Development Level

Tclin 591 | 612
Tchem 305 | 1,885

Collection

Ion Channel: IDG Consortium (T... 33 | 99
Kinase: IDG Consortium (Target... 12 | 125
Kinase: IDG Consortium (Comple... 5 | 37
GPCR: IDG Consortium (Targets) 4 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 46 | 979
preweaning lethality, incomple... 36 | 499
abnormal behavior 28 | 298
enlarged heart 17 | 210
decreased bone mineral content 14 | 151
decreased vertical activity 14 | 208
embryonic lethality prior to t... 13 | 278
hyperactivity 13 | 148
abnormal bone structure 12 | 187
abnormal heart morphology 12 | 162
decreased lean body mass 12 | 135
decreased total body fat amoun... 12 | 207
increased total body fat amoun... 10 | 134
abnormal embryo size 9 | 220
decreased bone mineral density 9 | 126
embryonic lethality prior to o... 9 | 239
improved glucose tolerance 9 | 79
abnormal lens morphology 8 | 81
decreased body weight 8 | 161
increased startle reflex 8 | 112
abnormal gait 7 | 69
abnormal seminal vesicle morph... 7 | 114
decreased body length 7 | 101
decreased circulating triglyce... 7 | 79
decreased lymphocyte cell numb... 7 | 83
impaired glucose tolerance 7 | 75
increased bone mineral content 7 | 108
increased circulating HDL chol... 7 | 80
increased circulating alkaline... 7 | 122
increased mean corpuscular vol... 7 | 92
male infertility 7 | 123
abnormal behavioral response t... 6 | 66
decreased circulating glucose ... 6 | 126
decreased grip strength 6 | 116
decreased heart weight 6 | 27
decreased hemoglobin content 6 | 68
decreased startle reflex 6 | 75
hypoactivity 6 | 132
increased lean body mass 6 | 172
increased monocyte cell number 6 | 63
decreased fasted circulating g... 5 | 65
decreased leukocyte cell numbe... 5 | 73
decreased neutrophil cell numb... 5 | 42
increased bone mineral density 5 | 72
increased circulating alanine ... 5 | 13
increased circulating choleste... 5 | 66
increased circulating sodium l... 5 | 71
increased hemoglobin content 5 | 45
small superior vagus ganglion 5 | 74
tremors 5 | 39
abnormal embryo turning 4 | 31
abnormal epididymis morphology 4 | 42
cataract 4 | 92
decreased circulating HDL chol... 4 | 68
decreased circulating choleste... 4 | 93
decreased circulating serum al... 4 | 82
decreased mean corpuscular vol... 4 | 79
decreased prepulse inhibition 4 | 82
edema 4 | 59
embryonic growth retardation 4 | 106
increased blood urea nitrogen ... 4 | 48
increased circulating serum al... 4 | 22
abnormal bone mineralization 3 | 38
abnormal eye anterior chamber ... 3 | 9
abnormal kidney morphology 3 | 65
abnormal locomotor behavior 3 | 24
abnormal pericardium morpholog... 3 | 26
abnormal retina morphology 3 | 71
abnormal sleep behavior 3 | 70
cardiovascular system phenotyp... 3 | 36
decreased circulating alanine ... 3 | 47
decreased circulating alkaline... 3 | 46
decreased circulating chloride... 3 | 30
decreased circulating sodium l... 3 | 22
decreased erythrocyte cell num... 3 | 62
decreased mean corpuscular hem... 3 | 31
female infertility 3 | 60
increased body length 3 | 32
increased circulating calcium ... 3 | 34
increased circulating chloride... 3 | 41
increased circulating creatini... 3 | 38
increased circulating potassiu... 3 | 29
increased fasted circulating g... 3 | 76
increased mean platelet volume 3 | 45
increased neutrophil cell numb... 3 | 46
increased vertical activity 3 | 24
limb grasping 3 | 41
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
short tibia 3 | 97
small heart 3 | 10
small testis 3 | 58
thrombocytopenia 3 | 56
abnormal heart left ventricle ... 2 | 16
abnormal pancreas morphology 2 | 13
abnormal retinal vasculature m... 2 | 27
decreased hematocrit 2 | 46
increased circulating aspartat... 2 | 15
increased circulating total pr... 2 | 28
increased hematocrit 2 | 46

