Development Level

Tchem 20 | 1,598
Tclin 19 | 613
Tbio 13 | 11,445

IMPC Phenotype

abnormal bone structure 4 | 187
abnormal behavior 3 | 298
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
increased bone mineral content 3 | 108
increased startle reflex 3 | 112
preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating triglyce... 2 | 42
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 92
thin ventricular wall 2 | 24
abnormal allantois morphology 1 | 8
abnormal behavioral response t... 1 | 66
abnormal chorioallantoic fusio... 1 | 8
abnormal cranium morphology 1 | 36
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart looping 1 | 5
abnormal hindbrain development 1 | 16
abnormal humerus morphology 1 | 11
abnormal iris morphology 1 | 13
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal pupil morphology 1 | 2
abnormal radius morphology 1 | 8
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal rib morphology 1 | 10
abnormal somite shape 1 | 5
abnormal tail bud morphology 1 | 8
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal visceral yolk sac mor... 1 | 6
cataract 1 | 92
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
hyperactivity 1 | 148
hypoactivity 1 | 132
increased B cell number 1 | 9
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased lactate dehydrogenas... 1 | 3
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
pale yolk sac 1 | 25
short tibia 1 | 97
small heart 1 | 10
small kidney 1 | 16
small spleen 1 | 19
tremors 1 | 39

Disease

Carcinoma 42 | 11,493
psoriasis 32 | 6,694
Cancer 28 | 2,499
osteosarcoma 27 | 7,950
ovarian cancer 26 | 8,520
malignant mesothelioma 22 | 3,232
medulloblastoma, large-cell 21 | 6,241
lung cancer 19 | 4,740
Endometriosis 18 | 540
glioblastoma 17 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
Breast cancer 15 | 3,578
atypical teratoid / rhabdoid tumor 15 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
invasive ductal carcinoma 15 | 2,951
ulcerative colitis 15 | 1,819
Obesity 14 | 678
adult high grade glioma 14 | 3,801
group 3 medulloblastoma 14 | 4,104
interstitial cystitis 14 | 2,312
primitive neuroectodermal tumor 14 | 3,035
diabetes mellitus 13 | 1,728
Bipolar Disorder 12 | 666
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
breast carcinoma 12 | 1,638
ductal carcinoma in situ 12 | 1,745
pituitary cancer 12 | 1,972
Acne vulgaris 11 | 14
Autosomal recessive predisposition 11 | 1,442
Schizophrenia 11 | 1,160
lung adenocarcinoma 11 | 2,716
pancreatic cancer 11 | 2,398
ependymoma 10 | 4,679
lung carcinoma 10 | 2,843
non-small cell lung cancer 10 | 2,890
adrenocortical carcinoma 9 | 1,428
cystic fibrosis 9 | 1,696
group 4 medulloblastoma 9 | 1,855
Astrocytoma, Pilocytic 8 | 3,081
Kaposi's Sarcoma Skin Lesions 8 | 8
Osteoporosis 8 | 363
astrocytic glioma 8 | 2,597
astrocytoma 8 | 1,146
tuberculosis 8 | 2,010
Atopic dermatitis 7 | 952
Carcinoma, Hepatocellular 7 | 228
Depressive disorder 7 | 409
Female infertility 7 | 30
Liver carcinoma 7 | 240
Menopausal flushing 7 | 17
Prostatic Neoplasms 7 | 495
colon cancer 7 | 1,478
cutaneous lupus erythematosus 7 | 1,057
oligodendroglioma 7 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
subependymal giant cell astrocytoma 7 | 2,287
Acquired metabolic disease 6 | 336
Adenocarcinoma 6 | 122
Adenoma 6 | 167
Atrophic vaginitis 6 | 14
Chloasma 6 | 6
Cholestasis 6 | 155
Fatty Liver 6 | 70
Hepatomegaly 6 | 285
Hypertension 6 | 396
Hypertensive disease 6 | 292
Infertility 6 | 188
Infertility, Female 6 | 28
Kidney cancer 6 | 2,613
Kidney disease 6 | 430
Mental Depression 6 | 333
Pick disease 6 | 1,894
Postmenopausal osteoporosis 6 | 19
chronic rhinosinusitis 6 | 512
Chemical and Drug Induced Liver Injury 5 | 195
Contraception 5 | 15
Fatty liver disease 5 | 103
Female hypogonadism syndrome 5 | 25
Heart disease 5 | 306
Hyperinsulinism 5 | 133
Hyperkeratosis 5 | 50
Inflammatory bowel disease 5 | 151
Insulin Resistance 5 | 72
Liver disease 5 | 237
Liver neoplasms 5 | 130
Male infertility 5 | 206
Mood Disorders 5 | 184
Multiple Sclerosis 5 | 540
Muscle hypotonia 5 | 571
Premenstrual dysphoric disorder 5 | 8
Primary physiologic amenorrhea 5 | 55
Rheumatoid arthritis 5 | 1,191
Stomach Neoplasms 5 | 300
acute quadriplegic myopathy 5 | 1,158
esophageal adenocarcinoma 5 | 737
nephrosclerosis 5 | 333
primary pancreatic ductal adenocarcinoma 5 | 1,109
urothelial carcinoma 5 | 318

Tissue

Endocrine System 52 | 18,159
Skin and soft tissues 52 | 17,230
Blood and immune system 51 | 16,909
Digestive Tract 51 | 17,369
Female tissues 51 | 17,400
Male tissues 50 | 17,142
Respiratory system 50 | 16,393
Liver and Pancreas 49 | 16,750
Urinary Tract 49 | 16,678
Nervous System 48 | 16,725
Cardiovascular System 44 | 15,192

Target Family

Nuclear Receptor 48 | 48
Enzyme 3 | 4,145
Non-IDG 1 | 12,091

DTO Protein Class (0)

Nuclear hormone receptor 52 | 52
GPCR 837 | 837
Kinase 604 | 604
Ion channel 346 | 346

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Photoreceptor-specific nuclear receptor NR2E3 Tbio Nuclear Receptor 0.00000 261
Steroid hormone receptor ERR2 ESRRB Tchem Nuclear Receptor -1.95523 86.9 173
Nuclear receptor subfamily 2 group C member 1 NR2C1 Tbio Nuclear Receptor -1.39182 24.4 294
Estrogen-related receptor gamma ESRRG Tchem Nuclear Receptor -2.16790 159.1 328
Nuclear receptor subfamily 0 group B member 1 NR0B1 Tbio Nuclear Receptor -2.73235 544.8 477
Retinoic acid receptor RXR-beta RXRB Tclin Nuclear Receptor -1.72557 49.3 274
Nuclear receptor subfamily 4 group A member 2 NR4A2 Tchem Nuclear Receptor -2.59490 415.4 307
Nuclear receptor subfamily 6 group A member 1 NR6A1 Tbio Nuclear Receptor -2.36193 227.5 236
COUP transcription factor 1 NR2F1 Tbio Nuclear Receptor -2.00427 106.7 184
Mineralocorticoid receptor NR3C2 Tclin Nuclear Receptor -3.08863 1005.8 203