Development Level

Tbio 5,307 | 10,625
Tchem 1,280 | 1,890
Tdark 737 | 7,003
Tclin 498 | 602

Collection

Eligible Ion Channel Proteins 46 | 117
Eligible Kinase Proteins 46 | 134
Eligible non-olfactory GPCR Proteins 26 | 145

IMPC Term

preweaning lethality, complete... 355 | 633
preweaning lethality, incomple... 142 | 260
abnormal behavior 123 | 226
embryonic lethality prior to t... 111 | 187
decreased lean body mass 107 | 195
decreased body weight 99 | 174
decreased total body fat amoun... 96 | 186
decreased bone mineral content 89 | 157
embryonic lethality prior to o... 78 | 148
increased circulating alkaline... 74 | 119
decreased grip strength 73 | 123
decreased bone mineral density 71 | 126
increased or absent threshold ... 70 | 128
abnormal embryo size 65 | 112
increased mean corpuscular hem... 64 | 93
abnormal bone structure 62 | 131
abnormal retina morphology 60 | 100
decreased circulating glucose ... 59 | 121
enlarged heart 59 | 111
decreased body length 57 | 108
hypoactivity 57 | 89
decreased circulating triglyce... 52 | 83
increased bone mineral content 50 | 92
decreased circulating choleste... 49 | 85
hyperactivity 49 | 108
increased lean body mass 49 | 107
increased mean corpuscular vol... 49 | 91
decreased circulating HDL chol... 47 | 77
decreased circulating insulin ... 47 | 75
increased grip strength 47 | 83
short tibia 44 | 82
abnormal lens morphology 42 | 73
increased circulating sodium l... 39 | 71
decreased circulating serum al... 38 | 79
abnormal sleep behavior 36 | 63
abnormal retinal pigmentation 35 | 61
decreased lumbar vertebrae num... 35 | 62
decreased startle reflex 35 | 48
decreased prepulse inhibition 34 | 52
increased fasted circulating g... 34 | 68
decreased circulating alanine ... 33 | 53
decreased rib number 33 | 59
increased circulating HDL chol... 33 | 63
improved glucose tolerance 32 | 56
increased sacral vertebrae num... 32 | 62
prenatal lethality prior to he... 32 | 64
abnormal seminal vesicle morph... 31 | 47
decreased heart weight 31 | 44
decreased hemoglobin content 31 | 53
decreased mean corpuscular vol... 31 | 50
impaired glucose tolerance 31 | 52
increased circulating choleste... 31 | 53
male infertility 31 | 62
abnormal coat/hair pigmentatio... 30 | 54
abnormal heart morphology 30 | 51
increased bone mineral density 30 | 52
abnormal bone mineralization 29 | 55
decreased fasted circulating g... 29 | 49
increased exploration in new e... 29 | 56
increased hemoglobin content 29 | 45
thrombocytopenia 29 | 46
increased total body fat amoun... 28 | 57
decreased erythrocyte cell num... 27 | 43
abnormal behavioral response t... 26 | 52
abnormal gait 26 | 51
decreased caudal vertebrae num... 26 | 49
abnormal neural tube closure 25 | 37
increased body weight 25 | 42
increased startle reflex 25 | 38
cardiovascular system phenotyp... 24 | 35
decreased leukocyte cell numbe... 24 | 54
increased blood urea nitrogen ... 24 | 44
small testis 24 | 37
decreased circulating alkaline... 23 | 41
decreased eosinophil cell numb... 23 | 41
abnormal eye morphology 22 | 38
increased leukocyte cell numbe... 22 | 37
decreased circulating total pr... 21 | 41
enlarged lymph nodes 21 | 27
increased circulating chloride... 21 | 43
increased heart weight 21 | 37
decreased circulating LDL chol... 20 | 37
decreased circulating calcium ... 20 | 33
decreased circulating free fat... 20 | 39
increased circulating potassiu... 20 | 31
increased hematocrit 20 | 36
limb grasping 20 | 35
abnormal cranium morphology 19 | 32
abnormal epididymis morphology 19 | 31
abnormal testis morphology 19 | 30
cataract 19 | 26
decreased mean corpuscular hem... 19 | 34
increased circulating calcium ... 19 | 32
increased rib number 19 | 41
tremors 19 | 34
abnormal kidney morphology 18 | 30
abnormal spleen morphology 18 | 36
decreased circulating chloride... 18 | 32
decreased circulating fructosa... 18 | 31
decreased threshold for audito... 18 | 32

