Development Level

Tbio 72 | 11,651
Tclin 8 | 612
Tdark 8 | 6,593
Tchem 7 | 1,388

Collection

Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal bone structure 3 | 187
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal tail morphology 2 | 25
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased neutrophil cell numb... 2 | 42
decreased vertical activity 2 | 208
edema 2 | 59
embryonic lethality prior to t... 2 | 278
hypoactivity 2 | 132
increased body weight 2 | 25
increased heart weight 2 | 62
increased startle reflex 2 | 112
abnormal bone mineralization 1 | 38
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal limb morphology 1 | 13
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal urinary bladder morph... 1 | 11
abnormal vocalization 1 | 21
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
cyanosis 1 | 7
decreased NK cell number 1 | 2
decreased T cell number 1 | 15
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased heart left ventricle... 1 | 28
decreased heart rate variabili... 1 | 13
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased red blood cell distr... 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased mean corpuscular vol... 1 | 92
increased vertical activity 1 | 24
male infertility 1 | 123
respiratory system phenotype 1 | 2
short tibia 1 | 97
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
shortened ST segment 1 | 10
syndactyly 1 | 23
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 75 | 11,493
ovarian cancer 50 | 8,520
psoriasis 44 | 6,694
glioblastoma 41 | 5,792
atypical teratoid / rhabdoid tumor 39 | 5,112
medulloblastoma, large-cell 39 | 6,241
lung cancer 38 | 4,740
Breast cancer 32 | 3,578
ependymoma 31 | 4,679
lung adenocarcinoma 31 | 2,716
osteosarcoma 31 | 7,950
Kidney cancer 29 | 2,613
pancreatic cancer 29 | 2,398
adult high grade glioma 28 | 3,801
colon cancer 28 | 1,478
invasive ductal carcinoma 28 | 2,951
non-small cell lung cancer 27 | 2,890
lung carcinoma 26 | 2,843
malignant mesothelioma 25 | 3,232
primitive neuroectodermal tumor 25 | 3,035
group 3 medulloblastoma 24 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
Astrocytoma, Pilocytic 22 | 3,081
Cardiomyopathy 22 | 116
Myopathy 21 | 185
acute quadriplegic myopathy 21 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
oligodendroglioma 21 | 2,850
Autosomal recessive predisposition 20 | 1,442
Dilated cardiomyopathy 18 | 56
astrocytic glioma 18 | 2,597
Liver cancer 17 | 604
breast carcinoma 17 | 1,638
Familial isolated dilated cardiomyopathy 16 | 41
LEFT VENTRICULAR NONCOMPACTION 10 16 | 40
LEFT VENTRICULAR NONCOMPACTION 8 16 | 40
ductal carcinoma in situ 16 | 1,745
Cardiomyopathy, Dilated 15 | 83
subependymal giant cell astrocytoma 15 | 2,287
tuberculosis 15 | 2,010
Hypertrophic Cardiomyopathy 14 | 117
Pick disease 14 | 1,894
group 4 medulloblastoma 14 | 1,855
pituitary cancer 14 | 1,972
Creatine phosphokinase serum increased 13 | 110
Elevated creatine kinase 13 | 110
Endometrial cancer 13 | 311
Heart disease 12 | 306
Muscular dystrophy 12 | 75
adrenocortical carcinoma 12 | 1,428
cystic fibrosis 12 | 1,696
Atrial Fibrillation 11 | 124
Muscle biopsy shows dystrophic changes 11 | 39
Skin cancer 11 | 469
astrocytoma 11 | 1,146
spina bifida 11 | 1,074
ulcerative colitis 11 | 1,819
Melanoma 10 | 711
active ulcerative colitis 10 | 764
Duchenne muscular dystrophy 9 | 601
Epilepsy 9 | 792
active Crohn's disease 9 | 922
dermatomyositis 9 | 966
juvenile dermatomyositis 9 | 1,187
primary pancreatic ductal adenocarcinoma 9 | 1,109
Atopic dermatitis 8 | 952
Bipolar Disorder 8 | 666
Cancer 8 | 2,499
Cardiac Arrhythmia 8 | 103
Cardiomyopathies 8 | 110
EMG: myopathic abnormalities 8 | 22
Intellectual disability 8 | 1,016
Seizures 8 | 596
Syncope 8 | 22
limb-girdle muscular dystrophy 8 | 37
nasopharyngeal carcinoma 8 | 1,058
pediatric high grade glioma 8 | 1,064
Acquired scoliosis 7 | 281
Bell Palsy 7 | 58
Contracture 7 | 96
Contracture of joint 7 | 93
Curvature of spine 7 | 282
Dull intelligence 7 | 645
Facial Paresis 7 | 59
Facial muscle weakness of muscles innervated by CN VII 7 | 58
Flexion contracture 7 | 93
Flexion contractures of joints 7 | 93
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Motor delay 7 | 147
No development of motor milestones 7 | 147
Poor school performance 7 | 645
Slow progression 7 | 89
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
cutaneous lupus erythematosus 7 | 1,057
hereditary spastic paraplegia 7 | 318
interstitial cystitis 7 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962

