Development Level

Tbio 937 | 10,625
Tchem 181 | 1,890
Tdark 139 | 7,003
Tclin 63 | 602

Collection

Eligible Ion Channel Proteins 8 | 117
Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, complete... 58 | 633
abnormal behavior 27 | 226
decreased body weight 26 | 174
decreased total body fat amoun... 26 | 186
embryonic lethality prior to t... 20 | 187
decreased lean body mass 19 | 195
decreased grip strength 18 | 123
hypoactivity 18 | 89
increased mean corpuscular hem... 17 | 93
preweaning lethality, incomple... 17 | 260
decreased bone mineral content 15 | 157
decreased circulating HDL chol... 15 | 77
abnormal bone structure 14 | 131
decreased body length 14 | 108
decreased circulating choleste... 13 | 85
increased or absent threshold ... 13 | 128
decreased bone mineral density 12 | 126
decreased mean corpuscular vol... 12 | 50
embryonic lethality prior to o... 12 | 148
increased circulating alkaline... 12 | 119
abnormal lens morphology 10 | 73
abnormal sleep behavior 10 | 63
increased bone mineral content 10 | 92
increased circulating sodium l... 10 | 71
abnormal retinal pigmentation 9 | 61
decreased circulating glucose ... 9 | 121
decreased circulating triglyce... 9 | 83
decreased heart weight 9 | 44
decreased mean corpuscular hem... 9 | 34
decreased prepulse inhibition 9 | 52
hyperactivity 9 | 108
increased body weight 9 | 42
increased lean body mass 9 | 107
cardiovascular system phenotyp... 8 | 35
decreased circulating LDL chol... 8 | 37
decreased hemoglobin content 8 | 53
increased bone mineral density 8 | 52
short tibia 8 | 82
abnormal retina morphology 7 | 100
decreased circulating serum al... 7 | 79
decreased rib number 7 | 59
increased blood urea nitrogen ... 7 | 44
increased fasted circulating g... 7 | 68
increased mean corpuscular vol... 7 | 91
abnormal bone mineralization 6 | 55
abnormal embryo size 6 | 112
abnormal kidney morphology 6 | 30
abnormal limb bud morphology 6 | 15
decreased mean corpuscular hem... 6 | 19
decreased vertical activity 6 | 22
enlarged heart 6 | 111
impaired glucose tolerance 6 | 52
improved glucose tolerance 6 | 56
increased circulating chloride... 6 | 43
increased circulating potassiu... 6 | 31
increased grip strength 6 | 83
increased leukocyte cell numbe... 6 | 37
increased sacral vertebrae num... 6 | 62
thrombocytopenia 6 | 46
thrombocytosis 6 | 23
decreased circulating amylase ... 5 | 24
decreased circulating free fat... 5 | 39
decreased circulating insulin ... 5 | 75
decreased eosinophil cell numb... 5 | 41
decreased erythrocyte cell num... 5 | 43
decreased lumbar vertebrae num... 5 | 62
male infertility 5 | 62
persistence of hyaloid vascula... 5 | 22
abnormal behavioral response t... 4 | 52
abnormal body wall morphology 4 | 7
abnormal coat/hair pigmentatio... 4 | 54
abnormal epididymis morphology 4 | 31
abnormal eye morphology 4 | 38
abnormal eye size 4 | 11
abnormal femur morphology 4 | 14
abnormal tibia morphology 4 | 14
abnormal vertebrae morphology 4 | 14
cataract 4 | 26
corneal opacity 4 | 25
decreased blood urea nitrogen ... 4 | 31
decreased caudal vertebrae num... 4 | 49
decreased circulating calcium ... 4 | 33
decreased leukocyte cell numbe... 4 | 54
decreased total retina thickne... 4 | 20
edema 4 | 11
hemorrhage 4 | 12
increased circulating HDL chol... 4 | 63
increased circulating LDL chol... 4 | 15
increased circulating choleste... 4 | 53
increased circulating serum al... 4 | 25
increased erythrocyte cell num... 4 | 26
increased heart weight 4 | 37
increased hemoglobin content 4 | 45
increased rib number 4 | 41
increased startle reflex 4 | 38
increased total body fat amoun... 4 | 57
limb grasping 4 | 35
polydactyly 4 | 22
prenatal lethality prior to he... 4 | 64
decreased heart rate variabili... 3 | 11

