Development Level

Tbio 32 | 11,445
Tchem 32 | 1,598
Tclin 2 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 6 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal embryo size 3 | 220
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
decreased bone mineral density 2 | 126
embryonic growth retardation 2 | 106
increased bone mineral content 2 | 108
persistence of hyaloid vascula... 2 | 33
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
microphthalmia 1 | 26
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58
thick ventricular wall 1 | 7
thin ventricular wall 1 | 24

Disease

Carcinoma 41 | 11,493
osteosarcoma 40 | 7,950
ovarian cancer 38 | 8,520
medulloblastoma, large-cell 37 | 6,241
glioblastoma 30 | 5,792
psoriasis 28 | 6,694
lung cancer 27 | 4,740
atypical teratoid / rhabdoid tumor 23 | 5,112
ependymoma 23 | 4,679
adult high grade glioma 19 | 3,801
primitive neuroectodermal tumor 17 | 3,035
invasive ductal carcinoma 16 | 2,951
non-small cell lung cancer 16 | 2,890
ulcerative colitis 16 | 1,819
group 3 medulloblastoma 15 | 4,104
malignant mesothelioma 15 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Autosomal recessive predisposition 14 | 1,442
Breast cancer 14 | 3,578
Cancer 14 | 2,499
pancreatic cancer 14 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
Schizophrenia 12 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
Kidney cancer 11 | 2,613
astrocytic glioma 11 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
subependymal giant cell astrocytoma 11 | 2,287
ductal carcinoma in situ 10 | 1,745
group 4 medulloblastoma 10 | 1,855
lung adenocarcinoma 10 | 2,716
oligodendroglioma 10 | 2,850
Astrocytoma, Pilocytic 9 | 3,081
lung carcinoma 9 | 2,843
Epilepsy 8 | 792
Pick disease 8 | 1,894
Seizures 8 | 596
Waldenstrons macroglobulinemia 8 | 765
astrocytoma 8 | 1,146
breast carcinoma 8 | 1,638
dermatomyositis 8 | 966
diabetes mellitus 8 | 1,728
interstitial cystitis 8 | 2,312
Failure to gain weight 7 | 365
Pediatric failure to thrive 7 | 365
pituitary cancer 7 | 1,972
primary pancreatic ductal adenocarcinoma 7 | 1,109
tuberculosis 7 | 2,010
Bipolar Disorder 6 | 666
Intellectual disability 6 | 1,016
Muscle hypotonia 6 | 571
Splenomegaly 6 | 190
acute quadriplegic myopathy 6 | 1,158
medulloblastoma 6 | 720
Cerebellar Ataxia 5 | 304
Dull intelligence 5 | 645
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Multiple myeloma 5 | 1,332
Poor school performance 5 | 645
Rheumatoid arthritis 5 | 1,191
adrenocortical carcinoma 5 | 1,428
colon cancer 5 | 1,478
esophageal adenocarcinoma 5 | 737
gastric carcinoma 5 | 807
juvenile dermatomyositis 5 | 1,187
primary Sjogren syndrome 5 | 735
Adenocarcinoma of lung 4 | 142
Carcinoma, Hepatocellular 4 | 228
Cerebral atrophy 4 | 178
Cognitive delay 4 | 608
DOID:2627 4 | 94
Degenerative brain disorder 4 | 100
Delayed speech and language development 4 | 112
Diarrhea 4 | 253
Diffuse large B-cell lymphoma 4 | 39
Global developmental delay 4 | 608
Language Delay 4 | 112
Liver Cirrhosis, Experimental 4 | 769
Liver carcinoma 4 | 240
Lymphoma, Large B-Cell, Diffuse 4 | 34
Mental and motor retardation 4 | 608
Speech Delay 4 | 112
Speech impairment 4 | 112
Supratentorial atrophy 4 | 94
acute myeloid leukemia 4 | 783
cystic fibrosis 4 | 1,696
follicular lymphoma 4 | 20
spina bifida 4 | 1,074
Endometrial cancer 3 | 311
Endometriosis 3 | 540
Hypoglycemia 3 | 152
Myocardial Ischemia 3 | 169
Prostatic Neoplasms 3 | 495
atypical teratoid/rhabdoid tumor 3 | 357
fibroadenoma 3 | 559
nephrosclerosis 3 | 333
pancreatic carcinoma 3 | 562
pediatric high grade glioma 3 | 1,064

Tissue

Endocrine System 67 | 18,159
Blood and immune system 66 | 16,909
Digestive Tract 66 | 17,369
Liver and Pancreas 66 | 16,750
Male tissues 66 | 17,142
Nervous System 66 | 16,725
Skin and soft tissues 66 | 17,230
Female tissues 65 | 17,400
Urinary Tract 65 | 16,678
Cardiovascular System 64 | 15,192
Respiratory system 64 | 16,393

