Development Level

Tchem 51 | 1,598
Tbio 28 | 11,445
Tdark 8 | 6,588

Collection

Kinase: IDG Consortium (Target... 32 | 125
Kinase: IDG Consortium (Comple... 7 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
decreased circulating glucose ... 3 | 126
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal spleen morphology 2 | 55
decreased circulating serum al... 2 | 82
decreased mean corpuscular hem... 2 | 50
enlarged lymph nodes 2 | 37
increased mean corpuscular vol... 2 | 92
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye anterior chamber ... 1 | 9
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal retinal outer nuclear... 1 | 3
abnormal sensory capabilities-... 1 | 8
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal spinal cord morpholog... 1 | 9
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged spleen 1 | 41
hydrometra 1 | 53
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased urine microalbumin l... 1 | 2
increased vertical activity 1 | 24
sclerocornea 1 | 2
short tibia 1 | 97
small superior vagus ganglion 1 | 74
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 65 | 11,493
ovarian cancer 51 | 8,520
osteosarcoma 44 | 7,950
medulloblastoma, large-cell 37 | 6,241
psoriasis 34 | 6,694
atypical teratoid / rhabdoid tumor 31 | 5,112
glioblastoma 29 | 5,792
ependymoma 26 | 4,679
Breast cancer 24 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
lung cancer 23 | 4,740
Cancer 22 | 2,499
invasive ductal carcinoma 21 | 2,951
non-small cell lung cancer 21 | 2,890
adult high grade glioma 20 | 3,801
group 3 medulloblastoma 20 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
Kidney cancer 19 | 2,613
lung adenocarcinoma 18 | 2,716
malignant mesothelioma 18 | 3,232
primitive neuroectodermal tumor 17 | 3,035
ductal carcinoma in situ 15 | 1,745
group 4 medulloblastoma 15 | 1,855
Astrocytoma, Pilocytic 14 | 3,081
adrenocortical carcinoma 14 | 1,428
pancreatic cancer 14 | 2,398
breast carcinoma 13 | 1,638
oligodendroglioma 13 | 2,850
Endometriosis 10 | 540
nasopharyngeal carcinoma 10 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Atopic dermatitis 9 | 952
Autosomal recessive predisposition 9 | 1,442
Renal Cell Carcinoma 9 | 214
astrocytic glioma 9 | 2,597
cystic fibrosis 9 | 1,696
lung carcinoma 9 | 2,843
pituitary cancer 9 | 1,972
spina bifida 9 | 1,074
subependymal giant cell astrocytoma 9 | 2,287
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
progressive supranuclear palsy 8 | 676
Pick disease 7 | 1,894
Schizophrenia 7 | 1,160
colon cancer 7 | 1,478
esophageal adenocarcinoma 7 | 737
Glaucoma 6 | 239
Intellectual disability 6 | 1,016
Liver cancer 6 | 604
Rheumatoid arthritis 6 | 1,191
Small head 6 | 374
astrocytoma 6 | 1,146
pediatric high grade glioma 6 | 1,064
Amyotrophic lateral sclerosis 5 | 451
Cataract 5 | 297
Dull intelligence 5 | 645
Gastrointestinal stromal tumor 5 | 62
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Neurodegenerative disease 5 | 414
Pancreatic Neuroendocrine Tumor 5 | 45
Parkinson's disease 5 | 392
Poor school performance 5 | 645
pancreatic carcinoma 5 | 562
posterior fossa group B ependymoma 5 | 416
primary Sjogren syndrome 5 | 735
tuberculosis 5 | 2,010
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Hypertension 4 | 396
Hypoplastic mandible condyle 4 | 275
Lens Opacities 4 | 231
Mandibular hypoplasia 4 | 275
Melanoma 4 | 711
Mental and motor retardation 4 | 608
Micrognathism 4 | 275
Prostatic Neoplasms 4 | 495
Pseudohypoaldosteronism 4 | 23
Short stature 4 | 531
Western equine encephalitis 4 | 13
chronic rhinosinusitis 4 | 512
cystic fibrosis and chronic rhinosinusitis 4 | 214
fibroadenoma 4 | 559
hepatocellular carcinoma 4 | 547
juvenile dermatomyositis 4 | 1,187
tuberculosis and treatment for 6 months 4 | 409
ulcerative colitis 4 | 1,819
Abnormally small eyeball 3 | 97
Bipolar Disorder 3 | 666
Decreased size of eyeball 3 | 97
Multiple myeloma 3 | 1,332
cutaneous lupus erythematosus 3 | 1,057
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
gastric cancer 3 | 459
gastric carcinoma 3 | 807
primary pancreatic ductal adenocarcinoma 3 | 1,109
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Endocrine System 87 | 18,159
Digestive Tract 86 | 17,369
Male tissues 86 | 17,142
Female tissues 85 | 17,400
Skin and soft tissues 85 | 17,230
Liver and Pancreas 84 | 16,750
Respiratory system 84 | 16,393
Blood and immune system 82 | 16,909
Nervous System 82 | 16,725
Urinary Tract 81 | 16,678
Cardiovascular System 78 | 15,192

Target Family

Kinase 82 | 634
Non-IDG 4 | 12,091
Enzyme 1 | 4,145

DTO Protein Class (2)

