Development Level

Tbio 10,248 | 11,445
Tdark 4,274 | 6,588
Tchem 1,478 | 1,598
Tclin 566 | 613

Collection

RFA-RM-18-021 295 | 328
Kinase: IDG Consortium (Target... 113 | 125
GPCR: IDG Consortium (Targets) 109 | 126
Ion Channel: IDG Consortium (T... 89 | 99
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 25 | 25

IMPC Phenotype

preweaning lethality, complete... 910 | 979
preweaning lethality, incomple... 466 | 499
abnormal behavior 275 | 298
embryonic lethality prior to t... 260 | 278
embryonic lethality prior to o... 224 | 239
abnormal embryo size 203 | 220
enlarged heart 202 | 210
decreased vertical activity 196 | 208
decreased total body fat amoun... 194 | 207
abnormal bone structure 180 | 187
increased lean body mass 160 | 172
abnormal heart morphology 156 | 162
decreased body weight 151 | 161
decreased bone mineral content 143 | 151
hyperactivity 139 | 148
decreased lean body mass 128 | 135
increased total body fat amoun... 128 | 134
hypoactivity 123 | 132
decreased circulating glucose ... 122 | 126
decreased bone mineral density 117 | 126
male infertility 116 | 123
increased circulating alkaline... 114 | 122
abnormal seminal vesicle morph... 108 | 114
decreased grip strength 106 | 116
embryonic growth retardation 104 | 106
increased startle reflex 103 | 112
increased bone mineral content 101 | 108
decreased body length 96 | 101
increased or absent threshold ... 96 | 101
short tibia 93 | 97
increased mean corpuscular hem... 91 | 96
decreased circulating choleste... 88 | 93
cataract 86 | 92
increased mean corpuscular vol... 85 | 92
decreased prepulse inhibition 81 | 82
decreased lymphocyte cell numb... 79 | 83
prenatal lethality prior to he... 78 | 87
decreased circulating serum al... 77 | 82
decreased circulating triglyce... 77 | 79
increased circulating HDL chol... 77 | 80
improved glucose tolerance 76 | 79
decreased mean corpuscular vol... 74 | 79
abnormal lens morphology 73 | 81
decreased circulating insulin ... 71 | 76
decreased startle reflex 71 | 75
impaired glucose tolerance 71 | 75
small superior vagus ganglion 71 | 74
decreased leukocyte cell numbe... 69 | 73
increased bone mineral density 68 | 72
increased fasted circulating g... 68 | 76
increased circulating sodium l... 67 | 71
abnormal eye morphology 65 | 68
abnormal sleep behavior 65 | 70
decreased circulating HDL chol... 64 | 68
decreased fasted circulating g... 64 | 65
increased circulating choleste... 64 | 66
abnormal kidney morphology 63 | 65
abnormal retina morphology 63 | 71
decreased hemoglobin content 63 | 68
abnormal gait 62 | 69
abnormal behavioral response t... 61 | 66
abnormal coat-hair pigmentatio... 61 | 64
increased monocyte cell number 60 | 63
increased heart weight 59 | 62
decreased erythrocyte cell num... 58 | 62
female infertility 58 | 60
small testis 55 | 58
edema 54 | 59
thrombocytopenia 54 | 56
abnormal spleen morphology 53 | 55
hydrometra 50 | 53
decreased blood urea nitrogen ... 48 | 51
decreased caudal vertebrae num... 48 | 53
abnormal skin morphology 47 | 50
decreased mean corpuscular hem... 47 | 50
decreased circulating total pr... 46 | 49
increased blood urea nitrogen ... 46 | 48
abnormal neural tube closure 44 | 46
decreased circulating alkaline... 44 | 46
decreased hematocrit 44 | 46
increased neutrophil cell numb... 44 | 46
decreased circulating alanine ... 43 | 47
increased leukocyte cell numbe... 42 | 47
increased mean platelet volume 42 | 45
abnormal testis morphology 41 | 43
increased circulating triglyce... 41 | 42
increased hemoglobin content 41 | 45
decreased neutrophil cell numb... 40 | 42
increased hematocrit 40 | 46
abnormal epididymis morphology 39 | 42
enlarged spleen 39 | 41
increased circulating chloride... 39 | 41
limb grasping 39 | 41
tremors 38 | 39
decreased red blood cell distr... 37 | 41
abnormal bone mineralization 36 | 38
decreased circulating calcium ... 36 | 36
increased circulating creatini... 36 | 38
increased erythrocyte cell num... 36 | 39
prolonged QT interval 36 | 38

