Development Level

Tbio 10 | 11,445

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal heart morphology 1 | 162
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased startle reflex 1 | 75
enlarged heart 1 | 210
hydrometra 1 | 53
hydrops fetalis 1 | 1
impaired glucose tolerance 1 | 75
increased circulating insulin ... 1 | 3
microphthalmia 1 | 26
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 8 | 11,493
psoriasis 8 | 6,694
atypical teratoid / rhabdoid tumor 7 | 5,112
ependymoma 7 | 4,679
ovarian cancer 7 | 8,520
Breast cancer 6 | 3,578
osteosarcoma 6 | 7,950
group 3 medulloblastoma 5 | 4,104
interstitial cystitis 5 | 2,312
lung cancer 5 | 4,740
glioblastoma 4 | 5,792
acute myeloid leukemia 3 | 783
breast carcinoma 3 | 1,638
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
medulloblastoma, large-cell 3 | 6,241
non-small cell lung cancer 3 | 2,890
primitive neuroectodermal tumor 3 | 3,035
Astrocytoma, Pilocytic 2 | 3,081
Cancer 2 | 2,499
Exudative vitreoretinopathy 2 | 15
Kidney cancer 2 | 2,613
Norrie disease 2 | 14
active Crohn's disease 2 | 922
astrocytic glioma 2 | 2,597
colon cancer 2 | 1,478
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 559
glioblastoma multiforme 2 | 142
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
malignant mesothelioma 2 | 3,232
non primary Sjogren syndrome sicca 2 | 891
oligodendroglioma 2 | 2,850
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
tuberculosis 2 | 2,010
Arachnodactyly 1 | 49
Autosomal dominant nonsyndromic deafness 25 1 | 6
Bipolar Disorder 1 | 666
Blind Vision 1 | 111
Blindness, Legal 1 | 110
Coloboma of eyelid 1 | 15
Colonic Neoplasms 1 | 142
Concave bridge of nose 1 | 195
Congenital ocular coloboma (disorder) 1 | 40
Craniofacial Abnormalities 1 | 151
Dental caries 1 | 164
Depressed nasal bridge 1 | 195
Depressed nasal root/bridge 1 | 195
Frequent fractures 1 | 53
Frontal bossing 1 | 157
Gaucher disease type 3 1 | 67
Hypotrophic malar bone 1 | 129
Increased fracture rate 1 | 53
Infantile onset 1 | 238
Liver Cirrhosis, Experimental 1 | 769
Long philtrum 1 | 137
MAJOR AFFECTIVE DISORDER 2 1 | 22
Malar flattening 1 | 129
Mood Disorders 1 | 184
Non-immune hydrops fetalis 1 | 11
Nonorganic psychosis 1 | 84
Omodysplasia 1 | 3
Pigmentary retinal degeneration 1 | 11
Psychotic Disorders 1 | 151
Reduced visual acuity 1 | 63
Retinal Detachment 1 | 51
Retinal Diseases 1 | 55
Retinal Neovascularization 1 | 4
Retinal exudates 1 | 11
Retinopathy of prematurity 1 | 22
Rhizomelia 1 | 25
Robinow syndrome 1 | 11
Short nose 1 | 132
Short upper arms 1 | 16
Slow progression 1 | 89
Small nose 1 | 132
Type 2 diabetes mellitus 1 | 272
Varying degree of multiple fractures 1 | 53
Vascular disease 1 | 319
Williams-Beuren syndrome 1 | 50
active ulcerative colitis 1 | 764
acute quadriplegic myopathy 1 | 1,158
adrenocortical carcinoma 1 | 1,428
aldosterone-producing adenoma 1 | 665
atypical teratoid/rhabdoid tumor 1 | 357
chronic kidney disease 1 | 90
chronic lymphosyte leukemia 1 | 204
interstitial lung disease 1 | 298
nasopharyngeal carcinoma 1 | 1,058
osteoporosis-pseudoglioma syndrome 1 | 9
posterior fossa group A ependymoma 1 | 468
primary pancreatic ductal adenocarcinoma 1 | 1,109
spina bifida 1 | 1,074
subependymal giant cell astrocytoma 1 | 2,287
substance-induced psychosis 1 | 8

Tissue

Blood and immune system 10 | 16,909
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Skin and soft tissues 10 | 17,230
Cardiovascular System 9 | 15,192
Liver and Pancreas 9 | 16,750
Respiratory system 9 | 16,393
Urinary Tract 9 | 16,678

Target Family

GPCR 10 | 408

DTO Protein Class (2)

