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Development Level

Tbio 2,887 | 11,651
Tdark 601 | 6,593
Tchem 357 | 1,388
Tclin 129 | 612

Collection

RFA-RM-18-021 35 | 328
Kinase: IDG Consortium (Target... 25 | 125
Kinase: IDG Consortium (Comple... 14 | 37
Ion Channel: IDG Consortium (T... 6 | 99
GPCR: IDG Consortium (Targets) 4 | 126

IMPC Phenotype

preweaning lethality, complete... 356 | 979
preweaning lethality, incomple... 147 | 499
embryonic lethality prior to t... 108 | 278
embryonic lethality prior to o... 92 | 239
abnormal embryo size 80 | 220
abnormal behavior 74 | 298
decreased total body fat amoun... 50 | 207
decreased body weight 48 | 161
abnormal bone structure 47 | 187
male infertility 46 | 123
decreased vertical activity 44 | 208
increased lean body mass 41 | 172
embryonic growth retardation 38 | 106
hyperactivity 38 | 148
decreased bone mineral content 37 | 151
decreased lean body mass 37 | 135
increased startle reflex 37 | 112
enlarged heart 36 | 210
decreased circulating glucose ... 35 | 126
increased circulating alkaline... 35 | 122
increased total body fat amoun... 33 | 134
abnormal heart morphology 32 | 162
decreased grip strength 31 | 116
decreased bone mineral density 30 | 126
decreased body length 29 | 101
impaired glucose tolerance 27 | 75
short tibia 27 | 97
decreased circulating choleste... 26 | 93
hypoactivity 26 | 132
prenatal lethality prior to he... 26 | 87
cataract 25 | 92
increased bone mineral content 25 | 108
edema 24 | 59
abnormal lens morphology 23 | 81
abnormal seminal vesicle morph... 23 | 114
improved glucose tolerance 23 | 79
increased mean corpuscular hem... 23 | 96
increased mean corpuscular vol... 23 | 92
increased or absent threshold ... 23 | 101
decreased mean corpuscular vol... 22 | 79
female infertility 22 | 60
increased circulating HDL chol... 22 | 80
increased fasted circulating g... 22 | 76
abnormal coat-hair pigmentatio... 21 | 64
increased heart weight 21 | 62
abnormal behavioral response t... 20 | 66
abnormal retina morphology 20 | 71
decreased circulating HDL chol... 20 | 68
decreased circulating serum al... 20 | 82
increased circulating chloride... 20 | 41
increased bone mineral density 19 | 72
decreased fasted circulating g... 18 | 65
small testis 18 | 58
decreased prepulse inhibition 17 | 82
abnormal gait 16 | 69
abnormal sleep behavior 16 | 70
decreased erythrocyte cell num... 16 | 62
decreased lymphocyte cell numb... 16 | 83
decreased startle reflex 16 | 75
increased circulating choleste... 16 | 66
increased circulating sodium l... 16 | 71
abnormal embryo turning 15 | 31
abnormal spleen morphology 15 | 55
decreased circulating alanine ... 15 | 47
small superior vagus ganglion 15 | 74
thrombocytopenia 15 | 56
tremors 15 | 39
decreased caudal vertebrae num... 14 | 53
decreased circulating total pr... 14 | 49
decreased leukocyte cell numbe... 14 | 73
abnormal eye morphology 13 | 68
abnormal neural tube closure 13 | 46
decreased blood urea nitrogen ... 13 | 51
decreased circulating insulin ... 13 | 76
decreased circulating triglyce... 13 | 79
increased blood urea nitrogen ... 13 | 48
increased body length 13 | 32
increased circulating triglyce... 13 | 42
pallor 13 | 34
abnormal kidney morphology 12 | 65
decreased circulating LDL chol... 12 | 38
decreased red blood cell distr... 12 | 41
increased hemoglobin content 12 | 45
increased monocyte cell number 12 | 63
prenatal lethality 12 | 28
abnormal bone mineralization 11 | 38
abnormal craniofacial morpholo... 11 | 33
abnormal skin morphology 11 | 50
cardiovascular system phenotyp... 11 | 36
decreased circulating alkaline... 11 | 46
decreased circulating iron lev... 11 | 32
decreased heart left ventricle... 11 | 28
decreased hemoglobin content 11 | 68
decreased mean corpuscular hem... 11 | 50
increased grip strength 11 | 41
increased hematocrit 11 | 46
increased neutrophil cell numb... 11 | 46
abnormal cornea morphology 10 | 31
abnormal testis morphology 10 | 43
decreased hematocrit 10 | 46

