Development Level

Tclin 2 | 613

IMPC Phenotype

decreased bone mineral content 1 | 151
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
increased circulating alkaline... 1 | 122
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 134
thin ventricular wall 1 | 24

Disease

Adenocarcinoma 2 | 122
Alzheimer's disease 2 | 658
Animal Mammary Neoplasms 2 | 136
Atrophic vaginitis 2 | 14
Bladder Neoplasm 2 | 112
Breast Neoplasms 2 | 445
Carcinoma 2 | 11,493
Coronary artery disease 2 | 268
Dyspareunia 2 | 12
Endometrial Neoplasms 2 | 55
Endometriosis 2 | 540
Female hypogonadism syndrome 2 | 25
Female infertility 2 | 30
Infertility 2 | 188
Infertility, Female 2 | 28
Male infertility 2 | 206
Mammary Neoplasms 2 | 425
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Menopausal flushing 2 | 17
Metastatic Breast Cancer Progression Post-Antiestrogen Therapy 2 | 4
Obesity 2 | 678
Osteoporosis 2 | 363
Postmenopausal osteoporosis 2 | 19
Prevention of Breast Carcinoma 2 | 5
Prostatic Intraepithelial Neoplasia 2 | 11
Prostatic Intraepithelial Neoplasias 2 | 11
Prostatic Neoplasms 2 | 495
Schizophrenia 2 | 1,160
Urinary Bladder Neoplasms 2 | 114
Vascular disease 2 | 319
astrocytoma 2 | 1,146
lung cancer 2 | 4,740
ovarian cancer 2 | 8,520
psoriasis 2 | 6,694
Abdominal pain, episodic 1 | 9
Absence of pubertal development 1 | 17
Absence of secondary sex characteristics 1 | 22
Acanthosis Nigricans 1 | 27
Acne 1 | 52
Acquired metabolic disease 1 | 336
Breast disease 1 | 7
Breast fibroadenoma 1 | 8
Carcinoma of female breast 1 | 20
Carcinoma, Transitional Cell 1 | 32
Carcinosarcoma 1 | 7
Cardiac Arrhythmia 1 | 103
Chemotherapy-induced nausea and vomiting 1 | 16
Colorectal Neoplasms 1 | 243
Colorectal cancer 1 | 25
Congenital hypoplasia of breast 1 | 25
Coronary Arteriosclerosis 1 | 6
Coronary Disease 1 | 25
Coronary heart disease 1 | 16
Delayed epiphyseal ossification 1 | 10
Delayed maturation of end part of long bone 1 | 10
Disease Models, Animal 1 | 155
ESTROGEN RESISTANCE 1 | 2
Elevated gonadotropins 1 | 15
Elevated tissue non-specific alkaline phosphatase 1 | 1
Enlarged polycystic ovaries 1 | 10
Female Urogenital Diseases 1 | 18
Feminization 1 | 1
Fetal overgrowth 1 | 16
Fibroid Tumor 1 | 6
Generalized osteopenia 1 | 99
Generalized overgrowth 1 | 16
Glomerulonephritis 1 | 46
Hyperinsulinism 1 | 133
Idiopathic scoliosis 1 | 31
Impaired glucose tolerance 1 | 28
Infantile uterus 1 | 23
Leiomyoma 1 | 32
Leiomyosarcoma 1 | 24
Lobular neoplasia 1 | 15
Lymphangioleiomyomatosis 1 | 16
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1 1 | 3
Marijuana Abuse 1 | 31
Marked delay in bone age 1 | 1
Mesothelioma 1 | 38
Metabolic Bone Disorder 1 | 11
Metastatic Breast Carcinoma 1 | 21
Metastatic Prostate Carcinoma 1 | 18
Migraine Disorders 1 | 76
Musculoskeletal Pain 1 | 3
Myocardial Infarction 1 | 151
Neoplasm Metastasis 1 | 168
Neoplasm Recurrence, Local 1 | 37
Neoplastic Cell Transformation 1 | 89
Oligospermia 1 | 36
Osteopenia 1 | 99
Overgrowth 1 | 16
Plaque build-up in arteries supplying blood to heart 1 | 6
Prevention of Post-Operative Nausea and Vomiting 1 | 14
Primary physiologic amenorrhea 1 | 55
Psychoses, Substance-Induced 1 | 17
Retinoblastoma 1 | 19
Shared Paranoid Disorder 1 | 5
Uterine fibroid 1 | 28
intermittent abdominal pain 1 | 9

