Development Level

Tbio 260 | 10,625
Tchem 44 | 1,890
Tdark 7 | 7,003
Tclin 4 | 602

Collection

Eligible Kinase Proteins 3 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 14 | 633
decreased lean body mass 9 | 195
preweaning lethality, incomple... 8 | 260
decreased total body fat amoun... 7 | 186
abnormal embryo size 6 | 112
decreased circulating HDL chol... 6 | 77
increased lean body mass 6 | 107
increased or absent threshold ... 6 | 128
decreased body weight 5 | 174
decreased circulating alanine ... 5 | 53
decreased bone mineral content 4 | 157
decreased circulating choleste... 4 | 85
decreased mean corpuscular vol... 4 | 50
embryonic lethality prior to t... 4 | 187
improved glucose tolerance 4 | 56
abnormal behavior 3 | 226
abnormal retina morphology 3 | 100
abnormal sleep behavior 3 | 63
decreased circulating LDL chol... 3 | 37
decreased fasted circulating g... 3 | 49
decreased mean corpuscular hem... 3 | 34
embryonic lethality prior to o... 3 | 148
impaired glucose tolerance 3 | 52
increased bone mineral density 3 | 52
abnormal bone structure 2 | 131
abnormal craniofacial morpholo... 2 | 12
abnormal head morphology 2 | 10
abnormal neural tube closure 2 | 37
abnormal pericardium morpholog... 2 | 11
abnormal vertebrae morphology 2 | 14
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 41
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased lactate dehydrogenas... 2 | 14
decreased leukocyte cell numbe... 2 | 54
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
increased body length 2 | 20
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating chloride... 2 | 43
increased circulating phosphat... 2 | 24
increased fasted circulating g... 2 | 68
increased grip strength 2 | 83
increased hematocrit 2 | 36
prenatal lethality prior to he... 2 | 64
short tibia 2 | 82
shortened RR interval 2 | 19
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal lens morphology 1 | 73
abnormal optic disc morphology 1 | 10
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal tail movements 1 | 12
absent pinna reflex 1 | 21
absent teeth 1 | 4
craniofacial phenotype 1 | 9
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased circulating bilirubi... 1 | 14
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased rib number 1 | 59
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
female infertility 1 | 34
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased circulating amylase ... 1 | 13
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased erythrocyte cell num... 1 | 26
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 25
increased total body fat amoun... 1 | 57
prenatal lethality 1 | 16
shortened ST segment 1 | 9
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 201 | 8,484
osteosarcoma 161 | 7,933
psoriasis 146 | 6,685
glioblastoma 138 | 5,572
medulloblastoma, large-cell 129 | 6,234
lung cancer 119 | 4,466
atypical teratoid / rhabdoid tumor 112 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 92 | 3,289
pancreatic cancer 86 | 2,300
Cancer 84 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 80 | 2,988
lung adenocarcinoma 77 | 2,713
Breast cancer 76 | 3,094
pediatric high grade glioma 72 | 2,712
Carcinoma 70 | 2,147
invasive ductal carcinoma 70 | 2,950
non-small cell lung cancer 70 | 2,798
ependymoma 69 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 68 | 2,956
malignant mesothelioma 65 | 3,162
Multiple myeloma 62 | 1,327
oligodendroglioma 60 | 2,849
pilocytic astrocytoma 59 | 3,086
subependymal giant cell astrocytoma 58 | 2,287
