Development Level

Tchem 4 | 1,598

Disease

Carcinoma 4 | 11,493
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
Multiple myeloma 2 | 1,332
Status Epilepticus 2 | 98
atypical teratoid / rhabdoid tumor 2 | 5,112
glioblastoma 2 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
psoriasis 2 | 6,694
Abnormal development of end part of bone 1 | 14
Abnormality of the metaphyses 1 | 48
Amino Acid Metabolism, Inborn Errors 1 | 13
Anemia, Hemolytic 1 | 55
Barrel chest 1 | 12
Brachydactyly 1 | 156
Carpal bone hypoplasia 1 | 6
Central nervous system disease 1 | 10
Chemical and Drug Induced Liver Injury 1 | 195
Chronic Liver Failure 1 | 2
Cone-shaped epiphyses of phalanges 1 | 15
Congenital Heart Defects 1 | 58
Congenital heart disease 1 | 93
Coxa valga 1 | 22
Coxa valga deformity 1 | 22
Death in early childhood 1 | 82
Death in infancy 1 | 82
Decreased size of teeth 1 | 62
Decreased width of tooth 1 | 59
Dehydration 1 | 40
Diabetes Mellitus, Insulin-Dependent 1 | 48
Disproportionately short middle phalanges 1 | 6
Elevated hepatic transaminases 1 | 81
Enlarged thorax 1 | 18
Epiphyseal dysplasia 1 | 14
Familial primary pulmonary hypertension 1 | 11
Flat epiphyses 1 | 7
Generalized osteopenia 1 | 99
Globe disease 1 | 67
Glycosuria 1 | 29
Hair Diseases 1 | 3
Hepatic enzyme increased 1 | 81
High forehead 1 | 102
Hyperglycemia 1 | 137
Hyperopia 1 | 70
Hypertension, Pulmonary 1 | 37
Hyperuricemia 1 | 49
Immune System Diseases 1 | 4
Infantile onset 1 | 238
Influenza 1 | 142
Influenza, Human 1 | 51
Insulin resistant diabetes 1 | 13
Intracerebral periventricular calcifications 1 | 2
Irregular carpal bones 1 | 2
Irregular tarsal ossification 1 | 1
Irregular vertebral endplates 1 | 16
Ivory epiphyses of the toes 1 | 1
Ketoacidosis 1 | 11
Knee joint valgus deformity 1 | 56
Liver Failure, Acute 1 | 29
Liver enzymes abnormal 1 | 81
Liver function test increased 1 | 81
Lordosis 1 | 54
Microdontia (disorder) 1 | 59
Microphthalmia with limb anomalies 1 | 40
Motor delay 1 | 147
Multiple epiphyseal dysplasia 1 | 18
Muscle Hypertonia 1 | 88
Muscular Diseases 1 | 27
Narrow iliac wings 1 | 7
Neutrophil count decreased 1 | 47
No development of motor milestones 1 | 147
ODONTOID HYPOPLASIA 1 | 16
Osteopenia 1 | 99
Osteoporosis 1 | 363
Platyspondyly 1 | 56
Preauricular Fistulae, Congenital 1 | 27
Preauricular dimple 1 | 27
Preauricular sinus 1 | 27
Primary pulmonary hypertension 1 | 14
Pulmonary capillary hemangiomatosis 1 | 2
Pulmonary hypertension 1 | 85
Reduced pancreatic beta cells 1 | 6
Renal tubular disorder 1 | 12
Respiratory Distress Syndrome, Adult 1 | 40
Sclerotic ivory phalangeal epiphyses 1 | 3
Short thorax 1 | 21
Small epiphyses 1 | 9
Small wrist bones 1 | 6
Steatorrhea 1 | 34
Subclinical abnormal liver function tests 1 | 81
Systemic lupus erythematosus 1 | 194
Tall forehead 1 | 102
Thalassemia 1 | 53
Transaminases increased 1 | 81
Transient neonatal diabetes mellitus 1 | 14
Triangular face 1 | 58
Weight decreased 1 | 103
Wolcott-Rallison syndrome 1 | 10
ileal Crohn's disease 1 | 9
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 4 | 16,909
Cardiovascular System 4 | 15,192
Digestive Tract 4 | 17,369
Endocrine System 4 | 18,159
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Skin and soft tissues 4 | 17,230
Urinary Tract 4 | 16,678

Target Family

Kinase 4 | 634

DTO Protein Class (3)

PEK family 4 | 4
STE20 family 31 | 31
CAMKL family 22 | 22
CDK family 21 | 21
MAPK family 15 | 15
EPH family 14 | 14
C-C chemokine receptor 13 | 13
STKR family 12 | 12
NEK family 11 | 11
PI3-PI4 kinase family 11 | 11
SRC family 11 | 11
DYRK family 10 | 10
MLK family 10 | 10
P2Y receptor 10 | 10
PKC family 9 | 9
DMPK family 8 | 8
PIKK family 8 | 8
RSK family 8 | 8
STE11 family 8 | 8
CK1 family 7 | 7
CLK family 7 | 7
GRK family 7 | 7
RAF family 7 | 7
STE7 family 7 | 7
Alpha adrenoceptor 6 | 6
MAST family 6 | 6
RGC family 6 | 6
SCY1 family 6 | 6
TEC family 6 | 6
5-HT1 receptor 5 | 5
5-HT3 receptor sub-subfamily 5 | 5
ABC1 family 5 | 5
Alpha family 5 | 5
CAMK1 family 5 | 5
CDKL family 5 | 5
DAPK family 5 | 5
MAPKAPK family 5 | 5
MLCK family 5 | 5
PDGFR family 5 | 5
PDHK family 5 | 5
PKA family 5 | 5
PLK family 5 | 5
RIPK family 5 | 5
TSSK family 5 | 5
ULK family 5 | 5
Adenylate kinase family 4 | 4
C-X-C chemokine receptor 4 | 4
CAMK2 family 4 | 4
CK2 family 4 | 4
EGFR family 4 | 4
FGFR family 4 | 4
Hexokinase family 4 | 4
IKK family 4 | 4
IRAK family 4 | 4
JAKA family 4 | 4
LISK family 4 | 4
NAK family 4 | 4
NDR family 4 | 4
PIM family 4 | 4
TRIO family 4 | 4
WNK family 4 | 4
5-HT2 receptor 3 | 3
AKT family 3 | 3
AUR family 3 | 3
AXL family 3 | 3
Beta adrenoceptor 3 | 3
DCAMKL family 3 | 3
DCK-DGK family 3 | 3
Diacylglycerol kinase family 3 | 3
INSR family 3 | 3
Inositol phosphokinase (IPK) f... 3 | 3
LMR family 3 | 3
MET family 3 | 3
NKF1 family 3 | 3
Other-UNIQUE family 3 | 3
PKD family 3 | 3
PKN family 3 | 3
RCK family 3 | 3
RIO family 3 | 3
SGK family 3 | 3
SRPK family 3 | 3
TRBL family 3 | 3
TRK family 3 | 3
Type II pantothenate kinase fa... 3 | 3
VEGFR family 3 | 3
VRK family 3 | 3
WEE family 3 | 3
YANK family 3 | 3
ABL family 2 | 2
ACK family 2 | 2
Alpha-7-CHRNA7 sub-subfamily 2 | 2
BUB family 2 | 2
CAMK-UNIQUE family 2 | 2
CSK family 2 | 2
FGGY kinase family 2 | 2
NRBP family 2 | 2
STE-UNIQUE family 2 | 2
TIE family 2 | 2
TRPM2 sub-subfamily 2 | 2
TTBK family 2 | 2

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