Development Level

Tbio 190 | 11,651
Tdark 21 | 6,593
Tchem 17 | 1,388
Tclin 1 | 612

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 19 | 979
preweaning lethality, incomple... 9 | 499
abnormal bone structure 8 | 187
decreased total body fat amoun... 7 | 207
increased heart weight 7 | 62
abnormal sleep behavior 6 | 70
abnormal behavior 5 | 298
abnormal behavioral response t... 5 | 66
decreased body weight 5 | 161
embryonic lethality prior to t... 5 | 278
increased mean corpuscular vol... 5 | 92
increased startle reflex 5 | 112
decreased circulating HDL chol... 4 | 68
decreased grip strength 4 | 116
embryonic lethality prior to o... 4 | 239
hypoactivity 4 | 132
increased bone mineral content 4 | 108
increased lean body mass 4 | 172
abnormal embryo size 3 | 220
abnormal retina morphology 3 | 71
decreased bone mineral density 3 | 126
decreased circulating choleste... 3 | 93
decreased circulating insulin ... 3 | 76
hyperactivity 3 | 148
increased bone mineral density 3 | 72
limb grasping 3 | 41
abnormal coat appearance 2 | 31
abnormal epididymis morphology 2 | 42
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal limb bud morphology 2 | 17
abnormal response to new envir... 2 | 10
abnormal snout morphology 2 | 23
abnormal tail movements 2 | 12
cataract 2 | 92
decreased B cell number 2 | 5
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating bilirubi... 2 | 19
decreased circulating creatini... 2 | 39
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
enlarged epididymis 2 | 31
enlarged heart 2 | 210
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased body weight 2 | 25
increased circulating alkaline... 2 | 122
increased fasted circulating g... 2 | 76
increased grip strength 2 | 41
increased or absent threshold ... 2 | 101
male infertility 2 | 123
premature death 2 | 5
abnormal body wall morphology 1 | 9
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
decreased IgE level 1 | 6
decreased T cell number 1 | 15
decreased circulating amylase ... 1 | 28
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased food intake 1 | 13
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired righting response 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased cardiac muscle contr... 1 | 8
increased circulating amylase ... 1 | 25
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased hematocrit 1 | 46
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 153 | 11,493
ovarian cancer 143 | 8,520
osteosarcoma 119 | 7,950
psoriasis 98 | 6,694
medulloblastoma, large-cell 91 | 6,241
glioblastoma 81 | 5,792
atypical teratoid / rhabdoid tumor 69 | 5,112
lung cancer 69 | 4,740
ependymoma 62 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 53 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 51 | 2,955
malignant mesothelioma 51 | 3,232
adult high grade glioma 50 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 49 | 2,989
Breast cancer 47 | 3,578
Astrocytoma, Pilocytic 46 | 3,081
lung carcinoma 45 | 2,843
Kidney cancer 44 | 2,613
invasive ductal carcinoma 41 | 2,951
astrocytic glioma 40 | 2,597
pancreatic cancer 39 | 2,398
Pick disease 38 | 1,894
group 3 medulloblastoma 38 | 4,104
subependymal giant cell astrocytoma 38 | 2,287
group 4 medulloblastoma 35 | 1,855
diabetes mellitus 34 | 1,728
oligodendroglioma 33 | 2,850
Cancer 32 | 2,499
interstitial cystitis 31 | 2,312
ductal carcinoma in situ 30 | 1,745
non-small cell lung cancer 30 | 2,890
primitive neuroectodermal tumor 29 | 3,035
breast carcinoma 28 | 1,638
Alzheimer's disease 27 | 658
lung adenocarcinoma 27 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
tuberculosis 26 | 2,010
Intellectual disability 24 | 1,016
Multiple myeloma 24 | 1,332
pituitary cancer 24 | 1,972
cystic fibrosis 23 | 1,696
astrocytoma 22 | 1,146
colon cancer 22 | 1,478
juvenile dermatomyositis 21 | 1,187
ulcerative colitis 21 | 1,819
Waldenstrons macroglobulinemia 20 | 765
acute quadriplegic myopathy 20 | 1,158
Neurodegenerative disease 19 | 414
Rheumatoid arthritis 19 | 1,191
adrenocortical carcinoma 19 | 1,428
pediatric high grade glioma 19 | 1,064
Autosomal recessive predisposition 18 | 1,442
Schizophrenia 18 | 1,160
Down syndrome 17 | 499
Liver cancer 17 | 604
primary pancreatic ductal adenocarcinoma 17 | 1,109
Cataract 8 multiple types 16 | 33
Epilepsy 15 | 792
dermatomyositis 15 | 966
progressive supranuclear palsy 15 | 676
Cognitive delay 14 | 608
Duchenne muscular dystrophy 14 | 601
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
active Crohn's disease 14 | 922
aldosterone-producing adenoma 14 | 665
Atopic dermatitis 13 | 952
Dull intelligence 13 | 645
Liver Cirrhosis, Experimental 13 | 769
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Multiple Sclerosis 13 | 540
Poor school performance 13 | 645
acute myeloid leukemia 13 | 783
spina bifida 13 | 1,074
tuberculosis and treatment for 6 months 13 | 409
Kidney disease 12 | 430
Seizures 12 | 596
Obesity 11 | 678
active ulcerative colitis 11 | 764
cutaneous lupus erythematosus 11 | 1,057
esophageal adenocarcinoma 11 | 737
gastric carcinoma 11 | 807
hereditary spastic paraplegia 11 | 318
limb girdle muscular dystrophy 2A 11 | 213
mucosa-associated lymphoid tissue lymphoma 11 | 484
nasopharyngeal carcinoma 11 | 1,058
non primary Sjogren syndrome sicca 11 | 891
Melanoma 10 | 711
Oculocerebrorenal syndrome 10 | 29
pancreatic carcinoma 10 | 562
primary Sjogren syndrome 10 | 735
sarcoidosis 10 | 370
Adenoma 9 | 167
Congenital disorder of glycosylation 9 | 54
Depressive disorder 9 | 409
Gaucher disease type 1 9 | 180
Microcephaly 9 | 166
Small head 9 | 374

Tissue

Endocrine System 217 | 18,159
Skin and soft tissues 217 | 17,230
Digestive Tract 216 | 17,369
Female tissues 216 | 17,400
Liver and Pancreas 215 | 16,750
Nervous System 215 | 16,725
Respiratory system 215 | 16,393
Blood and immune system 214 | 16,909
Male tissues 213 | 17,142
Urinary Tract 212 | 16,678
Cardiovascular System 209 | 15,192

Target Family

Non-IDG 164 | 12,091
Enzyme 49 | 4,145
Transporter 8 | 473
GPCR 4 | 408
Kinase 4 | 634

Compartment GO Term

trans-Golgi network 229 | 229
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239
Protein wntless homolog WLS Tbio Non-IDG -2.50699 316.3 71
RNA binding protein fox-1 homolog 1 RBFOX1 Tbio Non-IDG -2.00815 99.2 207
AP-4 complex subunit sigma-1 AP4S1 Tdark Non-IDG -0.68049 4.42 25
AP-1 complex subunit mu-2 AP1M2 Tbio Non-IDG -2.54240 341.5 68
Sorting nexin-9 SNX9 Tbio Non-IDG -2.00279 102.8 241
AP-4 complex subunit beta-1 AP4B1 Tbio Non-IDG -0.79214 6.23 124