Development Level

Tbio 11,380 | 11,651
Tdark 4,957 | 6,593
Tchem 1,374 | 1,388
Tclin 609 | 612

Collection

RFA-RM-18-021 316 | 328
GPCR: IDG Consortium (Targets) 124 | 126
Kinase: IDG Consortium (Target... 119 | 125
Ion Channel: IDG Consortium (T... 96 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 25 | 25

IMPC Phenotype

preweaning lethality, complete... 965 | 979
preweaning lethality, incomple... 488 | 499
abnormal behavior 294 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 216 | 220
decreased vertical activity 205 | 208
enlarged heart 205 | 210
decreased total body fat amoun... 202 | 207
abnormal bone structure 185 | 187
increased lean body mass 169 | 172
decreased body weight 159 | 161
abnormal heart morphology 158 | 162
decreased bone mineral content 147 | 151
hyperactivity 146 | 148
decreased lean body mass 132 | 135
increased total body fat amoun... 132 | 134
hypoactivity 131 | 132
decreased bone mineral density 122 | 126
decreased circulating glucose ... 121 | 126
increased circulating alkaline... 119 | 122
male infertility 116 | 123
decreased grip strength 114 | 116
abnormal seminal vesicle morph... 113 | 114
increased startle reflex 111 | 112
embryonic growth retardation 105 | 106
increased bone mineral content 104 | 108
decreased body length 100 | 101
increased or absent threshold ... 99 | 101
decreased circulating choleste... 93 | 93
increased mean corpuscular hem... 93 | 96
short tibia 92 | 97
cataract 90 | 92
increased mean corpuscular vol... 89 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 81 | 83
decreased prepulse inhibition 81 | 82
abnormal lens morphology 79 | 81
decreased circulating serum al... 79 | 82
improved glucose tolerance 79 | 79
increased circulating HDL chol... 79 | 80
decreased circulating triglyce... 78 | 79
decreased mean corpuscular vol... 77 | 79
decreased startle reflex 75 | 75
increased fasted circulating g... 75 | 76
decreased circulating insulin ... 74 | 76
impaired glucose tolerance 74 | 75
small superior vagus ganglion 73 | 74
increased bone mineral density 71 | 72
decreased leukocyte cell numbe... 70 | 73
increased circulating sodium l... 70 | 71
abnormal retina morphology 69 | 71
abnormal gait 68 | 69
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 67 | 68
abnormal eye morphology 66 | 68
abnormal kidney morphology 65 | 65
abnormal sleep behavior 65 | 70
increased circulating choleste... 65 | 66
decreased fasted circulating g... 64 | 65
abnormal behavioral response t... 63 | 66
increased heart weight 62 | 62
increased monocyte cell number 62 | 63
abnormal coat-hair pigmentatio... 61 | 64
decreased erythrocyte cell num... 59 | 62
edema 59 | 59
female infertility 58 | 60
small testis 57 | 58
abnormal spleen morphology 55 | 55
thrombocytopenia 54 | 56
hydrometra 52 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased caudal vertebrae num... 49 | 53
decreased mean corpuscular hem... 48 | 50
decreased circulating total pr... 47 | 49
increased blood urea nitrogen ... 47 | 48
decreased circulating alanine ... 46 | 47
decreased circulating alkaline... 46 | 46
increased leukocyte cell numbe... 46 | 47
abnormal neural tube closure 45 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
decreased hematocrit 44 | 46
increased hematocrit 44 | 46
increased neutrophil cell numb... 43 | 46
abnormal epididymis morphology 42 | 42
abnormal testis morphology 42 | 43
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
limb grasping 40 | 41
decreased red blood cell distr... 39 | 41
increased grip strength 39 | 41
tremors 39 | 39
abnormal bone mineralization 38 | 38
decreased circulating LDL chol... 38 | 38
decreased circulating creatini... 38 | 39
prolonged QT interval 38 | 38