Disease

ovarian cancer 4,166 | 8,492
osteosarcoma 3,616 | 7,933
psoriasis 3,384 | 6,685
medulloblastoma, large-cell 3,048 | 6,234
glioblastoma 2,891 | 5,572
lung cancer 2,616 | 4,473
atypical teratoid / rhabdoid tumor 2,147 | 4,369
malignant mesothelioma 1,812 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 1,794 | 3,289
Cancer 1,783 | 2,346
Breast cancer 1,724 | 3,099
invasive ductal carcinoma 1,712 | 2,950
pilocytic astrocytoma 1,691 | 3,086
lung carcinoma 1,654 | 2,844
non-small cell lung cancer 1,642 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 1,635 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,619 | 2,956
lung adenocarcinoma 1,584 | 2,714
primitive neuroectodermal tumor 1,539 | 3,031
oligodendroglioma 1,481 | 2,849
pediatric high grade glioma 1,475 | 2,712
interstitial cystitis 1,371 | 2,299
pancreatic cancer 1,356 | 2,300
ulcerative colitis 1,312 | 2,087
Carcinoma 1,291 | 2,147
ependymoma 1,226 | 2,514
subependymal giant cell astrocytoma 1,191 | 2,287
pituitary cancer 1,098 | 1,972
astrocytic glioma 1,066 | 2,241
ductal carcinoma in situ 1,047 | 1,745
group 3 medulloblastoma 1,045 | 2,254
cystic fibrosis 1,037 | 1,670
adult high grade glioma 1,035 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 982 | 1,795
breast carcinoma 966 | 1,614
group 4 medulloblastoma 961 | 1,875
Pick disease 957 | 1,893
colon cancer 944 | 1,475
tuberculosis 926 | 1,563
diabetes mellitus 901 | 1,663
astrocytoma 883 | 1,493
posterior fossa group A ependymoma 878 | 1,511
adrenocortical carcinoma 837 | 1,427
sonic hedgehog group medulloblastoma 767 | 1,482
medulloblastoma 756 | 1,524
Rheumatoid Arthritis 745 | 1,171
primary pancreatic ductal adenocarcinoma 712 | 1,271
Multiple myeloma 705 | 1,328
posterior fossa group B ependymoma 697 | 1,530
juvenile dermatomyositis 680 | 1,189
cutaneous lupus erythematosus 678 | 1,056
acute quadriplegic myopathy 662 | 1,157
nasopharyngeal carcinoma 597 | 1,056
Atopic dermatitis 587 | 944
atypical teratoid/rhabdoid tumor 567 | 1,095
dermatomyositis 564 | 967
Obesity 531 | 616
active Crohn's disease 531 | 918
gastric carcinoma 521 | 832
spina bifida 518 | 1,064
primary Sjogren syndrome 511 | 789
Intellectual disability 493 | 573
Prostatic Neoplasms 471 | 471
esophageal adenocarcinoma 466 | 737
Alzheimer's disease 459 | 644
IGA Glomerulonephritis 449 | 454
Waldenstrons macroglobulinemia 445 | 765
Schizophrenia 425 | 503
Mammary Neoplasms 410 | 410
Duchenne muscular dystrophy 408 | 602
Down syndrome 400 | 548
Endometriosis 400 | 535
aldosterone-producing adenoma 392 | 664
non primary Sjogren syndrome sicca 392 | 840
acute myeloid leukemia 373 | 785
Multiple Sclerosis 355 | 498
Neurodegenerative disease 351 | 383
autosomal dominant Emery-Dreifuss muscular dystrophy 349 | 499
fibroadenoma 339 | 557
progressive supranuclear palsy 332 | 674
Kidney disease 324 | 397
pancreatic carcinoma 319 | 567
Asthma 304 | 349
mucosa-associated lymphoid tissue lymphoma 301 | 480
Epilepsy 298 | 346
Peripheral Neuropathy 298 | 303
Amyotrophic Lateral Sclerosis 297 | 432
chronic rhinosinusitis 293 | 512
hepatocellular carcinoma 291 | 550
tuberculosis and treatment for 6 months 291 | 686
Autistic Disorder 290 | 320
Stomach Neoplasms 282 | 282
Polycystic Ovary Syndrome 281 | 335
non-small cell lung carcinoma 281 | 413
active ulcerative colitis 269 | 477
Parkinson's disease 264 | 364
Crohn's disease 250 | 304
Hypertension 250 | 293
Vascular disease 248 | 281
Atherosclerosis 243 | 275

Tissue

Nervous System 7,720 | 18,561
Digestive Tract 7,717 | 18,473
Female tissues 7,717 | 18,647
Endocrine System 7,698 | 18,512
Urinary Tract 7,684 | 18,444
Liver and Pancreas 7,653 | 18,136
Skin and soft tissues 7,622 | 18,115
Blood and immune system 7,613 | 17,995
Male tissues 7,611 | 17,969
Cardiovascular System 7,606 | 17,958
Respiratory system 7,504 | 17,484

Target Family

Non-IDG 4,129 | 11,969
Enzyme 1,894 | 4,146
Transcription Factor 579 | 1,400
Kinase 355 | 634
Transporter 261 | 473
GPCR 205 | 408
Ion Channel 203 | 341
Epigenetic 121 | 242
Nuclear Receptor 44 | 48
TF/Epigenetic 22 | 38
oGPCR 9 | 421

Data Source

DisGeNET 7,822 | 7,822
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
Psoriasis susceptibility 1 candidate gene 2 protein PSORS1C2 Tbio Non-IDG -1.03330 10.2 12
Ubiquitin-conjugating enzyme E2 Q2 UBE2Q2 Tbio Non-IDG -0.88971 8.59 121