Disease

Carcinoma 2,636 | 11,493
ovarian cancer 2,143 | 8,520
osteosarcoma 1,857 | 7,950
psoriasis 1,513 | 6,694
medulloblastoma, large-cell 1,506 | 6,241
glioblastoma 1,446 | 5,792
lung cancer 1,309 | 4,740
atypical teratoid / rhabdoid tumor 1,262 | 5,112
ependymoma 1,120 | 4,679
group 3 medulloblastoma 1,120 | 4,104
Breast cancer 1,005 | 3,578
Cancer 915 | 2,499
malignant mesothelioma 893 | 3,232
adult high grade glioma 862 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 828 | 3,291
primitive neuroectodermal tumor 800 | 3,035
non-small cell lung cancer 765 | 2,890
invasive ductal carcinoma 752 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 739 | 2,989
Kidney cancer 734 | 2,613
lung adenocarcinoma 685 | 2,716
oligodendroglioma 682 | 2,850
Astrocytoma, Pilocytic 654 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 648 | 2,955
pancreatic cancer 614 | 2,398
astrocytic glioma 578 | 2,597
lung carcinoma 568 | 2,843
subependymal giant cell astrocytoma 528 | 2,287
diabetes mellitus 478 | 1,728
colon cancer 470 | 1,478
ductal carcinoma in situ 466 | 1,745
Pick disease 464 | 1,894
breast carcinoma 462 | 1,638
interstitial cystitis 424 | 2,312
tuberculosis 423 | 2,010
group 4 medulloblastoma 419 | 1,855
Multiple myeloma 414 | 1,332
pituitary cancer 407 | 1,972
adrenocortical carcinoma 406 | 1,428
ulcerative colitis 399 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 398 | 1,962
Autosomal recessive predisposition 391 | 1,442
acute quadriplegic myopathy 367 | 1,158
Intellectual disability 361 | 1,016
cystic fibrosis 359 | 1,696
Schizophrenia 337 | 1,160
juvenile dermatomyositis 335 | 1,187
astrocytoma 327 | 1,146
nasopharyngeal carcinoma 318 | 1,058
Rheumatoid arthritis 306 | 1,191
pediatric high grade glioma 304 | 1,064
dermatomyositis 303 | 966
Waldenstrons macroglobulinemia 290 | 765
primary pancreatic ductal adenocarcinoma 281 | 1,109
spina bifida 259 | 1,074
Atopic dermatitis 239 | 952
cutaneous lupus erythematosus 237 | 1,057
Dull intelligence 235 | 645
Low intelligence 235 | 645
Mental Retardation 235 | 645
Mental deficiency 235 | 645
Poor school performance 235 | 645
non primary Sjogren syndrome sicca 233 | 891
Cognitive delay 221 | 608
Global developmental delay 221 | 608
Mental and motor retardation 221 | 608
acute myeloid leukemia 217 | 783
Obesity 216 | 678
Alzheimer's disease 213 | 658
Short stature 209 | 531
Epilepsy 205 | 792
Liver Cirrhosis, Experimental 198 | 769
Breast Neoplasms 195 | 445
Liver cancer 192 | 604
Melanoma 191 | 711
Endometriosis 189 | 540
esophageal adenocarcinoma 189 | 737
Mammary Neoplasms 187 | 425
gastric carcinoma 180 | 807
Bipolar Disorder 179 | 666
Duchenne muscular dystrophy 179 | 601
Seizures 177 | 596
active Crohn's disease 177 | 922
Amyotrophic lateral sclerosis 176 | 451
Muscle hypotonia 175 | 571
primary Sjogren syndrome 171 | 735
Small head 168 | 374
medulloblastoma 165 | 720
progressive supranuclear palsy 165 | 676
Neurodegenerative disease 161 | 414
Prostatic Neoplasms 155 | 495
Kidney disease 154 | 430
hepatocellular carcinoma 154 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 153 | 510
aldosterone-producing adenoma 151 | 665
Down syndrome 150 | 499
pancreatic carcinoma 142 | 562
Heart disease 140 | 306
active ulcerative colitis 140 | 764
Depressive disorder 138 | 409

Tissue

Endocrine System 3,874 | 18,159
Female tissues 3,810 | 17,400
Skin and soft tissues 3,804 | 17,230
Digestive Tract 3,799 | 17,369
Male tissues 3,780 | 17,142
Blood and immune system 3,756 | 16,909
Liver and Pancreas 3,726 | 16,750
Urinary Tract 3,722 | 16,678
Nervous System 3,721 | 16,725
Respiratory system 3,696 | 16,393
Cardiovascular System 3,550 | 15,192

Target Family

Non-IDG 2,619 | 12,091
Enzyme 721 | 4,145
Transcription Factor 255 | 1,400
Kinase 174 | 634
Epigenetic 111 | 242
Ion Channel 25 | 344
Transporter 23 | 473
Nuclear Receptor 20 | 48
TF/Epigenetic 13 | 38
GPCR 12 | 408
oGPCR 1 | 421

Compartment GO Term

non-membrane-bounded organelle 3,974 | 3,974
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11