Development Level

Tchem 33 | 1,598
Tbio 9 | 11,445
Tclin 2 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal embryo size 4 | 220
abnormal bone structure 3 | 187
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal lens morphology 2 | 81
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal clavicle morphology 1 | 6
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal eyelid morphology 1 | 7
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal gait 1 | 69
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal locomotor activation 1 | 16
abnormal locomotor behavior 1 | 24
abnormal mandible morphology 1 | 2
abnormal maxilla morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal rib morphology 1 | 10
abnormal snout morphology 1 | 23
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal zygomatic bone morpho... 1 | 3
absent teeth 1 | 3
absent vibrissae 1 | 12
anophthalmia 1 | 33
cataract 1 | 92
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating alkaline... 1 | 46
decreased eosinophil cell numb... 1 | 24
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased startle reflex 1 | 75
hyperactivity 1 | 148
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
long tibia 1 | 25
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
short tibia 1 | 97
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
small thymus 1 | 16
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

Carcinoma 43 | 11,493
ovarian cancer 27 | 8,520
osteosarcoma 26 | 7,950
atypical teratoid / rhabdoid tumor 22 | 5,112
glioblastoma 21 | 5,792
medulloblastoma, large-cell 19 | 6,241
psoriasis 19 | 6,694
Kidney cancer 17 | 2,613
ependymoma 16 | 4,679
Astrocytoma, Pilocytic 15 | 3,081
Cancer 15 | 2,499
adult high grade glioma 14 | 3,801
lung carcinoma 12 | 2,843
malignant mesothelioma 12 | 3,232
Breast cancer 11 | 3,578
group 3 medulloblastoma 11 | 4,104
lung cancer 11 | 4,740
primitive neuroectodermal tumor 11 | 3,035
astrocytic glioma 10 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
invasive ductal carcinoma 10 | 2,951
ulcerative colitis 10 | 1,819
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung adenocarcinoma 9 | 2,716
non-small cell lung cancer 9 | 2,890
oligodendroglioma 9 | 2,850
subependymal giant cell astrocytoma 9 | 2,287
pancreatic cancer 8 | 2,398
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
acute quadriplegic myopathy 7 | 1,158
cystic fibrosis 7 | 1,696
tuberculosis 7 | 2,010
Acquired scoliosis 6 | 281
Curvature of spine 6 | 282
Pick disease 6 | 1,894
breast carcinoma 6 | 1,638
ductal carcinoma in situ 6 | 1,745
pituitary cancer 6 | 1,972
Attention deficit hyperactivity disorder 5 | 278
Autosomal recessive predisposition 5 | 1,442
Byzanthine arch palate 5 | 194
Orbital separation excessive 5 | 244
Prostatic Neoplasms 5 | 495
Renal Cell Carcinoma 5 | 214
Short stature 5 | 531
active ulcerative colitis 5 | 764
acute myeloid leukemia 5 | 783
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
Bilateral fifth finger clinodactyly 4 | 110
Breast Neoplasms 4 | 445
Carcinoma of thyroid 4 | 17
Coronary artery disease 4 | 268
Curvature of little finger 4 | 110
Dull intelligence 4 | 645
Epilepsy 4 | 792
Eye Abnormalities 4 | 35
Fibrodysplasia ossificans progressiva 4 | 17
Hereditary hemorrhagic telangiectasia 4 | 13
Hypertensive disease 4 | 292
Increase in blood pressure 4 | 119
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mammary Neoplasms 4 | 425
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Muscle hypotonia 4 | 571
Parkinson's disease 4 | 392
Poor school performance 4 | 645
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
Sensorineural Hearing Loss (disorder) 4 | 284
diabetes mellitus 4 | 1,728
gastric carcinoma 4 | 807
primary pancreatic ductal adenocarcinoma 4 | 1,109
Adenoma 3 | 167
Alzheimer's disease 3 | 658
Broad flat nasal bridge 3 | 236
Congenital Epicanthus 3 | 177
Depressive disorder 3 | 409
Endometriosis 3 | 540
Heart disease 3 | 306
Lung Neoplasms 3 | 232
Nasal bridge wide 3 | 236
Seizures 3 | 596
Short nose 3 | 132
Small nose 3 | 132
Strabismus 3 | 270
active Crohn's disease 3 | 922
colon cancer 3 | 1,478
fibroadenoma 3 | 559
juvenile dermatomyositis 3 | 1,187
nasopharyngeal carcinoma 3 | 1,058
pediatric high grade glioma 3 | 1,064
spina bifida 3 | 1,074

Tissue

Blood and immune system 45 | 16,909
Digestive Tract 45 | 17,369
Endocrine System 45 | 18,159
Female tissues 45 | 17,400
Liver and Pancreas 45 | 16,750
Male tissues 45 | 17,142
Respiratory system 45 | 16,393
Skin and soft tissues 45 | 17,230
Urinary Tract 45 | 16,678
Cardiovascular System 44 | 15,192
Nervous System 44 | 16,725

Target Family

Kinase 43 | 634
Enzyme 2 | 4,145

DTO Protein Class (2)