Other group 87 | 87
Olfactory receptor 421 | 421
TK group 93 | 93
CAMK group 77 | 77
CMGC group 70 | 70
AGC group 65 | 65
STE group 48 | 48
TKL group 45 | 45
Lipid kinase 30 | 30
Atypical group 28 | 28
Chemokine receptor 24 | 24
Taste 2 receptor 24 | 24
Gamma-aminobutyric acid recept... 19 | 19
Purinoceptor 18 | 18
Acetylcholine receptor subfami... 17 | 17
Other small molecule kinase 15 | 15
5-hydroxytryptamine receptor 12 | 12
CK1 group 12 | 12
Frizzled receptor 10 | 10
Mas proto-oncogene and Mas-rel... 10 | 10
Adrenoceptor 9 | 9
Carbohydrate kinase 9 | 9
A (Shaker) subfamily 8 | 8
Calcium-activated subfamily 8 | 8
H (Eag) subfamily 8 | 8
LTrpC subfamily 8 | 8
Metabotropic glutamate recepto... 8 | 8
Histamine receptor 7 | 7
Nucleoside kinase 7 | 7
Dopamine receptor 6 | 6
Glucagon receptor 6 | 6
Lysophospholipid (LPA) recepto... 6 | 6
Melanin-concentrating hormone ... 6 | 6
Nucleotide kinase 6 | 6
RGC group 6 | 6
STrpC subfamily 6 | 6
TrpV subfamily 6 | 6
Vomeronasal receptor 6 | 6
5-hydroxytryptamine receptor s... 5 | 5
Acetylcholine receptor (muscar... 5 | 5
Adenosine receptor 5 | 5
Glycine receptor subfamily 5 | 5
KQT subfamily 5 | 5
Leukotriene receptor 5 | 5
Melanocortin receptor 5 | 5
Neuropeptide Y receptor 5 | 5
Angiotensin receptor 4 | 4
C (Shaw) subfamily 4 | 4
Cannabinoid receptor 4 | 4
Free fatty acid receptor 4 | 4
G subfamily 4 | 4
GABA-B receptor 4 | 4
KCNE subfamily 4 | 4
Latrophilin receptor 4 | 4
Proteinase-activated receptor 4 | 4
Anaphylatoxin receptor 3 | 3
Bombesin receptor 3 | 3
Cadherin EGF LAG (CELSR) recep... 3 | 3
D (Shal) subfamily 3 | 3
Endothelin receptor 3 | 3
Formyl peptide receptor 3 | 3
Galanin receptor 3 | 3
Hydroxycarboxylic acid recepto... 3 | 3
Polycystin subfamily 3 | 3
S subfamily 3 | 3
Tachykinin receptor 3 | 3
Taste 1 receptor 3 | 3
B (Shab) subfamily 2 | 2
Bradykinin receptor 2 | 2
CACNA1I subfamily 2 | 2
Calcitonin receptor 2 | 2
Calcium-sensing receptor 2 | 2
Cholecystokinin receptor 2 | 2
Corticotropin-releasing factor... 2 | 2
Glycoprotein hormone receptor 2 | 2
Gonadotrophin-releasing hormon... 2 | 2
KCNJ12 subfamily 2 | 2
Melatonin receptor 2 | 2
NR1-GRIN1 subfamily 2 | 2
Neuromedin U receptor 2 | 2
Neuropeptide FF-neuropeptide A... 2 | 2
Neuropeptide W-neuropeptide B ... 2 | 2
Neurotensin receptor 2 | 2
Parathyroid hormone receptor 2 | 2
Phosphorylase b kinase regulat... 2 | 2
Two pore calcium channel subfa... 2 | 2
V subfamily 2 | 2
CFTR transporter subfamily 1 | 1
CLCNKB subfamily 1 | 1
ClC-2-CLCN2 subfamily 1 | 1
ClC-3-CLCN3 subfamily 1 | 1
ClC-4-CLCN4 subfamily 1 | 1
ClC-5-CLCN5 subfamily 1 | 1
ClC-6-CLCN6 subfamily 1 | 1
ClC-7-CLCN7 subfamily 1 | 1
GRID2 subfamily 1 | 1
SCN4B family 1 | 1
SCNN1B subfamily 1 | 1
SCNN1D subfamily 1 | 1
SCNN1G subfamily 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase tousled-like 1 TLK1 Tchem Kinase -1.25235 19.2 305
Inactive serine/threonine-protein kinase PLK5 PLK5 Tbio Kinase -0.60609 4.07 119
Serine/threonine-protein kinase WNK2 WNK2 Tchem Kinase -0.94627 9.07 108
C-C motif chemokine 13 CCL13 Tbio Non-IDG -2.02640 99.2 264
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase PKMYT1 Tchem Kinase -1.27237 19.2 364
Serine/threonine-protein kinase WNK3 WNK3 Tchem Kinase -1.14290 17.3 193
Serine/threonine kinase-like domain-containing protein STKLD1 STKLD1 Tdark Kinase 0.00000 173
Inactive serine/threonine-protein kinase TEX14 TEX14 Tbio Kinase -0.97663 10.2 61
Tyrosine-protein kinase PRAG1 PRAG1 Tbio Kinase -0.70180 4.78 98
Calcium/calmodulin-dependent protein kinase kinase 2 CAMKK2 Tchem Kinase -2.09841 125.5 257