Development Level

Tbio 5,489 | 11,445
Tchem 1,126 | 1,598
Tclin 521 | 613
Tdark 495 | 6,588

Collection

RFA-RM-18-021 100 | 328
Ion Channel: IDG Consortium (T... 42 | 99
Kinase: IDG Consortium (Target... 36 | 125
GPCR: IDG Consortium (Targets) 28 | 126
Kinase: IDG Consortium (Comple... 16 | 37
GPCR: IDG Consortium (Complete... 11 | 25

IMPC Phenotype

preweaning lethality, complete... 542 | 979
preweaning lethality, incomple... 243 | 499
abnormal behavior 159 | 298
embryonic lethality prior to t... 155 | 278
embryonic lethality prior to o... 133 | 239
abnormal embryo size 129 | 220
enlarged heart 119 | 210
decreased vertical activity 118 | 208
decreased total body fat amoun... 103 | 207
abnormal heart morphology 97 | 162
abnormal bone structure 95 | 187
decreased body weight 87 | 161
decreased bone mineral content 82 | 151
hypoactivity 81 | 132
hyperactivity 77 | 148
increased lean body mass 73 | 172
abnormal seminal vesicle morph... 69 | 114
decreased bone mineral density 66 | 126
decreased grip strength 65 | 116
increased total body fat amoun... 65 | 134
decreased lean body mass 64 | 135
increased circulating alkaline... 64 | 122
embryonic growth retardation 62 | 106
increased mean corpuscular hem... 61 | 96
increased startle reflex 58 | 112
decreased circulating glucose ... 57 | 126
cataract 56 | 92
decreased circulating choleste... 56 | 93
increased bone mineral content 56 | 108
short tibia 56 | 97
abnormal lens morphology 53 | 81
prenatal lethality prior to he... 52 | 87
abnormal retina morphology 51 | 71
decreased body length 51 | 101
increased or absent threshold ... 51 | 101
decreased mean corpuscular vol... 50 | 79
increased mean corpuscular vol... 50 | 92
decreased lymphocyte cell numb... 49 | 83
male infertility 49 | 123
decreased prepulse inhibition 47 | 82
decreased circulating HDL chol... 46 | 68
impaired glucose tolerance 46 | 75
decreased circulating triglyce... 44 | 79
abnormal eye morphology 43 | 68
decreased circulating serum al... 43 | 82
decreased startle reflex 43 | 75
improved glucose tolerance 43 | 79
increased circulating HDL chol... 43 | 80
small superior vagus ganglion 43 | 74
increased fasted circulating g... 42 | 76
increased circulating choleste... 40 | 66
abnormal sleep behavior 39 | 70
decreased circulating insulin ... 39 | 76
increased circulating sodium l... 39 | 71
abnormal gait 38 | 69
decreased erythrocyte cell num... 36 | 62
decreased fasted circulating g... 35 | 65
increased bone mineral density 35 | 72
decreased leukocyte cell numbe... 34 | 73
decreased hemoglobin content 33 | 68
hydrometra 33 | 53
increased monocyte cell number 33 | 63
small testis 33 | 58
edema 32 | 59
increased heart weight 32 | 62
thrombocytopenia 32 | 56
abnormal coat-hair pigmentatio... 31 | 64
abnormal behavioral response t... 30 | 66
abnormal kidney morphology 30 | 65
increased leukocyte cell numbe... 30 | 47
abnormal spleen morphology 29 | 55
decreased blood urea nitrogen ... 29 | 51
decreased circulating alanine ... 28 | 47
decreased circulating alkaline... 28 | 46
increased circulating triglyce... 28 | 42
abnormal neural tube closure 27 | 46
increased neutrophil cell numb... 27 | 46
decreased mean corpuscular hem... 26 | 50
increased hemoglobin content 26 | 45
limb grasping 26 | 41
abnormal epididymis morphology 25 | 42
abnormal skin morphology 25 | 50
abnormal testis morphology 25 | 43
decreased circulating total pr... 25 | 49
decreased neutrophil cell numb... 25 | 42
decreased red blood cell distr... 25 | 41
enlarged spleen 25 | 41
increased blood urea nitrogen ... 25 | 48
increased circulating creatini... 25 | 38
decreased circulating LDL chol... 24 | 38
increased lymphocyte cell numb... 24 | 32
increased mean platelet volume 24 | 45
persistence of hyaloid vascula... 24 | 33
prolonged QT interval 24 | 38
decreased caudal vertebrae num... 23 | 53
decreased circulating aspartat... 23 | 34
decreased circulating creatini... 23 | 39
prolonged ST segment 23 | 36
tremors 23 | 39
pallor 22 | 34

