Development Level

Tbio 23 | 11,445
Tchem 16 | 1,598
Tclin 2 | 613

Collection

Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

increased red blood cell distr... 3 | 34
preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
decreased circulating LDL chol... 2 | 38
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean platelet volume 2 | 25
embryonic lethality prior to t... 2 | 278
enlarged spleen 2 | 41
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged thymus 1 | 5
impaired glucose tolerance 1 | 75
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased glycosylated hemoglo... 1 | 1
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased startle reflex 1 | 112
limb grasping 1 | 41
small testis 1 | 58

Disease

Carcinoma 29 | 11,493
ovarian cancer 22 | 8,520
osteosarcoma 21 | 7,950
Cancer 20 | 2,499
diabetes mellitus 20 | 1,728
Obesity 18 | 678
medulloblastoma, large-cell 18 | 6,241
psoriasis 15 | 6,694
glioblastoma 13 | 5,792
lung cancer 13 | 4,740
Hyperglycemia 11 | 137
adult high grade glioma 11 | 3,801
atypical teratoid / rhabdoid tumor 11 | 5,112
ependymoma 11 | 4,679
Breast cancer 10 | 3,578
Alzheimer's disease 9 | 658
Kidney cancer 9 | 2,613
group 3 medulloblastoma 9 | 4,104
group 4 medulloblastoma 9 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
malignant mesothelioma 9 | 3,232
non-small cell lung cancer 9 | 2,890
primitive neuroectodermal tumor 9 | 3,035
subependymal giant cell astrocytoma 9 | 2,287
Fatty liver disease 8 | 103
Hypertensive disease 8 | 292
Kidney disease 8 | 430
Schizophrenia 8 | 1,160
astrocytic glioma 8 | 2,597
invasive ductal carcinoma 8 | 2,951
Diabetes Mellitus, Non-Insulin-Dependent 7 | 145
Diabetes Mellitus, Type 2 7 | 142
Heart disease 7 | 306
Heart failure 7 | 162
Hyperinsulinism 7 | 133
Hypertension 7 | 396
Insulin Resistance 7 | 72
Osteoporosis 7 | 363
Parkinson's disease 7 | 392
Pick disease 7 | 1,894
Polycystic ovary syndrome 7 | 360
Renal Cell Carcinoma 7 | 214
Vascular disease 7 | 319
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
oligodendroglioma 7 | 2,850
Astrocytoma, Pilocytic 6 | 3,081
Epilepsy 6 | 792
Intellectual disability 6 | 1,016
adrenocortical carcinoma 6 | 1,428
breast carcinoma 6 | 1,638
colon cancer 6 | 1,478
lung adenocarcinoma 6 | 2,716
Arthritis 5 | 290
Atherosclerosis 5 | 291
Cognitive delay 5 | 608
Dull intelligence 5 | 645
Global developmental delay 5 | 608
Inflammation 5 | 120
Lipid metabolism disorder 5 | 114
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Poor school performance 5 | 645
Seizures 5 | 596
ductal carcinoma in situ 5 | 1,745
interstitial cystitis 5 | 2,312
pancreatic cancer 5 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Adenoma 4 | 167
Alzheimer Disease 4 | 83
Autosomal recessive predisposition 4 | 1,442
Bipolar Disorder 4 | 666
Cardiomegaly 4 | 116
Ceroid lipofuscinosis, neuronal 1, infantile 4 | 10
Depressive disorder 4 | 409
Diabetes Mellitus, Experimental 4 | 108
Glucose Intolerance 4 | 19
Impaired glucose tolerance 4 | 28
Kidney angiomyolipoma 4 | 8
Lipodystrophy 4 | 40
Liver disease 4 | 237
Lymphangioleiomyomatosis 4 | 16
Multiple myeloma 4 | 1,332
Muscular atrophy 4 | 71
Nerve Degeneration 4 | 121
Ovarian Neoplasms 4 | 102
Prostatic Neoplasms 4 | 495
Stomach Neoplasms 4 | 300
Toxic encephalopathy 4 | 141
cystic fibrosis 4 | 1,696
primary pancreatic ductal adenocarcinoma 4 | 1,109
ulcerative colitis 4 | 1,819
Anteverted nostril 3 | 191
Cerebrovascular disease 3 | 238
Coronary artery disease 3 | 268
Hepatomegaly 3 | 285
progressive supranuclear palsy 3 | 676
tuberculosis 3 | 2,010

Tissue

Cardiovascular System 41 | 15,192
Digestive Tract 41 | 17,369
Endocrine System 41 | 18,159
Female tissues 41 | 17,400
Skin and soft tissues 41 | 17,230
Blood and immune system 40 | 16,909
Liver and Pancreas 40 | 16,750
Male tissues 40 | 17,142
Nervous System 40 | 16,725
Respiratory system 40 | 16,393
Urinary Tract 40 | 16,678

Target Family

Non-IDG 15 | 12,091
Kinase 14 | 634
Enzyme 6 | 4,145
Transcription Factor 2 | 1,400
Transporter 2 | 473
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

nucleotide-activated protein k... 41 | 41
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bifunctional purine biosynthesis protein PURH ATIC Tchem Non-IDG -2.93014 835.0 246
Calcium/calmodulin-dependent protein kinase kinase 2 CAMKK2 Tchem Kinase -2.09841 125.5 257
Sestrin-2 SESN2 Tbio Non-IDG -1.88129 92.6 176
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818
STE20-like serine/threonine-protein kinase SLK Tchem Kinase -2.33861 211.4 200
Folliculin-interacting protein 2 FNIP2 Tbio Non-IDG -0.75931 4.81 135
TBC1 domain family member 4 TBC1D4 Tbio Non-IDG -2.06751 113.5 300
Transcription factor A, mitochondrial TFAM Tbio Transcription Factor -2.72618 499.4 378
Adiponectin receptor protein 2 ADIPOR2 Tbio Non-IDG -2.24463 128.8 185
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331