Development Level

Tclin 602 | 613
Tchem 308 | 1,598

Collection

RFA-RM-18-021 45 | 328
Ion Channel: IDG Consortium (T... 33 | 99
Kinase: IDG Consortium (Target... 12 | 125
Kinase: IDG Consortium (Comple... 5 | 37
GPCR: IDG Consortium (Targets) 4 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 49 | 979
preweaning lethality, incomple... 37 | 499
abnormal behavior 28 | 298
enlarged heart 17 | 210
decreased vertical activity 15 | 208
decreased bone mineral content 14 | 151
embryonic lethality prior to t... 14 | 278
hyperactivity 13 | 148
abnormal bone structure 12 | 187
abnormal heart morphology 12 | 162
decreased lean body mass 12 | 135
decreased total body fat amoun... 12 | 207
abnormal embryo size 11 | 220
increased total body fat amoun... 10 | 134
decreased bone mineral density 9 | 126
embryonic lethality prior to o... 9 | 239
improved glucose tolerance 9 | 79
abnormal lens morphology 8 | 81
abnormal seminal vesicle morph... 8 | 114
decreased body weight 8 | 161
increased bone mineral content 8 | 108
increased circulating alkaline... 8 | 122
increased startle reflex 8 | 112
abnormal gait 7 | 69
decreased body length 7 | 101
decreased circulating triglyce... 7 | 79
decreased lymphocyte cell numb... 7 | 83
impaired glucose tolerance 7 | 75
increased circulating HDL chol... 7 | 80
increased mean corpuscular vol... 7 | 92
male infertility 7 | 123
abnormal behavioral response t... 6 | 66
decreased circulating glucose ... 6 | 126
decreased grip strength 6 | 116
decreased heart weight 6 | 27
decreased hemoglobin content 6 | 68
decreased startle reflex 6 | 75
embryonic growth retardation 6 | 106
hypoactivity 6 | 132
increased lean body mass 6 | 172
increased monocyte cell number 6 | 63
decreased circulating HDL chol... 5 | 68
decreased circulating choleste... 5 | 93
decreased fasted circulating g... 5 | 65
decreased leukocyte cell numbe... 5 | 73
decreased neutrophil cell numb... 5 | 42
increased blood urea nitrogen ... 5 | 48
increased bone mineral density 5 | 72
increased circulating alanine ... 5 | 13
increased circulating choleste... 5 | 66
increased circulating sodium l... 5 | 71
increased hemoglobin content 5 | 45
small superior vagus ganglion 5 | 74
tremors 5 | 39
abnormal embryo turning 4 | 31
abnormal epididymis morphology 4 | 42
cataract 4 | 92
decreased circulating serum al... 4 | 82
decreased mean corpuscular vol... 4 | 79
decreased prepulse inhibition 4 | 82
edema 4 | 59
increased circulating serum al... 4 | 22
prolonged ST segment 4 | 36
abnormal bone mineralization 3 | 38
abnormal eye anterior chamber ... 3 | 9
abnormal eye morphology 3 | 68
abnormal kidney morphology 3 | 65
abnormal locomotor behavior 3 | 24
abnormal pericardium morpholog... 3 | 26
abnormal retina morphology 3 | 71
abnormal sleep behavior 3 | 70
cardiovascular system phenotyp... 3 | 36
decreased circulating alanine ... 3 | 47
decreased circulating alkaline... 3 | 46
decreased circulating chloride... 3 | 30
decreased circulating creatini... 3 | 39
decreased circulating sodium l... 3 | 22
decreased erythrocyte cell num... 3 | 62
decreased mean corpuscular hem... 3 | 31
female infertility 3 | 60
increased body length 3 | 32
increased circulating calcium ... 3 | 34
increased circulating chloride... 3 | 41
increased circulating creatini... 3 | 38
increased circulating potassiu... 3 | 29
increased fasted circulating g... 3 | 76
increased mean platelet volume 3 | 45
increased neutrophil cell numb... 3 | 46
increased vertical activity 3 | 24
limb grasping 3 | 41
pale yolk sac 3 | 25
pallor 3 | 34
prenatal lethality prior to he... 3 | 87
prolonged QT interval 3 | 38
short tibia 3 | 97
small heart 3 | 10
small testis 3 | 58
thrombocytopenia 3 | 56
abnormal pancreas morphology 2 | 13
increased hematocrit 2 | 46

