Development Level

Tclin 590 | 602
Tchem 299 | 1,890

Collection

Eligible Ion Channel Proteins 43 | 117
Eligible Kinase Proteins 12 | 134
Eligible non-olfactory GPCR Proteins 9 | 145

IMPC Term

preweaning lethality, complete... 34 | 633
preweaning lethality, incomple... 20 | 260
decreased lean body mass 18 | 195
abnormal behavior 17 | 226
decreased bone mineral content 11 | 157
decreased bone mineral density 10 | 126
decreased body length 9 | 108
decreased total body fat amoun... 9 | 186
embryonic lethality prior to t... 9 | 187
enlarged heart 9 | 111
increased circulating alkaline... 9 | 119
abnormal lens morphology 8 | 73
decreased body weight 8 | 174
abnormal bone structure 7 | 131
abnormal retina morphology 7 | 100
decreased grip strength 7 | 123
embryonic lethality prior to o... 7 | 148
increased circulating HDL chol... 7 | 63
increased total body fat amoun... 7 | 57
abnormal embryo size 6 | 112
abnormal gait 6 | 51
decreased circulating triglyce... 6 | 83
improved glucose tolerance 6 | 56
increased circulating alanine ... 6 | 11
increased grip strength 6 | 83
increased lean body mass 6 | 107
increased mean corpuscular vol... 6 | 91
increased or absent threshold ... 6 | 128
decreased circulating glucose ... 5 | 121
decreased fasted circulating g... 5 | 49
hyperactivity 5 | 108
increased blood urea nitrogen ... 5 | 44
increased bone mineral content 5 | 92
abnormal behavioral response t... 4 | 52
abnormal bone mineralization 4 | 55
abnormal heart morphology 4 | 51
abnormal seminal vesicle morph... 4 | 47
abnormal sleep behavior 4 | 63
decreased circulating HDL chol... 4 | 77
decreased circulating sodium l... 4 | 18
decreased hemoglobin content 4 | 53
hypoactivity 4 | 89
impaired glucose tolerance 4 | 52
increased circulating choleste... 4 | 53
increased circulating potassiu... 4 | 31
increased circulating sodium l... 4 | 71
increased circulating triglyce... 4 | 24
straub tail 4 | 26
tremors 4 | 34
abnormal epididymis morphology 3 | 31
abnormal maxilla morphology 3 | 16
abnormal retinal pigmentation 3 | 61
abnormal tooth morphology 3 | 24
decreased circulating alanine ... 3 | 53
decreased circulating choleste... 3 | 85
decreased circulating serum al... 3 | 79
decreased heart weight 3 | 44
decreased leukocyte cell numbe... 3 | 54
decreased prepulse inhibition 3 | 52
decreased rib number 3 | 59
decreased total retina thickne... 3 | 20
increased body weight 3 | 42
increased circulating aspartat... 3 | 17
increased circulating chloride... 3 | 43
increased circulating creatini... 3 | 29
increased circulating serum al... 3 | 25
increased fasted circulating g... 3 | 68
increased hemoglobin content 3 | 45
increased startle reflex 3 | 38
male infertility 3 | 62
short tibia 3 | 82
small testis 3 | 37
thrombocytopenia 3 | 46
abnormal embryo turning 2 | 15
abnormal kidney morphology 2 | 30
abnormal testis morphology 2 | 30
cardiovascular system phenotyp... 2 | 35
decreased NK T cell number 2 | 28
decreased caudal vertebrae num... 2 | 49
decreased circulating LDL chol... 2 | 37
decreased circulating chloride... 2 | 32
decreased circulating glycerol... 2 | 19
decreased effector memory CD8-... 2 | 24
decreased lumbar vertebrae num... 2 | 62
decreased neutrophil cell numb... 2 | 37
decreased startle reflex 2 | 48
female infertility 2 | 34
hydrops fetalis 2 | 22
impaired righting response 2 | 19
increased CD4-positive, CD25-p... 2 | 18
increased NK cell number 2 | 19
increased bone mineral density 2 | 52
increased circulating calcium ... 2 | 32
increased circulating magnesiu... 2 | 10
increased heart weight 2 | 37
increased hematocrit 2 | 36
increased mean corpuscular hem... 2 | 93
increased respiratory quotient 2 | 12
increased sacral vertebrae num... 2 | 62
vertebral fusion 2 | 23

