
Muscle hypotonia 542 | 571
Endometriosis 529 | 540
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Short stature 501 | 531
Down syndrome 490 | 499
Multiple Sclerosis 487 | 540
mucosa-associated lymphoid tissue lymphoma 484 | 484
Prostatic Neoplasms 468 | 495
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459
Amyotrophic lateral sclerosis 442 | 451

Tissue

Endocrine System 15,841 | 18,159
Female tissues 15,531 | 17,400
Digestive Tract 15,512 | 17,369
Skin and soft tissues 15,442 | 17,230
Male tissues 15,305 | 17,142
Blood and immune system 15,140 | 16,909
Liver and Pancreas 15,075 | 16,750
Urinary Tract 15,049 | 16,678
Nervous System 15,028 | 16,725
Respiratory system 14,806 | 16,393
Cardiovascular System 13,865 | 15,192

Target Family

Non-IDG 9,653 | 12,091
Enzyme 3,649 | 4,145
Transcription Factor 1,205 | 1,400
Kinase 590 | 634
Transporter 438 | 473
GPCR 328 | 408
Ion Channel 294 | 344
Epigenetic 226 | 242
oGPCR 119 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 36 | 38

Data Source

Expression Atlas 16,585 | 16,585
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Putative homeobox protein Meis3-like 2 MEIS3P2 Tdark Non-IDG 0.00000 0
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19