Development Level

Tbio 789 | 10,625
Tchem 165 | 1,890
Tdark 114 | 7,003
Tclin 57 | 602

Collection

Eligible Ion Channel Proteins 7 | 117
Eligible Kinase Proteins 6 | 134
Eligible non-olfactory GPCR Proteins 4 | 143

IMPC Term

preweaning lethality, complete... 47 | 633
abnormal behavior 22 | 226
embryonic lethality prior to t... 19 | 187
decreased grip strength 17 | 123
preweaning lethality, incomple... 17 | 260
decreased total body fat amoun... 15 | 186
increased or absent threshold ... 13 | 128
abnormal bone structure 12 | 131
decreased lean body mass 12 | 195
abnormal embryo size 11 | 112
decreased bone mineral content 11 | 157
decreased circulating HDL chol... 11 | 77
increased circulating alkaline... 11 | 119
decreased circulating choleste... 10 | 85
embryonic lethality prior to o... 10 | 148
enlarged heart 10 | 111
short tibia 10 | 82
hypoactivity 9 | 89
increased circulating sodium l... 9 | 71
abnormal coat/hair pigmentatio... 8 | 54
abnormal lens morphology 8 | 73
decreased body length 8 | 108
decreased fasted circulating g... 8 | 49
increased grip strength 8 | 83
abnormal sleep behavior 7 | 63
decreased body weight 7 | 174
decreased circulating LDL chol... 7 | 37
decreased circulating glucose ... 7 | 121
decreased mean corpuscular vol... 7 | 50
increased circulating HDL chol... 7 | 63
increased hematocrit 7 | 36
increased mean corpuscular hem... 7 | 93
abnormal retina morphology 6 | 100
cardiovascular system phenotyp... 6 | 35
decreased circulating insulin ... 6 | 75
decreased mean corpuscular hem... 6 | 34
hyperactivity 6 | 108
increased mean corpuscular vol... 6 | 91
increased total body fat amoun... 6 | 57
tremors 6 | 34
abnormal bone mineralization 5 | 55
abnormal kidney morphology 5 | 30
abnormal retinal pigmentation 5 | 61
cataract 5 | 26
decreased bone mineral density 5 | 126
decreased circulating serum al... 5 | 79
decreased mean corpuscular hem... 5 | 19
decreased prepulse inhibition 5 | 52
decreased vertical activity 5 | 22
improved glucose tolerance 5 | 56
increased body weight 5 | 42
increased circulating choleste... 5 | 53
increased lean body mass 5 | 107
increased mean corpuscular hem... 5 | 25
male infertility 5 | 62
thrombocytopenia 5 | 46
abnormal QRS complex 4 | 25
abnormal behavioral response t... 4 | 52
abnormal epididymis morphology 4 | 31
abnormal facial morphology 4 | 9
abnormal limb bud morphology 4 | 15
abnormal limb morphology 4 | 7
abnormal locomotor activation 4 | 26
abnormal neural tube closure 4 | 37
abnormal retinal blood vessel ... 4 | 18
abnormal seminal vesicle morph... 4 | 47
decreased circulating alkaline... 4 | 41
hydrops fetalis 4 | 22
increased blood urea nitrogen ... 4 | 44
increased bone mineral content 4 | 92
increased circulating chloride... 4 | 43
increased heart weight 4 | 37
increased hemoglobin content 4 | 45
prenatal lethality prior to he... 4 | 64
abnormal body wall morphology 3 | 7
abnormal eye morphology 3 | 38
abnormal hindbrain development 3 | 24
abnormal midbrain development 3 | 22
abnormal tail movements 3 | 12
abnormal tooth morphology 3 | 24
cleft palate 3 | 6
decreased circulating bilirubi... 3 | 14
decreased circulating triglyce... 3 | 83
decreased effector memory CD8-... 3 | 24
decreased gamma-delta T cell n... 3 | 18
decreased heart weight 3 | 44
decreased hemoglobin content 3 | 53
decreased neutrophil cell numb... 3 | 37
decreased threshold for audito... 3 | 32
enlarged epididymis 3 | 27
hemorrhage 3 | 12
impaired glucose tolerance 3 | 52
increased circulating free fat... 3 | 17
increased circulating potassiu... 3 | 31
increased circulating triglyce... 3 | 24
increased erythrocyte cell num... 3 | 26
increased fasted circulating g... 3 | 68
increased leukocyte cell numbe... 3 | 37
increased startle reflex 3 | 38
persistence of hyaloid vascula... 3 | 22

