Development Level

Tbio 10,497 | 10,625
Tdark 5,996 | 7,003
Tchem 1,882 | 1,890
Tclin 601 | 602

Collection

Eligible non-olfactory GPCR Proteins 135 | 145
Eligible Kinase Proteins 132 | 134
Eligible Ion Channel Proteins 115 | 117

IMPC Term

preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 194 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 173 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 130 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 125 | 126
decreased grip strength 122 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 110 | 111
decreased body length 108 | 108
hyperactivity 107 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased bone mineral content 92 | 92
increased mean corpuscular hem... 92 | 93
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
increased circulating HDL chol... 63 | 63
abnormal sleep behavior 62 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 60 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
abnormal bone mineralization 53 | 55
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased circulating alanine ... 52 | 53
decreased hemoglobin content 52 | 53
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased prepulse inhibition 51 | 52
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 43 | 44
increased circulating chloride... 43 | 43
decreased erythrocyte cell num... 42 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased heart weight 36 | 37
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
limb grasping 34 | 35
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
increased circulating calcium ... 32 | 32
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating creatini... 31 | 31
decreased circulating fructosa... 31 | 31
decreased threshold for audito... 31 | 32
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 8,433 | 8,492
osteosarcoma 7,833 | 7,933
psoriasis 6,545 | 6,685
medulloblastoma, large-cell 6,191 | 6,234
glioblastoma 5,540 | 5,572
lung cancer 4,448 | 4,473
atypical teratoid / rhabdoid tumor 4,343 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,263 | 3,289
malignant mesothelioma 3,144 | 3,163
Breast cancer 3,082 | 3,099
pilocytic astrocytoma 3,073 | 3,086
primitive neuroectodermal tumor 3,020 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,968 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,941 | 2,956
invasive ductal carcinoma 2,938 | 2,950
oligodendroglioma 2,835 | 2,849
lung carcinoma 2,816 | 2,844
non-small cell lung cancer 2,785 | 2,798
pediatric high grade glioma 2,699 | 2,712
lung adenocarcinoma 2,691 | 2,714
ependymoma 2,503 | 2,514
pancreatic cancer 2,289 | 2,300
interstitial cystitis 2,283 | 2,299
subependymal giant cell astrocytoma 2,270 | 2,287
Cancer 2,244 | 2,346
group 3 medulloblastoma 2,237 | 2,254
astrocytic glioma 2,227 | 2,241
Carcinoma 2,133 | 2,147
adult high grade glioma 2,130 | 2,148
ulcerative colitis 2,075 | 2,087
pituitary cancer 1,960 | 1,972
Pick disease 1,885 | 1,893
group 4 medulloblastoma 1,864 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,786 | 1,795
ductal carcinoma in situ 1,737 | 1,745
cystic fibrosis 1,659 | 1,670
breast carcinoma 1,604 | 1,614
diabetes mellitus 1,567 | 1,663
tuberculosis 1,551 | 1,563
posterior fossa group B ependymoma 1,516 | 1,530
medulloblastoma 1,514 | 1,524
posterior fossa group A ependymoma 1,503 | 1,511
astrocytoma 1,487 | 1,493
sonic hedgehog group medulloblastoma 1,475 | 1,482
colon cancer 1,464 | 1,475
adrenocortical carcinoma 1,418 | 1,427
Multiple myeloma 1,326 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,185 | 1,189
acute quadriplegic myopathy 1,155 | 1,157
Rheumatoid Arthritis 1,125 | 1,171
atypical teratoid/rhabdoid tumor 1,089 | 1,095
spina bifida 1,059 | 1,064
nasopharyngeal carcinoma 1,051 | 1,056
cutaneous lupus erythematosus 1,050 | 1,056
Atopic dermatitis 941 | 944
dermatomyositis 932 | 967
active Crohn's disease 913 | 918
non primary Sjogren syndrome sicca 827 | 840
gastric carcinoma 825 | 832
acute myeloid leukemia 783 | 785
primary Sjogren syndrome 783 | 789
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 734 | 737
tuberculosis and treatment for 6 months 683 | 686
progressive supranuclear palsy 669 | 674
aldosterone-producing adenoma 663 | 664
Alzheimer's disease 638 | 644
Obesity 611 | 616
Duchenne muscular dystrophy 597 | 602
Intellectual disability 572 | 573
pancreatic carcinoma 564 | 567
fibroadenoma 555 | 557
hepatocellular carcinoma 546 | 550
Down syndrome 543 | 548
Endometriosis 533 | 535
chronic rhinosinusitis 509 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Schizophrenia 498 | 503
mucosa-associated lymphoid tissue lymphoma 476 | 480
Multiple Sclerosis 471 | 498
active ulcerative colitis 471 | 477
Prostatic Neoplasms 470 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 431 | 436
Amyotrophic Lateral Sclerosis 430 | 432
Mammary Neoplasms 410 | 410
non-small cell lung carcinoma 408 | 413
inflammatory breast cancer 395 | 404
Neurodegenerative disease 380 | 383
Kidney disease 375 | 397
Parkinson's disease 362 | 364
sarcoidosis 355 | 368
Asthma 346 | 349
Epilepsy 345 | 346
glioblastoma multiforme 345 | 347
Polycystic Ovary Syndrome 332 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 324 | 327
Autistic Disorder 318 | 320

Tissue

Female tissues 18,647 | 18,647
Nervous System 18,561 | 18,561
Endocrine System 18,512 | 18,512
Digestive Tract 18,473 | 18,473
Urinary Tract 18,444 | 18,444
Liver and Pancreas 18,136 | 18,136
Skin and soft tissues 18,115 | 18,115
Blood and immune system 17,995 | 17,995
Male tissues 17,969 | 17,969
Cardiovascular System 17,958 | 17,958
Respiratory system 17,484 | 17,484

Target Family

Non-IDG 11,002 | 11,969
Enzyme 4,058 | 4,146
Transcription Factor 1,399 | 1,400
Kinase 629 | 634
Transporter 465 | 473
GPCR 398 | 408
oGPCR 358 | 421
Ion Channel 339 | 341
Epigenetic 242 | 242
Nuclear Receptor 48 | 48
TF/Epigenetic 38 | 38

Data Source

Consensus 18,976 | 18,976
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
NACHT, LRR and PYD domains-containing protein 14 NLRP14 Tbio Non-IDG -1.33032 17.6 30
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101