Development Level

Tbio 79 | 11,445
Tchem 38 | 1,598
Tclin 20 | 613
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 6 | 499
decreased vertical activity 5 | 208
embryonic lethality prior to t... 5 | 278
abnormal embryo size 4 | 220
increased circulating choleste... 4 | 66
abnormal seminal vesicle morph... 3 | 114
enlarged heart 3 | 210
increased circulating alkaline... 3 | 122
increased total body fat amoun... 3 | 134
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal snout morphology 2 | 23
abnormal tooth morphology 2 | 24
cataract 2 | 92
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating aspartat... 2 | 34
decreased circulating serum al... 2 | 82
decreased heart weight 2 | 27
decreased mean corpuscular vol... 2 | 79
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
increased circulating HDL chol... 2 | 80
increased circulating iron lev... 2 | 30
increased circulating triglyce... 2 | 42
increased leukocyte cell numbe... 2 | 47
small superior vagus ganglion 2 | 74
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal cecum morphology 1 | 7
abnormal coat- hair morphology 1 | 19
abnormal eating behavior 1 | 1
abnormal forced expiratory flo... 1 | 1
abnormal kidney morphology 1 | 65
abnormal neural tube morpholog... 1 | 12
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased body temperature 1 | 2
decreased cardiac muscle contr... 1 | 11
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating unsatura... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased food intake 1 | 13
decreased heart rate 1 | 18
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
enlarged cecum 1 | 5
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hydroencephaly 1 | 14
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating free fat... 1 | 20
increased circulating unsatura... 1 | 1
increased eosinophil cell numb... 1 | 11
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
limb grasping 1 | 41
pale yolk sac 1 | 25
prolonged PQ interval 1 | 5
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small testis 1 | 58
tremors 1 | 39

Disease

Atherosclerosis 108 | 291
Coronary artery disease 94 | 268
diabetes mellitus 94 | 1,728
Carcinoma 86 | 11,493
Obesity 75 | 678
Cancer 72 | 2,499
psoriasis 69 | 6,694
Hypertension 63 | 396
Lipid metabolism disorder 63 | 114
ovarian cancer 60 | 8,520
Kidney disease 59 | 430
lung cancer 59 | 4,740
Cerebrovascular disease 57 | 238
osteosarcoma 56 | 7,950
Heart disease 52 | 306
glioblastoma 47 | 5,792
Liver disease 46 | 237
invasive ductal carcinoma 46 | 2,951
malignant mesothelioma 43 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,955
non-small cell lung cancer 42 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,291
pancreatic cancer 41 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,989
lung carcinoma 40 | 2,843
Schizophrenia 39 | 1,160
Autosomal recessive predisposition 38 | 1,442
lung adenocarcinoma 38 | 2,716
medulloblastoma, large-cell 37 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,962
ulcerative colitis 37 | 1,819
Hyperglycemia 36 | 137
Hypertensive disease 36 | 292
tuberculosis 36 | 2,010
Liver Cirrhosis, Experimental 35 | 769
ependymoma 35 | 4,679
interstitial cystitis 35 | 2,312
Arthritis 33 | 290
Fatty liver disease 33 | 103
Alzheimer's disease 32 | 658
Breast cancer 32 | 3,578
adult high grade glioma 32 | 3,801
atypical teratoid / rhabdoid tumor 32 | 5,112
ductal carcinoma in situ 31 | 1,745
Anemia 30 | 365
Asthma 30 | 385
cystic fibrosis 30 | 1,696
Astrocytoma, Pilocytic 29 | 3,081
Hypersensitivity reaction type II disease 29 | 253
Lung disease 27 | 142
Prostatic Neoplasms 27 | 495
adrenocortical carcinoma 27 | 1,428
Heart failure 26 | 162
group 3 medulloblastoma 25 | 4,104
Cholestasis 24 | 155
Hyperinsulinism 24 | 133
Peripheral vascular disease 24 | 87
breast carcinoma 24 | 1,638
Bipolar Disorder 23 | 666
Cardiovascular Diseases 23 | 59
Inflammatory bowel disease 23 | 151
Kidney cancer 23 | 2,613
Myocardial Infarction 23 | 151
Pancreatitis 23 | 123
Atopic dermatitis 22 | 952
Brain disease 22 | 96
Rheumatoid arthritis 22 | 1,191
Vasculitis 22 | 80
Inflammation 21 | 120
Polycystic ovary syndrome 21 | 360
Depressive disorder 20 | 409
Diabetic retinopathy 20 | 56
Hypercholesterolemia 20 | 44
Cardiovascular system disease 19 | 246
Chemical and Drug Induced Liver Injury 19 | 195
Kidney Failure, Chronic 19 | 46
Major Depressive Disorder 19 | 301
oligodendroglioma 19 | 2,850
Diabetes Mellitus, Experimental 18 | 108
Multiple Sclerosis 18 | 540
Osteoporosis 18 | 363
Reperfusion Injury 18 | 86
Thrombocytopenia 18 | 197
astrocytic glioma 18 | 2,597
pituitary cancer 18 | 1,972
Alcoholic Intoxication, Chronic 17 | 289
Myocardial Ischemia 17 | 169
Unipolar Depression 17 | 250
sarcoidosis 17 | 370
Alzheimer Disease 16 | 83
Brain Ischemia 16 | 110
Breast Neoplasms 16 | 445
Dementia 16 | 175
Diarrhea 16 | 253
Hepatitis C 16 | 94
Mammary Neoplasms 16 | 425
Metabolic syndrome X 16 | 52
cutaneous lupus erythematosus 16 | 1,057
periodontitis 16 | 293
subependymal giant cell astrocytoma 16 | 2,287

Tissue

Digestive Tract 136 | 17,369
Endocrine System 136 | 18,159
Liver and Pancreas 136 | 16,750
Female tissues 133 | 17,400
Urinary Tract 132 | 16,678
Skin and soft tissues 131 | 17,230
Male tissues 130 | 17,142
Blood and immune system 123 | 16,909
Nervous System 123 | 16,725
Respiratory system 122 | 16,393
Cardiovascular System 109 | 15,192

Target Family

Non-IDG 82 | 12,091
Enzyme 41 | 4,145
Transporter 5 | 473
Kinase 4 | 634
Transcription Factor 4 | 1,400
Nuclear Receptor 3 | 48
GPCR 1 | 408

Compartment GO Term

low-density lipoprotein partic... 140 | 140
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MICOS complex subunit MIC26 APOO Tbio Non-IDG -1.25338 18.9 141
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Putative glutathione hydrolase 3 proenzyme GGT3P Tdark Enzyme -3.09193 1683.2 0
Conserved oligomeric Golgi complex subunit 1 COG1 Tbio Non-IDG -1.68066 45.6 91
Niemann-Pick C1-like protein 1 NPC1L1 Tclin Non-IDG -2.33312 222.7 139
Scavenger receptor class B member 1 SCARB1 Tchem Non-IDG -2.93920 915.7 378
Cadherin EGF LAG seven-pass G-type receptor 2 CELSR2 Tbio GPCR -1.22995 16.7 139
Prominin-1 PROM1 Tbio Non-IDG -3.30229 2035.0 351
Serotransferrin TF Tbio Non-IDG -4.15070 13447.9 1168
Niemann-Pick C1 protein NPC1 Tbio Non-IDG -2.71962 551.3 284