Development Level

Tbio 284 | 11,651
Tchem 22 | 1,388
Tdark 21 | 6,593
Tclin 10 | 612

Collection

Kinase: IDG Consortium (Comple... 2 | 37
RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 20 | 979
embryonic lethality prior to t... 10 | 278
preweaning lethality, incomple... 10 | 499
abnormal retina morphology 8 | 71
decreased total body fat amoun... 8 | 207
abnormal behavior 7 | 298
decreased bone mineral content 7 | 151
decreased vertical activity 7 | 208
embryonic lethality prior to o... 7 | 239
increased or absent threshold ... 7 | 101
abnormal embryo size 6 | 220
abnormal bone structure 5 | 187
decreased body length 5 | 101
decreased grip strength 5 | 116
enlarged heart 5 | 210
hypoactivity 5 | 132
increased lean body mass 5 | 172
abnormal heart morphology 4 | 162
abnormal pericardium morpholog... 4 | 26
abnormal sleep behavior 4 | 70
decreased body weight 4 | 161
decreased fasted circulating g... 4 | 65
hyperactivity 4 | 148
improved glucose tolerance 4 | 79
increased circulating alkaline... 4 | 122
increased total body fat amoun... 4 | 134
male infertility 4 | 123
abnormal neural tube closure 3 | 46
abnormal retinal vasculature m... 3 | 27
decreased bone mineral density 3 | 126
decreased circulating insulin ... 3 | 76
decreased lean body mass 3 | 135
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
hydrometra 3 | 53
increased blood urea nitrogen ... 3 | 48
increased bone mineral content 3 | 108
increased circulating triglyce... 3 | 42
increased heart weight 3 | 62
increased startle reflex 3 | 112
tremors 3 | 39
abnormal coat appearance 2 | 31
abnormal craniofacial morpholo... 2 | 33
abnormal gait 2 | 69
abnormal heart left ventricle ... 2 | 16
abnormal tail movements 2 | 12
abnormal testis morphology 2 | 43
absent startle reflex 2 | 24
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating serum al... 2 | 82
decreased eosinophil cell numb... 2 | 24
decreased threshold for audito... 2 | 26
edema 2 | 59
embryonic growth retardation 2 | 106
enlarged uterus 2 | 11
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating chloride... 2 | 41
increased circulating sodium l... 2 | 71
increased grip strength 2 | 41
increased vertical activity 2 | 24
mammalian phenotype 2 | 17
pale yolk sac 2 | 25
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
small superior vagus ganglion 2 | 74
small testis 2 | 58
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryo turning 1 | 31
abnormal heart looping 1 | 5
abnormal lens morphology 1 | 81
abnormal neural tube morpholog... 1 | 12
abnormal optic disc morphology 1 | 10
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased body length 1 | 32
increased cardiac muscle contr... 1 | 8
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased mean corpuscular vol... 1 | 92
prenatal lethality 1 | 28