Tissue

Endocrine System 95 | 18,159
Female tissues 95 | 17,400
Digestive Tract 94 | 17,369
Urinary Tract 93 | 16,678
Blood and immune system 92 | 16,909
Liver and Pancreas 92 | 16,750
Male tissues 92 | 17,142
Nervous System 92 | 16,725
Skin and soft tissues 92 | 17,230
Cardiovascular System 89 | 15,192
Respiratory system 89 | 16,393

Target Family

Non-IDG 66 | 12,091
Enzyme 13 | 4,145
Ion Channel 9 | 344
Kinase 3 | 634
Transporter 3 | 473
Epigenetic 1 | 242

Compartment GO Term

Z disc 95 | 95
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,108 | 14,108
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,783 | 8,783
Membrane 8,530 | 8,530
Nucleus 7,563 | 7,563
Cytosol 6,686 | 6,686
Membrane part 6,553 | 6,553
Plasma membrane 5,829 | 5,829
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,457 | 5,457
Cell periphery 5,381 | 5,381
Integral component of membrane 5,330 | 5,330
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,974 | 3,974
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,673 | 3,673
Organelle membrane 2,846 | 2,846
Extracellular region 2,731 | 2,731
Plasma membrane part 2,593 | 2,593
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,216 | 2,216
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,638 | 1,638
Extracellular region part 1,627 | 1,627
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 968 | 968
Supramolecular complex 967 | 967
Cell junction 960 | 960
Supramolecular fiber 960 | 960
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 927 | 927
Chromosomal part 889 | 889
GO:0098796 883 | 883
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 849 | 849
Cell surface 841 | 841
Plasma membrane region 841 | 841
Vesicle membrane 800 | 800
Cytoplasmic vesicle membrane 794 | 794
Polymeric cytoskeletal fiber 765 | 765
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 713 | 713
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Potassium voltage-gated channel subfamily E member 1 KCNE1 Tbio Ion Channel -2.67495 441.7 193
Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D Tclin Ion Channel -2.43448 273.2 215
Tropomodulin-4 TMOD4 Tbio Non-IDG -1.94209 70.0 114
Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C Tclin Ion Channel -2.75188 537.5 330
F-box and leucine-rich protein 22 FBXL22 Tdark Non-IDG 0.29 0.26 33
Protein AHNAK2 AHNAK2 Tbio Non-IDG -0.78071 6.06 78
Myosin-binding protein C, slow-type MYBPC1 Tbio Non-IDG -1.29409 20.0 185
Myosin-binding protein C, cardiac-type MYBPC3 Tbio Non-IDG -2.45618 287.6 139
Alpha-parvin PARVA Tbio Non-IDG -2.38332 236.6 0