Disease

ovarian cancer 552 | 8,484
osteosarcoma 491 | 7,933
psoriasis 476 | 6,685
glioblastoma 446 | 5,572
medulloblastoma, large-cell 425 | 6,234
atypical teratoid / rhabdoid tumor 323 | 4,369
Cancer 319 | 2,346
lung cancer 309 | 4,466
pilocytic astrocytoma 298 | 3,086
lung carcinoma 270 | 2,844
diabetes mellitus 245 | 1,663
pediatric high grade glioma 236 | 2,712
oligodendroglioma 233 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 231 | 3,289
malignant mesothelioma 230 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 229 | 2,956
invasive ductal carcinoma 228 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 220 | 2,988
pancreatic cancer 213 | 2,300
lung adenocarcinoma 210 | 2,713
primitive neuroectodermal tumor 210 | 3,031
Breast cancer 201 | 3,094
non-small cell lung cancer 191 | 2,798
subependymal giant cell astrocytoma 187 | 2,287
ependymoma 178 | 2,514
interstitial cystitis 165 | 2,299
astrocytoma 161 | 1,493
ulcerative colitis 158 | 2,087
Carcinoma 156 | 2,147
Pick disease 156 | 1,893
astrocytic glioma 149 | 2,241
pituitary cancer 149 | 1,972
tuberculosis 144 | 1,557
posterior fossa group A ependymoma 143 | 1,511
Rheumatoid Arthritis 135 | 1,160
cystic fibrosis 131 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 128 | 1,795
Multiple myeloma 127 | 1,327
adult high grade glioma 127 | 2,148
group 4 medulloblastoma 125 | 1,875
ductal carcinoma in situ 124 | 1,745
primary pancreatic ductal adenocarcinoma 119 | 1,271
breast carcinoma 117 | 1,614
medulloblastoma 112 | 1,524
group 3 medulloblastoma 108 | 2,254
juvenile dermatomyositis 107 | 1,189
acute quadriplegic myopathy 103 | 1,157
Alzheimer's disease 101 | 644
colon cancer 100 | 1,475
sonic hedgehog group medulloblastoma 100 | 1,482
Arthritis 99 | 248
posterior fossa group B ependymoma 98 | 1,530
adrenocortical carcinoma 97 | 1,427
Kidney disease 96 | 396
cutaneous lupus erythematosus 93 | 1,056
Hypersensitivity reaction type II disease 90 | 235
gastric carcinoma 86 | 832
dermatomyositis 84 | 933
Duchenne muscular dystrophy 80 | 602
esophageal adenocarcinoma 76 | 737
Schizophrenia 75 | 501
Obesity 74 | 616
atypical teratoid/rhabdoid tumor 74 | 1,095
Ankylosing spondylitis 73 | 138
Waldenstrons macroglobulinemia 73 | 765
active Crohn's disease 70 | 918
spina bifida 70 | 1,064
mucosa-associated lymphoid tissue lymphoma 69 | 480
Uveitis 66 | 103
Acquired immunodeficiency syndrome 65 | 164
Multiple Sclerosis 65 | 498
Juvenile rheumatoid arthritis 63 | 104
pancreatic carcinoma 62 | 567
Atherosclerosis 61 | 275
Liver disease 60 | 219
Neurodegenerative disease 60 | 383
Parkinson's disease 60 | 364
Down syndrome 59 | 548
Prostatic Neoplasms 58 | 471
nasopharyngeal carcinoma 58 | 1,056
Anemia 57 | 252
Atopic dermatitis 57 | 944
Behcet's disease 57 | 74
Hypertension 56 | 287
non primary Sjogren syndrome sicca 54 | 840
Epilepsy 53 | 346
Psoriatic arthritis 53 | 83
Vascular disease 51 | 281
Asthma 50 | 349
autosomal dominant Emery-Dreifuss muscular dystrophy 50 | 499
primary Sjogren syndrome 50 | 789
Cerebrovascular disease 49 | 231
Heart disease 47 | 279
acute myeloid leukemia 46 | 780
aldosterone-producing adenoma 46 | 664
Endometriosis 45 | 535
Intellectual disability 44 | 573
Coronary artery disease 43 | 240
fibroadenoma 43 | 557
IGA Glomerulonephritis 42 | 454

Tissue

Nervous System 1,045 | 18,561
Endocrine System 1,044 | 18,512
Digestive Tract 1,043 | 18,473
Female tissues 1,042 | 18,647
Urinary Tract 1,039 | 18,444
Liver and Pancreas 1,037 | 18,136
Cardiovascular System 1,030 | 17,958
Blood and immune system 1,029 | 17,995
Skin and soft tissues 1,028 | 18,115
Male tissues 1,027 | 17,969
Respiratory system 1,018 | 17,484

Target Family

Non-IDG 766 | 11,971
Enzyme 231 | 4,146
Transporter 35 | 473
Kinase 34 | 634
Ion Channel 33 | 341
GPCR 18 | 406
Transcription Factor 5 | 1,400
Epigenetic 2 | 242
TF/Epigenetic 1 | 38

Compartment GO Term

cytoplasmic, membrane-bounded ... 1,125 | 1,125
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
Vacuolar ATPase assembly integral membrane protein VMA21 VMA21 Tbio Enzyme 1.00 53
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
HLA class I histocompatibility antigen, B-27 alpha chain HLA-B Tbio Non-IDG 1568.8 0
HLA class I histocompatibility antigen, B-38 alpha chain HLA-B Tbio Non-IDG 1568.8 0