Development Level

Tbio 5,184 | 11,178
Tchem 1,237 | 1,885
Tclin 511 | 612
Tdark 484 | 6,569

Collection

Ion Channel: IDG Consortium (T... 42 | 99
Kinase: IDG Consortium (Target... 36 | 125
GPCR: IDG Consortium (Targets) 28 | 126
Kinase: IDG Consortium (Comple... 16 | 37
GPCR: IDG Consortium (Complete... 11 | 25

IMPC Phenotype

preweaning lethality, complete... 533 | 979
preweaning lethality, incomple... 238 | 499
abnormal behavior 157 | 298
embryonic lethality prior to t... 152 | 278
embryonic lethality prior to o... 132 | 239
abnormal embryo size 122 | 220
decreased vertical activity 117 | 208
enlarged heart 117 | 210
decreased total body fat amoun... 101 | 207
abnormal heart morphology 95 | 162
abnormal bone structure 94 | 187
decreased body weight 84 | 161
decreased bone mineral content 81 | 151
hyperactivity 76 | 148
hypoactivity 76 | 132
increased lean body mass 72 | 172
abnormal seminal vesicle morph... 68 | 114
decreased bone mineral density 65 | 126
decreased grip strength 64 | 116
decreased lean body mass 63 | 135
increased total body fat amoun... 63 | 134
increased circulating alkaline... 62 | 122
increased mean corpuscular hem... 58 | 96
embryonic growth retardation 57 | 106
cataract 56 | 92
decreased circulating glucose ... 56 | 126
increased startle reflex 56 | 112
increased bone mineral content 54 | 108
abnormal lens morphology 53 | 81
short tibia 53 | 97
decreased circulating choleste... 52 | 93
increased or absent threshold ... 50 | 101
prenatal lethality prior to he... 50 | 87
decreased body length 49 | 101
decreased lymphocyte cell numb... 49 | 83
decreased mean corpuscular vol... 49 | 79
male infertility 49 | 123
abnormal retina morphology 48 | 71
increased mean corpuscular vol... 48 | 92
decreased prepulse inhibition 46 | 82
impaired glucose tolerance 46 | 75
decreased circulating serum al... 43 | 82
improved glucose tolerance 43 | 79
increased circulating HDL chol... 43 | 80
small superior vagus ganglion 43 | 74
decreased circulating HDL chol... 42 | 68
decreased startle reflex 42 | 75
abnormal eye morphology 41 | 68
decreased circulating triglyce... 40 | 79
increased circulating choleste... 40 | 66
increased fasted circulating g... 40 | 76
decreased circulating insulin ... 39 | 76
abnormal sleep behavior 38 | 70
increased circulating sodium l... 38 | 71
abnormal gait 37 | 69
decreased erythrocyte cell num... 35 | 62
increased bone mineral density 34 | 72
decreased fasted circulating g... 33 | 65
decreased hemoglobin content 33 | 68
decreased leukocyte cell numbe... 33 | 73
hydrometra 33 | 53
increased monocyte cell number 33 | 63
small testis 33 | 58
edema 32 | 59
increased heart weight 31 | 62
thrombocytopenia 31 | 56
abnormal behavioral response t... 30 | 66
abnormal coat-hair pigmentatio... 30 | 64
abnormal kidney morphology 29 | 65
abnormal spleen morphology 29 | 55
decreased circulating alkaline... 28 | 46
increased leukocyte cell numbe... 28 | 47
decreased blood urea nitrogen ... 27 | 51
decreased circulating alanine ... 27 | 47
increased circulating triglyce... 27 | 42
increased neutrophil cell numb... 27 | 46
abnormal neural tube closure 26 | 46
decreased mean corpuscular hem... 26 | 50
increased hemoglobin content 26 | 45
limb grasping 26 | 41
abnormal testis morphology 25 | 43
decreased circulating total pr... 25 | 49
decreased neutrophil cell numb... 25 | 42
decreased red blood cell distr... 25 | 41
increased circulating creatini... 25 | 38
abnormal epididymis morphology 24 | 42
decreased circulating LDL chol... 24 | 38
enlarged spleen 24 | 41
increased mean platelet volume 24 | 45
persistence of hyaloid vascula... 24 | 33
abnormal skin morphology 23 | 50
decreased caudal vertebrae num... 23 | 53
increased blood urea nitrogen ... 23 | 48
increased lymphocyte cell numb... 23 | 32
prolonged QT interval 23 | 38
decreased circulating aspartat... 22 | 34
decreased circulating creatini... 22 | 39
enlarged lymph nodes 22 | 37
tremors 22 | 39
pallor 21 | 34

