Development Level

Tbio 5,367 | 11,445
Tchem 1,089 | 1,598
Tclin 504 | 613
Tdark 486 | 6,588

Collection

RFA-RM-18-021 86 | 328
Ion Channel: IDG Consortium (T... 33 | 99
Kinase: IDG Consortium (Target... 33 | 125
GPCR: IDG Consortium (Targets) 25 | 126
Kinase: IDG Consortium (Comple... 16 | 37
GPCR: IDG Consortium (Complete... 9 | 25

IMPC Phenotype

preweaning lethality, complete... 540 | 979
preweaning lethality, incomple... 249 | 499
abnormal behavior 151 | 298
embryonic lethality prior to t... 147 | 278
embryonic lethality prior to o... 128 | 239
abnormal embryo size 126 | 220
decreased vertical activity 117 | 208
enlarged heart 113 | 210
decreased total body fat amoun... 102 | 207
abnormal heart morphology 93 | 162
abnormal bone structure 88 | 187
decreased body weight 85 | 161
decreased bone mineral content 77 | 151
hypoactivity 77 | 132
increased lean body mass 75 | 172
hyperactivity 74 | 148
abnormal seminal vesicle morph... 70 | 114
decreased bone mineral density 65 | 126
decreased grip strength 65 | 116
decreased lean body mass 65 | 135
decreased circulating glucose ... 64 | 126
increased total body fat amoun... 64 | 134
increased circulating alkaline... 63 | 122
increased mean corpuscular hem... 61 | 96
embryonic growth retardation 60 | 106
increased startle reflex 58 | 112
increased bone mineral content 56 | 108
short tibia 56 | 97
cataract 55 | 92
decreased circulating choleste... 53 | 93
increased or absent threshold ... 52 | 101
male infertility 52 | 123
abnormal retina morphology 51 | 71
abnormal lens morphology 50 | 81
decreased body length 49 | 101
decreased mean corpuscular vol... 49 | 79
increased mean corpuscular vol... 48 | 92
decreased lymphocyte cell numb... 47 | 83
impaired glucose tolerance 46 | 75
prenatal lethality prior to he... 46 | 87
decreased circulating HDL chol... 45 | 68
decreased circulating triglyce... 44 | 79
decreased startle reflex 43 | 75
increased circulating HDL chol... 43 | 80
increased fasted circulating g... 43 | 76
abnormal eye morphology 42 | 68
decreased prepulse inhibition 42 | 82
improved glucose tolerance 41 | 79
increased circulating sodium l... 41 | 71
small superior vagus ganglion 40 | 74
abnormal sleep behavior 39 | 70
increased circulating choleste... 39 | 66
decreased circulating serum al... 38 | 82
abnormal gait 37 | 69
decreased circulating insulin ... 37 | 76
decreased erythrocyte cell num... 36 | 62
increased bone mineral density 35 | 72
decreased fasted circulating g... 34 | 65
small testis 34 | 58
edema 33 | 59
increased leukocyte cell numbe... 33 | 47
increased monocyte cell number 33 | 63
decreased hemoglobin content 32 | 68
decreased leukocyte cell numbe... 32 | 73
increased heart weight 32 | 62
thrombocytopenia 32 | 56
abnormal coat-hair pigmentatio... 30 | 64
hydrometra 30 | 53
abnormal behavioral response t... 29 | 66
abnormal kidney morphology 29 | 65
decreased blood urea nitrogen ... 29 | 51
abnormal spleen morphology 28 | 55
increased blood urea nitrogen ... 28 | 48
decreased mean corpuscular hem... 27 | 50
increased circulating triglyce... 27 | 42
abnormal testis morphology 26 | 43
decreased circulating alkaline... 26 | 46
increased neutrophil cell numb... 26 | 46
limb grasping 26 | 41
abnormal neural tube closure 25 | 46
abnormal skin morphology 25 | 50
decreased circulating alanine ... 25 | 47
decreased neutrophil cell numb... 25 | 42
increased hemoglobin content 25 | 45
increased mean platelet volume 25 | 45
decreased red blood cell distr... 24 | 41
increased circulating creatini... 24 | 38
increased lymphocyte cell numb... 24 | 32
persistence of hyaloid vascula... 24 | 33
abnormal epididymis morphology 23 | 42
decreased circulating total pr... 23 | 49
enlarged lymph nodes 23 | 37
enlarged spleen 23 | 41
female infertility 23 | 60
tremors 23 | 39
decreased circulating creatini... 22 | 39
prolonged QT interval 22 | 38
anophthalmia 21 | 33
decreased circulating LDL chol... 21 | 38
prolonged ST segment 21 | 36

