Development Level

Tbio 7,677 | 11,445
Tdark 1,989 | 6,588
Tchem 1,100 | 1,598
Tclin 366 | 613

Collection

RFA-RM-18-021 117 | 328
Kinase: IDG Consortium (Target... 78 | 125
Kinase: IDG Consortium (Comple... 27 | 37
Ion Channel: IDG Consortium (T... 22 | 99
GPCR: IDG Consortium (Targets) 21 | 126
GPCR: IDG Consortium (Complete... 7 | 25

IMPC Phenotype

preweaning lethality, complete... 804 | 979
preweaning lethality, incomple... 317 | 499
embryonic lethality prior to t... 237 | 278
embryonic lethality prior to o... 209 | 239
abnormal behavior 189 | 298
abnormal embryo size 171 | 220
decreased total body fat amoun... 139 | 207
abnormal bone structure 128 | 187
enlarged heart 127 | 210
decreased vertical activity 125 | 208
decreased body weight 118 | 161
increased lean body mass 110 | 172
decreased bone mineral content 106 | 151
hypoactivity 103 | 132
abnormal heart morphology 102 | 162
decreased lean body mass 102 | 135
increased total body fat amoun... 101 | 134
embryonic growth retardation 89 | 106
hyperactivity 88 | 148
increased startle reflex 86 | 112
decreased grip strength 84 | 116
increased circulating alkaline... 84 | 122
decreased bone mineral density 82 | 126
decreased circulating glucose ... 81 | 126
abnormal seminal vesicle morph... 74 | 114
decreased circulating choleste... 73 | 93
male infertility 70 | 123
increased bone mineral content 68 | 108
decreased body length 66 | 101
increased mean corpuscular vol... 66 | 92
increased mean corpuscular hem... 64 | 96
cataract 63 | 92
decreased circulating serum al... 62 | 82
prenatal lethality prior to he... 62 | 87
short tibia 62 | 97
increased or absent threshold ... 60 | 101
decreased lymphocyte cell numb... 59 | 83
decreased mean corpuscular vol... 59 | 79
abnormal lens morphology 57 | 81
decreased prepulse inhibition 57 | 82
impaired glucose tolerance 56 | 75
decreased circulating triglyce... 55 | 79
decreased circulating HDL chol... 54 | 68
increased fasted circulating g... 54 | 76
decreased hemoglobin content 53 | 68
decreased leukocyte cell numbe... 51 | 73
increased bone mineral density 51 | 72
increased circulating HDL chol... 50 | 80
abnormal kidney morphology 48 | 65
improved glucose tolerance 48 | 79
small superior vagus ganglion 48 | 74
abnormal gait 47 | 69
edema 47 | 59
increased circulating choleste... 47 | 66
abnormal retina morphology 46 | 71
decreased circulating insulin ... 46 | 76
decreased fasted circulating g... 46 | 65
increased circulating sodium l... 45 | 71
abnormal behavioral response t... 44 | 66
abnormal coat-hair pigmentatio... 44 | 64
increased heart weight 44 | 62
decreased startle reflex 43 | 75
abnormal eye morphology 42 | 68
decreased mean corpuscular hem... 42 | 50
decreased erythrocyte cell num... 41 | 62
increased monocyte cell number 41 | 63
abnormal neural tube closure 40 | 46
thrombocytopenia 39 | 56
abnormal sleep behavior 37 | 70
decreased caudal vertebrae num... 37 | 53
decreased circulating alkaline... 37 | 46
decreased circulating total pr... 37 | 49
female infertility 37 | 60
decreased blood urea nitrogen ... 36 | 51
decreased circulating alanine ... 36 | 47
small testis 36 | 58
abnormal spleen morphology 33 | 55
decreased hematocrit 33 | 46
increased blood urea nitrogen ... 33 | 48
decreased circulating LDL chol... 32 | 38
hydrometra 32 | 53
increased circulating triglyce... 32 | 42
increased hemoglobin content 32 | 45
increased leukocyte cell numbe... 32 | 47
increased neutrophil cell numb... 32 | 46
tremors 32 | 39
abnormal skin morphology 31 | 50
increased circulating chloride... 30 | 41
decreased circulating calcium ... 29 | 36
abnormal testis morphology 28 | 43
increased circulating creatini... 28 | 38
increased grip strength 28 | 41
increased mean platelet volume 28 | 45
abnormal craniofacial morpholo... 27 | 33
decreased circulating creatini... 27 | 39
increased hematocrit 27 | 46
enlarged spleen 26 | 41
increased body length 26 | 32
pallor 26 | 34
prolonged QT interval 26 | 38