Frizzled receptor 10 | 10
Olfactory receptor 421 | 421
TK group 93 | 93
Other group 87 | 87
CAMK group 77 | 77
CMGC group 70 | 70
AGC group 65 | 65
STE group 48 | 48
TKL group 45 | 45
Lipid kinase 30 | 30
Atypical group 28 | 28
Chemokine receptor 24 | 24
Taste 2 receptor 24 | 24
Gamma-aminobutyric acid recept... 19 | 19
Purinoceptor 18 | 18
Acetylcholine receptor subfami... 17 | 17
Other small molecule kinase 15 | 15
5-hydroxytryptamine receptor 12 | 12
CK1 group 12 | 12
Mas proto-oncogene and Mas-rel... 10 | 10
Adrenoceptor 9 | 9
Carbohydrate kinase 9 | 9
A (Shaker) subfamily 8 | 8
Calcium-activated subfamily 8 | 8
H (Eag) subfamily 8 | 8
LTrpC subfamily 8 | 8
Metabotropic glutamate recepto... 8 | 8
Histamine receptor 7 | 7
Nucleoside kinase 7 | 7
Dopamine receptor 6 | 6
Glucagon receptor 6 | 6
Lysophospholipid (LPA) recepto... 6 | 6
Melanin-concentrating hormone ... 6 | 6
Nucleotide kinase 6 | 6
RGC group 6 | 6
STrpC subfamily 6 | 6
TrpV subfamily 6 | 6
Vomeronasal receptor 6 | 6
5-hydroxytryptamine receptor s... 5 | 5
Acetylcholine receptor (muscar... 5 | 5
Adenosine receptor 5 | 5
Glycine receptor subfamily 5 | 5
KQT subfamily 5 | 5
Leukotriene receptor 5 | 5
Melanocortin receptor 5 | 5
Neuropeptide Y receptor 5 | 5
Angiotensin receptor 4 | 4
C (Shaw) subfamily 4 | 4
Cannabinoid receptor 4 | 4
Free fatty acid receptor 4 | 4
G subfamily 4 | 4
GABA-B receptor 4 | 4
KCNE subfamily 4 | 4
Latrophilin receptor 4 | 4
Proteinase-activated receptor 4 | 4
Anaphylatoxin receptor 3 | 3
Bombesin receptor 3 | 3
Cadherin EGF LAG (CELSR) recep... 3 | 3
D (Shal) subfamily 3 | 3
Endothelin receptor 3 | 3
Formyl peptide receptor 3 | 3
Galanin receptor 3 | 3
Hydroxycarboxylic acid recepto... 3 | 3
Polycystin subfamily 3 | 3
S subfamily 3 | 3
Tachykinin receptor 3 | 3
Taste 1 receptor 3 | 3
B (Shab) subfamily 2 | 2
Bradykinin receptor 2 | 2
CACNA1I subfamily 2 | 2
Calcitonin receptor 2 | 2
Calcium-sensing receptor 2 | 2
Cholecystokinin receptor 2 | 2
Corticotropin-releasing factor... 2 | 2
Glycoprotein hormone receptor 2 | 2
Gonadotrophin-releasing hormon... 2 | 2
KCNJ12 subfamily 2 | 2
Melatonin receptor 2 | 2
NR1-GRIN1 subfamily 2 | 2
Neuromedin U receptor 2 | 2
Neuropeptide FF-neuropeptide A... 2 | 2
Neuropeptide W-neuropeptide B ... 2 | 2
Neurotensin receptor 2 | 2
Parathyroid hormone receptor 2 | 2
Phosphorylase b kinase regulat... 2 | 2
Two pore calcium channel subfa... 2 | 2
V subfamily 2 | 2
CFTR transporter subfamily 1 | 1
CLCNKB subfamily 1 | 1
ClC-2-CLCN2 subfamily 1 | 1
ClC-3-CLCN3 subfamily 1 | 1
ClC-4-CLCN4 subfamily 1 | 1
ClC-5-CLCN5 subfamily 1 | 1
ClC-6-CLCN6 subfamily 1 | 1
ClC-7-CLCN7 subfamily 1 | 1
GRID2 subfamily 1 | 1
SCN4B family 1 | 1
SCNN1B subfamily 1 | 1
SCNN1D subfamily 1 | 1
SCNN1G subfamily 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Frizzled-9 FZD9 Tbio GPCR -1.77240 61.8 380
Frizzled-8 FZD8 Tbio GPCR -1.64874 42.5 233
Frizzled-6 FZD6 Tbio GPCR -1.63747 44.5 260
Frizzled-5 FZD5 Tbio GPCR -1.54924 30.5 307
Frizzled-1 FZD1 Tbio GPCR -2.07049 78.4 286
Frizzled-4 FZD4 Tbio GPCR -2.05508 106.8 313
Frizzled-10 FZD10 Tbio GPCR -1.39120 24.2 172
Frizzled-3 FZD3 Tbio GPCR -1.76528 56.4 314
Frizzled-2 FZD2 Tbio GPCR -1.91126 79.1 264