Tissue

Blood and immune system 2 | 16,909
Cardiovascular System 2 | 15,192
Digestive Tract 2 | 17,369
Endocrine System 2 | 18,159
Female tissues 2 | 17,400
Liver and Pancreas 2 | 16,750
Male tissues 2 | 17,142
Nervous System 2 | 16,725
Respiratory system 2 | 16,393
Skin and soft tissues 2 | 17,230
Urinary Tract 2 | 16,678

Target Family

Nuclear Receptor 2 | 48

DTO Protein Class (1)

Estrogen receptors 2 | 2
Class A rhodopsin like 749 | 749
Protein kinase 535 | 535
Non-protein kinase 67 | 67
Potassium channel family 52 | 52
Neurotransmitter receptor, cys... 47 | 47
Adhesion class 33 | 33
Transient receptor potential c... 24 | 24
Class C metabotropic glutamate... 23 | 23
Glutamate-gated ion channel (... 19 | 19
Class B secretin like 16 | 16
Inward rectifier-type potassiu... 16 | 16
Two pore domain potassium chan... 15 | 15
Calcium channel alpha-1 subuni... 13 | 13
Class F frizzled-type 12 | 12
Cyclic nucleotide-gated cation... 10 | 10
Sodium channel family 10 | 10
Amiloride-sensitive sodium cha... 9 | 9
Chloride channel family 9 | 9
Calcium channel auxiliary subu... 8 | 8
3-ketosteroid receptors 7 | 7
Atp-gated p2x receptor cation ... 7 | 7
Intracellular chloride channel... 6 | 6
Polycystin cation channel (pcc... 6 | 6
Ryanodine-inositol 1,4,5-triph... 6 | 6
Transmembrane channel (TMC) fa... 6 | 6
Calcium-dependent chloride cha... 5 | 5
Fxyd family 5 | 5
Anion channel-forming bestroph... 4 | 4
Calcium channel auxiliary subu... 4 | 4
Calcium channel auxiliary subu... 4 | 4
Calcium homeostasis modulator ... 4 | 4
Calcium-activated potassium ch... 4 | 4
Cation channel sperm-associate... 4 | 4
Epithelial chloride channel (e... 4 | 4
Other 7TM proteins 4 | 4
Sodium channel auxiliary subun... 4 | 4
Vitamin d receptor-like recept... 4 | 4
Anion channel tweety (tweety) ... 3 | 3
Coup-tf-like receptors 3 | 3
Estrogen-related receptors 3 | 3
Gap junction-forming innexin (... 3 | 3
Liver x receptor-like receptor... 3 | 3
Nerve growth factor ib-like re... 3 | 3
Peroxisome proliferator-activa... 3 | 3
Phagocyte (gp91(phox)) nadph o... 3 | 3
Retinoic acid receptors 3 | 3
Retinoic acid-related orphans 3 | 3
Retinoid x receptors 3 | 3
Voltage-gated potassium channe... 3 | 3
Dax-like receptors 2 | 2
FAM26 family 2 | 2
Fushi tarazu f1-like receptors 2 | 2
Golgi pH regulator family 2 | 2
Hepatocyte nuclear factor-4 re... 2 | 2
Mechanical nociceptor, piezo (... 2 | 2
Phospholemman (plm) family 2 | 2
Rev-erb receptors 2 | 2
SLC26A-SulP transporter family 2 | 2
Tailless-like receptors 2 | 2
Testicular receptors 2 | 2
Thyroid hormone receptors 2 | 2
Tmem38 family 2 | 2
Unclassified protein 2 | 2
ABCC family 1 | 1
Calcium release-activated calc... 1 | 1
Cation-nonselective channel fa... 1 | 1
Germ cell nuclear factor recep... 1 | 1
Intracellular chloride channel... 1 | 1
MCU family 1 | 1
Membrane protein mlc1 family 1 | 1
PMP-22-EMP-MP20 family 1 | 1
The phagocyte (gp91(phox)) nad... 1 | 1
Voltage-gated proton channel (... 1 | 1

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Estrogen receptor beta ESR2 Tclin Nuclear Receptor -3.57388 3765.2 1096
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610