Disease

Carcinoma 10,282 | 11,493
ovarian cancer 7,793 | 8,520
osteosarcoma 7,137 | 7,950
psoriasis 5,844 | 6,694
medulloblastoma, large-cell 5,686 | 6,241
glioblastoma 5,333 | 5,792
atypical teratoid / rhabdoid tumor 4,695 | 5,112
ependymoma 4,298 | 4,679
lung cancer 4,290 | 4,740
group 3 medulloblastoma 3,736 | 4,104
adult high grade glioma 3,476 | 3,801
Breast cancer 3,277 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,022 | 3,291
malignant mesothelioma 2,945 | 3,232
Astrocytoma, Pilocytic 2,835 | 3,081
primitive neuroectodermal tumor 2,796 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,741 | 2,989
invasive ductal carcinoma 2,730 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,719 | 2,955
non-small cell lung cancer 2,657 | 2,890
oligodendroglioma 2,619 | 2,850
lung carcinoma 2,599 | 2,843
lung adenocarcinoma 2,466 | 2,716
astrocytic glioma 2,378 | 2,597
Kidney cancer 2,367 | 2,613
Cancer 2,213 | 2,499
pancreatic cancer 2,196 | 2,398
interstitial cystitis 2,090 | 2,312
subependymal giant cell astrocytoma 2,078 | 2,287
tuberculosis 1,830 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,828 | 1,962
pituitary cancer 1,807 | 1,972
Pick disease 1,750 | 1,894
group 4 medulloblastoma 1,721 | 1,855
ulcerative colitis 1,664 | 1,819
ductal carcinoma in situ 1,617 | 1,745
cystic fibrosis 1,547 | 1,696
breast carcinoma 1,494 | 1,638
diabetes mellitus 1,457 | 1,728
Autosomal recessive predisposition 1,354 | 1,442
colon cancer 1,323 | 1,478
adrenocortical carcinoma 1,319 | 1,428
Multiple myeloma 1,237 | 1,332
juvenile dermatomyositis 1,098 | 1,187
acute quadriplegic myopathy 1,064 | 1,158
Schizophrenia 1,046 | 1,160
astrocytoma 1,043 | 1,146
Rheumatoid arthritis 1,042 | 1,191
primary pancreatic ductal adenocarcinoma 1,024 | 1,109
spina bifida 983 | 1,074
pediatric high grade glioma 973 | 1,064
nasopharyngeal carcinoma 967 | 1,058
cutaneous lupus erythematosus 941 | 1,057
Intellectual disability 923 | 1,016
dermatomyositis 866 | 966
Atopic dermatitis 860 | 952
active Crohn's disease 840 | 922
non primary Sjogren syndrome sicca 807 | 891
gastric carcinoma 752 | 807
Epilepsy 732 | 792
Waldenstrons macroglobulinemia 723 | 765
Liver Cirrhosis, Experimental 717 | 769
acute myeloid leukemia 714 | 783
active ulcerative colitis 693 | 764
esophageal adenocarcinoma 667 | 737
primary Sjogren syndrome 666 | 735
medulloblastoma 661 | 720
Melanoma 639 | 711
Obesity 635 | 678
aldosterone-producing adenoma 618 | 665
progressive supranuclear palsy 617 | 676
Bipolar Disorder 615 | 666
Alzheimer's disease 604 | 658
Dull intelligence 599 | 645
Low intelligence 599 | 645
Mental Retardation 599 | 645
Mental deficiency 599 | 645
Poor school performance 599 | 645
Cognitive delay 576 | 608
Global developmental delay 576 | 608
Mental and motor retardation 576 | 608
Seizures 559 | 596
Duchenne muscular dystrophy 546 | 601
Muscle hypotonia 543 | 571
Liver cancer 530 | 604
pancreatic carcinoma 513 | 562
fibroadenoma 511 | 559
hepatocellular carcinoma 493 | 547
Endometriosis 489 | 540
Multiple Sclerosis 485 | 540
Short stature 480 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 477 | 510
chronic rhinosinusitis 469 | 512
Down syndrome 462 | 499
Prostatic Neoplasms 461 | 495
posterior fossa group A ependymoma 427 | 468
mucosa-associated lymphoid tissue lymphoma 425 | 484
Skin cancer 424 | 469
gastric cancer 424 | 459
sonic hedgehog group medulloblastoma 420 | 467

Tissue

Endocrine System 16,025 | 18,159
Female tissues 15,472 | 17,400
Digestive Tract 15,467 | 17,369
Skin and soft tissues 15,355 | 17,230
Male tissues 15,295 | 17,142
Blood and immune system 15,089 | 16,909
Nervous System 15,010 | 16,725
Liver and Pancreas 14,997 | 16,750
Urinary Tract 14,940 | 16,678
Respiratory system 14,669 | 16,393
Cardiovascular System 13,718 | 15,192

Target Family

Non-IDG 9,477 | 12,091
Enzyme 3,672 | 4,145
Transcription Factor 1,208 | 1,400
Kinase 577 | 634
Transporter 423 | 473
GPCR 357 | 408
Ion Channel 310 | 344
oGPCR 250 | 421
Epigenetic 214 | 242
Nuclear Receptor 44 | 48
TF/Epigenetic 34 | 38

Data Source

EggNOG 16,566 | 16,566
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29