Disease

Carcinoma 6,921 | 11,493
ovarian cancer 5,751 | 8,520
osteosarcoma 5,174 | 7,950
psoriasis 4,046 | 6,694
medulloblastoma, large-cell 3,903 | 6,241
glioblastoma 3,680 | 5,792
lung cancer 3,230 | 4,740
atypical teratoid / rhabdoid tumor 3,174 | 5,112
ependymoma 2,755 | 4,679
group 3 medulloblastoma 2,664 | 4,104
Breast cancer 2,306 | 3,578
adult high grade glioma 2,227 | 3,801
malignant mesothelioma 2,185 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,123 | 3,291
Cancer 1,979 | 2,499
primitive neuroectodermal tumor 1,902 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 1,889 | 2,989
invasive ductal carcinoma 1,852 | 2,951
Astrocytoma, Pilocytic 1,807 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 1,807 | 2,955
non-small cell lung cancer 1,798 | 2,890
oligodendroglioma 1,767 | 2,850
lung adenocarcinoma 1,661 | 2,716
astrocytic glioma 1,598 | 2,597
lung carcinoma 1,571 | 2,843
Kidney cancer 1,557 | 2,613
pancreatic cancer 1,514 | 2,398
subependymal giant cell astrocytoma 1,401 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,378 | 1,962
tuberculosis 1,320 | 2,010
interstitial cystitis 1,274 | 2,312
Pick disease 1,256 | 1,894
group 4 medulloblastoma 1,186 | 1,855
pituitary cancer 1,172 | 1,972
diabetes mellitus 1,148 | 1,728
ulcerative colitis 1,100 | 1,819
Multiple myeloma 1,098 | 1,332
ductal carcinoma in situ 1,072 | 1,745
Autosomal recessive predisposition 1,045 | 1,442
breast carcinoma 1,039 | 1,638
cystic fibrosis 985 | 1,696
adrenocortical carcinoma 945 | 1,428
colon cancer 940 | 1,478
Rheumatoid arthritis 855 | 1,191
juvenile dermatomyositis 839 | 1,187
astrocytoma 822 | 1,146
acute quadriplegic myopathy 819 | 1,158
Intellectual disability 788 | 1,016
dermatomyositis 757 | 966
Schizophrenia 748 | 1,160
primary pancreatic ductal adenocarcinoma 715 | 1,109
pediatric high grade glioma 711 | 1,064
cutaneous lupus erythematosus 667 | 1,057
spina bifida 659 | 1,074
Waldenstrons macroglobulinemia 631 | 765
non primary Sjogren syndrome sicca 617 | 891
nasopharyngeal carcinoma 615 | 1,058
Epilepsy 593 | 792
active Crohn's disease 577 | 922
Atopic dermatitis 570 | 952
acute myeloid leukemia 567 | 783
Liver Cirrhosis, Experimental 530 | 769
Dull intelligence 511 | 645
Low intelligence 511 | 645
Mental Retardation 511 | 645
Mental deficiency 511 | 645
Poor school performance 511 | 645
gastric carcinoma 508 | 807
Cognitive delay 502 | 608
Global developmental delay 502 | 608
Mental and motor retardation 502 | 608
esophageal adenocarcinoma 491 | 737
Obesity 490 | 678
primary Sjogren syndrome 483 | 735
Seizures 480 | 596
Alzheimer's disease 469 | 658
active ulcerative colitis 468 | 764
aldosterone-producing adenoma 454 | 665
Muscle hypotonia 452 | 571
progressive supranuclear palsy 446 | 676
medulloblastoma 440 | 720
Bipolar Disorder 436 | 666
Short stature 429 | 531
Melanoma 398 | 711
hepatocellular carcinoma 387 | 547
Duchenne muscular dystrophy 380 | 601
pancreatic carcinoma 376 | 562
Prostatic Neoplasms 375 | 495
Down syndrome 347 | 499
Breast Neoplasms 346 | 445
Neurodegenerative disease 342 | 414
Endometriosis 339 | 540
Multiple Sclerosis 338 | 540
Liver cancer 337 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 337 | 510
Amyotrophic lateral sclerosis 332 | 451
Kidney disease 332 | 430
Mammary Neoplasms 331 | 425
fibroadenoma 319 | 559
gastric cancer 316 | 459

Tissue

Endocrine System 10,764 | 18,159
Digestive Tract 10,555 | 17,369
Female tissues 10,507 | 17,400
Skin and soft tissues 10,503 | 17,230
Male tissues 10,430 | 17,142
Blood and immune system 10,348 | 16,909
Liver and Pancreas 10,328 | 16,750
Urinary Tract 10,301 | 16,678
Nervous System 10,299 | 16,725
Respiratory system 10,156 | 16,393
Cardiovascular System 9,696 | 15,192

Target Family

Non-IDG 5,694 | 12,091
Enzyme 2,862 | 4,145
Transcription Factor 1,375 | 1,400
Kinase 426 | 634
Transporter 243 | 473
Epigenetic 219 | 242
GPCR 116 | 408
Ion Channel 108 | 344
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38
oGPCR 5 | 421

Compartment GO Term

membrane-bounded organelle 11,132 | 11,132
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
E3 ubiquitin-protein ligase TRIM39 TRIM39 Tbio Enzyme -1.24729 16.2 194