Development Level

Tclin 2 | 613

IMPC Phenotype

abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased total body fat amoun... 1 | 207
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
preweaning lethality, incomple... 1 | 499
tremors 1 | 39

Disease

Abdomen distended 2 | 43
Cancer 2 | 2,499
Carcinoma 2 | 11,493
Coarse facial features 2 | 108
Congenital hypothyroidism 2 | 26
Constipation 2 | 181
Delayed bone age 2 | 136
Diagnostic Test for Thyroid Dysfunction 2 | 3
Diaphragmatic Hernia 2 | 40
Dyschezia 2 | 135
Feeding difficulties 2 | 127
Goiter 2 | 38
Hernia, Diaphragmatic 2 | 40
Hyperlipidemia 2 | 43
Hyperthyroidism 2 | 53
Hyperthyroxinemia 2 | 9
Hypothyroidism 2 | 122
Icterus 2 | 82
Large bregma sutures 2 | 46
Large fontanelle 2 | 46
Large, late-closing fontanelle 2 | 46
Macroglossia 2 | 65
Malignant tumor of thyroid gland 2 | 3
Mild Hypothyroidism 2 | 2
Muscle hypotonia 2 | 571
Myxedema 2 | 11
Myxedema coma 2 | 2
Peripheral resistance to thyroid hormones 2 | 2
Simple goiter 2 | 2
Sleep disturbances 2 | 37
T3 Suppression for Thyroid Function Test 2 | 2
Thickened facial skin with coarse facial features 2 | 108
Thyroid Hormone Resistance Syndrome 2 | 5
Umbilical hernia 2 | 93
Wide bregma sutures 2 | 46
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
breast carcinoma 2 | 1,638
glioblastoma 2 | 5,792
medulloblastoma, large-cell 2 | 6,241
osteosarcoma 2 | 7,950
ovarian cancer 2 | 8,520
psoriasis 2 | 6,694
Adenocarcinoma, Follicular 1 | 2
Anemia 1 | 365
Attention deficit hyperactivity disorder 1 | 278
Becker muscular dystrophy 1 | 191
Congenital deafness 1 | 185
Congenital pectus carinatum 1 | 52
Convex nasal ridge 1 | 37
Craniofacial Abnormalities 1 | 151
Deafness 1 | 198
Delayed speech and language development 1 | 112
Drowsiness 1 | 7
Dry skin 1 | 75
Endometriosis 1 | 540
Enhanced S-cone syndrome 1 | 17
Exophthalmos 1 | 112
Follicular thyroid carcinoma 1 | 14
Graves' disease 1 | 24
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hashimoto Thyroiditis 1 | 2
Hearing Loss, Partial 1 | 185
Hemoglobin low 1 | 124
Hip Dislocation, Congenital 1 | 48
Language Delay 1 | 112
Late tooth eruption 1 | 61
Low Birth Weights 1 | 69
Peripheral vascular disease 1 | 87
Pituitary adenoma 1 | 38
Poor growth 1 | 114
Prominent eyes 1 | 96
Prominent globes 1 | 96
Protruding eyes 1 | 96
Raised TSH level 1 | 8
Relative macrocephaly 1 | 12
Sensorineural Hearing Loss (disorder) 1 | 284
Sickle Cell Anemia 1 | 53
Small for gestational age (disorder) 1 | 69
Speech Delay 1 | 112
Speech impairment 1 | 112
Sprengel deformity 1 | 16
Stippled epiphyses 1 | 28
Thyroid Diseases 1 | 24
Thyrotoxicosis 1 | 38
Very poor growth 1 | 114
Xerosis 1 | 75
adrenocortical carcinoma 1 | 1,428
colon cancer 1 | 1,478
cystic fibrosis 1 | 1,696
head and neck cancer 1 | 271
hearing impairment 1 | 199
hereditary spastic paraplegia 1 | 318
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
lung adenocarcinoma 1 | 2,716
oligodendroglioma 1 | 2,850
sonic hedgehog group medulloblastoma 1 | 467
subependymal giant cell astrocytoma 1 | 2,287

