1. Home
  2. Targets
Target Filters...

Development Level

Tbio 2,587 | 10,625
Tdark 661 | 7,003
Tchem 467 | 1,890
Tclin 124 | 602

Collection

Eligible Kinase Proteins 19 | 134
Eligible Ion Channel Proteins 6 | 117
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 216 | 633
preweaning lethality, incomple... 82 | 260
embryonic lethality prior to t... 66 | 187
embryonic lethality prior to o... 56 | 148
abnormal behavior 53 | 226
decreased body weight 53 | 174
decreased total body fat amoun... 50 | 186
decreased lean body mass 49 | 195
decreased bone mineral content 42 | 157
abnormal embryo size 39 | 112
decreased body length 36 | 108
decreased bone mineral density 36 | 126
increased or absent threshold ... 36 | 128
decreased grip strength 33 | 123
abnormal bone structure 32 | 131
hyperactivity 31 | 108
decreased circulating glucose ... 29 | 121
increased circulating alkaline... 29 | 119
increased lean body mass 29 | 107
abnormal retina morphology 27 | 100
decreased circulating choleste... 26 | 85
increased mean corpuscular hem... 25 | 93
increased mean corpuscular vol... 25 | 91
increased grip strength 24 | 83
decreased circulating HDL chol... 23 | 77
abnormal lens morphology 22 | 73
increased bone mineral content 22 | 92
male infertility 20 | 62
improved glucose tolerance 18 | 56
increased circulating HDL chol... 18 | 63
increased circulating chloride... 18 | 43
decreased circulating serum al... 17 | 79
decreased lumbar vertebrae num... 17 | 62
enlarged heart 17 | 111
increased fasted circulating g... 17 | 68
increased sacral vertebrae num... 17 | 62
prenatal lethality prior to he... 17 | 64
short tibia 17 | 82
abnormal coat/hair pigmentatio... 16 | 54
abnormal sleep behavior 16 | 63
decreased mean corpuscular vol... 16 | 50
increased circulating choleste... 16 | 53
abnormal bone mineralization 14 | 55
decreased circulating alanine ... 14 | 53
decreased circulating triglyce... 14 | 83
increased blood urea nitrogen ... 14 | 44
hypoactivity 13 | 89
increased body weight 13 | 42
increased bone mineral density 13 | 52
increased circulating sodium l... 13 | 71
increased heart weight 13 | 37
thrombocytopenia 13 | 46
abnormal behavioral response t... 12 | 52
abnormal retinal pigmentation 12 | 61
decreased caudal vertebrae num... 12 | 49
decreased fasted circulating g... 12 | 49
decreased heart weight 12 | 44
decreased startle reflex 12 | 48
increased exploration in new e... 12 | 56
abnormal gait 11 | 51
decreased circulating LDL chol... 11 | 37
decreased circulating free fat... 11 | 39
decreased circulating insulin ... 11 | 75
decreased rib number 11 | 59
embryonic growth retardation 11 | 28
increased rib number 11 | 41
abnormal cornea morphology 10 | 24
abnormal limb bud morphology 10 | 15
abnormal neural tube closure 10 | 37
abnormal spleen morphology 10 | 36
cardiovascular system phenotyp... 10 | 35
cataract 10 | 26
decreased eosinophil cell numb... 10 | 41
decreased leukocyte cell numbe... 10 | 54
decreased prepulse inhibition 10 | 52
female infertility 10 | 34
increased hemoglobin content 10 | 45
increased startle reflex 10 | 38
decreased blood urea nitrogen ... 9 | 31
decreased circulating aspartat... 9 | 27
decreased circulating iron lev... 9 | 25
decreased hemoglobin content 9 | 53
decreased mean corpuscular hem... 9 | 34
hydrops fetalis 9 | 22
impaired glucose tolerance 9 | 52
increased circulating iron lev... 9 | 25
increased circulating triglyce... 9 | 24
increased leukocyte cell numbe... 9 | 37
increased mean corpuscular hem... 9 | 25
increased total body fat amoun... 9 | 57
limb grasping 9 | 35
polydactyly 9 | 22
abnormal coat appearance 8 | 25
decreased circulating alkaline... 8 | 41
decreased circulating total pr... 8 | 41
increased circulating serum al... 8 | 25
increased hematocrit 8 | 36
shortened RR interval 8 | 19
small testis 8 | 37
tremors 8 | 34

