Development Level

Tbio 451 | 10,625
Tchem 69 | 1,890
Tdark 25 | 7,003
Tclin 12 | 602

Collection

Eligible Kinase Proteins 4 | 134
Eligible Ion Channel Proteins 2 | 117
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 22 | 633
decreased total body fat amoun... 14 | 186
decreased lean body mass 13 | 195
preweaning lethality, incomple... 12 | 260
decreased bone mineral content 10 | 157
embryonic lethality prior to t... 10 | 187
increased or absent threshold ... 10 | 128
increased lean body mass 9 | 107
abnormal behavior 8 | 226
decreased body weight 8 | 174
decreased circulating HDL chol... 8 | 77
abnormal embryo size 7 | 112
abnormal retina morphology 7 | 100
decreased circulating alanine ... 7 | 53
decreased circulating choleste... 7 | 85
abnormal sleep behavior 6 | 63
decreased circulating insulin ... 6 | 75
embryonic lethality prior to o... 6 | 148
abnormal bone structure 5 | 131
decreased grip strength 5 | 123
enlarged heart 5 | 111
improved glucose tolerance 5 | 56
increased bone mineral content 5 | 92
decreased bone mineral density 4 | 126
decreased mean corpuscular vol... 4 | 50
hyperactivity 4 | 108
increased bone mineral density 4 | 52
increased circulating alkaline... 4 | 119
increased circulating chloride... 4 | 43
increased grip strength 4 | 83
shortened RR interval 4 | 19
abnormal neural tube closure 3 | 37
abnormal pericardium morpholog... 3 | 11
abnormal retinal pigmentation 3 | 61
decreased body length 3 | 108
decreased circulating LDL chol... 3 | 37
decreased circulating triglyce... 3 | 83
decreased fasted circulating g... 3 | 49
decreased leukocyte cell numbe... 3 | 54
decreased mean corpuscular hem... 3 | 34
decreased prepulse inhibition 3 | 52
decreased startle reflex 3 | 48
decreased threshold for audito... 3 | 32
hypoactivity 3 | 89
impaired glucose tolerance 3 | 52
increased blood urea nitrogen ... 3 | 44
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased circulating phosphat... 3 | 24
increased hematocrit 3 | 36
increased total body fat amoun... 3 | 57
male infertility 3 | 62
prenatal lethality prior to he... 3 | 64
tremors 3 | 34
abnormal bone mineralization 2 | 55
abnormal craniofacial morpholo... 2 | 12
abnormal embryo turning 2 | 15
abnormal gait 2 | 51
abnormal head morphology 2 | 10
abnormal lens morphology 2 | 73
abnormal skin morphology 2 | 23
abnormal vertebrae morphology 2 | 14
absent startle reflex 2 | 15
cardiovascular system phenotyp... 2 | 35
decreased circulating alkaline... 2 | 41
decreased circulating aspartat... 2 | 27
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating free fat... 2 | 39
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased effector memory CD8-... 2 | 24
decreased eosinophil cell numb... 2 | 41
decreased lactate dehydrogenas... 2 | 14
decreased mature B cell number 2 | 25
decreased rib number 2 | 59
embryonic growth retardation 2 | 28
enlarged lymph nodes 2 | 27
hydrometra 2 | 13
immune system phenotype 2 | 17
increased body length 2 | 20
increased body weight 2 | 42
increased circulating creatini... 2 | 29
increased fasted circulating g... 2 | 68
increased red blood cell distr... 2 | 21
pale yolk sac 2 | 12
pallor 2 | 13
short tibia 2 | 82
abnormal heart morphology 1 | 51
abnormal neural tube morpholog... 1 | 8
abnormal rib morphology 1 | 28
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
absent pinna reflex 1 | 21
corneal opacity 1 | 25
impaired righting response 1 | 19
increased NK cell number 1 | 19
prenatal lethality 1 | 16

