Development Level

Tclin 126 | 613
Tbio 108 | 11,445
Tchem 87 | 1,598
Tdark 25 | 6,588

Collection

Ion Channel: IDG Consortium (T... 96 | 99

IMPC Phenotype

preweaning lethality, complete... 15 | 979
abnormal behavior 9 | 298
decreased vertical activity 7 | 208
hyperactivity 7 | 148
increased startle reflex 7 | 112
embryonic lethality prior to t... 6 | 278
enlarged heart 6 | 210
abnormal embryo size 5 | 220
impaired glucose tolerance 5 | 75
abnormal epididymis morphology 4 | 42
abnormal gait 4 | 69
abnormal heart morphology 4 | 162
decreased body weight 4 | 161
decreased fasted circulating g... 4 | 65
preweaning lethality, incomple... 4 | 499
abnormal bone structure 3 | 187
abnormal seminal vesicle morph... 3 | 114
decreased grip strength 3 | 116
decreased lymphocyte cell numb... 3 | 83
embryonic growth retardation 3 | 106
hydrometra 3 | 53
increased bone mineral content 3 | 108
increased circulating triglyce... 3 | 42
increased lean body mass 3 | 172
increased mean corpuscular vol... 3 | 92
increased mean platelet volume 3 | 45
increased monocyte cell number 3 | 63
increased total body fat amoun... 3 | 134
limb grasping 3 | 41
small superior vagus ganglion 3 | 74
abnormal behavioral response t... 2 | 66
abnormal bone mineralization 2 | 38
abnormal pancreas morphology 2 | 13
decreased cardiac stroke volum... 2 | 6
decreased circulating alkaline... 2 | 46
decreased circulating glucose ... 2 | 126
decreased circulating glycerol... 2 | 16
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased heart weight 2 | 27
decreased hemoglobin content 2 | 68
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
enlarged epididymis 2 | 31
enlarged uterus 2 | 11
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 76
increased spleen weight 2 | 10
prenatal lethality prior to he... 2 | 87
abnormal brain morphology 1 | 13
abnormal embryo turning 1 | 31
abnormal facial morphology 1 | 17
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal pelvic girdle bone mo... 1 | 12
abnormal placenta vasculature 1 | 2
abnormal response to new envir... 1 | 10
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
abnormal vocalization 1 | 21
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cyanosis 1 | 7
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating iron lev... 1 | 32
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
edema 1 | 59
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
hydroencephaly 1 | 14
increased aggression 1 | 4
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased eosinophil cell numb... 1 | 11
increased heart rate 1 | 23
increased heart weight 1 | 62
increased vertical activity 1 | 24
prenatal lethality 1 | 28
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
small testis 1 | 58
syndactyly 1 | 23
tremors 1 | 39