Disease

Carcinoma 5,002 | 11,493
ovarian cancer 3,983 | 8,520
osteosarcoma 3,423 | 7,950
psoriasis 3,215 | 6,694
medulloblastoma, large-cell 2,901 | 6,241
glioblastoma 2,869 | 5,792
lung cancer 2,624 | 4,740
atypical teratoid / rhabdoid tumor 2,396 | 5,112
ependymoma 2,247 | 4,679
Breast cancer 1,921 | 3,578
group 3 medulloblastoma 1,900 | 4,104
Cancer 1,859 | 2,499
adult high grade glioma 1,822 | 3,801
malignant mesothelioma 1,817 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,696 | 3,291
non-small cell lung cancer 1,644 | 2,890
invasive ductal carcinoma 1,634 | 2,951
Astrocytoma, Pilocytic 1,601 | 3,081
lung carcinoma 1,592 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 1,560 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,538 | 2,955
lung adenocarcinoma 1,503 | 2,716
primitive neuroectodermal tumor 1,441 | 3,035
Autosomal recessive predisposition 1,430 | 1,442
oligodendroglioma 1,424 | 2,850
pancreatic cancer 1,399 | 2,398
Kidney cancer 1,383 | 2,613
interstitial cystitis 1,320 | 2,312
astrocytic glioma 1,240 | 2,597
subependymal giant cell astrocytoma 1,163 | 2,287
tuberculosis 1,099 | 2,010
ulcerative colitis 1,078 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 1,065 | 1,962
pituitary cancer 1,057 | 1,972
cystic fibrosis 1,014 | 1,696
ductal carcinoma in situ 993 | 1,745
breast carcinoma 955 | 1,638
diabetes mellitus 952 | 1,728
Intellectual disability 942 | 1,016
colon cancer 910 | 1,478
Pick disease 906 | 1,894
Schizophrenia 870 | 1,160
group 4 medulloblastoma 830 | 1,855
adrenocortical carcinoma 805 | 1,428
Liver Cirrhosis, Experimental 769 | 769
Epilepsy 734 | 792
Rheumatoid arthritis 708 | 1,191
Multiple myeloma 663 | 1,332
cutaneous lupus erythematosus 660 | 1,057
astrocytoma 658 | 1,146
juvenile dermatomyositis 656 | 1,187
acute quadriplegic myopathy 632 | 1,158
Dull intelligence 631 | 645
Low intelligence 631 | 645
Mental Retardation 631 | 645
Mental deficiency 631 | 645
Poor school performance 631 | 645
primary pancreatic ductal adenocarcinoma 616 | 1,109
Seizures 592 | 596
Cognitive delay 591 | 608
Global developmental delay 591 | 608
Mental and motor retardation 591 | 608
Obesity 569 | 678
Atopic dermatitis 563 | 952
nasopharyngeal carcinoma 559 | 1,058
pediatric high grade glioma 550 | 1,064
Muscle hypotonia 549 | 571
dermatomyositis 533 | 966
spina bifida 518 | 1,074
active Crohn's disease 513 | 922
Short stature 510 | 531
Bipolar Disorder 497 | 666
Melanoma 496 | 711
Prostatic Neoplasms 495 | 495
gastric carcinoma 473 | 807
esophageal adenocarcinoma 470 | 737
active ulcerative colitis 458 | 764
Breast Neoplasms 445 | 445
primary Sjogren syndrome 434 | 735
Mammary Neoplasms 425 | 425
non primary Sjogren syndrome sicca 421 | 891
Alzheimer's disease 420 | 658
Waldenstrons macroglobulinemia 415 | 765
Duchenne muscular dystrophy 406 | 601
Depressive disorder 382 | 409
Endometriosis 379 | 540
Neurodegenerative disease 379 | 414
Liver cancer 371 | 604
medulloblastoma 369 | 720
acute myeloid leukemia 365 | 783
aldosterone-producing adenoma 365 | 665
Failure to gain weight 361 | 365
Pediatric failure to thrive 361 | 365
Small head 360 | 374
Hypertension 354 | 396
Multiple Sclerosis 345 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 344 | 510
Kidney disease 333 | 430
fibroadenoma 327 | 559
Down syndrome 325 | 499

Tissue

Endocrine System 7,281 | 18,159
Digestive Tract 7,159 | 17,369
Female tissues 7,112 | 17,400
Skin and soft tissues 7,098 | 17,230
Male tissues 7,025 | 17,142
Blood and immune system 6,980 | 16,909
Liver and Pancreas 6,954 | 16,750
Urinary Tract 6,947 | 16,678
Nervous System 6,930 | 16,725
Respiratory system 6,803 | 16,393
Cardiovascular System 6,372 | 15,192

Target Family

Non-IDG 3,867 | 12,091
Enzyme 1,839 | 4,145
Transcription Factor 545 | 1,400
Kinase 347 | 634
Transporter 252 | 473
GPCR 210 | 408
Ion Channel 197 | 344
Epigenetic 116 | 242
Nuclear Receptor 44 | 48
TF/Epigenetic 23 | 38
oGPCR 6 | 421

Data Source

CTD 7,446 | 7,446
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.18122 1.46 28