1. Home
  2. Targets
Target Filters...

Development Level

Tbio 2,587 | 10,625
Tdark 661 | 7,003
Tchem 467 | 1,890
Tclin 124 | 602

Collection

Eligible Kinase Proteins 19 | 134
Eligible Ion Channel Proteins 6 | 117
Eligible non-olfactory GPCR Proteins 2 | 145

IMPC Term

preweaning lethality, complete... 216 | 633
preweaning lethality, incomple... 82 | 260
embryonic lethality prior to t... 66 | 187
embryonic lethality prior to o... 56 | 148
abnormal behavior 53 | 226
decreased body weight 53 | 174
decreased total body fat amoun... 50 | 186
decreased lean body mass 49 | 195
decreased bone mineral content 42 | 157
abnormal embryo size 39 | 112
decreased body length 36 | 108
decreased bone mineral density 36 | 126
increased or absent threshold ... 36 | 128
decreased grip strength 33 | 123
abnormal bone structure 32 | 131
hyperactivity 31 | 108
decreased circulating glucose ... 29 | 121
increased circulating alkaline... 29 | 119
increased lean body mass 29 | 107
abnormal retina morphology 27 | 100
decreased circulating choleste... 26 | 85
increased mean corpuscular hem... 25 | 93
increased mean corpuscular vol... 25 | 91
increased grip strength 24 | 83
decreased circulating HDL chol... 23 | 77
abnormal lens morphology 22 | 73
increased bone mineral content 22 | 92
male infertility 20 | 62
improved glucose tolerance 18 | 56
increased circulating HDL chol... 18 | 63
increased circulating chloride... 18 | 43
decreased circulating serum al... 17 | 79
decreased lumbar vertebrae num... 17 | 62
enlarged heart 17 | 111
increased fasted circulating g... 17 | 68
increased sacral vertebrae num... 17 | 62
prenatal lethality prior to he... 17 | 64
short tibia 17 | 82
abnormal coat/hair pigmentatio... 16 | 54
abnormal sleep behavior 16 | 63
decreased mean corpuscular vol... 16 | 50
increased circulating choleste... 16 | 53
abnormal bone mineralization 14 | 55
decreased circulating alanine ... 14 | 53
decreased circulating triglyce... 14 | 83
increased blood urea nitrogen ... 14 | 44
hypoactivity 13 | 89
increased body weight 13 | 42
increased bone mineral density 13 | 52
increased circulating sodium l... 13 | 71
increased heart weight 13 | 37
thrombocytopenia 13 | 46
abnormal behavioral response t... 12 | 52
abnormal retinal pigmentation 12 | 61
decreased caudal vertebrae num... 12 | 49
decreased fasted circulating g... 12 | 49
decreased heart weight 12 | 44
decreased startle reflex 12 | 48
increased exploration in new e... 12 | 56
abnormal gait 11 | 51
decreased circulating LDL chol... 11 | 37
decreased circulating free fat... 11 | 39
decreased circulating insulin ... 11 | 75
decreased rib number 11 | 59
embryonic growth retardation 11 | 28
increased rib number 11 | 41
abnormal cornea morphology 10 | 24
abnormal limb bud morphology 10 | 15
abnormal neural tube closure 10 | 37
abnormal spleen morphology 10 | 36
cardiovascular system phenotyp... 10 | 35
cataract 10 | 26
decreased eosinophil cell numb... 10 | 41
decreased leukocyte cell numbe... 10 | 54
decreased prepulse inhibition 10 | 52
female infertility 10 | 34
increased hemoglobin content 10 | 45
increased startle reflex 10 | 38
decreased blood urea nitrogen ... 9 | 31
decreased circulating aspartat... 9 | 27
decreased circulating iron lev... 9 | 25
decreased hemoglobin content 9 | 53
decreased mean corpuscular hem... 9 | 34
hydrops fetalis 9 | 22
impaired glucose tolerance 9 | 52
increased circulating iron lev... 9 | 25
increased circulating triglyce... 9 | 24
increased leukocyte cell numbe... 9 | 37
increased mean corpuscular hem... 9 | 25
increased total body fat amoun... 9 | 57
limb grasping 9 | 35
polydactyly 9 | 22
abnormal coat appearance 8 | 25
decreased circulating alkaline... 8 | 41
decreased circulating total pr... 8 | 41
increased circulating serum al... 8 | 25
increased hematocrit 8 | 36
shortened RR interval 8 | 19
small testis 8 | 37
tremors 8 | 34

