Development Level

Tbio 35 | 11,651
Tchem 6 | 1,388
Tclin 2 | 612
Tdark 2 | 6,593

IMPC Phenotype

preweaning lethality, complete... 3 | 979
embryonic lethality prior to t... 2 | 278
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal heart morphology 1 | 162
abnormal placement of pupils 1 | 6
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased circulating insulin ... 1 | 76
decreased lymphocyte cell numb... 1 | 83
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
increased bone mineral density 1 | 72
increased circulating potassiu... 1 | 29
increased hemoglobin content 1 | 45
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
small testis 1 | 58

Disease

Carcinoma 30 | 11,493
ovarian cancer 30 | 8,520
osteosarcoma 29 | 7,950
Cancer 26 | 2,499
group 3 medulloblastoma 23 | 4,104
Cockayne syndrome 22 | 60
Xeroderma pigmentosum 20 | 43
lung cancer 18 | 4,740
Autosomal recessive predisposition 15 | 1,442
medulloblastoma, large-cell 15 | 6,241
glioblastoma 14 | 5,792
malignant mesothelioma 14 | 3,232
psoriasis 14 | 6,694
Basal cell carcinoma 12 | 54
Breast cancer 12 | 3,578
Stomach Neoplasms 12 | 300
atypical teratoid / rhabdoid tumor 12 | 5,112
Cataract 11 | 297
Fatigue 11 | 182
Hypogonadism 11 | 173
Melanoma 11 | 711
Seizures 11 | 596
Sensorineural Hearing Loss (disorder) 11 | 284
Cryptorchidism 10 | 296
Epilepsy 10 | 792
Hyperpigmented macules 10 | 42
Kidney cancer 10 | 2,613
Lens Opacities 10 | 231
Photosensitive trichothiodystrophy 10 | 30
Photosensitivity of skin 10 | 51
Strabismus 10 | 270
Xeroderma pigmentosum group F 10 | 22
Xeroderma pigmentosum group G 10 | 16
primitive neuroectodermal tumor 10 | 3,035
Atrophic condition of skin 9 | 25
Basal cell nevi 9 | 23
Dry skin 9 | 75
Freckles 9 | 33
Intellectual disability 9 | 1,016
Muscle hypotonia 9 | 571
Optic Atrophy 9 | 242
Prostatic Neoplasms 9 | 495
Small head 9 | 374
Xeroderma pigmentosum group D 9 | 33
Xerosis 9 | 75
ependymoma 9 | 4,679
Death in early childhood 8 | 82
Death in infancy 8 | 82
Dull intelligence 8 | 645
Electroencephalogram abnormal 8 | 101
Erythema 8 | 58
Failure to gain weight 8 | 365
Keratitis 8 | 62
Low intelligence 8 | 645
Lynch syndrome 8 | 35
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Muscle Hypertonia 8 | 88
Papilloma 8 | 44
Pediatric failure to thrive 8 | 365
Poikiloderma 8 | 14
Poor school performance 8 | 645
Short stature 8 | 531
hypopigmented skin patch 8 | 59
lung adenocarcinoma 8 | 2,716
Arthralgia 7 | 90
Bloom syndrome 7 | 29
Cerebellar Ataxia 7 | 304
Colorectal Neoplasms 7 | 243
Conjunctival telangiectasis 7 | 14
Defective DNA repair after ultraviolet radiation damage 7 | 7
Dental abnormalities 7 | 60
Developmental regression 7 | 95
Familial adenomatous polyposis 7 | 32
Fanconi anemia 7 | 56
Fever 7 | 138
Flushing 7 | 60
Hyperkeratosis 7 | 50
Impaired cognition 7 | 96
Loss of developmental milestones 7 | 95
Mental deterioration in childhood 7 | 95
Mental impairment 7 | 95
Neurodevelopmental regression 7 | 95
Progressive mental retardation 7 | 37
Psychomotor regression 7 | 95
Psychomotor regression beginning in infancy 7 | 95
Psychomotor regression in infants 7 | 95
Psychomotor regression, progressive 7 | 95
Telangiectasia of the skin 7 | 39
Thin skin 7 | 47
Tooth Abnormalities 7 | 69
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
non-small cell lung cancer 7 | 2,890
Astrocytoma, Pilocytic 6 | 3,081
Hydrocephalus 6 | 152
Muscle Spasticity 6 | 195
Waldenstrons macroglobulinemia 6 | 765
diabetes mellitus 6 | 1,728
invasive ductal carcinoma 6 | 2,951
nasopharyngeal carcinoma 6 | 1,058

Tissue

Blood and immune system 44 | 16,909
Cardiovascular System 44 | 15,192
Digestive Tract 44 | 17,369
Endocrine System 44 | 18,159
Female tissues 44 | 17,400
Liver and Pancreas 44 | 16,750
Male tissues 44 | 17,142
Nervous System 44 | 16,725
Respiratory system 44 | 16,393
Skin and soft tissues 44 | 17,230
Urinary Tract 44 | 16,678

Target Family

Non-IDG 24 | 12,091
Enzyme 18 | 4,145
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

Compartment GO Term

nucleotide-excision repair com... 45 | 45
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
MMS19 nucleotide excision repair protein homolog MMS19 Tbio Non-IDG -1.66416 46.5 122
DNA repair protein complementing XP-C cells XPC Tbio Non-IDG -2.21142 154.0 208
Flap endonuclease 1 FEN1 Tchem Enzyme -2.79171 617.0 406
Cullin-4A CUL4A Tbio Non-IDG -1.92199 80.1 276
Crossover junction endonuclease MUS81 MUS81 Tbio Enzyme -2.06893 119.1 95
UV excision repair protein RAD23 homolog B RAD23B Tbio Non-IDG -1.99412 96.8 313
UV excision repair protein RAD23 homolog A RAD23A Tbio Non-IDG -1.57282 35.7 356
DNA mismatch repair protein Mlh1 MLH1 Tbio Non-IDG -3.34283 2352.6 495