Development Level

Tchem 54 | 1,598
Tbio 10 | 11,445
Tclin 4 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 22 | 125
Kinase: IDG Consortium (Comple... 11 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 4 | 499
increased or absent threshold ... 3 | 101
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
male infertility 2 | 123
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal cecum morphology 1 | 7
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal neural tube closure 1 | 46
abnormal response to tactile s... 1 | 17
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
decreased body length 1 | 101
decreased circulating calcium ... 1 | 36
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating magnesiu... 1 | 13
decreased granulocyte number 1 | 6
decreased grip strength 1 | 116
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
female infertility 1 | 60
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased erythrocyte cell num... 1 | 39
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased kidney weight 1 | 6
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
megacolon 1 | 2
microphthalmia 1 | 26
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74
tremors 1 | 39

Disease

Carcinoma 52 | 11,493
osteosarcoma 37 | 7,950
ovarian cancer 34 | 8,520
medulloblastoma, large-cell 32 | 6,241
psoriasis 30 | 6,694
glioblastoma 27 | 5,792
atypical teratoid / rhabdoid tumor 24 | 5,112
ependymoma 24 | 4,679
lung cancer 23 | 4,740
Cancer 19 | 2,499
adult high grade glioma 19 | 3,801
group 3 medulloblastoma 18 | 4,104
Pick disease 16 | 1,894
malignant mesothelioma 16 | 3,232
oligodendroglioma 15 | 2,850
primitive neuroectodermal tumor 15 | 3,035
Astrocytoma, Pilocytic 14 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
group 4 medulloblastoma 12 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
Breast cancer 11 | 3,578
Intellectual disability 11 | 1,016
Rheumatoid arthritis 11 | 1,191
astrocytic glioma 11 | 2,597
non-small cell lung cancer 11 | 2,890
subependymal giant cell astrocytoma 11 | 2,287
tuberculosis 10 | 2,010
adrenocortical carcinoma 9 | 1,428
invasive ductal carcinoma 9 | 2,951
lung adenocarcinoma 9 | 2,716
Alzheimer's disease 8 | 658
Schizophrenia 8 | 1,160
Down syndrome 7 | 499
Dull intelligence 7 | 645
Kidney cancer 7 | 2,613
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Renal Cell Carcinoma 7 | 214
acute myeloid leukemia 7 | 783
cystic fibrosis 7 | 1,696
diabetes mellitus 7 | 1,728
juvenile dermatomyositis 7 | 1,187
Multiple myeloma 6 | 1,332
Vascular disease 6 | 319
colon cancer 6 | 1,478
dermatomyositis 6 | 966
pituitary cancer 6 | 1,972
Autosomal recessive predisposition 5 | 1,442
Carcinoma, Squamous Cell 5 | 110
Hamman-Rich syndrome 5 | 34
Hyperalgesia 5 | 83
Parkinson's disease 5 | 392
Small head 5 | 374
Squamous cell carcinoma 5 | 129
acute quadriplegic myopathy 5 | 1,158
astrocytoma 5 | 1,146
pancreatic cancer 5 | 2,398
Amyotrophic lateral sclerosis 4 | 451
Arthritis 4 | 290
Asthma 4 | 385
Cardiomyopathies 4 | 110
Cholestasis, Extrahepatic 4 | 25
Cognitive delay 4 | 608
Depressive disorder 4 | 409
Disease Models, Animal 4 | 155
Gastrointestinal stromal tumor 4 | 62
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
Neoplasm Metastasis 4 | 168
Obesity 4 | 678
Pancreatic Neuroendocrine Tumor 4 | 45
Stomach Neoplasms 4 | 300
Toxic encephalopathy 4 | 141
Trigeminal Neuralgia 4 | 24
Waldenstrons macroglobulinemia 4 | 765
aldosterone-producing adenoma 4 | 665
interstitial cystitis 4 | 2,312
lung carcinoma 4 | 2,843
medulloblastoma 4 | 720
primary pancreatic ductal adenocarcinoma 4 | 1,109
Bipolar Disorder 3 | 666
Brain Ischemia 3 | 110
Dilated ventricles (finding) 3 | 121
Lung Neoplasms 3 | 232
Lung disease 3 | 142
Melanoma 3 | 711
Mental Depression 3 | 333
Microcephaly 3 | 166
Neurodegenerative disease 3 | 414
ductal carcinoma in situ 3 | 1,745
hereditary spastic paraplegia 3 | 318
nasopharyngeal carcinoma 3 | 1,058
pediatric high grade glioma 3 | 1,064
progressive supranuclear palsy 3 | 676
sonic hedgehog group medulloblastoma 3 | 467
tuberculosis and treatment for 6 months 3 | 409
ulcerative colitis 3 | 1,819

Tissue

Digestive Tract 69 | 17,369
Endocrine System 69 | 18,159
Female tissues 69 | 17,400
Male tissues 69 | 17,142
Nervous System 69 | 16,725
Skin and soft tissues 69 | 17,230
Urinary Tract 69 | 16,678
Liver and Pancreas 68 | 16,750
Respiratory system 68 | 16,393
Blood and immune system 67 | 16,909
Cardiovascular System 66 | 15,192

Target Family

Kinase 66 | 634
Enzyme 2 | 4,145
Non-IDG 2 | 12,091

DTO Protein Class (2)