Disease

Carcinoma 695 | 11,192
osteosarcoma 406 | 7,766
ovarian cancer 405 | 8,297
psoriasis 391 | 6,514
medulloblastoma, large-cell 346 | 6,086
glioblastoma 332 | 5,635
Cancer 312 | 2,388
lung cancer 311 | 4,607
atypical teratoid / rhabdoid tumor 288 | 4,971
ependymoma 263 | 4,559
adult high grade glioma 246 | 3,701
Kidney cancer 225 | 2,548
lung carcinoma 222 | 2,755
malignant mesothelioma 217 | 3,135
group 3 medulloblastoma 215 | 4,002
Astrocytoma, Pilocytic 212 | 3,006
Schizophrenia 212 | 1,136
Breast cancer 207 | 3,469
non-small cell lung cancer 206 | 2,799
intraductal papillary-mucinous neoplasm (IPMN) 194 | 3,204
invasive ductal carcinoma 181 | 2,867
primitive neuroectodermal tumor 180 | 2,957
oligodendroglioma 179 | 2,768
Autosomal recessive predisposition 171 | 1,407
interstitial cystitis 168 | 2,237
intraductal papillary-mucinous adenoma (IPMA) 168 | 2,872
lung adenocarcinoma 163 | 2,627
intraductal papillary-mucinous carcinoma (IPMC) 162 | 2,902
astrocytic glioma 161 | 2,530
pancreatic cancer 155 | 2,322
Epilepsy 154 | 775
ulcerative colitis 153 | 1,765
diabetes mellitus 150 | 1,683
Bipolar Disorder 148 | 646
tuberculosis 145 | 1,963
colon cancer 129 | 1,428
subependymal giant cell astrocytoma 126 | 2,230
Depressive disorder 124 | 401
pituitary cancer 121 | 1,915
cystic fibrosis 117 | 1,629
pancreatic ductal adenocarcinoma liver metastasis 117 | 1,911
Obesity 115 | 655
breast carcinoma 106 | 1,589
ductal carcinoma in situ 106 | 1,686
Seizures 104 | 584
Hypertension 103 | 372
Rheumatoid arthritis 100 | 1,156
Mental Depression 99 | 325
Multiple Sclerosis 98 | 527
Alcoholic Intoxication, Chronic 94 | 283
Pick disease 92 | 1,856
Asthma 91 | 370
Multiple myeloma 91 | 1,296
cutaneous lupus erythematosus 91 | 1,016
Intellectual disability 88 | 998
adrenocortical carcinoma 88 | 1,385
group 4 medulloblastoma 85 | 1,806
Major Depressive Disorder 84 | 293
astrocytoma 83 | 1,113
Renal Cell Carcinoma 82 | 211
Cognitive delay 79 | 596
Global developmental delay 79 | 596
Mental and motor retardation 79 | 596
Parkinson's disease 77 | 378
Atopic dermatitis 76 | 915
Melanoma 74 | 689
Muscle hypotonia 73 | 562
Autistic Disorder 72 | 358
Hypertensive disease 72 | 278
Endometriosis 70 | 521
Liver Cirrhosis, Experimental 70 | 733
Mood Disorders 70 | 181
Diabetes mellitus type 2 69 | 69
Breast Neoplasms 68 | 423
Mammary Neoplasms 68 | 403
Kidney disease 67 | 411
Unipolar Depression 67 | 244
Alzheimer's disease 66 | 640
Prostatic Neoplasms 65 | 472
Dull intelligence 64 | 634
Low intelligence 64 | 634
Mental Retardation 64 | 634
Mental deficiency 64 | 634
Poor school performance 64 | 634
primary Sjogren syndrome 63 | 710
primary pancreatic ductal adenocarcinoma 63 | 1,071
Atrial Fibrillation 62 | 120
Heart disease 61 | 288
Failure to gain weight 60 | 359
Pediatric failure to thrive 60 | 359
Skin cancer 60 | 451
Chronic Myelocytic Leukemia Accelerated Phase 59 | 59
Blastic phase chronic myeloid leukemia 58 | 58
Diarrhea 56 | 245
Hypertensive disorder 56 | 56
Short stature 55 | 514
Atherosclerosis 54 | 276
Gastrointestinal stromal tumor 54 | 62
gastric carcinoma 54 | 781
Osteoporosis 53 | 348

Tissue

Endocrine System 878 | 18,159
Digestive Tract 851 | 17,369
Female tissues 845 | 17,400
Nervous System 835 | 16,725
Skin and soft tissues 830 | 17,230
Male tissues 828 | 17,142
Urinary Tract 818 | 16,678
Blood and immune system 813 | 16,909
Liver and Pancreas 811 | 16,750
Respiratory system 785 | 16,393
Cardiovascular System 719 | 15,192

Target Family

Enzyme 235 | 4,145
Kinase 168 | 634
Ion Channel 153 | 344
Non-IDG 130 | 12,091
GPCR 122 | 408
Transporter 44 | 473
Nuclear Receptor 23 | 48
Epigenetic 13 | 242
Transcription Factor 8 | 1,400

Data Source

DrugCentral Indication 896 | 896
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Somatostatin receptor type 4 SSTR4 Tclin GPCR -1.72615 44.8 147
Cannabinoid receptor 2 CNR2 Tchem GPCR -2.45761 269.7 345
T-lymphocyte activation antigen CD80 CD80 Tclin Non-IDG -3.39216 2405.6 1323
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103
Solute carrier family 22 member 8 SLC22A8 Tclin Transporter -2.40126 258.4 113
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Serine/threonine-protein kinase D1 PRKD1 Tchem Kinase -2.88440 775.2 667
Serine/threonine-protein kinase N1 PKN1 Tchem Kinase -2.03368 117.6 153
Serine/threonine-protein kinase N2 PKN2 Tchem Kinase -2.01264 103.6 159