Disease

ovarian cancer 396 | 8,492
osteosarcoma 395 | 7,933
psoriasis 386 | 6,685
medulloblastoma, large-cell 341 | 6,234
glioblastoma 314 | 5,572
Cancer 293 | 2,346
lung cancer 284 | 4,473
atypical teratoid / rhabdoid tumor 241 | 4,369
lung carcinoma 223 | 2,844
Carcinoma 213 | 2,147
pilocytic astrocytoma 212 | 3,086
malignant mesothelioma 205 | 3,163
non-small cell lung cancer 199 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 194 | 3,289
invasive ductal carcinoma 180 | 2,950
oligodendroglioma 177 | 2,849
Breast cancer 175 | 3,099
primitive neuroectodermal tumor 175 | 3,031
pediatric high grade glioma 166 | 2,712
interstitial cystitis 165 | 2,299
lung adenocarcinoma 165 | 2,714
intraductal papillary-mucinous adenoma (IPMA) 164 | 2,956
ulcerative colitis 163 | 2,087
intraductal papillary-mucinous carcinoma (IPMC) 161 | 2,988
pancreatic cancer 146 | 2,300
diabetes mellitus 138 | 1,663
ependymoma 138 | 2,514
astrocytic glioma 134 | 2,241
colon cancer 128 | 1,475
tuberculosis 128 | 1,563
subependymal giant cell astrocytoma 126 | 2,287
adult high grade glioma 120 | 2,148
pituitary cancer 120 | 1,972
cystic fibrosis 116 | 1,670
pancreatic ductal adenocarcinoma liver metastasis 112 | 1,795
astrocytoma 106 | 1,493
Schizophrenia 105 | 503
ductal carcinoma in situ 103 | 1,745
breast carcinoma 102 | 1,614
Rheumatoid Arthritis 101 | 1,171
Epilepsy 100 | 346
Obesity 99 | 616
group 3 medulloblastoma 99 | 2,254
posterior fossa group A ependymoma 99 | 1,511
medulloblastoma 95 | 1,524
Multiple Sclerosis 94 | 498
Multiple myeloma 94 | 1,328
cutaneous lupus erythematosus 92 | 1,056
group 4 medulloblastoma 92 | 1,875
Pick disease 88 | 1,893
Asthma 87 | 349
adrenocortical carcinoma 86 | 1,427
Hypertension 80 | 293
Renal Cell Carcinoma 79 | 199
Atopic dermatitis 76 | 944
Parkinson's disease 75 | 364
posterior fossa group B ependymoma 72 | 1,530
sonic hedgehog group medulloblastoma 72 | 1,482
Diabetes mellitus type 2 69 | 69
Endometriosis 69 | 535
primary pancreatic ductal adenocarcinoma 69 | 1,271
Alzheimer's disease 67 | 644
Mammary Neoplasms 67 | 410
Kidney disease 66 | 397
Prostatic Neoplasms 65 | 471
Autistic Disorder 64 | 320
primary Sjogren syndrome 63 | 789
Atrial Fibrillation 62 | 110
Bipolar Disorder 60 | 266
Chronic Myelocytic Leukemia Accelerated Phase 59 | 59
Blastic phase chronic myeloid leukemia 58 | 58
Hypertensive disorder 58 | 58
atypical teratoid/rhabdoid tumor 58 | 1,095
Atherosclerosis 56 | 275
gastric carcinoma 55 | 832
Cerebrovascular disease 54 | 231
Gastrointestinal stromal tumor 54 | 61
General anesthesia 53 | 53
Heart disease 53 | 279
Hypertensive disease 53 | 193
Treatment Refractory Type 2 Diabetes Mellitus 53 | 53
acute quadriplegic myopathy 50 | 1,157
dermatomyositis 49 | 967
esophageal adenocarcinoma 49 | 737
non primary Sjogren syndrome sicca 49 | 840
Coronary artery disease 48 | 240
Philadelphia chromosome-positive acute lymphoblastic leukemia 47 | 47
Stomach Neoplasms 47 | 282
Chronic heart failure 46 | 46
Intellectual disability 46 | 573
non-small cell lung carcinoma 46 | 413
Alcohol dependence 45 | 107
Chronic phase chronic myeloid leukemia 45 | 45
Pancreatic Neuroendocrine Tumor 45 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 45 | 45
Vascular disease 44 | 281
nasopharyngeal carcinoma 43 | 1,056
Waldenstrons macroglobulinemia 42 | 765
fibroadenoma 41 | 557
juvenile dermatomyositis 41 | 1,189

Tissue

Nervous System 883 | 18,561
Digestive Tract 882 | 18,473
Urinary Tract 882 | 18,444
Endocrine System 881 | 18,512
Female tissues 881 | 18,647
Liver and Pancreas 871 | 18,136
Skin and soft tissues 869 | 18,115
Cardiovascular System 867 | 17,958
Male tissues 861 | 17,969
Blood and immune system 860 | 17,995
Respiratory system 853 | 17,484

Target Family

Enzyme 246 | 4,146
Ion Channel 156 | 341
Kinase 154 | 634
Non-IDG 127 | 11,969
GPCR 121 | 408
Transporter 42 | 473
Nuclear Receptor 22 | 48
Epigenetic 13 | 242
Transcription Factor 8 | 1,400

Data Source

DrugCentral Indication 889 | 889
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Serine/threonine-protein kinase RIO1 RIOK1 Tchem Kinase -0.72835 5.14 142
Mitogen-activated protein kinase kinase kinase kinase 5 MAP4K5 Tchem Kinase -1.76072 56.9 0
DNA topoisomerase 2-beta TOP2B Tchem Enzyme -2.44063 235.4 189
Tubulin beta-3 chain TUBB3 Tclin Non-IDG -2.04546 78.8 485
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 Tclin Ion Channel -2.46222 253.3 121
Smoothened homolog SMO Tclin GPCR -1.11229 12.5 388
Proton-coupled folate transporter SLC46A1 Tchem Transporter -2.19727 163.1 71
Tryptophan 5-hydroxylase 1 TPH1 Tclin Enzyme -2.90440 740.7 364