Development Level

Tbio 9,557 | 10,625
Tdark 4,698 | 7,003
Tchem 1,756 | 1,890
Tclin 556 | 602

Collection

Eligible Kinase Proteins 117 | 134
Eligible non-olfactory GPCR Proteins 98 | 145
Eligible Ion Channel Proteins 92 | 117

IMPC Term

preweaning lethality, complete... 598 | 633
preweaning lethality, incomple... 247 | 260
abnormal behavior 215 | 226
decreased lean body mass 186 | 195
decreased total body fat amoun... 176 | 186
embryonic lethality prior to t... 173 | 187
decreased body weight 166 | 174
decreased bone mineral content 144 | 157
embryonic lethality prior to o... 136 | 148
abnormal bone structure 121 | 131
increased or absent threshold ... 117 | 128
decreased bone mineral density 116 | 126
decreased grip strength 113 | 123
increased circulating alkaline... 110 | 119
abnormal embryo size 106 | 112
decreased body length 104 | 108
decreased circulating glucose ... 104 | 121
hyperactivity 104 | 108
increased lean body mass 100 | 107
enlarged heart 99 | 111
abnormal retina morphology 95 | 100
increased bone mineral content 88 | 92
increased mean corpuscular hem... 86 | 93
hypoactivity 84 | 89
increased mean corpuscular vol... 84 | 91
decreased circulating choleste... 79 | 85
short tibia 77 | 82
decreased circulating triglyce... 76 | 83
increased grip strength 74 | 83
decreased circulating HDL chol... 71 | 77
decreased circulating insulin ... 71 | 75
decreased circulating serum al... 71 | 79
abnormal lens morphology 70 | 73
prenatal lethality prior to he... 62 | 64
increased circulating sodium l... 61 | 71
increased fasted circulating g... 60 | 68
abnormal sleep behavior 59 | 63
decreased lumbar vertebrae num... 58 | 62
male infertility 58 | 62
increased circulating HDL chol... 57 | 63
increased sacral vertebrae num... 57 | 62
increased total body fat amoun... 57 | 57
decreased rib number 56 | 59
abnormal retinal pigmentation 54 | 61
improved glucose tolerance 52 | 56
abnormal coat/hair pigmentatio... 51 | 54
decreased circulating alanine ... 51 | 53
decreased leukocyte cell numbe... 51 | 54
abnormal bone mineralization 50 | 55
decreased mean corpuscular vol... 49 | 50
increased bone mineral density 49 | 52
increased circulating choleste... 49 | 53
increased exploration in new e... 49 | 56
decreased hemoglobin content 48 | 53
impaired glucose tolerance 48 | 52
abnormal behavioral response t... 47 | 52
abnormal gait 47 | 51
decreased caudal vertebrae num... 47 | 49
decreased prepulse inhibition 47 | 52
decreased startle reflex 46 | 48
abnormal heart morphology 44 | 51
increased hemoglobin content 44 | 45
thrombocytopenia 44 | 46
decreased fasted circulating g... 43 | 49
decreased erythrocyte cell num... 42 | 43
decreased heart weight 41 | 44
abnormal seminal vesicle morph... 40 | 47
increased circulating chloride... 40 | 43
decreased circulating alkaline... 38 | 41
decreased circulating total pr... 38 | 41
increased blood urea nitrogen ... 38 | 44
increased body weight 38 | 42
increased rib number 38 | 41
increased startle reflex 38 | 38
abnormal eye morphology 35 | 38
decreased circulating LDL chol... 35 | 37
decreased circulating free fat... 35 | 39
decreased eosinophil cell numb... 35 | 41
abnormal spleen morphology 34 | 36
decreased neutrophil cell numb... 34 | 37
increased hematocrit 34 | 36
limb grasping 34 | 35
abnormal neural tube closure 33 | 37
decreased mean corpuscular hem... 33 | 34
increased leukocyte cell numbe... 33 | 37
abnormal cranium morphology 32 | 32
cardiovascular system phenotyp... 32 | 35
decreased circulating calcium ... 32 | 33
increased circulating calcium ... 32 | 32
increased heart weight 32 | 37
tremors 32 | 34
small testis 31 | 37
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31
female infertility 30 | 34
abnormal kidney morphology 29 | 30
decreased circulating chloride... 29 | 32
decreased circulating creatini... 29 | 31
decreased circulating fructosa... 29 | 31
increased circulating potassiu... 28 | 31

Disease

ovarian cancer 8,489 | 8,492
osteosarcoma 7,929 | 7,933
psoriasis 6,625 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,568 | 5,572
lung cancer 4,466 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,092 | 3,099
pilocytic astrocytoma 3,084 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,795 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
interstitial cystitis 2,297 | 2,299
pancreatic cancer 2,293 | 2,300
subependymal giant cell astrocytoma 2,286 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Cancer 2,118 | 2,346
ulcerative colitis 2,074 | 2,087
Carcinoma 1,998 | 2,147
pituitary cancer 1,968 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,670
breast carcinoma 1,614 | 1,614
tuberculosis 1,549 | 1,563
diabetes mellitus 1,547 | 1,663
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,522 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,426 | 1,427
Multiple myeloma 1,324 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
Rheumatoid Arthritis 1,091 | 1,171
spina bifida 1,060 | 1,064
nasopharyngeal carcinoma 1,056 | 1,056
cutaneous lupus erythematosus 1,055 | 1,056
Atopic dermatitis 934 | 944
dermatomyositis 931 | 967
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 784 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 672 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 613 | 644
Duchenne muscular dystrophy 600 | 602
Obesity 570 | 616
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 544 | 550
Down syndrome 535 | 548
Intellectual disability 532 | 573
Endometriosis 525 | 535
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Schizophrenia 457 | 503
Multiple Sclerosis 448 | 498
Prostatic Neoplasms 445 | 471
IGA Glomerulonephritis 442 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 426 | 432
non-small cell lung carcinoma 411 | 413
inflammatory breast cancer 404 | 404
Mammary Neoplasms 393 | 410
Neurodegenerative disease 362 | 383
sarcoidosis 351 | 368
glioblastoma multiforme 347 | 347
Parkinson's disease 343 | 364
Kidney disease 337 | 397
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Polycystic Ovary Syndrome 323 | 335
Asthma 320 | 349
Epilepsy 319 | 346
urothelial carcinoma 318 | 318

Tissue

Female tissues 16,120 | 18,647
Nervous System 16,117 | 18,561
Digestive Tract 16,095 | 18,473
Endocrine System 16,068 | 18,512
Urinary Tract 16,049 | 18,444
Liver and Pancreas 15,938 | 18,136
Skin and soft tissues 15,918 | 18,115
Cardiovascular System 15,834 | 17,958
Blood and immune system 15,833 | 17,995
Male tissues 15,807 | 17,969
Respiratory system 15,577 | 17,484

Target Family

Non-IDG 9,640 | 11,969
Enzyme 3,648 | 4,146
Transcription Factor 1,206 | 1,400
Kinase 587 | 634
Transporter 438 | 473
GPCR 329 | 408
Ion Channel 291 | 341
Epigenetic 226 | 242
oGPCR 119 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 36 | 38

Data Source

Expression Atlas 16,567 | 16,567
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Keratin-associated protein 9-1 KRTAP9-1 Tdark Non-IDG 0.00000 0