Development Level

Tbio 141 | 11,445
Tdark 55 | 6,588
Tchem 12 | 1,598
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 19 | 979
preweaning lethality, incomple... 11 | 499
embryonic lethality prior to o... 8 | 239
embryonic lethality prior to t... 7 | 278
abnormal embryo size 6 | 220
decreased lean body mass 6 | 135
increased circulating HDL chol... 6 | 80
abnormal heart morphology 4 | 162
decreased bone mineral content 4 | 151
decreased grip strength 4 | 116
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
decreased circulating creatini... 3 | 39
decreased circulating glucose ... 3 | 126
decreased leukocyte cell numbe... 3 | 73
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
increased circulating choleste... 3 | 66
increased circulating creatini... 3 | 38
increased circulating glucose ... 3 | 24
increased grip strength 3 | 41
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
male infertility 3 | 123
short tibia 3 | 97
abnormal joint morphology 2 | 23
abnormal placenta size 2 | 20
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
anophthalmia 2 | 33
brachydactyly 2 | 19
decreased basophil cell number 2 | 16
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating alanine ... 2 | 47
decreased circulating alkaline... 2 | 46
decreased circulating chloride... 2 | 30
decreased circulating choleste... 2 | 93
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
female infertility 2 | 60
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased heart weight 2 | 62
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased mean platelet volume 2 | 45
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
small adrenal glands 2 | 16
syndactyly 2 | 23
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal skin coloration 1 | 25
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased hematocrit 1 | 46
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
hypoactivity 1 | 132
impaired righting response 1 | 26
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating bilirubi... 1 | 16
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
prenatal lethality 1 | 28
small kidney 1 | 16
small spleen 1 | 19
small testis 1 | 58
small thymus 1 | 16
thrombocytosis 1 | 27
urinary bladder obstruction 1 | 4

Disease

Carcinoma 140 | 11,493
ovarian cancer 123 | 8,520
osteosarcoma 102 | 7,950
medulloblastoma, large-cell 100 | 6,241
glioblastoma 91 | 5,792
atypical teratoid / rhabdoid tumor 83 | 5,112
psoriasis 78 | 6,694
ependymoma 62 | 4,679
adult high grade glioma 60 | 3,801
Breast cancer 57 | 3,578
group 3 medulloblastoma 57 | 4,104
lung cancer 55 | 4,740
primitive neuroectodermal tumor 55 | 3,035
oligodendroglioma 50 | 2,850
Cancer 48 | 2,499
malignant mesothelioma 48 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 46 | 3,291
invasive ductal carcinoma 40 | 2,951
Astrocytoma, Pilocytic 38 | 3,081
astrocytic glioma 35 | 2,597
group 4 medulloblastoma 34 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
subependymal giant cell astrocytoma 33 | 2,287
non-small cell lung cancer 32 | 2,890
pituitary cancer 32 | 1,972
Multiple myeloma 30 | 1,332
pancreatic cancer 30 | 2,398
Kidney cancer 29 | 2,613
adrenocortical carcinoma 28 | 1,428
interstitial cystitis 26 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
lung adenocarcinoma 25 | 2,716
breast carcinoma 24 | 1,638
lung carcinoma 24 | 2,843
ductal carcinoma in situ 23 | 1,745
ulcerative colitis 22 | 1,819
colon cancer 21 | 1,478
tuberculosis 20 | 2,010
Intellectual disability 19 | 1,016
diabetes mellitus 19 | 1,728
Pick disease 18 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Atopic dermatitis 16 | 952
Waldenstrons macroglobulinemia 15 | 765
acute quadriplegic myopathy 15 | 1,158
astrocytoma 15 | 1,146
nasopharyngeal carcinoma 15 | 1,058
pediatric high grade glioma 15 | 1,064
primary Sjogren syndrome 15 | 735
Rheumatoid arthritis 13 | 1,191
spina bifida 13 | 1,074
Dull intelligence 12 | 645
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Parkinson's disease 12 | 392
Poor school performance 12 | 645
dermatomyositis 12 | 966
juvenile dermatomyositis 12 | 1,187
primary pancreatic ductal adenocarcinoma 12 | 1,109
Alzheimer's disease 11 | 658
Autosomal recessive predisposition 11 | 1,442
Epilepsy 11 | 792
Short stature 11 | 531
Small head 11 | 374
medulloblastoma 11 | 720
Endometriosis 10 | 540
Schizophrenia 10 | 1,160
cystic fibrosis 10 | 1,696
hepatocellular carcinoma 10 | 547
non primary Sjogren syndrome sicca 10 | 891
posterior fossa group A ependymoma 10 | 468
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
cutaneous lupus erythematosus 9 | 1,057
esophageal adenocarcinoma 9 | 737
gastric carcinoma 9 | 807
Bipolar Disorder 8 | 666
Cryptorchidism 8 | 296
Multiple Sclerosis 8 | 540
Seizures 8 | 596
acute myeloid leukemia 8 | 783
aldosterone-producing adenoma 8 | 665
pancreatic carcinoma 8 | 562
sonic hedgehog group medulloblastoma 8 | 467
tuberculosis and treatment for 6 months 8 | 409
Acquired metabolic disease 7 | 336
Glaucoma 7 | 239
gastric cancer 7 | 459
Cataract 6 | 297
Fetal Growth Retardation 6 | 189
Hypoplastic mandible condyle 6 | 275
Infant, Small for Gestational Age 6 | 176
Intrauterine retardation 6 | 176
Lens Opacities 6 | 231
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Muscle hypotonia 6 | 571
Nystagmus 6 | 317

Tissue

Endocrine System 212 | 18,159
Skin and soft tissues 211 | 17,230
Nervous System 210 | 16,725
Digestive Tract 209 | 17,369
Male tissues 209 | 17,142
Blood and immune system 208 | 16,909
Female tissues 208 | 17,400
Liver and Pancreas 205 | 16,750
Urinary Tract 205 | 16,678
Respiratory system 204 | 16,393
Cardiovascular System 198 | 15,192

Target Family

Non-IDG 173 | 12,091
Enzyme 23 | 4,145
Kinase 7 | 634
Transcription Factor 7 | 1,400
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

cullin-RING ubiquitin ligase c... 212 | 212
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166
Anaphase-promoting complex subunit 4 ANAPC4 Tbio Enzyme 0.43 0.13 156
F-box/LRR-repeat protein 2 FBXL2 Tbio Non-IDG -0.89339 8.63 129
Cullin-7 CUL7 Tbio Non-IDG -1.49747 38.0 139
RNA binding protein fox-1 homolog 3 RBFOX3 Tbio Non-IDG -3.23341 1462.9 208
Anaphase-promoting complex subunit 7 ANAPC7 Tbio Enzyme -0.17118 1.40 73
Eomesodermin homolog EOMES Tbio Transcription Factor -2.37902 230.4 333
DDB1- and CUL4-associated factor 16 DCAF16 Tdark Non-IDG 0.08 0.54 13
CDK2-associated and cullin domain-containing protein 1 CACUL1 Tbio Non-IDG -0.58734 5.65 98