Development Level

Tbio 7,669 | 10,625
Tdark 2,376 | 7,003
Tchem 1,370 | 1,890
Tclin 378 | 602

Collection

Kinase: IDG Consortium (Targets) 81 | 125
Kinase: IDG Consortium (Complete/Control) 30 | 37
Ion Channel: IDG Consortium (Targets) 27 | 102
GPCR: IDG Consortium (Targets) 16 | 127
GPCR: IDG Consortium (Complete/Control) 5 | 26

IMPC Phenotype

preweaning lethality, complete... 527 | 633
preweaning lethality, incomple... 178 | 260
embryonic lethality prior to t... 163 | 187
abnormal behavior 162 | 226
decreased lean body mass 146 | 195
embryonic lethality prior to o... 135 | 148
decreased total body fat amoun... 131 | 186
decreased body weight 130 | 174
decreased bone mineral content 115 | 157
abnormal bone structure 95 | 131
decreased grip strength 95 | 123
abnormal embryo size 90 | 112
decreased bone mineral density 90 | 126
increased circulating alkaline... 90 | 119
decreased body length 82 | 108
increased or absent threshold ... 82 | 128
decreased circulating glucose ... 80 | 121
abnormal retina morphology 78 | 100
increased lean body mass 73 | 107
enlarged heart 71 | 111
hyperactivity 71 | 108
hypoactivity 67 | 89
increased mean corpuscular hem... 67 | 93
increased mean corpuscular vol... 66 | 91
increased bone mineral content 65 | 92
abnormal lens morphology 63 | 73
decreased circulating choleste... 62 | 85
increased grip strength 60 | 83
short tibia 60 | 82
decreased circulating HDL chol... 58 | 77
decreased circulating triglyce... 58 | 83
decreased circulating serum al... 55 | 79
decreased circulating insulin ... 51 | 75
increased circulating sodium l... 49 | 71
prenatal lethality prior to he... 49 | 64
increased fasted circulating g... 48 | 68
decreased lumbar vertebrae num... 45 | 62
abnormal retinal pigmentation 44 | 61
increased sacral vertebrae num... 44 | 62
abnormal bone mineralization 43 | 55
increased total body fat amoun... 43 | 57
decreased leukocyte cell numbe... 41 | 54
decreased mean corpuscular vol... 41 | 50
impaired glucose tolerance 41 | 52
decreased circulating alanine ... 40 | 53
decreased hemoglobin content 40 | 53
increased circulating HDL chol... 40 | 63
abnormal coat-hair pigmentatio... 39 | 54
decreased rib number 38 | 59
increased bone mineral density 38 | 52
increased circulating choleste... 38 | 53
male infertility 38 | 62
decreased fasted circulating g... 37 | 49
abnormal behavioral response t... 36 | 52
decreased heart weight 36 | 44
decreased prepulse inhibition 36 | 52
improved glucose tolerance 36 | 56
increased exploration in new e... 36 | 56
thrombocytopenia 36 | 46
abnormal gait 35 | 51
decreased caudal vertebrae num... 35 | 49
abnormal seminal vesicle morph... 34 | 47
increased blood urea nitrogen ... 33 | 44
abnormal neural tube closure 32 | 37
abnormal sleep behavior 32 | 63
abnormal heart morphology 31 | 51
decreased circulating alkaline... 31 | 41
decreased erythrocyte cell num... 31 | 43
increased circulating chloride... 31 | 43
decreased startle reflex 30 | 48
increased hemoglobin content 30 | 45
decreased circulating LDL chol... 29 | 37
decreased eosinophil cell numb... 29 | 41
abnormal eye morphology 28 | 38
decreased mean corpuscular hem... 28 | 34
increased startle reflex 28 | 38
cardiovascular system phenotyp... 27 | 35
increased heart weight 27 | 37
tremors 27 | 34
decreased circulating total pr... 26 | 41
increased body weight 26 | 42
increased leukocyte cell numbe... 26 | 37
abnormal kidney morphology 25 | 30
decreased blood urea nitrogen ... 24 | 31
decreased threshold for audito... 24 | 32
abnormal spleen morphology 23 | 36
decreased T cell number 23 | 31
decreased circulating fructosa... 23 | 31
increased circulating creatini... 23 | 29
small testis 23 | 37
abnormal cranium morphology 22 | 32
abnormal rib morphology 22 | 28
decreased B cell number 22 | 30
decreased circulating calcium ... 22 | 33
decreased hematocrit 22 | 25
decreased neutrophil cell numb... 22 | 37
embryonic growth retardation 22 | 28
increased circulating calcium ... 22 | 32
increased hematocrit 22 | 36
increased rib number 22 | 41