Disease

Carcinoma 242 | 11,493
ovarian cancer 201 | 8,520
osteosarcoma 169 | 7,950
psoriasis 165 | 6,694
medulloblastoma, large-cell 146 | 6,241
glioblastoma 144 | 5,792
atypical teratoid / rhabdoid tumor 136 | 5,112
ependymoma 131 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 111 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 107 | 2,989
Breast cancer 106 | 3,578
lung cancer 106 | 4,740
non-small cell lung cancer 105 | 2,890
Cancer 102 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 99 | 2,955
adult high grade glioma 98 | 3,801
lung adenocarcinoma 94 | 2,716
invasive ductal carcinoma 93 | 2,951
pancreatic cancer 91 | 2,398
interstitial cystitis 90 | 2,312
group 3 medulloblastoma 87 | 4,104
Kidney cancer 85 | 2,613
malignant mesothelioma 82 | 3,232
Astrocytoma, Pilocytic 78 | 3,081
oligodendroglioma 74 | 2,850
primitive neuroectodermal tumor 74 | 3,035
lung carcinoma 72 | 2,843
ductal carcinoma in situ 67 | 1,745
pituitary cancer 64 | 1,972
subependymal giant cell astrocytoma 63 | 2,287
astrocytic glioma 62 | 2,597
spina bifida 62 | 1,074
breast carcinoma 59 | 1,638
cystic fibrosis 59 | 1,696
ulcerative colitis 51 | 1,819
primary pancreatic ductal adenocarcinoma 50 | 1,109
group 4 medulloblastoma 47 | 1,855
diabetes mellitus 42 | 1,728
esophageal adenocarcinoma 41 | 737
colon cancer 40 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 40 | 1,962
Pick disease 39 | 1,894
tuberculosis 39 | 2,010
Autosomal recessive predisposition 37 | 1,442
Schizophrenia 37 | 1,160
adrenocortical carcinoma 33 | 1,428
Liver Cirrhosis, Experimental 32 | 769
juvenile dermatomyositis 31 | 1,187
Melanoma 30 | 711
Prostatic Neoplasms 30 | 495
pediatric high grade glioma 30 | 1,064
Skin cancer 29 | 469
acute quadriplegic myopathy 29 | 1,158
nasopharyngeal carcinoma 29 | 1,058
Atopic dermatitis 28 | 952
Intellectual disability 27 | 1,016
Kidney disease 27 | 430
Liver cancer 27 | 604
Rheumatoid arthritis 27 | 1,191
astrocytoma 27 | 1,146
gastric carcinoma 27 | 807
dermatomyositis 25 | 966
Multiple myeloma 24 | 1,332
Breast Neoplasms 23 | 445
active Crohn's disease 23 | 922
cutaneous lupus erythematosus 23 | 1,057
Hypertension 22 | 396
Mammary Neoplasms 22 | 425
Multiple Sclerosis 22 | 540
aldosterone-producing adenoma 22 | 665
Alzheimer's disease 20 | 658
Duchenne muscular dystrophy 20 | 601
Epilepsy 20 | 792
active ulcerative colitis 20 | 764
Bipolar Disorder 19 | 666
Dull intelligence 19 | 645
Low intelligence 19 | 645
Mental Retardation 19 | 645
Mental deficiency 19 | 645
Poor school performance 19 | 645
acute myeloid leukemia 19 | 783
non primary Sjogren syndrome sicca 19 | 891
Heart disease 18 | 306
Obesity 18 | 678
fibroadenoma 18 | 559
Autistic Disorder 17 | 364
Endometriosis 17 | 540
Hypertensive disease 17 | 292
autosomal dominant Emery-Dreifuss muscular dystrophy 17 | 510
interstitial lung disease 17 | 298
medulloblastoma 17 | 720
Endometrial cancer 16 | 311
Osteoporosis 16 | 363
Polycystic ovary syndrome 16 | 360
Waldenstrons macroglobulinemia 16 | 765
mucosa-associated lymphoid tissue lymphoma 16 | 484
Down syndrome 15 | 499
Neoplasm Metastasis 15 | 168
Cognitive delay 14 | 608
Global developmental delay 14 | 608

Tissue

Endocrine System 324 | 18,159
Digestive Tract 323 | 17,369
Female tissues 322 | 17,400
Urinary Tract 319 | 16,678
Skin and soft tissues 317 | 17,230
Male tissues 316 | 17,142
Blood and immune system 313 | 16,909
Nervous System 312 | 16,725
Liver and Pancreas 311 | 16,750
Respiratory system 304 | 16,393
Cardiovascular System 287 | 15,192

Target Family

Non-IDG 268 | 12,091
Enzyme 33 | 4,145
Kinase 17 | 634
Ion Channel 10 | 344
Transcription Factor 3 | 1,400
Epigenetic 2 | 242
GPCR 2 | 408
Transporter 2 | 473

Compartment GO Term

cell-cell junction 337 | 337
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Desmoglein-3 DSG3 Tbio Non-IDG -2.57795 402.0 381
Gap junction beta-6 protein GJB6 Tbio Non-IDG -2.99235 908.9 170
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Claudin-12 CLDN12 Tbio Non-IDG -1.03235 8.71 137
Claudin-8 CLDN8 Tbio Non-IDG -1.50382 29.7 184
Claudin-6 CLDN6 Tbio Non-IDG -1.76879 66.0 370
Claudin-15 CLDN15 Tbio Non-IDG -1.33932 19.3 154
Desmoglein-1 DSG1 Tbio Non-IDG -2.72159 516.2 406
Desmocollin-2 DSC2 Tbio Non-IDG -1.89689 79.7 173
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075