Development Level

Tbio 292 | 10,625
Tchem 68 | 1,890
Tclin 18 | 602
Tdark 16 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 19 | 633
preweaning lethality, incomple... 11 | 260
decreased body weight 8 | 174
abnormal behavior 7 | 226
decreased total body fat amoun... 7 | 186
abnormal retina morphology 6 | 100
decreased lean body mass 6 | 195
embryonic lethality prior to t... 5 | 187
abnormal embryo size 4 | 112
decreased circulating choleste... 4 | 85
decreased circulating glucose ... 4 | 121
decreased eosinophil cell numb... 4 | 41
improved glucose tolerance 4 | 56
increased lean body mass 4 | 107
abnormal retinal pigmentation 3 | 61
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating insulin ... 3 | 75
decreased circulating iron lev... 3 | 25
hypoactivity 3 | 89
increased blood urea nitrogen ... 3 | 44
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased circulating triglyce... 3 | 24
increased leukocyte cell numbe... 3 | 37
increased mean corpuscular vol... 3 | 91
increased or absent threshold ... 3 | 128
abnormal bone mineralization 2 | 55
abnormal head morphology 2 | 10
abnormal pericardium morpholog... 2 | 11
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
cardiovascular system phenotyp... 2 | 35
decreased NK T cell number 2 | 28
decreased basophil cell number 2 | 11
decreased circulating free fat... 2 | 39
decreased circulating fructosa... 2 | 31
decreased circulating serum al... 2 | 79
decreased fasted circulating g... 2 | 49
decreased hematocrit 2 | 25
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased startle reflex 2 | 48
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
hydrops fetalis 2 | 22
hyperactivity 2 | 108
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased heart rate 2 | 17
increased mean corpuscular hem... 2 | 93
increased vertical activity 2 | 18
shortened ST segment 2 | 9
thrombocytosis 2 | 23
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal gait 1 | 51
abnormal neural tube closure 1 | 37
abnormal response to new envir... 1 | 8
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
decreased Ly6C high monocyte n... 1 | 18
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased neutrophil cell numb... 1 | 37
decreased vertical activity 1 | 22
enlarged spleen 1 | 26
female infertility 1 | 34
increased blood uric acid leve... 1 | 5
increased body length 1 | 20
increased circulating amylase ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating glycerol... 1 | 11
increased circulating iron lev... 1 | 25
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 57
long tibia 1 | 13
polycystic kidney 1 | 9
prenatal lethality 1 | 16
short tibia 1 | 82
shortened PQ interval 1 | 6
small thymus 1 | 11
straub tail 1 | 26
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 259 | 8,484
osteosarcoma 220 | 7,933
glioblastoma 198 | 5,572
medulloblastoma, large-cell 166 | 6,234
psoriasis 159 | 6,685
Cancer 150 | 2,346
lung cancer 145 | 4,466
atypical teratoid / rhabdoid tumor 141 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 125 | 3,289
pancreatic cancer 123 | 2,300
invasive ductal carcinoma 113 | 2,950
pediatric high grade glioma 113 | 2,712
pilocytic astrocytoma 112 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 111 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 111 | 2,988
non-small cell lung cancer 106 | 2,798
lung adenocarcinoma 105 | 2,713
Breast cancer 102 | 3,094
lung carcinoma 102 | 2,844
malignant mesothelioma 97 | 3,162
oligodendroglioma 95 | 2,849
primary pancreatic ductal adenocarcinoma 92 | 1,271
primitive neuroectodermal tumor 87 | 3,031
ependymoma 86 | 2,514
astrocytoma 78 | 1,493
ulcerative colitis 76 | 2,087
Carcinoma 74 | 2,147
interstitial cystitis 72 | 2,299
juvenile dermatomyositis 72 | 1,189
diabetes mellitus 71 | 1,663
acute quadriplegic myopathy 70 | 1,157
group 4 medulloblastoma 70 | 1,875
subependymal giant cell astrocytoma 69 | 2,287
tuberculosis 66 | 1,557
astrocytic glioma 64 | 2,241
Multiple myeloma 63 | 1,327
breast carcinoma 63 | 1,614
cystic fibrosis 61 | 1,665
dermatomyositis 61 | 933
colon cancer 60 | 1,475
Pick disease 55 | 1,893
ductal carcinoma in situ 55 | 1,745
sonic hedgehog group medulloblastoma 55 | 1,482
pituitary cancer 53 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
Duchenne muscular dystrophy 50 | 602
Rheumatoid Arthritis 47 | 1,160
adrenocortical carcinoma 46 | 1,427
gastric carcinoma 46 | 832
posterior fossa group A ependymoma 46 | 1,511
Waldenstrons macroglobulinemia 45 | 765
adult high grade glioma 42 | 2,148
autosomal dominant Emery-Dreifuss muscular dystrophy 42 | 499
medulloblastoma 42 | 1,524
Prostatic Neoplasms 37 | 471
group 3 medulloblastoma 37 | 2,254
Down syndrome 35 | 548
esophageal adenocarcinoma 35 | 737
spina bifida 35 | 1,064
Alzheimer's disease 31 | 644
posterior fossa group B ependymoma 31 | 1,530
Mammary Neoplasms 29 | 410
Vascular disease 28 | 281
cutaneous lupus erythematosus 28 | 1,056
active Crohn's disease 27 | 918
fibroadenoma 27 | 557
IGA Glomerulonephritis 25 | 454
Kidney disease 25 | 396
pancreatic carcinoma 25 | 567
Neoplasm Metastasis 24 | 138
atypical teratoid/rhabdoid tumor 24 | 1,095
Neoplasm Invasiveness 23 | 127
nasopharyngeal carcinoma 23 | 1,056
Stomach Neoplasms 22 | 282
mucosa-associated lymphoid tissue lymphoma 22 | 480
tuberculosis and treatment for 6 months 22 | 686
aldosterone-producing adenoma 21 | 664
primary Sjogren syndrome 21 | 789
Becker muscular dystrophy 20 | 187
acute myeloid leukemia 20 | 780
progressive supranuclear palsy 20 | 674
Atopic dermatitis 19 | 944
Hypertension 19 | 287
hereditary spastic paraplegia 19 | 313
Mammary Neoplasms, Experimental 18 | 150
non primary Sjogren syndrome sicca 18 | 840
non-small cell lung carcinoma 18 | 413
Amyotrophic Lateral Sclerosis 17 | 431
Animal Mammary Neoplasms 17 | 136
Liver carcinoma 17 | 217
gastric cancer 17 | 430
interstitial lung disease 17 | 291
Endometriosis 16 | 535
Intellectual disability 16 | 573
Leukemia, Myelocytic, Acute 16 | 113
Squamous cell carcinoma 16 | 94
Arthritis 15 | 248
Barrett's esophagus 15 | 183
COPD 15 | 113
Renal Cell Carcinoma 15 | 199

