Development Level

Tbio 3 | 11,445

IMPC Phenotype

abnormal head morphology 1 | 10
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
decreased body weight 1 | 161
decreased prepulse inhibition 1 | 82
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17

Disease

Breast cancer 3 | 3,578
Carcinoma 3 | 11,493
Kidney cancer 3 | 2,613
glioblastoma 3 | 5,792
lung cancer 3 | 4,740
psoriasis 3 | 6,694
Bladder exstrophy 2 | 32
Liver cancer 2 | 604
atypical teratoid / rhabdoid tumor 2 | 5,112
ependymoma 2 | 4,679
invasive ductal carcinoma 2 | 2,951
lung carcinoma 2 | 2,843
malignant mesothelioma 2 | 3,232
osteosarcoma 2 | 7,950
pediatric high grade glioma 2 | 1,064
subependymal giant cell astrocytoma 2 | 2,287
Anencephaly 1 | 26
Astrocytoma, Pilocytic 1 | 3,081
Atherosclerosis 1 | 291
Cardiovascular system disease 1 | 246
Chronic Lymphocytic Leukemia 1 | 262
Coronary artery disease 1 | 268
Endometrial Hyperplasia 1 | 5
Endometrial cancer 1 | 311
Hereditary lymphedema 1 | 2
Hyperopia 1 | 70
Immune system cancer 1 | 140
Lipid metabolism disorder 1 | 114
Lymphoid leukemia 1 | 160
Myocardial Infarction 1 | 151
Neural Tube Defects, Susceptibility to 1 | 8
Neurodegenerative disease 1 | 414
Schizophrenia 1 | 1,160
Schizophrenia, Catatonic 1 | 4
Skin cancer 1 | 469
Vascular disease 1 | 319
active Crohn's disease 1 | 922
breast carcinoma 1 | 1,638
colon cancer 1 | 1,478
ductal carcinoma in situ 1 | 1,745
esophageal adenocarcinoma 1 | 737
fibroadenoma 1 | 559
group 3 medulloblastoma 1 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
lung adenocarcinoma 1 | 2,716
medulloblastoma 1 | 720
medulloblastoma, large-cell 1 | 6,241
non-small cell lung cancer 1 | 2,890
orofaciodigital syndrome III 1 | 3
pancreatic cancer 1 | 2,398
pituitary cancer 1 | 1,972
spina bifida 1 | 1,074

Tissue

Blood and immune system 3 | 16,909
Digestive Tract 3 | 17,369
Endocrine System 3 | 18,159
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Nervous System 3 | 16,725
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678
Cardiovascular System 2 | 15,192

Target Family

GPCR 3 | 408

DTO Protein Class (2)

Cadherin EGF LAG (CELSR) recep... 3 | 3
Olfactory receptor 421 | 421
TK group 93 | 93
Other group 87 | 87
CAMK group 77 | 77
CMGC group 70 | 70
AGC group 65 | 65
STE group 48 | 48
TKL group 45 | 45
Lipid kinase 30 | 30
Atypical group 28 | 28
Chemokine receptor 24 | 24
Taste 2 receptor 24 | 24
Gamma-aminobutyric acid recept... 19 | 19
Purinoceptor 18 | 18
Acetylcholine receptor subfami... 17 | 17
Other small molecule kinase 15 | 15
5-hydroxytryptamine receptor 12 | 12
CK1 group 12 | 12
Frizzled receptor 10 | 10
Mas proto-oncogene and Mas-rel... 10 | 10
Adrenoceptor 9 | 9
Carbohydrate kinase 9 | 9
A (Shaker) subfamily 8 | 8
Calcium-activated subfamily 8 | 8
H (Eag) subfamily 8 | 8
LTrpC subfamily 8 | 8
Metabotropic glutamate recepto... 8 | 8
Histamine receptor 7 | 7
Nucleoside kinase 7 | 7
Dopamine receptor 6 | 6
Glucagon receptor 6 | 6
Lysophospholipid (LPA) recepto... 6 | 6
Melanin-concentrating hormone ... 6 | 6
Nucleotide kinase 6 | 6
RGC group 6 | 6
STrpC subfamily 6 | 6
TrpV subfamily 6 | 6
Vomeronasal receptor 6 | 6
5-hydroxytryptamine receptor s... 5 | 5
Acetylcholine receptor (muscar... 5 | 5
Adenosine receptor 5 | 5
Glycine receptor subfamily 5 | 5
KQT subfamily 5 | 5
Leukotriene receptor 5 | 5
Melanocortin receptor 5 | 5
Neuropeptide Y receptor 5 | 5
Angiotensin receptor 4 | 4
C (Shaw) subfamily 4 | 4
Cannabinoid receptor 4 | 4
Free fatty acid receptor 4 | 4
G subfamily 4 | 4
GABA-B receptor 4 | 4
KCNE subfamily 4 | 4
Latrophilin receptor 4 | 4
Proteinase-activated receptor 4 | 4
Anaphylatoxin receptor 3 | 3
Bombesin receptor 3 | 3
D (Shal) subfamily 3 | 3
Endothelin receptor 3 | 3
Formyl peptide receptor 3 | 3
Galanin receptor 3 | 3
Hydroxycarboxylic acid recepto... 3 | 3
Polycystin subfamily 3 | 3
S subfamily 3 | 3
Tachykinin receptor 3 | 3
Taste 1 receptor 3 | 3
B (Shab) subfamily 2 | 2
Bradykinin receptor 2 | 2
CACNA1I subfamily 2 | 2
Calcitonin receptor 2 | 2
Calcium-sensing receptor 2 | 2
Cholecystokinin receptor 2 | 2
Corticotropin-releasing factor... 2 | 2
Glycoprotein hormone receptor 2 | 2
Gonadotrophin-releasing hormon... 2 | 2
KCNJ12 subfamily 2 | 2
Melatonin receptor 2 | 2
NR1-GRIN1 subfamily 2 | 2
Neuromedin U receptor 2 | 2
Neuropeptide FF-neuropeptide A... 2 | 2
Neuropeptide W-neuropeptide B ... 2 | 2
Neurotensin receptor 2 | 2
Parathyroid hormone receptor 2 | 2
Phosphorylase b kinase regulat... 2 | 2
Two pore calcium channel subfa... 2 | 2
V subfamily 2 | 2
CFTR transporter subfamily 1 | 1
CLCNKB subfamily 1 | 1
ClC-2-CLCN2 subfamily 1 | 1
ClC-3-CLCN3 subfamily 1 | 1
ClC-4-CLCN4 subfamily 1 | 1
ClC-5-CLCN5 subfamily 1 | 1
ClC-6-CLCN6 subfamily 1 | 1
ClC-7-CLCN7 subfamily 1 | 1
GRID2 subfamily 1 | 1
SCN4B family 1 | 1
SCNN1B subfamily 1 | 1
SCNN1D subfamily 1 | 1
SCNN1G subfamily 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cadherin EGF LAG seven-pass G-type receptor 2 CELSR2 Tbio GPCR -1.22995 16.7 139
Cadherin EGF LAG seven-pass G-type receptor 1 CELSR1 Tbio GPCR -1.47924 34.4 115
Cadherin EGF LAG seven-pass G-type receptor 3 CELSR3 Tbio GPCR -1.38072 25.3 190