Development Level

Tchem 9 | 1,598
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
decreased bone mineral content 1 | 151
decreased heart left ventricle... 1 | 28
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hyperactivity 1 | 148
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased startle reflex 1 | 112
thin ventricular wall 1 | 24

Disease

Carcinoma 9 | 11,493
Kidney cancer 7 | 2,613
osteosarcoma 6 | 7,950
ovarian cancer 6 | 8,520
atypical teratoid / rhabdoid tumor 5 | 5,112
glioblastoma 5 | 5,792
adult high grade glioma 4 | 3,801
ependymoma 4 | 4,679
medulloblastoma, large-cell 4 | 6,241
psoriasis 4 | 6,694
Astrocytoma, Pilocytic 3 | 3,081
Cataract 7 3 | 32
group 4 medulloblastoma 3 | 1,855
lung cancer 3 | 4,740
malignant mesothelioma 3 | 3,232
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
Acute myeloid leukemia, disease 2 | 30
Aggressive systemic mastocytosis 2 | 20
Breast cancer 2 | 3,578
Chronic Myelocytic Leukemia Accelerated Phase 2 | 59
Chronic phase chronic myeloid leukemia 2 | 45
Mast cell leukemia 2 | 13
Parkinson's disease 2 | 392
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 2 | 45
Pick disease 2 | 1,894
adrenocortical carcinoma 2 | 1,428
astrocytic glioma 2 | 2,597
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
ductal carcinoma in situ 2 | 1,745
gastric carcinoma 2 | 807
group 3 medulloblastoma 2 | 4,104
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
primary pancreatic ductal adenocarcinoma 2 | 1,109
ulcerative colitis 2 | 1,819
Abnormality of the metaphyses 1 | 48
Abnormally-shaped vertebrae 1 | 31
Acquired metabolic disease 1 | 336
Acquired scoliosis 1 | 281
Advanced bone age 1 | 35
Agenesis of teeth 1 | 21
Alexander disease 1 | 11
Alzheimer's disease 1 | 658
Atrial Fibrillation 1 | 124
Blastic phase chronic myeloid leukemia 1 | 58
Brain Ischemia 1 | 110
Byzanthine arch palate 1 | 194
Carcinoma of thyroid 1 | 17
Cardiomyopathy 1 | 116
Cardiomyopathy, Dilated 1 | 83
Cholestasis, Extrahepatic 1 | 25
Chronic obstructive pulmonary disease 1 | 184
Cocaine-Related Disorders 1 | 92
Colonic Polyps 1 | 3
Conductive hearing loss 1 | 123
Congenital sensorineural hearing loss 1 | 12
Curvature of spine 1 | 282
Dental abnormalities 1 | 60
Disorder of eye 1 | 27
Downward slant of palpebral fissure 1 | 158
Epilepsy 1 | 792
Eye Abnormalities 1 | 35
Flexion contracture of proximal interphalangeal joint 1 | 75
Freckles 1 | 33
Hamman-Rich syndrome 1 | 34
Hyperplasia of supraorbital margins 1 | 19
Hyperplasia of supraorbital ridge 1 | 19
Hypertrophy of supraorbital margins 1 | 19
Hypertrophy of supraorbital ridge 1 | 19
Hypoplasia of muscle 1 | 5
Joint stiffness 1 | 84
Kidney disease 1 | 430
Liver Cirrhosis, Experimental 1 | 769
Liver cell carcinoma 1 | 15
Melanoma 1 | 711
Mesothelioma, Malignant 1 | 105
Mitral regurgitation, mild 1 | 32
Mitral valve insufficiency 1 | 49
Mucocele of salivary gland 1 | 5
Philadelphia chromosome-positive acute lymphoblastic leukemia 1 | 47
Prominent supraorbital ridges 1 | 19
Reduced number of teeth 1 | 21
Renal Cell Carcinoma 1 | 214
Sensorineural Hearing Loss (disorder) 1 | 284
Short thumb terminal phalanx 1 | 5
Tooth Abnormalities 1 | 69
Ulnar deviation of the fingers 1 | 21
active Crohn's disease 1 | 922
acute quadriplegic myopathy 1 | 1,158
breast carcinoma 1 | 1,638
fibroadenoma 1 | 559
medulloblastoma 1 | 720
nasopharyngeal carcinoma 1 | 1,058
permanent atrial fibrillation 1 | 45
severe Alzheimer's disease 1 | 47
tuberculosis 1 | 2,010

