Development Level

Tbio 24 | 11,445
Tchem 14 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased vertical activity 3 | 208
abnormal kidney morphology 2 | 65
decreased body weight 2 | 161
embryonic lethality prior to t... 2 | 278
increased blood urea nitrogen ... 2 | 48
preweaning lethality, incomple... 2 | 499
abnormal cranium morphology 1 | 36
abnormal eating behavior 1 | 1
abnormal embryo size 1 | 220
abnormal forced expiratory flo... 1 | 1
abnormal hair texture 1 | 4
abnormal incisor morphology 1 | 4
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
cataract 1 | 92
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body temperature 1 | 2
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased lactate dehydrogenas... 1 | 16
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased tidal volume 1 | 1
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged seminal vesicle 1 | 10
hemorrhage 1 | 23
hydroencephaly 1 | 14
improved glucose tolerance 1 | 79
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
respiratory system phenotype 1 | 2
small testis 1 | 58
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 29 | 11,493
medulloblastoma, large-cell 24 | 6,241
Alzheimer's disease 23 | 658
glioblastoma 23 | 5,792
ovarian cancer 23 | 8,520
osteosarcoma 21 | 7,950
Cancer 20 | 2,499
psoriasis 19 | 6,694
atypical teratoid / rhabdoid tumor 16 | 5,112
lung cancer 16 | 4,740
ependymoma 15 | 4,679
malignant mesothelioma 15 | 3,232
Astrocytoma, Pilocytic 13 | 3,081
Breast cancer 13 | 3,578
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
oligodendroglioma 11 | 2,850
pediatric high grade glioma 11 | 1,064
Dementia 10 | 175
Schizophrenia 10 | 1,160
group 3 medulloblastoma 10 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
invasive ductal carcinoma 10 | 2,951
lung carcinoma 10 | 2,843
Neurodegenerative disease 9 | 414
astrocytic glioma 9 | 2,597
subependymal giant cell astrocytoma 9 | 2,287
Carcinoma, Pancreatic Ductal 8 | 20
Kidney cancer 8 | 2,613
adult high grade glioma 8 | 3,801
astrocytoma 8 | 1,146
diabetes mellitus 8 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung adenocarcinoma 8 | 2,716
Alzheimer Disease 7 | 83
Amyloidosis 7 | 67
Down syndrome 7 | 499
gastric carcinoma 7 | 807
interstitial cystitis 7 | 2,312
juvenile dermatomyositis 7 | 1,187
non-small cell lung cancer 7 | 2,890
pancreatic cancer 7 | 2,398
primitive neuroectodermal tumor 7 | 3,035
Cerebrovascular disease 6 | 238
Lung Neoplasms 6 | 232
Rheumatoid arthritis 6 | 1,191
acute quadriplegic myopathy 6 | 1,158
cystic fibrosis 6 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
ulcerative colitis 6 | 1,819
Alagille syndrome 5 | 15
Bipolar Disorder 5 | 666
Brachydactyly 5 | 156
Duchenne muscular dystrophy 5 | 601
Failure to gain weight 5 | 365
Hypertension 5 | 396
Multiple Sclerosis 5 | 540
Nerve Degeneration 5 | 121
Pediatric failure to thrive 5 | 365
Short distal phalanges 5 | 50
Skin Neoplasms 5 | 69
adrenocortical carcinoma 5 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109
sonic hedgehog group medulloblastoma 5 | 467
tuberculosis 5 | 2,010
ALZHEIMER DISEASE 2 4 | 5
Amyotrophic lateral sclerosis 4 | 451
Atopic dermatitis 4 | 952
Autosomal recessive predisposition 4 | 1,442
Cadasil 4 | 10
Carcinoma, Squamous Cell 4 | 110
Cataract 4 | 297
Cerebral amyloid angiopathy 4 | 13
Depressive disorder 4 | 409
Hydrocephalus 4 | 152
Lens Opacities 4 | 231
Liver Cirrhosis 4 | 181
Liver cancer 4 | 604
Neurofibrillary degeneration (morphologic abnormality) 4 | 9
Pick disease 4 | 1,894
Seizures 4 | 596
Short stature 4 | 531
Splenomegaly 4 | 190
Strabismus 4 | 270
Tetralogy of Fallot 4 | 63
Toxic encephalopathy 4 | 141
aldosterone-producing adenoma 4 | 665
dermatomyositis 4 | 966
group 4 medulloblastoma 4 | 1,855
posterior fossa group B ependymoma 4 | 416
progressive supranuclear palsy 4 | 676
Acquired scoliosis 3 | 281
Curvature of spine 3 | 282
Epilepsy 3 | 792
Heart disease 3 | 306
Kidney disease 3 | 430
Waldenstrons macroglobulinemia 3 | 765

Tissue

Digestive Tract 38 | 17,369
Blood and immune system 37 | 16,909
Endocrine System 37 | 18,159
Skin and soft tissues 37 | 17,230
Cardiovascular System 36 | 15,192
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Respiratory system 36 | 16,393
Urinary Tract 36 | 16,678

Target Family

Non-IDG 20 | 12,091
Enzyme 12 | 4,145
Transcription Factor 6 | 1,400
Kinase 1 | 634

Compartment GO Term

gamma-secretase complex 39 | 39
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335
Insulin-degrading enzyme IDE Tchem Enzyme -2.57779 392.8 331
Delta-like protein 3 DLL3 Tbio Non-IDG -1.68978 48.6 214
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.08501 97.6 139
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84761 677.3 204
Gamma-secretase-activating protein GSAP Tchem Enzyme -1.15790 16.8 134
Amyloid-like protein 1 APLP1 Tbio Non-IDG -1.88769 62.6 162
Corneodesmosin CDSN Tbio Non-IDG -3.23661 1709.5 0
Receptor tyrosine-protein kinase erbB-4 ERBB4 Tclin Kinase -2.78704 558.2 1072