Development Level

Tbio 26 | 11,445
Tchem 6 | 1,598
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal incisor morphology 1 | 4
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal vertebral arch morpho... 1 | 9
cataract 1 | 92
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased kidney weight 1 | 1
decreased leukocyte cell numbe... 1 | 73
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged heart 1 | 210
female infertility 1 | 60
fusion of vertebral arches 1 | 7
increased anti-nuclear antigen... 1 | 19
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating creatine... 1 | 5
increased circulating potassiu... 1 | 29
increased grip strength 1 | 41
increased heart rate 1 | 23
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased vertical activity 1 | 24
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
shortened RR interval 1 | 17
thrombocytopenia 1 | 56
vertebral transformation 1 | 12

Disease

Carcinoma 24 | 11,493
ovarian cancer 24 | 8,520
osteosarcoma 16 | 7,950
psoriasis 12 | 6,694
Cancer 11 | 2,499
Pick disease 10 | 1,894
glioblastoma 9 | 5,792
group 3 medulloblastoma 9 | 4,104
lung cancer 9 | 4,740
malignant mesothelioma 9 | 3,232
medulloblastoma, large-cell 9 | 6,241
Cockayne syndrome 8 | 60
Photosensitive trichothiodystrophy 8 | 30
ependymoma 8 | 4,679
Breast cancer 7 | 3,578
Intellectual disability 7 | 1,016
astrocytic glioma 7 | 2,597
Kidney cancer 6 | 2,613
Xeroderma pigmentosum 6 | 43
oligodendroglioma 6 | 2,850
Xeroderma pigmentosum group B 5 | 20
adult high grade glioma 5 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
pancreatic cancer 5 | 2,398
Autosomal recessive predisposition 4 | 1,442
Dull intelligence 4 | 645
Leukemia 4 | 104
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Poor school performance 4 | 645
Rheumatoid arthritis 4 | 1,191
Xeroderma pigmentosum group D 4 | 33
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
astrocytoma 4 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
juvenile dermatomyositis 4 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primitive neuroectodermal tumor 4 | 3,035
progressive supranuclear palsy 4 | 676
Acquired immunodeficiency syndrome 3 | 197
Cryptorchidism 3 | 296
Short stature 3 | 531
Small head 3 | 374
Xeroderma pigmentosum group G 3 | 16
adrenocortical carcinoma 3 | 1,428
atypical teratoid / rhabdoid tumor 3 | 5,112
dermatomyositis 3 | 966
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
lung adenocarcinoma 3 | 2,716
non-small cell lung cancer 3 | 2,890
pancreatic carcinoma 3 | 562
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
ulcerative colitis 3 | 1,819
Arthralgia 2 | 90
Congenital deafness 2 | 185
Conjunctival telangiectasis 2 | 14
Deafness 2 | 198
Developmental regression 2 | 95
Electroencephalogram abnormal 2 | 101
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Fatigue 2 | 182
Fever 2 | 138
Gaucher disease type 1 2 | 180
Hearing Loss, Partial 2 | 185
Impaired cognition 2 | 96
Keratitis 2 | 62
Loss of developmental milestones 2 | 95
Melanoma 2 | 711
Mental deterioration in childhood 2 | 95
Mental impairment 2 | 95
Muscle Spasticity 2 | 195
Neurodevelopmental regression 2 | 95
Pediatric failure to thrive 2 | 365
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Retinal Diseases 2 | 55
Seizures 2 | 596
Sensorineural Hearing Loss (disorder) 2 | 284
Strabismus 2 | 270
Thin skin 2 | 47
Waldenstrons macroglobulinemia 2 | 765
aldosterone-producing adenoma 2 | 665
chronic lymphosyte leukemia 2 | 204
hearing impairment 2 | 199
hepatocellular carcinoma 2 | 547
interstitial lung disease 2 | 298
nasopharyngeal carcinoma 2 | 1,058
pediatric high grade glioma 2 | 1,064
sonic hedgehog group medulloblastoma 2 | 467
spina bifida 2 | 1,074
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 33 | 16,909
Cardiovascular System 33 | 15,192
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Nervous System 33 | 16,725
Respiratory system 33 | 16,393
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678

Target Family

Non-IDG 20 | 12,091
Enzyme 5 | 4,145
Kinase 4 | 634
Transcription Factor 3 | 1,400
Epigenetic 1 | 242

Compartment GO Term

carboxy-terminal domain protei... 33 | 33
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 970 | 970
Neuron part 969 | 969
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 950 | 950
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 711 | 711
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RNA-binding protein 8A RBM8A Tbio Non-IDG -3.16448 1415.1 94
Protein AF-9 MLLT3 Tbio Non-IDG -1.99555 93.8 210
AF4/FMR2 family member 3 AFF3 Tbio Transcription Factor -1.37981 25.3 50
AF4/FMR2 family member 1 AFF1 Tbio Transcription Factor -2.60388 403.1 201
Cyclin-dependent kinase 12 CDK12 Tchem Kinase -1.38476 29.4 157
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.32757 20.2 148
HIV Tat-specific factor 1 HTATSF1 Tbio Non-IDG -1.13052 11.7 211
Transcription elongation factor SPT5 SUPT5H Tbio Non-IDG -1.92374 80.5 135
Protein ENL MLLT1 Tbio Non-IDG -2.46931 301.2 119
La-related protein 7 LARP7 Tbio Non-IDG -1.37179 13.8 144