TKL group 45 | 45
Olfactory receptor 421 | 421
TK group 93 | 93
Other group 87 | 87
CAMK group 77 | 77
CMGC group 70 | 70
AGC group 65 | 65
STE group 48 | 48
Lipid kinase 30 | 30
Atypical group 28 | 28
Chemokine receptor 24 | 24
Taste 2 receptor 24 | 24
Gamma-aminobutyric acid recept... 19 | 19
Purinoceptor 18 | 18
Acetylcholine receptor subfami... 17 | 17
Other small molecule kinase 15 | 15
5-hydroxytryptamine receptor 12 | 12
CK1 group 12 | 12
Frizzled receptor 10 | 10
Mas proto-oncogene and Mas-rel... 10 | 10
Adrenoceptor 9 | 9
Carbohydrate kinase 9 | 9
A (Shaker) subfamily 8 | 8
Calcium-activated subfamily 8 | 8
H (Eag) subfamily 8 | 8
LTrpC subfamily 8 | 8
Metabotropic glutamate recepto... 8 | 8
Histamine receptor 7 | 7
Nucleoside kinase 7 | 7
Dopamine receptor 6 | 6
Glucagon receptor 6 | 6
Lysophospholipid (LPA) recepto... 6 | 6
Melanin-concentrating hormone ... 6 | 6
Nucleotide kinase 6 | 6
RGC group 6 | 6
STrpC subfamily 6 | 6
TrpV subfamily 6 | 6
Vomeronasal receptor 6 | 6
5-hydroxytryptamine receptor s... 5 | 5
Acetylcholine receptor (muscar... 5 | 5
Adenosine receptor 5 | 5
Glycine receptor subfamily 5 | 5
KQT subfamily 5 | 5
Leukotriene receptor 5 | 5
Melanocortin receptor 5 | 5
Neuropeptide Y receptor 5 | 5
Angiotensin receptor 4 | 4
C (Shaw) subfamily 4 | 4
Cannabinoid receptor 4 | 4
Free fatty acid receptor 4 | 4
G subfamily 4 | 4
GABA-B receptor 4 | 4
KCNE subfamily 4 | 4
Latrophilin receptor 4 | 4
Proteinase-activated receptor 4 | 4
Anaphylatoxin receptor 3 | 3
Bombesin receptor 3 | 3
Cadherin EGF LAG (CELSR) recep... 3 | 3
D (Shal) subfamily 3 | 3
Endothelin receptor 3 | 3
Formyl peptide receptor 3 | 3
Galanin receptor 3 | 3
Hydroxycarboxylic acid recepto... 3 | 3
Polycystin subfamily 3 | 3
S subfamily 3 | 3
Tachykinin receptor 3 | 3
Taste 1 receptor 3 | 3
B (Shab) subfamily 2 | 2
Bradykinin receptor 2 | 2
CACNA1I subfamily 2 | 2
Calcitonin receptor 2 | 2
Calcium-sensing receptor 2 | 2
Cholecystokinin receptor 2 | 2
Corticotropin-releasing factor... 2 | 2
Glycoprotein hormone receptor 2 | 2
Gonadotrophin-releasing hormon... 2 | 2
KCNJ12 subfamily 2 | 2
Melatonin receptor 2 | 2
NR1-GRIN1 subfamily 2 | 2
Neuromedin U receptor 2 | 2
Neuropeptide FF-neuropeptide A... 2 | 2
Neuropeptide W-neuropeptide B ... 2 | 2
Neurotensin receptor 2 | 2
Parathyroid hormone receptor 2 | 2
Phosphorylase b kinase regulat... 2 | 2
Two pore calcium channel subfa... 2 | 2
V subfamily 2 | 2
CFTR transporter subfamily 1 | 1
CLCNKB subfamily 1 | 1
ClC-2-CLCN2 subfamily 1 | 1
ClC-3-CLCN3 subfamily 1 | 1
ClC-4-CLCN4 subfamily 1 | 1
ClC-5-CLCN5 subfamily 1 | 1
ClC-6-CLCN6 subfamily 1 | 1
ClC-7-CLCN7 subfamily 1 | 1
GRID2 subfamily 1 | 1
SCN4B family 1 | 1
SCNN1B subfamily 1 | 1
SCNN1D subfamily 1 | 1
SCNN1G subfamily 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Connector enhancer of kinase suppressor of ras 2 CNKSR2 Tbio Enzyme -1.11551 14.5 71
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Mitogen-activated protein kinase kinase kinase 10 MAP3K10 Tchem Kinase -1.20048 15.1 221
Mitogen-activated protein kinase kinase kinase 21 MAP3K21 Tdark Kinase -0.42420 4.24 174
Mitogen-activated protein kinase kinase kinase 12 MAP3K12 Tchem Kinase -2.06440 121.0 134
Kinase suppressor of Ras 2 KSR2 Tbio Kinase -0.90433 8.77 280
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
Mitogen-activated protein kinase kinase kinase 20 MAP3K20 Tchem Kinase -1.18567 14.9 215
Mixed lineage kinase domain-like protein MLKL Tchem Kinase -2.75630 549.8 171
Receptor-interacting serine/threonine-protein kinase 4 RIPK4 Tchem Kinase -1.97522 99.6 230