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Kinase 10 | 634

DTO Protein Class (3)

MLK family 10 | 10
STE20 family 31 | 31
CAMKL family 22 | 22
CDK family 21 | 21
MAPK family 15 | 15
EPH family 14 | 14
C-C chemokine receptor 13 | 13
STKR family 12 | 12
NEK family 11 | 11
PI3-PI4 kinase family 11 | 11
SRC family 11 | 11
DYRK family 10 | 10
P2Y receptor 10 | 10
PKC family 9 | 9
DMPK family 8 | 8
PIKK family 8 | 8
RSK family 8 | 8
STE11 family 8 | 8
CK1 family 7 | 7
CLK family 7 | 7
GRK family 7 | 7
RAF family 7 | 7
STE7 family 7 | 7
Alpha adrenoceptor 6 | 6
MAST family 6 | 6
RGC family 6 | 6
SCY1 family 6 | 6
TEC family 6 | 6
5-HT1 receptor 5 | 5
5-HT3 receptor sub-subfamily 5 | 5
ABC1 family 5 | 5
Alpha family 5 | 5
CAMK1 family 5 | 5
CDKL family 5 | 5
DAPK family 5 | 5
MAPKAPK family 5 | 5
MLCK family 5 | 5
PDGFR family 5 | 5
PDHK family 5 | 5
PKA family 5 | 5
PLK family 5 | 5
RIPK family 5 | 5
TSSK family 5 | 5
ULK family 5 | 5
Adenylate kinase family 4 | 4
C-X-C chemokine receptor 4 | 4
CAMK2 family 4 | 4
CK2 family 4 | 4
EGFR family 4 | 4
FGFR family 4 | 4
Hexokinase family 4 | 4
IKK family 4 | 4
IRAK family 4 | 4
JAKA family 4 | 4
LISK family 4 | 4
NAK family 4 | 4
NDR family 4 | 4
PEK family 4 | 4
PIM family 4 | 4
TRIO family 4 | 4
WNK family 4 | 4
5-HT2 receptor 3 | 3
AKT family 3 | 3
AUR family 3 | 3
AXL family 3 | 3
Beta adrenoceptor 3 | 3
DCAMKL family 3 | 3
DCK-DGK family 3 | 3
Diacylglycerol kinase family 3 | 3
INSR family 3 | 3
Inositol phosphokinase (IPK) f... 3 | 3
LMR family 3 | 3
MET family 3 | 3
NKF1 family 3 | 3
Other-UNIQUE family 3 | 3
PKD family 3 | 3
PKN family 3 | 3
RCK family 3 | 3
RIO family 3 | 3
SGK family 3 | 3
SRPK family 3 | 3
TRBL family 3 | 3
TRK family 3 | 3
Type II pantothenate kinase fa... 3 | 3
VEGFR family 3 | 3
VRK family 3 | 3
WEE family 3 | 3
YANK family 3 | 3
ABL family 2 | 2
ACK family 2 | 2
Alpha-7-CHRNA7 sub-subfamily 2 | 2
BUB family 2 | 2
CAMK-UNIQUE family 2 | 2
CSK family 2 | 2
FGGY kinase family 2 | 2
NRBP family 2 | 2
STE-UNIQUE family 2 | 2
TIE family 2 | 2
TRPM2 sub-subfamily 2 | 2
TTBK family 2 | 2

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 10 MAP3K10 Tchem Kinase -1.20048 15.1 221
Mitogen-activated protein kinase kinase kinase 21 MAP3K21 Tdark Kinase -0.42420 4.24 174
Mitogen-activated protein kinase kinase kinase 12 MAP3K12 Tchem Kinase -2.06440 121.0 134
Mitogen-activated protein kinase kinase kinase 20 MAP3K20 Tchem Kinase -1.18567 14.9 215
Mitogen-activated protein kinase kinase kinase 11 MAP3K11 Tchem Kinase -1.86198 89.8 205
Mitogen-activated protein kinase kinase kinase 9 MAP3K9 Tchem Kinase -1.42881 24.7 265
Mitogen-activated protein kinase kinase kinase 13 MAP3K13 Tchem Kinase -1.97318 83.8 177
Integrin-linked protein kinase ILK Tchem Kinase -2.75450 679.1 608
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Serine/threonine-protein kinase TNNI3K TNNI3K Tchem Kinase -1.42338 16.0 105