Disease

ovarian cancer 342 | 8,484
osteosarcoma 275 | 7,933
psoriasis 261 | 6,685
medulloblastoma, large-cell 234 | 6,234
glioblastoma 232 | 5,572
atypical teratoid / rhabdoid tumor 190 | 4,369
lung cancer 181 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 164 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 155 | 2,988
Cancer 147 | 2,346
lung adenocarcinoma 146 | 2,713
pancreatic cancer 144 | 2,300
Breast cancer 142 | 3,094
non-small cell lung cancer 142 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 141 | 2,956
invasive ductal carcinoma 135 | 2,950
pediatric high grade glioma 131 | 2,712
Carcinoma 127 | 2,147
malignant mesothelioma 118 | 3,162
pilocytic astrocytoma 115 | 3,086
ependymoma 110 | 2,514
oligodendroglioma 110 | 2,849
primitive neuroectodermal tumor 109 | 3,031
interstitial cystitis 108 | 2,299
lung carcinoma 98 | 2,844
subependymal giant cell astrocytoma 97 | 2,287
primary pancreatic ductal adenocarcinoma 92 | 1,271
spina bifida 91 | 1,064
ductal carcinoma in situ 89 | 1,745
group 4 medulloblastoma 87 | 1,875
astrocytic glioma 81 | 2,241
Multiple myeloma 79 | 1,327
breast carcinoma 78 | 1,614
cystic fibrosis 78 | 1,665
ulcerative colitis 77 | 2,087
astrocytoma 75 | 1,493
pituitary cancer 74 | 1,972
diabetes mellitus 69 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 69 | 1,795
Pick disease 67 | 1,893
adult high grade glioma 65 | 2,148
dermatomyositis 65 | 933
medulloblastoma 64 | 1,524
posterior fossa group A ependymoma 64 | 1,511
colon cancer 61 | 1,475
esophageal adenocarcinoma 60 | 737
acute quadriplegic myopathy 59 | 1,157
juvenile dermatomyositis 59 | 1,189
tuberculosis 58 | 1,557
Waldenstrons macroglobulinemia 57 | 765
Rheumatoid Arthritis 54 | 1,160
sonic hedgehog group medulloblastoma 54 | 1,482
adrenocortical carcinoma 51 | 1,427
group 3 medulloblastoma 47 | 2,254
gastric carcinoma 44 | 832
nasopharyngeal carcinoma 43 | 1,056
posterior fossa group B ependymoma 43 | 1,530
atypical teratoid/rhabdoid tumor 37 | 1,095
Atopic dermatitis 35 | 944
Down syndrome 35 | 548
Prostatic Neoplasms 35 | 471
active Crohn's disease 35 | 918
cutaneous lupus erythematosus 35 | 1,056
Alzheimer's disease 33 | 644
Duchenne muscular dystrophy 33 | 602
Kidney disease 31 | 396
Mammary Neoplasms 31 | 410
acute myeloid leukemia 31 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 31 | 499
aldosterone-producing adenoma 30 | 664
Amyotrophic Lateral Sclerosis 29 | 431
Obesity 29 | 616
Multiple Sclerosis 28 | 498
Schizophrenia 28 | 501
non primary Sjogren syndrome sicca 27 | 840
progressive supranuclear palsy 27 | 674
Osteoporosis 26 | 257
primary Sjogren syndrome 25 | 789
pancreatic carcinoma 24 | 567
Polycystic Ovary Syndrome 23 | 332
interstitial lung disease 23 | 291
mucosa-associated lymphoid tissue lymphoma 23 | 480
Endometriosis 22 | 535
Neurodegenerative disease 22 | 383
active ulcerative colitis 22 | 477
hereditary spastic paraplegia 22 | 313
sarcoidosis 22 | 358
Intellectual disability 21 | 573
Liver carcinoma 21 | 217
Parkinson's disease 21 | 364
fibroadenoma 21 | 557
Hypertension 20 | 287
IGA Glomerulonephritis 20 | 454
Neoplasm Invasiveness 20 | 127
Neoplasm Metastasis 20 | 138
Stomach Neoplasms 20 | 282
gastric cancer 20 | 430
Animal Mammary Neoplasms 19 | 136
Cardiomyopathy 19 | 110
Cerebrovascular disease 19 | 231

Tissue

Digestive Tract 545 | 18,473
Endocrine System 545 | 18,512
Female tissues 545 | 18,647
Liver and Pancreas 544 | 18,136
Nervous System 544 | 18,561
Urinary Tract 544 | 18,444
Blood and immune system 542 | 17,995
Cardiovascular System 542 | 17,958
Skin and soft tissues 542 | 18,115
Male tissues 540 | 17,969
Respiratory system 540 | 17,484

Target Family

Non-IDG 431 | 11,971
Enzyme 71 | 4,146
Kinase 30 | 634
Ion Channel 9 | 341
Transcription Factor 5 | 1,400
Transporter 5 | 473
Epigenetic 3 | 242
GPCR 3 | 406

Compartment GO Term

cell-cell junction 557 | 557
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139
Keratin, type II cytoskeletal 74 KRT74 Tbio Non-IDG -2.22050 159.7 35
Receptor-type tyrosine-protein phosphatase eta PTPRJ Tbio Enzyme -1.94494 110.6 235
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
Fatty acid synthase FASN Tchem Enzyme -2.49948 348.5 388
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Striatin STRN Tbio Non-IDG -1.63637 51.0 118
Emerin EMD Tbio Non-IDG -2.77469 617.6 238