primitive neuroectodermal tumor 57 | 3,031
primary pancreatic ductal adenocarcinoma 55 | 1,271
spina bifida 53 | 1,064
astrocytoma 51 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
group 4 medulloblastoma 50 | 1,875
Waldenstrons macroglobulinemia 49 | 765
dermatomyositis 48 | 933
interstitial cystitis 48 | 2,299
astrocytic glioma 45 | 2,241
lung carcinoma 45 | 2,844
acute quadriplegic myopathy 42 | 1,157
diabetes mellitus 41 | 1,663
ductal carcinoma in situ 41 | 1,745
breast carcinoma 39 | 1,614
Pick disease 38 | 1,893
pituitary cancer 38 | 1,972
juvenile dermatomyositis 37 | 1,189
sonic hedgehog group medulloblastoma 36 | 1,482
tuberculosis 36 | 1,557
Rheumatoid Arthritis 35 | 1,160
adult high grade glioma 35 | 2,148
esophageal adenocarcinoma 33 | 737
medulloblastoma 33 | 1,524
posterior fossa group A ependymoma 32 | 1,511
ulcerative colitis 32 | 2,087
colon cancer 31 | 1,475
cystic fibrosis 30 | 1,665
adrenocortical carcinoma 27 | 1,427
group 3 medulloblastoma 26 | 2,254
nasopharyngeal carcinoma 24 | 1,056
Down syndrome 22 | 548
gastric carcinoma 22 | 832
cutaneous lupus erythematosus 21 | 1,056
Alzheimer's disease 20 | 644
Amyotrophic Lateral Sclerosis 20 | 431
Duchenne muscular dystrophy 20 | 602
acute myeloid leukemia 20 | 780
posterior fossa group B ependymoma 20 | 1,530
Osteoporosis 19 | 257
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 499
atypical teratoid/rhabdoid tumor 17 | 1,095
hereditary spastic paraplegia 17 | 313
tuberculosis and treatment for 6 months 17 | 686
Mammary Neoplasms 16 | 410
non primary Sjogren syndrome sicca 16 | 840
progressive supranuclear palsy 16 | 674
Neurodegenerative disease 15 | 383
Liver carcinoma 14 | 217
Schizophrenia 14 | 501
active Crohn's disease 14 | 918
active ulcerative colitis 14 | 477
aldosterone-producing adenoma 14 | 664
primary Sjogren syndrome 14 | 789
Atopic dermatitis 13 | 944
IGA Glomerulonephritis 13 | 454
Intellectual disability 13 | 573
Neoplasm Invasiveness 13 | 127
Parkinson's disease 13 | 364
Prostatic Neoplasms 13 | 471
mucosa-associated lymphoid tissue lymphoma 13 | 480
Animal Mammary Neoplasms 12 | 136
Cardiomyopathy 12 | 110
Obesity 12 | 616
gastric cancer 12 | 430
pancreatic carcinoma 12 | 567
Mammary Neoplasms, Experimental 11 | 150
Neoplasm Metastasis 11 | 138
Stomach Neoplasms 11 | 282
Disease Progression 10 | 125
Squamous cell carcinoma of esophagus 10 | 82
non-small cell lung carcinoma 10 | 413
Becker muscular dystrophy 9 | 187
Vascular disease 9 | 281
fibroadenoma 9 | 557
hepatocellular carcinoma 9 | 532

Tissue

Blood and immune system 310 | 17,995
Cardiovascular System 310 | 17,958
Digestive Tract 310 | 18,473
Endocrine System 310 | 18,512
Female tissues 310 | 18,647
Liver and Pancreas 310 | 18,136
Male tissues 310 | 17,969
Nervous System 310 | 18,561
Respiratory system 310 | 17,484
Urinary Tract 310 | 18,444
Skin and soft tissues 309 | 18,115

Target Family

Non-IDG 246 | 11,971
Enzyme 45 | 4,146
Kinase 16 | 634
Transporter 3 | 473
Transcription Factor 2 | 1,400
Epigenetic 1 | 242
GPCR 1 | 406
Ion Channel 1 | 341

Compartment GO Term

cell-cell adherens junction 315 | 315
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
Fatty acid synthase FASN Tchem Enzyme -2.49948 348.5 388
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Emerin EMD Tbio Non-IDG -2.77469 617.6 238
Neuroblast differentiation-associated protein AHNAK AHNAK Tbio Non-IDG -1.61845 51.3 82
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.66015 45.9 60
Golgin subfamily A member 2 GOLGA2 Tbio Non-IDG -1.94177 80.5 168