Development Level

Tchem 37 | 1,598
Tbio 8 | 11,445
Tclin 2 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 6 | 125
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

abnormal bone structure 2 | 187
decreased bone mineral content 2 | 151
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal gait 1 | 69
abnormal pelvic girdle bone mo... 1 | 12
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
convulsive seizures 1 | 13
decreased body weight 1 | 161
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased caudal vertebrae num... 1 | 7
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased urine magnesium leve... 1 | 2

Disease

Carcinoma 44 | 11,493
ovarian cancer 35 | 8,520
osteosarcoma 26 | 7,950
lung cancer 20 | 4,740
medulloblastoma, large-cell 20 | 6,241
psoriasis 20 | 6,694
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
Kidney cancer 17 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
atypical teratoid / rhabdoid tumor 15 | 5,112
ependymoma 15 | 4,679
glioblastoma 15 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
malignant mesothelioma 14 | 3,232
non-small cell lung cancer 13 | 2,890
Blastic phase chronic myeloid leukemia 12 | 58
Cancer 12 | 2,499
Chronic Myelocytic Leukemia Accelerated Phase 12 | 59
pancreatic cancer 12 | 2,398
astrocytic glioma 11 | 2,597
oligodendroglioma 11 | 2,850
primitive neuroectodermal tumor 11 | 3,035
Pick disease 10 | 1,894
adult high grade glioma 10 | 3,801
group 3 medulloblastoma 10 | 4,104
lung carcinoma 10 | 2,843
Astrocytoma, Pilocytic 9 | 3,081
Breast cancer 8 | 3,578
HER2-positive carcinoma of breast 8 | 21
Renal Cell Carcinoma 8 | 214
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis 8 | 2,010
Gastrointestinal stromal tumor 7 | 62
Pancreatic Neuroendocrine Tumor 7 | 45
interstitial cystitis 7 | 2,312
pituitary cancer 7 | 1,972
cystic fibrosis 6 | 1,696
diabetes mellitus 6 | 1,728
group 4 medulloblastoma 6 | 1,855
invasive ductal carcinoma 6 | 2,951
primary pancreatic ductal adenocarcinoma 6 | 1,109
Hemangioma 5 | 69
Intellectual disability 5 | 1,016
Multiple myeloma 5 | 1,332
Rheumatoid arthritis 5 | 1,191
spina bifida 5 | 1,074
Epilepsy 4 | 792
Hamman-Rich syndrome 4 | 34
Melanoma 4 | 711
Schizophrenia 4 | 1,160
Waldenstrons macroglobulinemia 4 | 765
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
aldosterone-producing adenoma 4 | 665
dermatomyositis 4 | 966
juvenile dermatomyositis 4 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
ulcerative colitis 4 | 1,819
Adenocarcinoma of pancreas 3 | 14
Anteverted nostril 3 | 191
Atopic dermatitis 3 | 952
Atrial Septal Defects 3 | 85
Autosomal recessive predisposition 3 | 1,442
Breast Neoplasms 3 | 445
Byzanthine arch palate 3 | 194
Cardiofaciocutaneous syndrome 3 | 15
Chronic Lymphocytic Leukemia 3 | 262
Costello Syndrome 3 | 17
Cryptorchidism 3 | 296
Dull intelligence 3 | 645
Hypertension 3 | 396
Langerhans-cell histiocytosis 3 | 12
Large auricle 3 | 87
Large dysplastic ears 3 | 87
Large pinnae 3 | 87
Large prominent ears 3 | 87
Large protruding ears 3 | 87
Large, floppy ears 3 | 87
Low intelligence 3 | 645
Lung Neoplasms 3 | 232
Macrotia 3 | 87
Mammary Neoplasms 3 | 425
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Noonan syndrome 3 | 34
Parkinson's disease 3 | 392
Poor school performance 3 | 645
Pseudohypoaldosteronism 3 | 23
Short nose 3 | 132
Small nose 3 | 132
Vascular disease 3 | 319
active Crohn's disease 3 | 922
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
cutaneous lupus erythematosus 3 | 1,057
lung adenocarcinoma 3 | 2,716
medulloblastoma 3 | 720
progressive supranuclear palsy 3 | 676
Frontal bossing 2 | 157
Skin hyperelastic 2 | 32

Tissue

Endocrine System 47 | 18,159
Female tissues 47 | 17,400
Male tissues 46 | 17,142
Respiratory system 46 | 16,393
Urinary Tract 46 | 16,678
Digestive Tract 45 | 17,369
Liver and Pancreas 45 | 16,750
Nervous System 45 | 16,725
Skin and soft tissues 45 | 17,230
Blood and immune system 44 | 16,909
Cardiovascular System 43 | 15,192

Target Family

Kinase 47 | 634
Non-IDG 1 | 12,091

DTO Protein Class (2)

