Development Level

Tbio 2,736 | 11,178
Tdark 595 | 6,569
Tchem 461 | 1,885
Tclin 125 | 612

Collection

Kinase: IDG Consortium (Target... 25 | 125
Kinase: IDG Consortium (Comple... 14 | 37
Ion Channel: IDG Consortium (T... 6 | 99
GPCR: IDG Consortium (Targets) 4 | 126

IMPC Phenotype

preweaning lethality, complete... 353 | 979
preweaning lethality, incomple... 143 | 499
embryonic lethality prior to t... 107 | 278
embryonic lethality prior to o... 92 | 239
abnormal embryo size 78 | 220
abnormal behavior 73 | 298
decreased total body fat amoun... 48 | 207
decreased body weight 47 | 161
abnormal bone structure 46 | 187
male infertility 46 | 123
decreased vertical activity 43 | 208
increased lean body mass 41 | 172
hyperactivity 38 | 148
embryonic growth retardation 37 | 106
increased startle reflex 37 | 112
decreased bone mineral content 36 | 151
enlarged heart 36 | 210
decreased circulating glucose ... 35 | 126
decreased lean body mass 35 | 135
increased circulating alkaline... 35 | 122
increased total body fat amoun... 33 | 134
abnormal heart morphology 32 | 162
decreased grip strength 30 | 116
decreased bone mineral density 28 | 126
decreased body length 27 | 101
impaired glucose tolerance 27 | 75
decreased circulating choleste... 26 | 93
hypoactivity 26 | 132
prenatal lethality prior to he... 26 | 87
short tibia 26 | 97
cataract 25 | 92
increased bone mineral content 25 | 108
abnormal lens morphology 23 | 81
edema 23 | 59
improved glucose tolerance 23 | 79
increased mean corpuscular vol... 23 | 92
increased or absent threshold ... 23 | 101
abnormal seminal vesicle morph... 22 | 114
decreased mean corpuscular vol... 22 | 79
increased circulating HDL chol... 22 | 80
increased fasted circulating g... 22 | 76
abnormal coat-hair pigmentatio... 21 | 64
female infertility 21 | 60
increased heart weight 21 | 62
increased mean corpuscular hem... 21 | 96
abnormal behavioral response t... 20 | 66
decreased circulating HDL chol... 20 | 68
decreased circulating serum al... 20 | 82
increased circulating chloride... 20 | 41
increased bone mineral density 19 | 72
abnormal retina morphology 18 | 71
small testis 18 | 58
decreased fasted circulating g... 17 | 65
decreased erythrocyte cell num... 16 | 62
decreased lymphocyte cell numb... 16 | 83
decreased prepulse inhibition 16 | 82
decreased startle reflex 16 | 75
increased circulating choleste... 16 | 66
increased circulating sodium l... 16 | 71
abnormal embryo turning 15 | 31
abnormal gait 15 | 69
abnormal sleep behavior 15 | 70
abnormal spleen morphology 15 | 55
decreased circulating alanine ... 15 | 47
small superior vagus ganglion 15 | 74
thrombocytopenia 15 | 56
decreased caudal vertebrae num... 14 | 53
decreased circulating total pr... 14 | 49
decreased leukocyte cell numbe... 14 | 73
tremors 14 | 39
abnormal eye morphology 13 | 68
abnormal neural tube closure 13 | 46
decreased circulating insulin ... 13 | 76
decreased circulating triglyce... 13 | 79
increased body length 13 | 32
increased circulating triglyce... 13 | 42
pallor 13 | 34
abnormal kidney morphology 12 | 65
decreased blood urea nitrogen ... 12 | 51
decreased circulating LDL chol... 12 | 38
decreased red blood cell distr... 12 | 41
increased blood urea nitrogen ... 12 | 48
increased hemoglobin content 12 | 45
increased monocyte cell number 12 | 63
prenatal lethality 12 | 28
abnormal bone mineralization 11 | 38
abnormal craniofacial morpholo... 11 | 33
abnormal skin morphology 11 | 50
cardiovascular system phenotyp... 11 | 36
decreased circulating alkaline... 11 | 46
decreased circulating iron lev... 11 | 32
decreased heart left ventricle... 11 | 28
decreased hemoglobin content 11 | 68
decreased mean corpuscular hem... 11 | 50
increased grip strength 11 | 41
increased hematocrit 11 | 46
increased neutrophil cell numb... 11 | 46
abnormal cornea morphology 10 | 31
abnormal testis morphology 10 | 43
decreased hematocrit 10 | 46