Target Family

Kinase 64 | 634
Non-IDG 3 | 12,091

DTO Protein Class (1)

Non-protein kinase 67 | 67
Class A rhodopsin like 749 | 749
Protein kinase 535 | 535
Potassium channel family 52 | 52
Neurotransmitter receptor, cys... 47 | 47
Adhesion class 33 | 33
Transient receptor potential c... 24 | 24
Class C metabotropic glutamate... 23 | 23
Glutamate-gated ion channel (... 19 | 19
Class B secretin like 16 | 16
Inward rectifier-type potassiu... 16 | 16
Two pore domain potassium chan... 15 | 15
Calcium channel alpha-1 subuni... 13 | 13
Class F frizzled-type 12 | 12
Cyclic nucleotide-gated cation... 10 | 10
Sodium channel family 10 | 10
Amiloride-sensitive sodium cha... 9 | 9
Chloride channel family 9 | 9
Calcium channel auxiliary subu... 8 | 8
3-ketosteroid receptors 7 | 7
Atp-gated p2x receptor cation ... 7 | 7
Intracellular chloride channel... 6 | 6
Polycystin cation channel (pcc... 6 | 6
Ryanodine-inositol 1,4,5-triph... 6 | 6
Transmembrane channel (TMC) fa... 6 | 6
Calcium-dependent chloride cha... 5 | 5
Fxyd family 5 | 5
Anion channel-forming bestroph... 4 | 4
Calcium channel auxiliary subu... 4 | 4
Calcium channel auxiliary subu... 4 | 4
Calcium homeostasis modulator ... 4 | 4
Calcium-activated potassium ch... 4 | 4
Cation channel sperm-associate... 4 | 4
Epithelial chloride channel (e... 4 | 4
Other 7TM proteins 4 | 4
Sodium channel auxiliary subun... 4 | 4
Vitamin d receptor-like recept... 4 | 4
Anion channel tweety (tweety) ... 3 | 3
Coup-tf-like receptors 3 | 3
Estrogen-related receptors 3 | 3
Gap junction-forming innexin (... 3 | 3
Liver x receptor-like receptor... 3 | 3
Nerve growth factor ib-like re... 3 | 3
Peroxisome proliferator-activa... 3 | 3
Phagocyte (gp91(phox)) nadph o... 3 | 3
Retinoic acid receptors 3 | 3
Retinoic acid-related orphans 3 | 3
Retinoid x receptors 3 | 3
Voltage-gated potassium channe... 3 | 3
Dax-like receptors 2 | 2
Estrogen receptors 2 | 2
FAM26 family 2 | 2
Fushi tarazu f1-like receptors 2 | 2
Golgi pH regulator family 2 | 2
Hepatocyte nuclear factor-4 re... 2 | 2
Mechanical nociceptor, piezo (... 2 | 2
Phospholemman (plm) family 2 | 2
Rev-erb receptors 2 | 2
SLC26A-SulP transporter family 2 | 2
Tailless-like receptors 2 | 2
Testicular receptors 2 | 2
Thyroid hormone receptors 2 | 2
Tmem38 family 2 | 2
Unclassified protein 2 | 2
ABCC family 1 | 1
Calcium release-activated calc... 1 | 1
Cation-nonselective channel fa... 1 | 1
Germ cell nuclear factor recep... 1 | 1
Intracellular chloride channel... 1 | 1
MCU family 1 | 1
Membrane protein mlc1 family 1 | 1
PMP-22-EMP-MP20 family 1 | 1
The phagocyte (gp91(phox)) nad... 1 | 1
Voltage-gated proton channel (... 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate kinase 2, mitochondrial AK2 Tbio Kinase -2.00007 98.7 330
Diacylglycerol kinase eta DGKH Tbio Kinase -1.45863 29.5 92
GTP:AMP phosphotransferase AK3, mitochondrial AK3 Tbio Kinase -1.37969 23.5 249
Tachykinin-4 TAC4 Tbio Non-IDG -1.56554 37.9 57
Protein Hook homolog 1 HOOK1 Tbio Non-IDG -1.16190 13.1 187
Adenylate kinase 4, mitochondrial AK4 Tbio Kinase -1.83029 66.5 272
Calsyntenin-1 CLSTN1 Tbio Non-IDG -1.09760 15.0 131
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Adenylate kinase isoenzyme 1 AK1 Tbio Kinase -2.37718 230.1 422
Phosphoglycerate kinase 1 PGK1 Tchem Kinase -2.79738 602.5 340