Disease

Carcinoma 4,982 | 11,192
ovarian cancer 3,952 | 8,297
osteosarcoma 3,428 | 7,766
psoriasis 3,189 | 6,514
medulloblastoma, large-cell 2,897 | 6,086
glioblastoma 2,844 | 5,635
lung cancer 2,623 | 4,607
atypical teratoid / rhabdoid tumor 2,373 | 4,971
ependymoma 2,237 | 4,559
group 3 medulloblastoma 1,920 | 4,002
Breast cancer 1,879 | 3,469
adult high grade glioma 1,834 | 3,701
Cancer 1,810 | 2,388
malignant mesothelioma 1,798 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 1,670 | 3,204
invasive ductal carcinoma 1,620 | 2,867
non-small cell lung cancer 1,618 | 2,799
Astrocytoma, Pilocytic 1,615 | 3,006
lung carcinoma 1,585 | 2,755
intraductal papillary-mucinous carcinoma (IPMC) 1,532 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 1,531 | 2,872
lung adenocarcinoma 1,489 | 2,627
primitive neuroectodermal tumor 1,441 | 2,957
oligodendroglioma 1,416 | 2,768
Autosomal recessive predisposition 1,407 | 1,407
Kidney cancer 1,386 | 2,548
pancreatic cancer 1,371 | 2,322
interstitial cystitis 1,299 | 2,237
astrocytic glioma 1,232 | 2,530
subependymal giant cell astrocytoma 1,175 | 2,230
tuberculosis 1,089 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,065 | 1,911
ulcerative colitis 1,065 | 1,765
Schizophrenia 1,062 | 1,136
pituitary cancer 1,062 | 1,915
cystic fibrosis 981 | 1,629
ductal carcinoma in situ 968 | 1,686
breast carcinoma 928 | 1,589
Intellectual disability 918 | 998
diabetes mellitus 918 | 1,683
Pick disease 907 | 1,856
colon cancer 878 | 1,428
group 4 medulloblastoma 842 | 1,806
adrenocortical carcinoma 787 | 1,385
Liver Cirrhosis, Experimental 732 | 733
Epilepsy 727 | 775
Rheumatoid arthritis 699 | 1,156
juvenile dermatomyositis 661 | 1,147
cutaneous lupus erythematosus 650 | 1,016
Multiple myeloma 649 | 1,296
astrocytoma 649 | 1,113
Dull intelligence 634 | 634
Low intelligence 634 | 634
Mental Retardation 634 | 634
Mental deficiency 634 | 634
Poor school performance 634 | 634
acute quadriplegic myopathy 632 | 1,133
Cognitive delay 596 | 596
Global developmental delay 596 | 596
Mental and motor retardation 596 | 596
primary pancreatic ductal adenocarcinoma 594 | 1,071
Seizures 584 | 584
Bipolar Disorder 579 | 646
Muscle hypotonia 562 | 562
Obesity 553 | 655
pediatric high grade glioma 545 | 1,035
Atopic dermatitis 544 | 915
nasopharyngeal carcinoma 542 | 1,024
dermatomyositis 535 | 941
spina bifida 526 | 1,053
Short stature 514 | 514
active Crohn's disease 498 | 882
Melanoma 492 | 689
Prostatic Neoplasms 466 | 472
gastric carcinoma 464 | 781
esophageal adenocarcinoma 445 | 696
primary Sjogren syndrome 437 | 710
active ulcerative colitis 433 | 736
Alzheimer's disease 419 | 640
Duchenne muscular dystrophy 414 | 587
Breast Neoplasms 413 | 423
non primary Sjogren syndrome sicca 411 | 861
Waldenstrons macroglobulinemia 405 | 742
Mammary Neoplasms 403 | 403
Depressive disorder 401 | 401
Small head 366 | 366
Neurodegenerative disease 365 | 402
Liver cancer 363 | 589
medulloblastoma 363 | 702
Endometriosis 361 | 521
Failure to gain weight 359 | 359
Pediatric failure to thrive 359 | 359
acute myeloid leukemia 359 | 760
aldosterone-producing adenoma 357 | 646
Multiple Sclerosis 348 | 527
autosomal dominant Emery-Dreifuss muscular dystrophy 344 | 492
Autistic Disorder 333 | 358
Hypertension 330 | 372
Down syndrome 320 | 480
Kidney disease 320 | 411

Tissue

Endocrine System 7,242 | 18,159
Digestive Tract 7,125 | 17,369
Female tissues 7,066 | 17,400
Skin and soft tissues 7,058 | 17,230
Male tissues 6,984 | 17,142
Blood and immune system 6,933 | 16,909
Liver and Pancreas 6,916 | 16,750
Urinary Tract 6,913 | 16,678
Nervous System 6,906 | 16,725
Respiratory system 6,758 | 16,393
Cardiovascular System 6,336 | 15,192

Target Family

Non-IDG 3,889 | 12,091
Enzyme 1,764 | 4,145
Transcription Factor 520 | 1,400
Kinase 355 | 634
Transporter 261 | 473
GPCR 228 | 408
Ion Channel 213 | 344
Epigenetic 115 | 242
Nuclear Receptor 43 | 48
TF/Epigenetic 23 | 38
oGPCR 5 | 421

Data Source

DisGeNET 7,416 | 7,416
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Hydroxyacylglutathione hydrolase, mitochondrial HAGH Tbio Enzyme -1.95974 82.6 162
Nidogen-2 NID2 Tbio Non-IDG -1.62355 40.1 116
Zinc finger protein 526 ZNF526 Tdark Transcription Factor 0.70 0.20 51
Somatostatin receptor type 4 SSTR4 Tclin GPCR -1.72615 44.8 147
LIM homeobox transcription factor 1-alpha LMX1A Tbio Transcription Factor -1.82498 66.0 175