Development Level

Tbio 10,383 | 10,625
Tdark 5,391 | 7,003
Tchem 1,865 | 1,890
Tclin 599 | 602

Collection

Eligible non-olfactory GPCR Proteins 134 | 143
Eligible Kinase Proteins 127 | 134
Eligible Ion Channel Proteins 112 | 117

IMPC Term

preweaning lethality, complete... 625 | 633
preweaning lethality, incomple... 254 | 260
abnormal behavior 224 | 226
decreased lean body mass 189 | 195
embryonic lethality prior to t... 185 | 187
decreased total body fat amoun... 181 | 186
decreased body weight 170 | 174
decreased bone mineral content 155 | 157
embryonic lethality prior to o... 147 | 148
abnormal bone structure 129 | 131
increased or absent threshold ... 125 | 128
decreased bone mineral density 123 | 126
decreased grip strength 119 | 123
increased circulating alkaline... 117 | 119
decreased circulating glucose ... 116 | 121
abnormal embryo size 110 | 112
enlarged heart 107 | 111
decreased body length 106 | 108
hyperactivity 105 | 108
increased lean body mass 104 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 91 | 93
increased bone mineral content 89 | 92
hypoactivity 88 | 89
increased mean corpuscular vol... 88 | 91
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 80 | 83
short tibia 80 | 82
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
decreased circulating serum al... 75 | 79
abnormal lens morphology 73 | 73
increased circulating sodium l... 69 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
increased circulating HDL chol... 62 | 63
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 60 | 62
abnormal retinal pigmentation 59 | 61
abnormal sleep behavior 59 | 63
male infertility 58 | 62
decreased rib number 57 | 59
improved glucose tolerance 56 | 56
increased total body fat amoun... 55 | 57
abnormal bone mineralization 54 | 55
increased exploration in new e... 54 | 56
abnormal coat/hair pigmentatio... 53 | 54
decreased circulating alanine ... 53 | 53
increased circulating choleste... 53 | 53
decreased leukocyte cell numbe... 52 | 54
impaired glucose tolerance 52 | 52
abnormal behavioral response t... 51 | 52
decreased hemoglobin content 51 | 53
decreased prepulse inhibition 51 | 52
abnormal gait 50 | 51
increased bone mineral density 50 | 52
decreased fasted circulating g... 49 | 49
decreased mean corpuscular vol... 49 | 50
abnormal heart morphology 48 | 51
decreased caudal vertebrae num... 48 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
thrombocytopenia 44 | 46
increased circulating chloride... 43 | 43
decreased erythrocyte cell num... 41 | 43
increased body weight 41 | 42
increased rib number 41 | 41
decreased circulating alkaline... 40 | 41
decreased eosinophil cell numb... 39 | 41
abnormal eye morphology 38 | 38
decreased circulating LDL chol... 37 | 37
decreased circulating free fat... 37 | 39
decreased circulating total pr... 37 | 41
increased heart weight 37 | 37
abnormal neural tube closure 36 | 37
abnormal spleen morphology 35 | 36
cardiovascular system phenotyp... 35 | 35
increased hematocrit 35 | 36
increased leukocyte cell numbe... 35 | 37
increased startle reflex 35 | 38
small testis 35 | 37
decreased neutrophil cell numb... 34 | 37
limb grasping 34 | 35
tremors 34 | 34
decreased circulating calcium ... 33 | 33
female infertility 33 | 34
abnormal cranium morphology 32 | 32
decreased mean corpuscular hem... 32 | 34
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating chloride... 31 | 32
abnormal kidney morphology 30 | 30
decreased circulating creatini... 30 | 31
decreased threshold for audito... 30 | 32

