Development Level

Tbio 67 | 11,445
Tchem 44 | 1,598
Tclin 6 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 18 | 979
embryonic lethality prior to t... 8 | 278
preweaning lethality, incomple... 8 | 499
embryonic lethality prior to o... 7 | 239
abnormal embryo size 6 | 220
abnormal bone structure 3 | 187
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal neural tube closure 2 | 46
abnormal testis morphology 2 | 43
decreased blood urea nitrogen ... 2 | 51
decreased circulating insulin ... 2 | 76
decreased eosinophil cell numb... 2 | 24
decreased red blood cell distr... 2 | 41
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
edema 2 | 59
enlarged epididymis 2 | 31
enlarged heart 2 | 210
female infertility 2 | 60
increased lean body mass 2 | 172
increased startle reflex 2 | 112
male infertility 2 | 123
microphthalmia 2 | 26
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
absent vibrissae 1 | 12
anophthalmia 1 | 33
decreased IgG1 level 1 | 8
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased T cell number 1 | 15
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating magnesiu... 1 | 13
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased monocyte cell number 1 | 8
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
pale yolk sac 1 | 25
pallor 1 | 34
shortened RR interval 1 | 17
small adrenal glands 1 | 16
small seminal vesicle 1 | 10
tremors 1 | 39
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

Carcinoma 80 | 11,493
ovarian cancer 80 | 8,520
Cancer 73 | 2,499
osteosarcoma 67 | 7,950
lung cancer 49 | 4,740
glioblastoma 47 | 5,792
psoriasis 47 | 6,694
medulloblastoma, large-cell 42 | 6,241
group 3 medulloblastoma 40 | 4,104
Breast cancer 37 | 3,578
malignant mesothelioma 34 | 3,232
atypical teratoid / rhabdoid tumor 33 | 5,112
ependymoma 33 | 4,679
primitive neuroectodermal tumor 29 | 3,035
Kidney cancer 28 | 2,613
adult high grade glioma 27 | 3,801
oligodendroglioma 26 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
diabetes mellitus 24 | 1,728
Schizophrenia 23 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
pancreatic cancer 23 | 2,398
lung adenocarcinoma 22 | 2,716
ulcerative colitis 22 | 1,819
Astrocytoma, Pilocytic 21 | 3,081
non-small cell lung cancer 21 | 2,890
astrocytic glioma 20 | 2,597
invasive ductal carcinoma 20 | 2,951
Pick disease 19 | 1,894
astrocytoma 19 | 1,146
acute quadriplegic myopathy 18 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
subependymal giant cell astrocytoma 18 | 2,287
tuberculosis 18 | 2,010
Breast Neoplasms 17 | 445
Mammary Neoplasms 17 | 425
breast carcinoma 17 | 1,638
Liver Cirrhosis, Experimental 16 | 769
lung carcinoma 16 | 2,843
Autosomal recessive predisposition 15 | 1,442
Prostatic Neoplasms 15 | 495
Vascular disease 15 | 319
acute myeloid leukemia 15 | 783
colon cancer 15 | 1,478
cystic fibrosis 15 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Intellectual disability 14 | 1,016
Lung Neoplasms 14 | 232
Rheumatoid arthritis 14 | 1,191
Stomach Neoplasms 14 | 300
ductal carcinoma in situ 14 | 1,745
Anemia 13 | 365
Carcinoma, Hepatocellular 13 | 228
Epilepsy 13 | 792
Liver carcinoma 13 | 240
adrenocortical carcinoma 13 | 1,428
interstitial cystitis 13 | 2,312
nasopharyngeal carcinoma 13 | 1,058
Colorectal Neoplasms 12 | 243
Kidney disease 12 | 430
Melanoma 12 | 711
Obesity 12 | 678
Waldenstrons macroglobulinemia 12 | 765
juvenile dermatomyositis 12 | 1,187
primary pancreatic ductal adenocarcinoma 12 | 1,109
Atopic dermatitis 11 | 952
Colonic Neoplasms 11 | 142
Hypertensive disease 11 | 292
Multiple myeloma 11 | 1,332
Seizures 11 | 596
Toxic encephalopathy 11 | 141
Xeroderma pigmentosum 11 | 43
group 4 medulloblastoma 11 | 1,855
Asthma 10 | 385
Nijmegen breakage syndrome 10 | 24
Renal Cell Carcinoma 10 | 214
Short stature 10 | 531
Squamous cell carcinoma 10 | 129
dermatomyositis 10 | 966
pediatric high grade glioma 10 | 1,064
Acquired scoliosis 9 | 281
Alzheimer's disease 9 | 658
Ataxia telangiectasia 9 | 34
Carcinoma, Squamous Cell 9 | 110
Cleft Palate 9 | 271
Cockayne syndrome 9 | 60
Curvature of spine 9 | 282
Dull intelligence 9 | 645
Endometriosis 9 | 540
Heart disease 9 | 306
Hypertension 9 | 396
Inflammatory bowel disease 9 | 151
Liver disease 9 | 237
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Pancreatic Neoplasm 9 | 85
Poor school performance 9 | 645
Small head 9 | 374
pituitary cancer 9 | 1,972

Tissue

Blood and immune system 118 | 16,909
Female tissues 118 | 17,400
Nervous System 118 | 16,725
Skin and soft tissues 118 | 17,230
Digestive Tract 117 | 17,369
Endocrine System 117 | 18,159
Liver and Pancreas 117 | 16,750
Male tissues 117 | 17,142
Respiratory system 117 | 16,393
Urinary Tract 117 | 16,678
Cardiovascular System 115 | 15,192

Target Family

Non-IDG 56 | 12,091
Kinase 36 | 634
Transcription Factor 14 | 1,400
Enzyme 11 | 4,145
Epigenetic 2 | 242

Compartment GO Term

serine/threonine protein kinas... 119 | 119
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
RNA-binding protein 8A RBM8A Tbio Non-IDG -3.16448 1415.1 94
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Mitogen-activated protein kinase kinase kinase kinase 4 MAP4K4 Tchem Kinase -2.19064 152.6 547
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
Cyclin-Y CCNY Tbio Non-IDG -1.48139 30.1 120
Cyclin-dependent kinase 12 CDK12 Tchem Kinase -1.38476 29.4 157
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.32757 20.2 148
ALK tyrosine kinase receptor ALK Tclin Kinase -3.44312 2942.9 976