Disease

ovarian cancer 6,059 | 8,491
osteosarcoma 5,361 | 7,933
psoriasis 4,326 | 6,685
medulloblastoma, large-cell 4,116 | 6,234
glioblastoma 3,753 | 5,572
lung cancer 3,283 | 4,473
atypical teratoid / rhabdoid tumor 2,857 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,327 | 3,289
malignant mesothelioma 2,278 | 3,163
Breast cancer 2,159 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 2,060 | 2,988
invasive ductal carcinoma 2,015 | 2,950
primitive neuroectodermal tumor 2,006 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 1,973 | 2,956
Cancer 1,957 | 2,346
pilocytic astrocytoma 1,942 | 3,086
non-small cell lung cancer 1,903 | 2,798
oligodendroglioma 1,873 | 2,849
lung adenocarcinoma 1,816 | 2,714
pediatric high grade glioma 1,814 | 2,712
lung carcinoma 1,729 | 2,844
ependymoma 1,674 | 2,514
pancreatic cancer 1,618 | 2,300
group 3 medulloblastoma 1,577 | 2,254
subependymal giant cell astrocytoma 1,482 | 2,287
astrocytic glioma 1,436 | 2,241
interstitial cystitis 1,399 | 2,299
ulcerative colitis 1,376 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 1,364 | 1,795
Carcinoma 1,340 | 2,147
Pick disease 1,314 | 1,893
adult high grade glioma 1,300 | 2,148
group 4 medulloblastoma 1,271 | 1,875
pituitary cancer 1,259 | 1,972
ductal carcinoma in situ 1,190 | 1,745
diabetes mellitus 1,164 | 1,663
Multiple myeloma 1,159 | 1,327
breast carcinoma 1,124 | 1,614
astrocytoma 1,117 | 1,493
cystic fibrosis 1,095 | 1,670
tuberculosis 1,060 | 1,563
colon cancer 1,046 | 1,475
medulloblastoma 1,010 | 1,524
adrenocortical carcinoma 996 | 1,427
posterior fossa group A ependymoma 987 | 1,511
sonic hedgehog group medulloblastoma 958 | 1,482
primary pancreatic ductal adenocarcinoma 917 | 1,271
juvenile dermatomyositis 879 | 1,189
Rheumatoid Arthritis 876 | 1,170
acute quadriplegic myopathy 857 | 1,157
posterior fossa group B ependymoma 830 | 1,530
dermatomyositis 791 | 966
atypical teratoid/rhabdoid tumor 720 | 1,095
spina bifida 720 | 1,064
cutaneous lupus erythematosus 692 | 1,056
nasopharyngeal carcinoma 690 | 1,056
Waldenstrons macroglobulinemia 664 | 764
Atopic dermatitis 628 | 944
active Crohn's disease 625 | 918
acute myeloid leukemia 590 | 785
non primary Sjogren syndrome sicca 589 | 840
gastric carcinoma 565 | 832
esophageal adenocarcinoma 547 | 737
primary Sjogren syndrome 535 | 788
tuberculosis and treatment for 6 months 495 | 686
aldosterone-producing adenoma 488 | 664
progressive supranuclear palsy 470 | 674
Alzheimer's disease 466 | 644
Obesity 448 | 616
Intellectual disability 442 | 573
Duchenne muscular dystrophy 430 | 602
Down syndrome 411 | 548
Prostatic Neoplasms 400 | 471
pancreatic carcinoma 397 | 567
hepatocellular carcinoma 396 | 550
Endometriosis 382 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 375 | 499
fibroadenoma 364 | 557
IGA Glomerulonephritis 361 | 454
Schizophrenia 338 | 503
Mammary Neoplasms 332 | 410
Kidney disease 330 | 397
Multiple Sclerosis 329 | 498
Amyotrophic Lateral Sclerosis 326 | 432
Neurodegenerative disease 325 | 383
active ulcerative colitis 323 | 477
mucosa-associated lymphoid tissue lymphoma 311 | 480
gastric cancer 308 | 436
inflammatory breast cancer 290 | 404
chronic rhinosinusitis 281 | 512
Parkinson's disease 280 | 364
Polycystic Ovary Syndrome 263 | 334
hereditary spastic paraplegia 256 | 313
non-small cell lung carcinoma 249 | 413
Stomach Neoplasms 245 | 282
sarcoidosis 243 | 368
glioblastoma multiforme 237 | 347
nephrosclerosis 233 | 329
Hypertension 231 | 293
Vascular disease 230 | 281

Tissue

Female tissues 11,533 | 18,646
Nervous System 11,520 | 18,560
Endocrine System 11,505 | 18,511
Digestive Tract 11,493 | 18,472
Urinary Tract 11,462 | 18,443
Liver and Pancreas 11,418 | 18,135
Blood and immune system 11,406 | 17,994
Male tissues 11,394 | 17,968
Cardiovascular System 11,363 | 17,957
Skin and soft tissues 11,356 | 18,114
Respiratory system 11,187 | 17,483

Target Family

Non-IDG 6,108 | 11,969
Enzyme 3,064 | 4,146
Transcription Factor 1,381 | 1,400
Kinase 448 | 634
Transporter 275 | 473
Epigenetic 216 | 242
Ion Channel 117 | 341
GPCR 98 | 408
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
oGPCR 2 | 421

Compartment GO Term

membrane-bounded organelle 11,793 | 11,793
cellular_component 18,237 | 18,237
Cell 15,806 | 15,806
Cell part 15,806 | 15,806
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,648 | 12,648
Intracellular organelle 11,617 | 11,617
Intracellular membrane-bounded... 10,618 | 10,618
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,169 | 8,169
Intracellular organelle part 8,011 | 8,011
Cytoplasmic part 7,830 | 7,830
Nucleus 7,577 | 7,577
Membrane part 6,470 | 6,470
Cytosol 6,035 | 6,035
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,929 | 4,929
Extracellular region 4,606 | 4,606
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,330 | 4,330
Organelle lumen 4,330 | 4,330
membrane-enclosed lumen 4,330 | 4,330
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,839 | 3,839
non-membrane-bounded organelle 3,838 | 3,838
Nuclear part 3,807 | 3,807
Endomembrane system 3,720 | 3,720
Vesicle 3,666 | 3,666
membrane-bounded vesicle 3,494 | 3,494
Nuclear lumen 3,464 | 3,464
Extracellular organelle 2,849 | 2,849
Extracellular vesicle 2,848 | 2,848
Extracellular exosome 2,828 | 2,828
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,531 | 1,531
Cell projection 1,426 | 1,426
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,305 | 1,305
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 989 | 989
Nucleoli 952 | 952
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 793 | 793
Intracellular ribonucleoprotei... 789 | 789
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66
Zinc finger protein 214 ZNF214 Tdark Transcription Factor -0.49369 2.48 88
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95