Tissue

Blood and immune system 2 | 16,909
Cardiovascular System 2 | 15,192
Digestive Tract 2 | 17,369
Endocrine System 2 | 18,159
Female tissues 2 | 17,400
Liver and Pancreas 2 | 16,750
Male tissues 2 | 17,142
Nervous System 2 | 16,725
Respiratory system 2 | 16,393
Skin and soft tissues 2 | 17,230
Urinary Tract 2 | 16,678

Target Family

Nuclear Receptor 2 | 48

DTO Protein Class (1)

Thyroid hormone receptors 2 | 2
Class A rhodopsin like 749 | 749
Protein kinase 535 | 535
Non-protein kinase 67 | 67
Potassium channel family 52 | 52
Neurotransmitter receptor, cys... 47 | 47
Adhesion class 33 | 33
Transient receptor potential c... 24 | 24
Class C metabotropic glutamate... 23 | 23
Glutamate-gated ion channel (... 19 | 19
Class B secretin like 16 | 16
Inward rectifier-type potassiu... 16 | 16
Two pore domain potassium chan... 15 | 15
Calcium channel alpha-1 subuni... 13 | 13
Class F frizzled-type 12 | 12
Cyclic nucleotide-gated cation... 10 | 10
Sodium channel family 10 | 10
Amiloride-sensitive sodium cha... 9 | 9
Chloride channel family 9 | 9
Calcium channel auxiliary subu... 8 | 8
3-ketosteroid receptors 7 | 7
Atp-gated p2x receptor cation ... 7 | 7
Intracellular chloride channel... 6 | 6
Polycystin cation channel (pcc... 6 | 6
Ryanodine-inositol 1,4,5-triph... 6 | 6
Transmembrane channel (TMC) fa... 6 | 6
Calcium-dependent chloride cha... 5 | 5
Fxyd family 5 | 5
Anion channel-forming bestroph... 4 | 4
Calcium channel auxiliary subu... 4 | 4
Calcium channel auxiliary subu... 4 | 4
Calcium homeostasis modulator ... 4 | 4
Calcium-activated potassium ch... 4 | 4
Cation channel sperm-associate... 4 | 4
Epithelial chloride channel (e... 4 | 4
Other 7TM proteins 4 | 4
Sodium channel auxiliary subun... 4 | 4
Vitamin d receptor-like recept... 4 | 4
Anion channel tweety (tweety) ... 3 | 3
Coup-tf-like receptors 3 | 3
Estrogen-related receptors 3 | 3
Gap junction-forming innexin (... 3 | 3
Liver x receptor-like receptor... 3 | 3
Nerve growth factor ib-like re... 3 | 3
Peroxisome proliferator-activa... 3 | 3
Phagocyte (gp91(phox)) nadph o... 3 | 3
Retinoic acid receptors 3 | 3
Retinoic acid-related orphans 3 | 3
Retinoid x receptors 3 | 3
Voltage-gated potassium channe... 3 | 3
Dax-like receptors 2 | 2
Estrogen receptors 2 | 2
FAM26 family 2 | 2
Fushi tarazu f1-like receptors 2 | 2
Golgi pH regulator family 2 | 2
Hepatocyte nuclear factor-4 re... 2 | 2
Mechanical nociceptor, piezo (... 2 | 2
Phospholemman (plm) family 2 | 2
Rev-erb receptors 2 | 2
SLC26A-SulP transporter family 2 | 2
Tailless-like receptors 2 | 2
Testicular receptors 2 | 2
Tmem38 family 2 | 2
Unclassified protein 2 | 2
ABCC family 1 | 1
Calcium release-activated calc... 1 | 1
Cation-nonselective channel fa... 1 | 1
Germ cell nuclear factor recep... 1 | 1
Intracellular chloride channel... 1 | 1
MCU family 1 | 1
Membrane protein mlc1 family 1 | 1
PMP-22-EMP-MP20 family 1 | 1
The phagocyte (gp91(phox)) nad... 1 | 1
Voltage-gated proton channel (... 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroid hormone receptor alpha THRA Tclin Nuclear Receptor -2.72292 527.4 453
Thyroid hormone receptor beta THRB Tclin Nuclear Receptor -2.82486 627.3 399