Disease

Carcinoma 11,113 | 11,493
ovarian cancer 8,192 | 8,520
osteosarcoma 7,555 | 7,950
psoriasis 6,389 | 6,694
medulloblastoma, large-cell 5,991 | 6,241
glioblastoma 5,595 | 5,792
atypical teratoid / rhabdoid tumor 4,916 | 5,112
lung cancer 4,601 | 4,740
ependymoma 4,479 | 4,679
group 3 medulloblastoma 3,951 | 4,104
adult high grade glioma 3,666 | 3,801
Breast cancer 3,459 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,171 | 3,291
malignant mesothelioma 3,136 | 3,232
Astrocytoma, Pilocytic 2,994 | 3,081
primitive neuroectodermal tumor 2,937 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,882 | 2,989
invasive ductal carcinoma 2,850 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,848 | 2,955
non-small cell lung cancer 2,801 | 2,890
oligodendroglioma 2,742 | 2,850
lung carcinoma 2,738 | 2,843
lung adenocarcinoma 2,620 | 2,716
Kidney cancer 2,554 | 2,613
astrocytic glioma 2,492 | 2,597
Cancer 2,488 | 2,499
pancreatic cancer 2,334 | 2,398
interstitial cystitis 2,210 | 2,312
subependymal giant cell astrocytoma 2,199 | 2,287
tuberculosis 1,924 | 2,010
pituitary cancer 1,901 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,899 | 1,962
Pick disease 1,838 | 1,894
group 4 medulloblastoma 1,783 | 1,855
ulcerative colitis 1,750 | 1,819
ductal carcinoma in situ 1,697 | 1,745
diabetes mellitus 1,658 | 1,728
cystic fibrosis 1,641 | 1,696
breast carcinoma 1,597 | 1,638
colon cancer 1,439 | 1,478
Autosomal recessive predisposition 1,425 | 1,442
adrenocortical carcinoma 1,377 | 1,428
Multiple myeloma 1,300 | 1,332
Rheumatoid arthritis 1,163 | 1,191
juvenile dermatomyositis 1,152 | 1,187
Schizophrenia 1,141 | 1,160
acute quadriplegic myopathy 1,128 | 1,158
astrocytoma 1,117 | 1,146
primary pancreatic ductal adenocarcinoma 1,081 | 1,109
pediatric high grade glioma 1,026 | 1,064
spina bifida 1,024 | 1,074
cutaneous lupus erythematosus 1,020 | 1,057
Intellectual disability 1,010 | 1,016
nasopharyngeal carcinoma 999 | 1,058
dermatomyositis 955 | 966
Atopic dermatitis 929 | 952
active Crohn's disease 891 | 922
non primary Sjogren syndrome sicca 858 | 891
Epilepsy 790 | 792
gastric carcinoma 778 | 807
Waldenstrons macroglobulinemia 756 | 765
Liver Cirrhosis, Experimental 753 | 769
acute myeloid leukemia 753 | 783
active ulcerative colitis 747 | 764
esophageal adenocarcinoma 723 | 737
primary Sjogren syndrome 713 | 735
Melanoma 693 | 711
medulloblastoma 689 | 720
Obesity 673 | 678
Bipolar Disorder 659 | 666
progressive supranuclear palsy 652 | 676
aldosterone-producing adenoma 649 | 665
Alzheimer's disease 644 | 658
Dull intelligence 642 | 645
Low intelligence 642 | 645
Mental Retardation 642 | 645
Mental deficiency 642 | 645
Poor school performance 642 | 645
Cognitive delay 606 | 608
Global developmental delay 606 | 608
Mental and motor retardation 606 | 608
Seizures 594 | 596
Liver cancer 593 | 604
Duchenne muscular dystrophy 590 | 601
Muscle hypotonia 570 | 571
fibroadenoma 546 | 559
pancreatic carcinoma 541 | 562
Endometriosis 529 | 540
Multiple Sclerosis 525 | 540
Short stature 525 | 531
hepatocellular carcinoma 524 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 497 | 510
Prostatic Neoplasms 491 | 495
Down syndrome 488 | 499
chronic rhinosinusitis 473 | 512
mucosa-associated lymphoid tissue lymphoma 470 | 484
Skin cancer 460 | 469
sonic hedgehog group medulloblastoma 452 | 467
posterior fossa group A ependymoma 447 | 468
Amyotrophic lateral sclerosis 445 | 451

Tissue

Endocrine System 17,150 | 18,159
Digestive Tract 16,513 | 17,369
Female tissues 16,512 | 17,400
Skin and soft tissues 16,380 | 17,230
Male tissues 16,274 | 17,142
Blood and immune system 16,076 | 16,909
Liver and Pancreas 15,939 | 16,750
Nervous System 15,928 | 16,725
Urinary Tract 15,887 | 16,678
Respiratory system 15,584 | 16,393
Cardiovascular System 14,520 | 15,192

Target Family

Non-IDG 10,445 | 12,091
Enzyme 3,958 | 4,145
Transcription Factor 1,393 | 1,400
Kinase 623 | 634
Transporter 465 | 473
GPCR 398 | 408
oGPCR 380 | 421
Ion Channel 339 | 344
Epigenetic 234 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 38 | 38

Compartment GO Term

cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115