Disease

ovarian cancer 2,081 | 8,492
osteosarcoma 1,811 | 7,933
medulloblastoma, large-cell 1,491 | 6,234
psoriasis 1,477 | 6,685
glioblastoma 1,382 | 5,572
lung cancer 1,242 | 4,473
atypical teratoid / rhabdoid tumor 1,056 | 4,369
Cancer 849 | 2,346
Breast cancer 847 | 3,099
malignant mesothelioma 838 | 3,163
primitive neuroectodermal tumor 807 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 798 | 3,289
pediatric high grade glioma 731 | 2,712
invasive ductal carcinoma 727 | 2,950
non-small cell lung cancer 719 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 718 | 2,988
oligodendroglioma 695 | 2,849
lung adenocarcinoma 656 | 2,714
pilocytic astrocytoma 651 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 633 | 2,956
ependymoma 606 | 2,514
group 3 medulloblastoma 605 | 2,254
Carcinoma 601 | 2,147
pancreatic cancer 569 | 2,300
lung carcinoma 544 | 2,844
subependymal giant cell astrocytoma 522 | 2,287
astrocytic glioma 494 | 2,241
colon cancer 459 | 1,475
Pick disease 454 | 1,893
ductal carcinoma in situ 451 | 1,745
diabetes mellitus 431 | 1,663
group 4 medulloblastoma 428 | 1,875
ulcerative colitis 424 | 2,087
breast carcinoma 422 | 1,614
adult high grade glioma 415 | 2,148
Multiple myeloma 409 | 1,328
interstitial cystitis 408 | 2,299
astrocytoma 407 | 1,493
pituitary cancer 398 | 1,972
adrenocortical carcinoma 389 | 1,427
sonic hedgehog group medulloblastoma 387 | 1,482
acute quadriplegic myopathy 361 | 1,157
posterior fossa group A ependymoma 356 | 1,511
medulloblastoma 353 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 350 | 1,795
posterior fossa group B ependymoma 347 | 1,530
cystic fibrosis 334 | 1,670
juvenile dermatomyositis 325 | 1,189
tuberculosis 319 | 1,563
primary pancreatic ductal adenocarcinoma 313 | 1,271
atypical teratoid/rhabdoid tumor 303 | 1,095
nasopharyngeal carcinoma 303 | 1,056
dermatomyositis 295 | 967
Waldenstrons macroglobulinemia 291 | 765
Rheumatoid Arthritis 290 | 1,171
spina bifida 258 | 1,064
Atopic dermatitis 228 | 944
cutaneous lupus erythematosus 219 | 1,056
non primary Sjogren syndrome sicca 215 | 840
Intellectual disability 211 | 573
acute myeloid leukemia 211 | 785
Alzheimer's disease 207 | 644
Obesity 189 | 616
Endometriosis 188 | 535
gastric carcinoma 188 | 832
esophageal adenocarcinoma 179 | 737
Mammary Neoplasms 175 | 410
Duchenne muscular dystrophy 174 | 602
primary Sjogren syndrome 168 | 789
progressive supranuclear palsy 167 | 674
tuberculosis and treatment for 6 months 167 | 686
Amyotrophic Lateral Sclerosis 166 | 432
Down syndrome 163 | 548
active Crohn's disease 163 | 918
hepatocellular carcinoma 152 | 550
Prostatic Neoplasms 147 | 471
Schizophrenia 147 | 503
pancreatic carcinoma 145 | 567
Neurodegenerative disease 144 | 383
aldosterone-producing adenoma 144 | 664
Kidney disease 143 | 397
autosomal dominant Emery-Dreifuss muscular dystrophy 141 | 499
IGA Glomerulonephritis 134 | 454
Parkinson's disease 130 | 364
gastric cancer 130 | 436
chronic rhinosinusitis 127 | 512
Heart disease 126 | 279
Stomach Neoplasms 120 | 282
fibroadenoma 117 | 557
Vascular disease 113 | 281
Cerebrovascular disease 110 | 231
Multiple Sclerosis 106 | 498
inflammatory breast cancer 106 | 404
non-small cell lung carcinoma 103 | 413
Hypertension 99 | 293
mucosa-associated lymphoid tissue lymphoma 99 | 480
Neuropathy 96 | 210
Asthma 92 | 349
Peripheral Neuropathy 92 | 303
Polycystic Ovary Syndrome 91 | 335

Tissue

Female tissues 3,790 | 18,647
Nervous System 3,780 | 18,561
Endocrine System 3,771 | 18,512
Digestive Tract 3,768 | 18,473
Urinary Tract 3,757 | 18,444
Male tissues 3,755 | 17,969
Liver and Pancreas 3,752 | 18,136
Blood and immune system 3,744 | 17,995
Cardiovascular System 3,743 | 17,958
Skin and soft tissues 3,722 | 18,115
Respiratory system 3,699 | 17,484

Target Family

Non-IDG 2,555 | 11,969
Enzyme 676 | 4,146
Transcription Factor 235 | 1,400
Kinase 165 | 634
Epigenetic 106 | 242
Ion Channel 32 | 341
Transporter 22 | 473
Nuclear Receptor 19 | 48
TF/Epigenetic 15 | 38
GPCR 13 | 408
oGPCR 1 | 421

Compartment GO Term

non-membrane-bounded organelle 3,839 | 3,839
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
Protein BRICK1 BRK1 Tbio Non-IDG -1.42109 29.2 53
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
MARVEL domain-containing protein 1 MARVELD1 Tbio Non-IDG -1.56013 36.2 57
Lebercilin LCA5 Tbio Non-IDG -1.21162 16.7 65
tRNA-splicing endonuclease subunit Sen15 TSEN15 Tdark Enzyme -0.33090 2.16 47
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.67656 3.42 165