Disease

ovarian cancer 8,136 | 8,484
osteosarcoma 7,526 | 7,933
psoriasis 6,350 | 6,685
medulloblastoma, large-cell 5,973 | 6,234
glioblastoma 5,373 | 5,572
lung cancer 4,329 | 4,466
atypical teratoid / rhabdoid tumor 4,186 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,163 | 3,289
malignant mesothelioma 3,059 | 3,162
pilocytic astrocytoma 2,988 | 3,086
Breast cancer 2,982 | 3,094
primitive neuroectodermal tumor 2,933 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,873 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,840 | 2,956
invasive ductal carcinoma 2,840 | 2,950
oligodendroglioma 2,743 | 2,849
lung carcinoma 2,730 | 2,844
non-small cell lung cancer 2,710 | 2,798
pediatric high grade glioma 2,625 | 2,712
lung adenocarcinoma 2,608 | 2,713
ependymoma 2,418 | 2,514
Cancer 2,337 | 2,346
pancreatic cancer 2,235 | 2,300
interstitial cystitis 2,201 | 2,299
subependymal giant cell astrocytoma 2,184 | 2,287
group 3 medulloblastoma 2,151 | 2,254
astrocytic glioma 2,145 | 2,241
Carcinoma 2,095 | 2,147
adult high grade glioma 2,050 | 2,148
ulcerative colitis 2,011 | 2,087
pituitary cancer 1,891 | 1,972
Pick disease 1,835 | 1,893
group 4 medulloblastoma 1,811 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,740 | 1,795
ductal carcinoma in situ 1,692 | 1,745
cystic fibrosis 1,609 | 1,665
breast carcinoma 1,575 | 1,614
diabetes mellitus 1,575 | 1,663
tuberculosis 1,482 | 1,557
medulloblastoma 1,475 | 1,524
posterior fossa group A ependymoma 1,462 | 1,511
astrocytoma 1,457 | 1,493
colon cancer 1,437 | 1,475
sonic hedgehog group medulloblastoma 1,415 | 1,482
posterior fossa group B ependymoma 1,403 | 1,530
adrenocortical carcinoma 1,371 | 1,427
Multiple myeloma 1,302 | 1,327
primary pancreatic ductal adenocarcinoma 1,234 | 1,271
juvenile dermatomyositis 1,150 | 1,189
Rheumatoid Arthritis 1,140 | 1,160
acute quadriplegic myopathy 1,126 | 1,157
atypical teratoid/rhabdoid tumor 1,056 | 1,095
cutaneous lupus erythematosus 1,019 | 1,056
spina bifida 1,012 | 1,064
nasopharyngeal carcinoma 991 | 1,056
dermatomyositis 919 | 933
Atopic dermatitis 907 | 944
active Crohn's disease 885 | 918
non primary Sjogren syndrome sicca 803 | 840
gastric carcinoma 799 | 832
primary Sjogren syndrome 760 | 789
Waldenstrons macroglobulinemia 752 | 765
acute myeloid leukemia 750 | 780
esophageal adenocarcinoma 721 | 737
tuberculosis and treatment for 6 months 660 | 686
progressive supranuclear palsy 649 | 674
aldosterone-producing adenoma 648 | 664
Alzheimer's disease 626 | 644
Obesity 606 | 616
Duchenne muscular dystrophy 589 | 602
Intellectual disability 566 | 573
pancreatic carcinoma 548 | 567
fibroadenoma 543 | 557
Down syndrome 537 | 548
Endometriosis 523 | 535
hepatocellular carcinoma 510 | 532
Schizophrenia 493 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 488 | 499
Multiple Sclerosis 482 | 498
mucosa-associated lymphoid tissue lymphoma 468 | 480
Prostatic Neoplasms 467 | 471
chronic rhinosinusitis 466 | 512
active ulcerative colitis 463 | 477
IGA Glomerulonephritis 446 | 454
Amyotrophic Lateral Sclerosis 425 | 431
gastric cancer 408 | 430
Mammary Neoplasms 407 | 410
Kidney disease 395 | 396
non-small cell lung carcinoma 394 | 413
inflammatory breast cancer 390 | 404
Neurodegenerative disease 382 | 383
Parkinson's disease 357 | 364
Epilepsy 344 | 346
Asthma 343 | 349
sarcoidosis 342 | 358
glioblastoma multiforme 337 | 347
Polycystic Ovary Syndrome 324 | 332
nephrosclerosis 322 | 329
Autistic Disorder 318 | 320
tuberculosis and treatment for 3 months 312 | 327

Tissue

Female tissues 17,551 | 18,647
Nervous System 17,464 | 18,561
Endocrine System 17,437 | 18,512
Digestive Tract 17,384 | 18,473
Urinary Tract 17,375 | 18,444
Skin and soft tissues 17,098 | 18,115
Liver and Pancreas 17,075 | 18,136
Blood and immune system 16,955 | 17,995
Cardiovascular System 16,939 | 17,958
Male tissues 16,933 | 17,969
Respiratory system 16,532 | 17,484

Target Family

Non-IDG 10,362 | 11,971
Enzyme 3,961 | 4,146
Transcription Factor 1,394 | 1,400
Kinase 622 | 634
Transporter 466 | 473
GPCR 397 | 406
oGPCR 380 | 421
Ion Channel 336 | 341
Epigenetic 235 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 38 | 38

Compartment GO Term

cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345