Disease

Carcinoma 2,597 | 11,192
ovarian cancer 2,106 | 8,297
osteosarcoma 1,833 | 7,766
psoriasis 1,488 | 6,514
medulloblastoma, large-cell 1,484 | 6,086
glioblastoma 1,426 | 5,635
lung cancer 1,286 | 4,607
atypical teratoid / rhabdoid tumor 1,242 | 4,971
ependymoma 1,105 | 4,559
group 3 medulloblastoma 1,104 | 4,002
Breast cancer 982 | 3,469
Cancer 886 | 2,388
malignant mesothelioma 876 | 3,135
adult high grade glioma 854 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 817 | 3,204
primitive neuroectodermal tumor 787 | 2,957
non-small cell lung cancer 748 | 2,799
invasive ductal carcinoma 742 | 2,867
intraductal papillary-mucinous carcinoma (IPMC) 727 | 2,902
Kidney cancer 720 | 2,548
oligodendroglioma 672 | 2,768
lung adenocarcinoma 667 | 2,627
Astrocytoma, Pilocytic 644 | 3,006
intraductal papillary-mucinous adenoma (IPMA) 640 | 2,872
pancreatic cancer 603 | 2,322
astrocytic glioma 572 | 2,530
lung carcinoma 556 | 2,755
subependymal giant cell astrocytoma 519 | 2,230
diabetes mellitus 467 | 1,683
Pick disease 461 | 1,856
colon cancer 458 | 1,428
ductal carcinoma in situ 457 | 1,686
breast carcinoma 452 | 1,589
interstitial cystitis 416 | 2,237
tuberculosis 414 | 1,963
group 4 medulloblastoma 412 | 1,806
Multiple myeloma 405 | 1,296
pituitary cancer 403 | 1,915
adrenocortical carcinoma 398 | 1,385
pancreatic ductal adenocarcinoma liver metastasis 396 | 1,911
ulcerative colitis 390 | 1,765
Autosomal recessive predisposition 380 | 1,407
acute quadriplegic myopathy 363 | 1,133
Intellectual disability 354 | 998
cystic fibrosis 348 | 1,629
Schizophrenia 330 | 1,136
juvenile dermatomyositis 329 | 1,147
astrocytoma 322 | 1,113
nasopharyngeal carcinoma 313 | 1,024
Rheumatoid arthritis 299 | 1,156
pediatric high grade glioma 299 | 1,035
dermatomyositis 298 | 941
Waldenstrons macroglobulinemia 285 | 742
primary pancreatic ductal adenocarcinoma 275 | 1,071
spina bifida 257 | 1,053
Atopic dermatitis 233 | 915
Dull intelligence 231 | 634
Low intelligence 231 | 634
Mental Retardation 231 | 634
Mental deficiency 231 | 634
Poor school performance 231 | 634
non primary Sjogren syndrome sicca 231 | 861
cutaneous lupus erythematosus 230 | 1,016
Cognitive delay 217 | 596
Global developmental delay 217 | 596
Mental and motor retardation 217 | 596
acute myeloid leukemia 214 | 760
Obesity 210 | 655
Alzheimer's disease 208 | 640
Short stature 203 | 514
Epilepsy 201 | 775
Liver cancer 188 | 589
Melanoma 188 | 689
Liver Cirrhosis, Experimental 187 | 733
Breast Neoplasms 186 | 423
esophageal adenocarcinoma 182 | 696
Endometriosis 181 | 521
Mammary Neoplasms 178 | 403
Duchenne muscular dystrophy 177 | 587
gastric carcinoma 176 | 781
Amyotrophic lateral sclerosis 175 | 437
active Crohn's disease 174 | 882
Bipolar Disorder 173 | 646
Seizures 173 | 584
Muscle hypotonia 171 | 562
primary Sjogren syndrome 166 | 710
Small head 165 | 366
progressive supranuclear palsy 164 | 656
medulloblastoma 162 | 702
Neurodegenerative disease 156 | 402
hepatocellular carcinoma 152 | 536
autosomal dominant Emery-Dreifuss muscular dystrophy 150 | 492
aldosterone-producing adenoma 149 | 646
Prostatic Neoplasms 147 | 472
Kidney disease 146 | 411
Down syndrome 145 | 480
pancreatic carcinoma 142 | 555
active ulcerative colitis 136 | 736
chronic rhinosinusitis 136 | 505
Stomach Neoplasms 134 | 287

Tissue

Endocrine System 3,818 | 18,159
Female tissues 3,755 | 17,400
Skin and soft tissues 3,748 | 17,230
Digestive Tract 3,743 | 17,369
Male tissues 3,724 | 17,142
Blood and immune system 3,702 | 16,909
Liver and Pancreas 3,673 | 16,750
Urinary Tract 3,669 | 16,678
Nervous System 3,666 | 16,725
Respiratory system 3,642 | 16,393
Cardiovascular System 3,499 | 15,192

Target Family

Non-IDG 2,605 | 12,091
Enzyme 696 | 4,145
Transcription Factor 239 | 1,400
Kinase 174 | 634
Epigenetic 110 | 242
Ion Channel 25 | 344
Transporter 23 | 473
Nuclear Receptor 19 | 48
TF/Epigenetic 13 | 38
GPCR 12 | 408
oGPCR 1 | 421

Compartment GO Term

non-membrane-bounded organelle 3,917 | 3,917
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
MyoD family inhibitor domain-containing protein MDFIC Tbio Non-IDG -2.90969 749.0 122
Protein RCC2 RCC2 Tbio Non-IDG -1.49831 31.4 148
Histone H2A-Bbd type 2/3 H2AFB3 Tdark Non-IDG -0.25594 2.36 13
Mitogen-activated protein kinase-binding protein 1 MAPKBP1 Tbio Enzyme -0.46630 4.01 51
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103