CMGC group 70 | 70
Olfactory receptor 421 | 421
TK group 93 | 93
Other group 87 | 87
CAMK group 77 | 77
AGC group 65 | 65
STE group 48 | 48
TKL group 45 | 45
Lipid kinase 30 | 30
Atypical group 28 | 28
Chemokine receptor 24 | 24
Taste 2 receptor 24 | 24
Gamma-aminobutyric acid recept... 19 | 19
Purinoceptor 18 | 18
Acetylcholine receptor subfami... 17 | 17
Other small molecule kinase 15 | 15
5-hydroxytryptamine receptor 12 | 12
CK1 group 12 | 12
Frizzled receptor 10 | 10
Mas proto-oncogene and Mas-rel... 10 | 10
Adrenoceptor 9 | 9
Carbohydrate kinase 9 | 9
A (Shaker) subfamily 8 | 8
Calcium-activated subfamily 8 | 8
H (Eag) subfamily 8 | 8
LTrpC subfamily 8 | 8
Metabotropic glutamate recepto... 8 | 8
Histamine receptor 7 | 7
Nucleoside kinase 7 | 7
Dopamine receptor 6 | 6
Glucagon receptor 6 | 6
Lysophospholipid (LPA) recepto... 6 | 6
Melanin-concentrating hormone ... 6 | 6
Nucleotide kinase 6 | 6
RGC group 6 | 6
STrpC subfamily 6 | 6
TrpV subfamily 6 | 6
Vomeronasal receptor 6 | 6
5-hydroxytryptamine receptor s... 5 | 5
Acetylcholine receptor (muscar... 5 | 5
Adenosine receptor 5 | 5
Glycine receptor subfamily 5 | 5
KQT subfamily 5 | 5
Leukotriene receptor 5 | 5
Melanocortin receptor 5 | 5
Neuropeptide Y receptor 5 | 5
Angiotensin receptor 4 | 4
C (Shaw) subfamily 4 | 4
Cannabinoid receptor 4 | 4
Free fatty acid receptor 4 | 4
G subfamily 4 | 4
GABA-B receptor 4 | 4
KCNE subfamily 4 | 4
Latrophilin receptor 4 | 4
Proteinase-activated receptor 4 | 4
Anaphylatoxin receptor 3 | 3
Bombesin receptor 3 | 3
Cadherin EGF LAG (CELSR) recep... 3 | 3
D (Shal) subfamily 3 | 3
Endothelin receptor 3 | 3
Formyl peptide receptor 3 | 3
Galanin receptor 3 | 3
Hydroxycarboxylic acid recepto... 3 | 3
Polycystin subfamily 3 | 3
S subfamily 3 | 3
Tachykinin receptor 3 | 3
Taste 1 receptor 3 | 3
B (Shab) subfamily 2 | 2
Bradykinin receptor 2 | 2
CACNA1I subfamily 2 | 2
Calcitonin receptor 2 | 2
Calcium-sensing receptor 2 | 2
Cholecystokinin receptor 2 | 2
Corticotropin-releasing factor... 2 | 2
Glycoprotein hormone receptor 2 | 2
Gonadotrophin-releasing hormon... 2 | 2
KCNJ12 subfamily 2 | 2
Melatonin receptor 2 | 2
NR1-GRIN1 subfamily 2 | 2
Neuromedin U receptor 2 | 2
Neuropeptide FF-neuropeptide A... 2 | 2
Neuropeptide W-neuropeptide B ... 2 | 2
Neurotensin receptor 2 | 2
Parathyroid hormone receptor 2 | 2
Phosphorylase b kinase regulat... 2 | 2
Two pore calcium channel subfa... 2 | 2
V subfamily 2 | 2
CFTR transporter subfamily 1 | 1
CLCNKB subfamily 1 | 1
ClC-2-CLCN2 subfamily 1 | 1
ClC-3-CLCN3 subfamily 1 | 1
ClC-4-CLCN4 subfamily 1 | 1
ClC-5-CLCN5 subfamily 1 | 1
ClC-6-CLCN6 subfamily 1 | 1
ClC-7-CLCN7 subfamily 1 | 1
GRID2 subfamily 1 | 1
SCN4B family 1 | 1
SCNN1B subfamily 1 | 1
SCNN1D subfamily 1 | 1
SCNN1G subfamily 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Serine/threonine-protein kinase PRP4 homolog PRPF4B Tchem Kinase -1.17233 14.7 144
Dual specificity tyrosine-phosphorylation-regulated kinase 1B DYRK1B Tchem Kinase -1.63295 52.7 289
SRSF protein kinase 3 SRPK3 Tchem Kinase -0.48565 2.96 103
Cyclin-dependent kinase 12 CDK12 Tchem Kinase -1.38476 29.4 157
Homeodomain-interacting protein kinase 4 HIPK4 Tchem Kinase -0.41775 3.17 232
Telomere length regulation protein TEL2 homolog TELO2 Tbio Non-IDG -0.93554 9.48 94
Dual specificity tyrosine-phosphorylation-regulated kinase 3 DYRK3 Tchem Kinase -1.46121 29.1 191
Cyclin-dependent kinase 20 CDK20 Tbio Kinase -1.82269 67.7 248
Serine/threonine-protein kinase ICK ICK Tchem Kinase -2.63650 422.2 179