Tissue

Blood and immune system 388 | 17,995
Cardiovascular System 388 | 17,958
Digestive Tract 388 | 18,473
Endocrine System 388 | 18,512
Female tissues 388 | 18,647
Liver and Pancreas 388 | 18,136
Male tissues 388 | 17,969
Nervous System 388 | 18,561
Urinary Tract 387 | 18,444
Respiratory system 386 | 17,484
Skin and soft tissues 385 | 18,115

Target Family

Non-IDG 277 | 11,971
Enzyme 72 | 4,146
Kinase 33 | 634
Transcription Factor 4 | 1,400
GPCR 3 | 406
Transporter 3 | 473
Epigenetic 1 | 242
Ion Channel 1 | 341

Compartment GO Term

cell-substrate adherens juncti... 394 | 394
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Neuroblast differentiation-associated protein AHNAK AHNAK Tbio Non-IDG -1.61845 51.3 82
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.66015 45.9 60
60S ribosomal protein L18 RPL18 Tbio Non-IDG -1.73537 50.7 134
Lipoma-preferred partner LPP Tbio Non-IDG -2.68601 520.6 153
Beta-1-syntrophin SNTB1 Tbio Non-IDG -1.02258 8.71 102
60S ribosomal protein L38 RPL38 Tdark Non-IDG -1.39563 24.2 45