Disease

Carcinoma 5,129 | 11,493
ovarian cancer 4,069 | 8,520
osteosarcoma 3,505 | 7,950
psoriasis 3,296 | 6,694
medulloblastoma, large-cell 2,976 | 6,241
glioblastoma 2,938 | 5,792
lung cancer 2,706 | 4,740
atypical teratoid / rhabdoid tumor 2,455 | 5,112
ependymoma 2,308 | 4,679
group 3 medulloblastoma 1,974 | 4,104
Breast cancer 1,956 | 3,578
Cancer 1,901 | 2,499
adult high grade glioma 1,887 | 3,801
malignant mesothelioma 1,864 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,727 | 3,291
non-small cell lung cancer 1,681 | 2,890
invasive ductal carcinoma 1,677 | 2,951
Astrocytoma, Pilocytic 1,661 | 3,081
lung carcinoma 1,636 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 1,589 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,583 | 2,955
lung adenocarcinoma 1,547 | 2,716
primitive neuroectodermal tumor 1,483 | 3,035
oligodendroglioma 1,462 | 2,850
Autosomal recessive predisposition 1,442 | 1,442
pancreatic cancer 1,427 | 2,398
Kidney cancer 1,422 | 2,613
interstitial cystitis 1,346 | 2,312
astrocytic glioma 1,268 | 2,597
subependymal giant cell astrocytoma 1,209 | 2,287
tuberculosis 1,116 | 2,010
ulcerative colitis 1,099 | 1,819
pituitary cancer 1,095 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,094 | 1,962
Schizophrenia 1,082 | 1,160
cystic fibrosis 1,027 | 1,696
ductal carcinoma in situ 1,010 | 1,745
breast carcinoma 965 | 1,638
diabetes mellitus 951 | 1,728
Intellectual disability 936 | 1,016
Pick disease 924 | 1,894
colon cancer 915 | 1,478
group 4 medulloblastoma 868 | 1,855
adrenocortical carcinoma 815 | 1,428
Liver Cirrhosis, Experimental 768 | 769
Epilepsy 742 | 792
Rheumatoid arthritis 717 | 1,191
juvenile dermatomyositis 677 | 1,187
cutaneous lupus erythematosus 675 | 1,057
astrocytoma 673 | 1,146
Multiple myeloma 669 | 1,332
acute quadriplegic myopathy 647 | 1,158
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
primary pancreatic ductal adenocarcinoma 622 | 1,109
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Bipolar Disorder 597 | 666
Seizures 596 | 596
Obesity 572 | 678
Muscle hypotonia 571 | 571
Atopic dermatitis 570 | 952
nasopharyngeal carcinoma 566 | 1,058
pediatric high grade glioma 563 | 1,064
dermatomyositis 550 | 966
spina bifida 535 | 1,074
Short stature 531 | 531
active Crohn's disease 525 | 922
Melanoma 506 | 711
Prostatic Neoplasms 489 | 495
gastric carcinoma 481 | 807
esophageal adenocarcinoma 474 | 737
active ulcerative colitis 452 | 764
primary Sjogren syndrome 451 | 735
Breast Neoplasms 435 | 445
Alzheimer's disease 432 | 658
non primary Sjogren syndrome sicca 431 | 891
Duchenne muscular dystrophy 425 | 601
Mammary Neoplasms 425 | 425
Waldenstrons macroglobulinemia 418 | 765
Depressive disorder 409 | 409
Endometriosis 377 | 540
medulloblastoma 376 | 720
Neurodegenerative disease 375 | 414
Small head 374 | 374
Liver cancer 373 | 604
acute myeloid leukemia 371 | 783
aldosterone-producing adenoma 371 | 665
Failure to gain weight 365 | 365
Pediatric failure to thrive 365 | 365
Multiple Sclerosis 359 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 357 | 510
Hypertension 354 | 396
Kidney disease 339 | 430
Autistic Disorder 338 | 364
Down syndrome 334 | 499

Tissue

Endocrine System 7,451 | 18,159
Digestive Tract 7,323 | 17,369
Female tissues 7,266 | 17,400
Skin and soft tissues 7,256 | 17,230
Male tissues 7,178 | 17,142
Blood and immune system 7,128 | 16,909
Liver and Pancreas 7,106 | 16,750
Urinary Tract 7,102 | 16,678
Nervous System 7,099 | 16,725
Respiratory system 6,941 | 16,393
Cardiovascular System 6,500 | 15,192

Target Family

Non-IDG 3,940 | 12,091
Enzyme 1,872 | 4,145
Transcription Factor 571 | 1,400
Kinase 355 | 634
Transporter 263 | 473
GPCR 228 | 408
Ion Channel 213 | 344
Epigenetic 116 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 23 | 38
oGPCR 5 | 421

Data Source

DisGeNET 7,631 | 7,631
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.18122 1.46 28
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267