Development Level

Tbio 4,085 | 11,445
Tdark 1,525 | 6,588
Tchem 602 | 1,598
Tclin 188 | 613

Collection

RFA-RM-18-021 105 | 328
Kinase: IDG Consortium (Target... 53 | 125
Ion Channel: IDG Consortium (T... 35 | 99
GPCR: IDG Consortium (Targets) 20 | 126
GPCR: IDG Consortium (Complete... 9 | 25
Kinase: IDG Consortium (Comple... 7 | 37

IMPC Phenotype

preweaning lethality, complete... 368 | 979
preweaning lethality, incomple... 180 | 499
embryonic lethality prior to t... 104 | 278
embryonic lethality prior to o... 99 | 239
abnormal behavior 96 | 298
abnormal embryo size 86 | 220
enlarged heart 86 | 210
decreased vertical activity 72 | 208
abnormal bone structure 71 | 187
decreased total body fat amoun... 70 | 207
abnormal heart morphology 61 | 162
increased lean body mass 61 | 172
increased total body fat amoun... 57 | 134
decreased body weight 54 | 161
decreased bone mineral content 53 | 151
hyperactivity 52 | 148
decreased lean body mass 51 | 135
abnormal seminal vesicle morph... 50 | 114
male infertility 48 | 123
decreased bone mineral density 47 | 126
increased startle reflex 47 | 112
decreased circulating glucose ... 45 | 126
increased circulating alkaline... 45 | 122
decreased grip strength 44 | 116
hypoactivity 42 | 132
decreased body length 41 | 101
cataract 39 | 92
embryonic growth retardation 39 | 106
short tibia 39 | 97
decreased circulating triglyce... 38 | 79
increased bone mineral content 38 | 108
increased mean corpuscular hem... 35 | 96
small superior vagus ganglion 35 | 74
increased mean corpuscular vol... 33 | 92
increased or absent threshold ... 33 | 101
abnormal lens morphology 32 | 81
decreased circulating choleste... 32 | 93
decreased lymphocyte cell numb... 32 | 83
improved glucose tolerance 32 | 79
abnormal sleep behavior 31 | 70
decreased prepulse inhibition 30 | 82
abnormal behavioral response t... 29 | 66
hydrometra 28 | 53
increased circulating HDL chol... 28 | 80
small testis 28 | 58
abnormal retina morphology 27 | 71
increased fasted circulating g... 27 | 76
decreased mean corpuscular vol... 26 | 79
abnormal eye morphology 25 | 68
abnormal gait 25 | 69
abnormal kidney morphology 25 | 65
decreased circulating HDL chol... 25 | 68
increased bone mineral density 25 | 72
decreased leukocyte cell numbe... 24 | 73
decreased startle reflex 24 | 75
impaired glucose tolerance 24 | 75
increased monocyte cell number 24 | 63
thrombocytopenia 24 | 56
abnormal spleen morphology 23 | 55
decreased erythrocyte cell num... 23 | 62
decreased hemoglobin content 23 | 68
decreased circulating insulin ... 22 | 76
edema 22 | 59
female infertility 22 | 60
prenatal lethality prior to he... 22 | 87
abnormal skin morphology 21 | 50
increased circulating choleste... 21 | 66
increased circulating sodium l... 21 | 71
increased leukocyte cell numbe... 21 | 47
decreased blood urea nitrogen ... 20 | 51
decreased caudal vertebrae num... 20 | 53
increased heart weight 20 | 62
decreased circulating serum al... 19 | 82
decreased fasted circulating g... 19 | 65
increased circulating triglyce... 19 | 42
abnormal testis morphology 18 | 43
increased grip strength 18 | 41
abnormal retinal vasculature m... 17 | 27
decreased circulating LDL chol... 17 | 38
enlarged spleen 17 | 41
abnormal bone mineralization 16 | 38
abnormal coat-hair pigmentatio... 16 | 64
abnormal neural tube closure 16 | 46
decreased hematocrit 16 | 46
increased red blood cell distr... 16 | 34
thrombocytosis 16 | 27
decreased circulating alanine ... 15 | 47
decreased circulating aspartat... 15 | 34
increased circulating calcium ... 15 | 34
increased circulating chloride... 15 | 41
abnormal epididymis morphology 14 | 42
cardiovascular system phenotyp... 14 | 36
decreased mean corpuscular hem... 14 | 50
decreased neutrophil cell numb... 14 | 42
increased blood urea nitrogen ... 14 | 48
increased body length 14 | 32
increased circulating creatini... 14 | 38
increased mean platelet volume 14 | 45
increased neutrophil cell numb... 14 | 46
prolonged ST segment 14 | 36

