Development Level

Tbio 137 | 11,445
Tchem 22 | 1,598
Tclin 10 | 613
Tdark 6 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 13 | 979
preweaning lethality, incomple... 8 | 499
embryonic lethality prior to t... 6 | 278
abnormal behavior 5 | 298
decreased vertical activity 5 | 208
embryonic lethality prior to o... 4 | 239
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
abnormal sleep behavior 3 | 70
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased circulating serum al... 3 | 82
decreased fasted circulating g... 3 | 65
decreased mean corpuscular hem... 3 | 50
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
hyperactivity 3 | 148
increased circulating alkaline... 3 | 122
increased circulating sodium l... 3 | 71
increased or absent threshold ... 3 | 101
increased total body fat amoun... 3 | 134
abnormal cecum morphology 2 | 7
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal neural tube closure 2 | 46
abnormal testis morphology 2 | 43
decreased body weight 2 | 161
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
embryonic growth retardation 2 | 106
enlarged cecum 2 | 5
enlarged lymph nodes 2 | 37
enlarged seminal vesicle 2 | 10
hydrometra 2 | 53
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased circulating potassiu... 2 | 29
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular vol... 2 | 92
increased vertical activity 2 | 24
microphthalmia 2 | 26
pallor 2 | 34
small superior vagus ganglion 2 | 74
small testis 2 | 58
tremors 2 | 39
abnormal allantois morphology 1 | 8
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal left-right axis patte... 1 | 2
abnormal neural tube morpholog... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal sensory capabilities-... 1 | 8
abnormal somite shape 1 | 5
abnormal tooth morphology 1 | 24
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
brachydactyly 1 | 19
cataract 1 | 92
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased mean corpuscular hem... 1 | 31
edema 1 | 59
enlarged epididymis 1 | 31
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased body length 1 | 32
increased body weight 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
syndactyly 1 | 23
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 118 | 11,493
ovarian cancer 100 | 8,520
psoriasis 88 | 6,694
osteosarcoma 83 | 7,950
glioblastoma 72 | 5,792
medulloblastoma, large-cell 72 | 6,241
atypical teratoid / rhabdoid tumor 62 | 5,112
ependymoma 60 | 4,679
lung cancer 60 | 4,740
lung carcinoma 50 | 2,843
Astrocytoma, Pilocytic 44 | 3,081
adult high grade glioma 42 | 3,801
malignant mesothelioma 41 | 3,232
group 3 medulloblastoma 40 | 4,104
Breast cancer 39 | 3,578
astrocytic glioma 39 | 2,597
oligodendroglioma 39 | 2,850
invasive ductal carcinoma 38 | 2,951
Cancer 37 | 2,499
diabetes mellitus 37 | 1,728
non-small cell lung cancer 37 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,955
Pick disease 35 | 1,894
primitive neuroectodermal tumor 35 | 3,035
Kidney cancer 33 | 2,613
interstitial cystitis 32 | 2,312
subependymal giant cell astrocytoma 32 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,989
lung adenocarcinoma 31 | 2,716
Autosomal recessive predisposition 29 | 1,442
pancreatic cancer 29 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
pituitary cancer 27 | 1,972
tuberculosis 26 | 2,010
cutaneous lupus erythematosus 24 | 1,057
Rheumatoid arthritis 23 | 1,191
Alzheimer's disease 22 | 658
Cataract 8 multiple types 22 | 33
ductal carcinoma in situ 22 | 1,745
Multiple myeloma 21 | 1,332
breast carcinoma 21 | 1,638
cystic fibrosis 21 | 1,696
Schizophrenia 20 | 1,160
Bipolar Disorder 18 | 666
esophageal adenocarcinoma 17 | 737
pediatric high grade glioma 17 | 1,064
Down syndrome 16 | 499
Kidney disease 16 | 430
group 4 medulloblastoma 16 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Alcoholic Intoxication, Chronic 15 | 289
Hypersensitivity reaction type II disease 15 | 253
Multiple Sclerosis 15 | 540
adrenocortical carcinoma 15 | 1,428
astrocytoma 15 | 1,146
Epilepsy 14 | 792
primary pancreatic ductal adenocarcinoma 14 | 1,109
Dull intelligence 13 | 645
Intellectual disability 13 | 1,016
Liver disease 13 | 237
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Parkinson's disease 13 | 392
Poor school performance 13 | 645
juvenile dermatomyositis 13 | 1,187
ulcerative colitis 13 | 1,819
Diarrhea 12 | 253
Melanoma 12 | 711
acute quadriplegic myopathy 12 | 1,158
dermatomyositis 12 | 966
progressive supranuclear palsy 12 | 676
Atopic dermatitis 11 | 952
Neurodegenerative disease 11 | 414
Obesity 11 | 678
gastric carcinoma 11 | 807
non primary Sjogren syndrome sicca 11 | 891
sarcoidosis 11 | 370
Asthma 10 | 385
Atherosclerosis 10 | 291
Failure to gain weight 10 | 365
Heart disease 10 | 306
Hypertension 10 | 396
Pediatric failure to thrive 10 | 365
Seizures 10 | 596
Vascular disease 10 | 319
Waldenstrons macroglobulinemia 10 | 765
active Crohn's disease 10 | 922
acute myeloid leukemia 10 | 783
mucosa-associated lymphoid tissue lymphoma 10 | 484
spina bifida 10 | 1,074
Cognitive delay 9 | 608
Coronary artery disease 9 | 268
Gaucher disease type 1 9 | 180
Global developmental delay 9 | 608
Hypertensive disease 9 | 292
Liver cancer 9 | 604
Major Depressive Disorder 9 | 301
Mental and motor retardation 9 | 608
Skin cancer 9 | 469

Tissue

Digestive Tract 169 | 17,369
Endocrine System 169 | 18,159
Skin and soft tissues 169 | 17,230
Female tissues 167 | 17,400
Male tissues 166 | 17,142
Blood and immune system 165 | 16,909
Liver and Pancreas 162 | 16,750
Respiratory system 162 | 16,393
Urinary Tract 162 | 16,678
Nervous System 161 | 16,725
Cardiovascular System 152 | 15,192

Target Family

Non-IDG 131 | 12,091
Enzyme 18 | 4,145
Transporter 11 | 473
Kinase 7 | 634
GPCR 6 | 408
Ion Channel 1 | 344
Transcription Factor 1 | 1,400

Compartment GO Term

clathrin-coated vesicle 175 | 175
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Solute carrier family 2, facilitated glucose transporter member 8 SLC2A8 Tbio Transporter -1.54482 35.6 110
Transcription factor-like 5 protein TCFL5 Tbio Transcription Factor -2.62447 404.7 161
Folate receptor alpha FOLR1 Tchem Non-IDG -2.33242 206.1 303
Clathrin heavy chain 2 CLTCL1 Tbio Non-IDG -1.29555 21.3 39
5,6-dihydroxyindole-2-carboxylic acid oxidase TYRP1 Tbio Enzyme -2.95336 876.7 309
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
Cell migration-inducing and hyaluronan-binding protein CEMIP Tbio Non-IDG -1.58210 41.5 144
Synaptotagmin-2 SYT2 Tbio Non-IDG -1.93503 86.7 222
C-type lectin domain family 4 member K CD207 Tbio Non-IDG -2.49714 321.5 295