STE group 48 | 48
Olfactory receptor 421 | 421
TK group 93 | 93
Other group 87 | 87
CAMK group 77 | 77
CMGC group 70 | 70
AGC group 65 | 65
TKL group 45 | 45
Lipid kinase 30 | 30
Atypical group 28 | 28
Chemokine receptor 24 | 24
Taste 2 receptor 24 | 24
Gamma-aminobutyric acid recept... 19 | 19
Purinoceptor 18 | 18
Acetylcholine receptor subfami... 17 | 17
Other small molecule kinase 15 | 15
5-hydroxytryptamine receptor 12 | 12
CK1 group 12 | 12
Frizzled receptor 10 | 10
Mas proto-oncogene and Mas-rel... 10 | 10
Adrenoceptor 9 | 9
Carbohydrate kinase 9 | 9
A (Shaker) subfamily 8 | 8
Calcium-activated subfamily 8 | 8
H (Eag) subfamily 8 | 8
LTrpC subfamily 8 | 8
Metabotropic glutamate recepto... 8 | 8
Histamine receptor 7 | 7
Nucleoside kinase 7 | 7
Dopamine receptor 6 | 6
Glucagon receptor 6 | 6
Lysophospholipid (LPA) recepto... 6 | 6
Melanin-concentrating hormone ... 6 | 6
Nucleotide kinase 6 | 6
RGC group 6 | 6
STrpC subfamily 6 | 6
TrpV subfamily 6 | 6
Vomeronasal receptor 6 | 6
5-hydroxytryptamine receptor s... 5 | 5
Acetylcholine receptor (muscar... 5 | 5
Adenosine receptor 5 | 5
Glycine receptor subfamily 5 | 5
KQT subfamily 5 | 5
Leukotriene receptor 5 | 5
Melanocortin receptor 5 | 5
Neuropeptide Y receptor 5 | 5
Angiotensin receptor 4 | 4
C (Shaw) subfamily 4 | 4
Cannabinoid receptor 4 | 4
Free fatty acid receptor 4 | 4
G subfamily 4 | 4
GABA-B receptor 4 | 4
KCNE subfamily 4 | 4
Latrophilin receptor 4 | 4
Proteinase-activated receptor 4 | 4
Anaphylatoxin receptor 3 | 3
Bombesin receptor 3 | 3
Cadherin EGF LAG (CELSR) recep... 3 | 3
D (Shal) subfamily 3 | 3
Endothelin receptor 3 | 3
Formyl peptide receptor 3 | 3
Galanin receptor 3 | 3
Hydroxycarboxylic acid recepto... 3 | 3
Polycystin subfamily 3 | 3
S subfamily 3 | 3
Tachykinin receptor 3 | 3
Taste 1 receptor 3 | 3
B (Shab) subfamily 2 | 2
Bradykinin receptor 2 | 2
CACNA1I subfamily 2 | 2
Calcitonin receptor 2 | 2
Calcium-sensing receptor 2 | 2
Cholecystokinin receptor 2 | 2
Corticotropin-releasing factor... 2 | 2
Glycoprotein hormone receptor 2 | 2
Gonadotrophin-releasing hormon... 2 | 2
KCNJ12 subfamily 2 | 2
Melatonin receptor 2 | 2
NR1-GRIN1 subfamily 2 | 2
Neuromedin U receptor 2 | 2
Neuropeptide FF-neuropeptide A... 2 | 2
Neuropeptide W-neuropeptide B ... 2 | 2
Neurotensin receptor 2 | 2
Parathyroid hormone receptor 2 | 2
Phosphorylase b kinase regulat... 2 | 2
Two pore calcium channel subfa... 2 | 2
V subfamily 2 | 2
CFTR transporter subfamily 1 | 1
CLCNKB subfamily 1 | 1
ClC-2-CLCN2 subfamily 1 | 1
ClC-3-CLCN3 subfamily 1 | 1
ClC-4-CLCN4 subfamily 1 | 1
ClC-5-CLCN5 subfamily 1 | 1
ClC-6-CLCN6 subfamily 1 | 1
ClC-7-CLCN7 subfamily 1 | 1
GRID2 subfamily 1 | 1
SCN4B family 1 | 1
SCNN1B subfamily 1 | 1
SCNN1D subfamily 1 | 1
SCNN1G subfamily 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 4 MAP3K4 Tbio Kinase -1.49704 31.8 244
Serine/threonine-protein kinase TAO2 TAOK2 Tchem Kinase -1.52454 36.1 154
Serine/threonine-protein kinase 24 STK24 Tchem Kinase -2.24110 132.9 243
Myosin-IIIb MYO3B Tbio Kinase -0.73450 5.14 127
Mitogen-activated protein kinase kinase kinase kinase 5 MAP4K5 Tchem Kinase -1.76819 60.5 0
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Mitogen-activated protein kinase kinase kinase kinase 4 MAP4K4 Tchem Kinase -2.19064 152.6 547
Mitogen-activated protein kinase kinase kinase 2 MAP3K2 Tchem Kinase -1.47034 26.6 199
Serine/threonine-protein kinase OSR1 OXSR1 Tbio Kinase -0.99836 9.44 355
Mitogen-activated protein kinase kinase kinase kinase 2 MAP4K2 Tchem Kinase -1.60423 35.3 193