Disease

Carcinoma 269 | 11,493
medulloblastoma, large-cell 142 | 6,241
psoriasis 133 | 6,694
atypical teratoid / rhabdoid tumor 131 | 5,112
glioblastoma 129 | 5,792
ependymoma 122 | 4,679
osteosarcoma 118 | 7,950
adult high grade glioma 115 | 3,801
Kidney cancer 104 | 2,613
Astrocytoma, Pilocytic 100 | 3,081
group 3 medulloblastoma 92 | 4,104
oligodendroglioma 91 | 2,850
ovarian cancer 90 | 8,520
primitive neuroectodermal tumor 87 | 3,035
lung cancer 82 | 4,740
lung carcinoma 81 | 2,843
Epilepsy 80 | 792
astrocytic glioma 72 | 2,597
subependymal giant cell astrocytoma 68 | 2,287
Schizophrenia 64 | 1,160
malignant mesothelioma 59 | 3,232
Breast cancer 57 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,955
Bipolar Disorder 53 | 666
pituitary cancer 52 | 1,972
lung adenocarcinoma 48 | 2,716
Pick disease 47 | 1,894
cystic fibrosis 47 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,291
Multiple Sclerosis 45 | 540
interstitial cystitis 42 | 2,312
Autosomal recessive predisposition 40 | 1,442
Eaton-Lambert syndrome 40 | 40
General anesthesia 39 | 53
Intellectual disability 39 | 1,016
pancreatic cancer 39 | 2,398
non-small cell lung cancer 36 | 2,890
Tonic-clonic epilepsy 35 | 47
invasive ductal carcinoma 35 | 2,951
Seizures 33 | 596
Autistic Disorder 31 | 364
Liver cancer 31 | 604
Melanoma 31 | 711
ulcerative colitis 31 | 1,819
Local anesthesia 30 | 40
colon cancer 30 | 1,478
Skin cancer 29 | 469
group 4 medulloblastoma 29 | 1,855
Atrial Fibrillation 27 | 124
Alcoholic Intoxication, Chronic 26 | 289
Muscle hypotonia 26 | 571
Lennox-Gastaut syndrome 25 | 34
Dull intelligence 23 | 645
Hypertension 23 | 396
Low intelligence 23 | 645
Mental Depression 23 | 333
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
ductal carcinoma in situ 23 | 1,745
Depressive disorder 22 | 409
Epilepsy characterized by intractable complex partial seizures 22 | 28
Infantile onset 22 | 238
Simple partial seizure 22 | 26
breast carcinoma 22 | 1,638
Alcohol dependence 21 | 107
Cognitive delay 21 | 608
Global developmental delay 21 | 608
Mental and motor retardation 21 | 608
adrenocortical carcinoma 21 | 1,428
cutaneous lupus erythematosus 21 | 1,057
Long QT syndrome 20 | 39
active Crohn's disease 20 | 922
Parkinson's disease 19 | 392
Brugada syndrome 18 | 29
Cerebellar Ataxia 18 | 304
Nicotine dependence 18 | 54
Status Epilepticus 18 | 98
non primary Sjogren syndrome sicca 18 | 891
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
tuberculosis 18 | 2,010
Anxiety 17 | 136
Cancer 17 | 2,499
Endometrial cancer 17 | 311
Heart disease 16 | 306
Insomnia 16 | 20
Spasticity 16 | 26
active ulcerative colitis 16 | 764
astrocytoma 16 | 1,146
gastric carcinoma 16 | 807
nasopharyngeal carcinoma 16 | 1,058
Hypertensive disorder 15 | 56
Neurodegenerative disease 15 | 414
Neuropathy 15 | 261
Partial Epilepsy Treatment Adjunct 15 | 16
diabetes mellitus 15 | 1,728
Hypertensive disease 14 | 292
primary Sjogren syndrome 14 | 735
progressive supranuclear palsy 14 | 676

Tissue

Endocrine System 335 | 18,159
Nervous System 314 | 16,725
Digestive Tract 310 | 17,369
Female tissues 306 | 17,400
Skin and soft tissues 302 | 17,230
Male tissues 296 | 17,142
Blood and immune system 285 | 16,909
Urinary Tract 282 | 16,678
Liver and Pancreas 280 | 16,750
Respiratory system 265 | 16,393
Cardiovascular System 220 | 15,192

Target Family

Ion Channel 340 | 344
Non-IDG 4 | 12,091
Enzyme 2 | 4,145

DTO Protein Class (0)

Ion channel 346 | 346
GPCR 837 | 837
Kinase 604 | 604
Nuclear hormone receptor 52 | 52

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transient receptor potential cation channel subfamily V member 2 TRPV2 Tchem Ion Channel -2.28525 197.9 203
Calcium-activated potassium channel subunit beta-2 KCNMB2 Tbio Ion Channel 1.28 0.09 191
Leucine-rich repeat-containing protein 26 LRRC26 Tbio Ion Channel -1.02699 11.3 81
Calcium homeostasis modulator protein 3 CALHM3 Tdark Ion Channel -0.10646 0.35 86
Sodium channel protein type 10 subunit alpha SCN10A Tclin Ion Channel -3.17690 1469.3 126
Pannexin-3 PANX3 Tbio Ion Channel -1.66465 45.0 71
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 HCN2 Tclin Ion Channel -1.16715 13.3 162
Potassium voltage-gated channel subfamily H member 3 KCNH3 Tclin Ion Channel -1.07866 11.8 67
Potassium voltage-gated channel subfamily A member 7 KCNA7 Tclin Ion Channel -0.87978 7.43 59
Pannexin-1 PANX1 Tbio Ion Channel -2.59888 418.5 154