Disease

Carcinoma 704 | 11,493
ovarian cancer 414 | 8,520
osteosarcoma 413 | 7,950
psoriasis 398 | 6,694
medulloblastoma, large-cell 350 | 6,241
glioblastoma 335 | 5,792
Cancer 321 | 2,499
lung cancer 317 | 4,740
atypical teratoid / rhabdoid tumor 291 | 5,112
ependymoma 266 | 4,679
adult high grade glioma 247 | 3,801
Kidney cancer 228 | 2,613
lung carcinoma 228 | 2,843
malignant mesothelioma 221 | 3,232
group 3 medulloblastoma 217 | 4,104
Schizophrenia 214 | 1,160
Astrocytoma, Pilocytic 213 | 3,081
Breast cancer 211 | 3,578
non-small cell lung cancer 210 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 200 | 3,291
invasive ductal carcinoma 186 | 2,951
oligodendroglioma 181 | 2,850
primitive neuroectodermal tumor 180 | 3,035
Autosomal recessive predisposition 175 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 171 | 2,955
interstitial cystitis 170 | 2,312
lung adenocarcinoma 168 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 166 | 2,989
astrocytic glioma 162 | 2,597
pancreatic cancer 159 | 2,398
Epilepsy 155 | 792
diabetes mellitus 154 | 1,728
ulcerative colitis 154 | 1,819
Bipolar Disorder 149 | 666
tuberculosis 146 | 2,010
colon cancer 131 | 1,478
subependymal giant cell astrocytoma 129 | 2,287
Depressive disorder 125 | 409
pancreatic ductal adenocarcinoma liver metastasis 123 | 1,962
cystic fibrosis 121 | 1,696
pituitary cancer 121 | 1,972
Obesity 116 | 678
ductal carcinoma in situ 109 | 1,745
Hypertension 108 | 396
breast carcinoma 108 | 1,638
Seizures 105 | 596
Rheumatoid arthritis 101 | 1,191
Mental Depression 99 | 333
Multiple Sclerosis 98 | 540
Multiple myeloma 96 | 1,332
Alcoholic Intoxication, Chronic 95 | 289
Pick disease 93 | 1,894
cutaneous lupus erythematosus 93 | 1,057
Asthma 92 | 385
Intellectual disability 90 | 1,016
adrenocortical carcinoma 88 | 1,428
Major Depressive Disorder 85 | 301
group 4 medulloblastoma 85 | 1,855
astrocytoma 84 | 1,146
Renal Cell Carcinoma 82 | 214
Cognitive delay 80 | 608
Global developmental delay 80 | 608
Mental and motor retardation 80 | 608
Parkinson's disease 78 | 392
Atopic dermatitis 77 | 952
Hypertensive disease 75 | 292
Autistic Disorder 74 | 364
Liver Cirrhosis, Experimental 74 | 769
Melanoma 74 | 711
Muscle hypotonia 73 | 571
Endometriosis 71 | 540
Alzheimer's disease 70 | 658
Breast Neoplasms 70 | 445
Mammary Neoplasms 70 | 425
Diabetes mellitus type 2 69 | 69
Kidney disease 69 | 430
Mood Disorders 69 | 184
Prostatic Neoplasms 69 | 495
Unipolar Depression 68 | 250
Dull intelligence 65 | 645
Low intelligence 65 | 645
Mental Retardation 65 | 645
Mental deficiency 65 | 645
Poor school performance 65 | 645
Atrial Fibrillation 64 | 124
primary Sjogren syndrome 64 | 735
primary pancreatic ductal adenocarcinoma 64 | 1,109
Heart disease 63 | 306
Failure to gain weight 61 | 365
Pediatric failure to thrive 61 | 365
Skin cancer 60 | 469
Chronic Myelocytic Leukemia Accelerated Phase 59 | 59
Blastic phase chronic myeloid leukemia 58 | 58
Atherosclerosis 57 | 291
Diarrhea 57 | 253
Cerebrovascular disease 56 | 238
Hypertensive disorder 56 | 56
Short stature 55 | 531
Gastrointestinal stromal tumor 54 | 62
gastric carcinoma 54 | 807

Tissue

Endocrine System 892 | 18,159
Digestive Tract 865 | 17,369
Female tissues 859 | 17,400
Nervous System 849 | 16,725
Skin and soft tissues 845 | 17,230
Male tissues 842 | 17,142
Urinary Tract 832 | 16,678
Blood and immune system 828 | 16,909
Liver and Pancreas 826 | 16,750
Respiratory system 800 | 16,393
Cardiovascular System 733 | 15,192

Target Family

Enzyme 248 | 4,145
Kinase 168 | 634
Ion Channel 153 | 344
Non-IDG 132 | 12,091
GPCR 120 | 408
Transporter 45 | 473
Nuclear Receptor 23 | 48
Epigenetic 13 | 242
Transcription Factor 8 | 1,400

Data Source

DrugCentral Indication 910 | 910
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 Tclin Enzyme -1.42734 26.2 214
Sodium/bile acid cotransporter SLC10A1 Tchem Transporter -2.69150 476.1 163
TRAF2 and NCK-interacting protein kinase TNIK Tchem Kinase -1.33394 28.5 441
Potassium voltage-gated channel subfamily C member 2 KCNC2 Tclin Ion Channel -1.45272 28.7 178
5-hydroxytryptamine receptor 1F HTR1F Tchem GPCR -2.39159 244.1 131
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 Tclin Ion Channel -2.48671 270.6 121