Disease

ovarian cancer 2,076 | 8,484
osteosarcoma 1,811 | 7,933
medulloblastoma, large-cell 1,491 | 6,234
psoriasis 1,477 | 6,685
glioblastoma 1,382 | 5,572
lung cancer 1,239 | 4,466
atypical teratoid / rhabdoid tumor 1,056 | 4,369
Cancer 849 | 2,346
Breast cancer 845 | 3,094
malignant mesothelioma 837 | 3,162
primitive neuroectodermal tumor 807 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 798 | 3,289
pediatric high grade glioma 731 | 2,712
invasive ductal carcinoma 727 | 2,950
non-small cell lung cancer 719 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 718 | 2,988
oligodendroglioma 695 | 2,849
lung adenocarcinoma 656 | 2,713
pilocytic astrocytoma 651 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 633 | 2,956
ependymoma 606 | 2,514
group 3 medulloblastoma 605 | 2,254
Carcinoma 601 | 2,147
pancreatic cancer 569 | 2,300
lung carcinoma 544 | 2,844
subependymal giant cell astrocytoma 522 | 2,287
astrocytic glioma 494 | 2,241
colon cancer 459 | 1,475
Pick disease 454 | 1,893
ductal carcinoma in situ 451 | 1,745
diabetes mellitus 431 | 1,663
group 4 medulloblastoma 428 | 1,875
ulcerative colitis 424 | 2,087
breast carcinoma 422 | 1,614
adult high grade glioma 415 | 2,148
Multiple myeloma 409 | 1,327
interstitial cystitis 408 | 2,299
astrocytoma 407 | 1,493
pituitary cancer 398 | 1,972
adrenocortical carcinoma 389 | 1,427
sonic hedgehog group medulloblastoma 387 | 1,482
acute quadriplegic myopathy 361 | 1,157
posterior fossa group A ependymoma 356 | 1,511
medulloblastoma 353 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 350 | 1,795
posterior fossa group B ependymoma 347 | 1,530
cystic fibrosis 334 | 1,665
juvenile dermatomyositis 325 | 1,189
tuberculosis 319 | 1,557
primary pancreatic ductal adenocarcinoma 313 | 1,271
atypical teratoid/rhabdoid tumor 303 | 1,095
nasopharyngeal carcinoma 303 | 1,056
dermatomyositis 295 | 933
Waldenstrons macroglobulinemia 291 | 765
Rheumatoid Arthritis 290 | 1,160
spina bifida 258 | 1,064
Atopic dermatitis 228 | 944
cutaneous lupus erythematosus 219 | 1,056
non primary Sjogren syndrome sicca 215 | 840
Intellectual disability 211 | 573
acute myeloid leukemia 210 | 780
Alzheimer's disease 207 | 644
Obesity 189 | 616
Endometriosis 188 | 535
gastric carcinoma 188 | 832
esophageal adenocarcinoma 179 | 737
Mammary Neoplasms 175 | 410
Duchenne muscular dystrophy 174 | 602
primary Sjogren syndrome 168 | 789
progressive supranuclear palsy 167 | 674
tuberculosis and treatment for 6 months 167 | 686
Amyotrophic Lateral Sclerosis 165 | 431
Down syndrome 163 | 548
active Crohn's disease 163 | 918
Prostatic Neoplasms 147 | 471
Schizophrenia 145 | 501
pancreatic carcinoma 145 | 567
Neurodegenerative disease 144 | 383
aldosterone-producing adenoma 144 | 664
Kidney disease 142 | 396
autosomal dominant Emery-Dreifuss muscular dystrophy 141 | 499
hepatocellular carcinoma 141 | 532
IGA Glomerulonephritis 134 | 454
Parkinson's disease 130 | 364
chronic rhinosinusitis 127 | 512
Heart disease 126 | 279
gastric cancer 126 | 430
Stomach Neoplasms 120 | 282
fibroadenoma 117 | 557
Vascular disease 113 | 281
Cerebrovascular disease 110 | 231
Multiple Sclerosis 106 | 498
inflammatory breast cancer 106 | 404
non-small cell lung carcinoma 103 | 413
mucosa-associated lymphoid tissue lymphoma 99 | 480
Hypertension 98 | 287
Neuropathy 96 | 210
Asthma 92 | 349
Peripheral Neuropathy 92 | 303
Polycystic Ovary Syndrome 91 | 332

Tissue

Female tissues 3,790 | 18,647
Nervous System 3,780 | 18,561
Endocrine System 3,771 | 18,512
Digestive Tract 3,768 | 18,473
Urinary Tract 3,757 | 18,444
Male tissues 3,755 | 17,969
Liver and Pancreas 3,752 | 18,136
Blood and immune system 3,744 | 17,995
Cardiovascular System 3,743 | 17,958
Skin and soft tissues 3,722 | 18,115
Respiratory system 3,699 | 17,484

Target Family

Non-IDG 2,555 | 11,971
Enzyme 676 | 4,146
Transcription Factor 235 | 1,400
Kinase 165 | 634
Epigenetic 106 | 242
Ion Channel 32 | 341
Transporter 22 | 473
Nuclear Receptor 19 | 48
TF/Epigenetic 15 | 38
GPCR 13 | 406
oGPCR 1 | 421

Compartment GO Term

non-membrane-bounded organelle 3,839 | 3,839
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345