Disease

Carcinoma 3,734 | 11,493
ovarian cancer 3,097 | 8,520
osteosarcoma 2,787 | 7,950
psoriasis 2,325 | 6,694
medulloblastoma, large-cell 2,165 | 6,241
glioblastoma 2,061 | 5,792
atypical teratoid / rhabdoid tumor 1,782 | 5,112
lung cancer 1,768 | 4,740
ependymoma 1,646 | 4,679
group 3 medulloblastoma 1,442 | 4,104
adult high grade glioma 1,325 | 3,801
Breast cancer 1,243 | 3,578
malignant mesothelioma 1,209 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,164 | 3,291
Astrocytoma, Pilocytic 1,102 | 3,081
invasive ductal carcinoma 1,071 | 2,951
primitive neuroectodermal tumor 1,064 | 3,035
non-small cell lung cancer 1,062 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 1,056 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,038 | 2,955
oligodendroglioma 1,013 | 2,850
lung carcinoma 1,003 | 2,843
lung adenocarcinoma 960 | 2,716
Cancer 921 | 2,499
astrocytic glioma 901 | 2,597
pancreatic cancer 841 | 2,398
subependymal giant cell astrocytoma 826 | 2,287
interstitial cystitis 817 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 741 | 1,962
tuberculosis 705 | 2,010
pituitary cancer 667 | 1,972
ulcerative colitis 662 | 1,819
Pick disease 649 | 1,894
ductal carcinoma in situ 647 | 1,745
group 4 medulloblastoma 642 | 1,855
diabetes mellitus 604 | 1,728
cystic fibrosis 590 | 1,696
breast carcinoma 580 | 1,638
Kidney cancer 570 | 2,613
Multiple myeloma 566 | 1,332
colon cancer 556 | 1,478
adrenocortical carcinoma 547 | 1,428
Autosomal recessive predisposition 494 | 1,442
cutaneous lupus erythematosus 430 | 1,057
acute quadriplegic myopathy 429 | 1,158
Rheumatoid arthritis 427 | 1,191
astrocytoma 409 | 1,146
pediatric high grade glioma 405 | 1,064
juvenile dermatomyositis 401 | 1,187
primary pancreatic ductal adenocarcinoma 388 | 1,109
Schizophrenia 387 | 1,160
nasopharyngeal carcinoma 378 | 1,058
spina bifida 369 | 1,074
dermatomyositis 358 | 966
active Crohn's disease 355 | 922
Atopic dermatitis 352 | 952
non primary Sjogren syndrome sicca 335 | 891
Intellectual disability 313 | 1,016
Liver Cirrhosis, Experimental 310 | 769
primary Sjogren syndrome 304 | 735
Waldenstrons macroglobulinemia 298 | 765
acute myeloid leukemia 295 | 783
gastric carcinoma 293 | 807
esophageal adenocarcinoma 281 | 737
Epilepsy 268 | 792
active ulcerative colitis 256 | 764
Obesity 238 | 678
medulloblastoma 231 | 720
progressive supranuclear palsy 230 | 676
Bipolar Disorder 229 | 666
aldosterone-producing adenoma 228 | 665
Alzheimer's disease 225 | 658
Endometriosis 225 | 540
Cognitive delay 222 | 608
Global developmental delay 222 | 608
Mental and motor retardation 222 | 608
Duchenne muscular dystrophy 220 | 601
Seizures 213 | 596
pancreatic carcinoma 211 | 562
hepatocellular carcinoma 208 | 547
Prostatic Neoplasms 205 | 495
Down syndrome 204 | 499
Dull intelligence 203 | 645
Low intelligence 203 | 645
Mental Retardation 203 | 645
Mental deficiency 203 | 645
Poor school performance 203 | 645
Muscle hypotonia 197 | 571
fibroadenoma 193 | 559
Multiple Sclerosis 192 | 540
Melanoma 184 | 711
mucosa-associated lymphoid tissue lymphoma 183 | 484
Short stature 176 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 175 | 510
gastric cancer 171 | 459
Kidney disease 170 | 430
chronic rhinosinusitis 170 | 512
tuberculosis and treatment for 6 months 169 | 409
sonic hedgehog group medulloblastoma 168 | 467
Breast Neoplasms 163 | 445

Tissue

Endocrine System 6,238 | 18,159
Female tissues 6,082 | 17,400
Digestive Tract 6,069 | 17,369
Skin and soft tissues 6,030 | 17,230
Male tissues 6,013 | 17,142
Blood and immune system 5,949 | 16,909
Liver and Pancreas 5,926 | 16,750
Urinary Tract 5,918 | 16,678
Nervous System 5,886 | 16,725
Respiratory system 5,812 | 16,393
Cardiovascular System 5,464 | 15,192

Target Family

Non-IDG 3,812 | 12,091
Enzyme 1,562 | 4,145
Transcription Factor 363 | 1,400
Kinase 228 | 634
Transporter 124 | 473
Ion Channel 97 | 344
GPCR 82 | 408
Epigenetic 70 | 242
oGPCR 30 | 421
Nuclear Receptor 21 | 48
TF/Epigenetic 11 | 38

Data Source

BioPlex 6,400 | 6,400
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ankyrin repeat and SOCS box protein 3 ASB3 Tdark Non-IDG -0.63324 4.85 134
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.76391 516.8 355
Adaptin ear-binding coat-associated protein 2 NECAP2 Tdark Non-IDG 0.03 1.27 37
Hydroxyacid oxidase 1 HAO1 Tchem Enzyme -3.03218 1057.3 229
[Protein ADP-ribosylarginine] hydrolase ADPRH Tbio Enzyme -0.88930 6.68 116
Galectin-3 LGALS3 Tchem Non-IDG -3.36655 2447.4 1101
Trafficking protein particle complex subunit 12 TRAPPC12 Tbio Non-IDG -0.50060 3.07 61
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Sodium/hydrogen exchanger 5 SLC9A5 Tchem Transporter -1.15040 17.1 43
Zinc finger protein 221 ZNF221 Tdark Transcription Factor 0.00000 0