Disease

ovarian cancer 741 | 8,492
osteosarcoma 592 | 7,933
psoriasis 533 | 6,685
medulloblastoma, large-cell 528 | 6,234
glioblastoma 501 | 5,572
lung cancer 374 | 4,473
atypical teratoid / rhabdoid tumor 367 | 4,369
Cancer 318 | 2,346
pilocytic astrocytoma 295 | 3,086
lung carcinoma 278 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 274 | 3,289
invasive ductal carcinoma 270 | 2,950
pediatric high grade glioma 258 | 2,712
oligodendroglioma 257 | 2,849
malignant mesothelioma 251 | 3,163
intraductal papillary-mucinous adenoma (IPMA) 238 | 2,956
diabetes mellitus 235 | 1,663
Breast cancer 229 | 3,099
intraductal papillary-mucinous carcinoma (IPMC) 228 | 2,988
pancreatic cancer 225 | 2,300
subependymal giant cell astrocytoma 225 | 2,287
primitive neuroectodermal tumor 220 | 3,031
non-small cell lung cancer 219 | 2,798
ependymoma 210 | 2,514
lung adenocarcinoma 209 | 2,714
Pick disease 196 | 1,893
astrocytic glioma 192 | 2,241
interstitial cystitis 187 | 2,299
ulcerative colitis 185 | 2,087
astrocytoma 182 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 163 | 1,795
Carcinoma 160 | 2,147
tuberculosis 160 | 1,563
group 4 medulloblastoma 158 | 1,875
adult high grade glioma 154 | 2,148
Rheumatoid Arthritis 153 | 1,171
dermatomyositis 153 | 967
Multiple myeloma 152 | 1,328
pituitary cancer 152 | 1,972
posterior fossa group A ependymoma 143 | 1,511
ductal carcinoma in situ 142 | 1,745
breast carcinoma 141 | 1,614
primary pancreatic ductal adenocarcinoma 141 | 1,271
cystic fibrosis 136 | 1,670
juvenile dermatomyositis 132 | 1,189
group 3 medulloblastoma 125 | 2,254
medulloblastoma 122 | 1,524
acute quadriplegic myopathy 119 | 1,157
colon cancer 118 | 1,475
cutaneous lupus erythematosus 117 | 1,056
sonic hedgehog group medulloblastoma 114 | 1,482
adrenocortical carcinoma 111 | 1,427
Alzheimer's disease 103 | 644
posterior fossa group B ependymoma 102 | 1,530
Hypersensitivity reaction type II disease 91 | 235
primary Sjogren syndrome 91 | 789
gastric carcinoma 89 | 832
spina bifida 89 | 1,064
Arthritis 88 | 248
Neurodegenerative disease 86 | 383
esophageal adenocarcinoma 85 | 737
active Crohn's disease 84 | 918
atypical teratoid/rhabdoid tumor 83 | 1,095
Waldenstrons macroglobulinemia 80 | 765
Ankylosing spondylitis 79 | 138
Multiple Sclerosis 78 | 498
Kidney disease 76 | 397
Obesity 72 | 616
Duchenne muscular dystrophy 70 | 602
Schizophrenia 69 | 503
aldosterone-producing adenoma 69 | 664
Acquired immunodeficiency syndrome 68 | 164
Down syndrome 67 | 548
Uveitis 65 | 103
Juvenile rheumatoid arthritis 64 | 105
mucosa-associated lymphoid tissue lymphoma 64 | 480
Human immunodeficiency virus infectious disease 62 | 129
Parkinson's disease 62 | 364
progressive supranuclear palsy 60 | 674
Atopic dermatitis 59 | 944
IGA Glomerulonephritis 58 | 454
Behcet's disease 57 | 74
fibroadenoma 57 | 557
Stevens-Johnson syndrome 56 | 91
Psoriatic arthritis 55 | 85
non primary Sjogren syndrome sicca 55 | 840
pancreatic carcinoma 55 | 567
nasopharyngeal carcinoma 54 | 1,056
Anemia 53 | 252
Prostatic Neoplasms 53 | 471
acute myeloid leukemia 53 | 785
Liver disease 51 | 219
autosomal dominant Emery-Dreifuss muscular dystrophy 51 | 499
hereditary spastic paraplegia 48 | 313
tuberculosis and treatment for 6 months 48 | 686
Epilepsy 47 | 346
active ulcerative colitis 47 | 477
Dermatitis 46 | 141
Hypertension 46 | 293
Intellectual disability 45 | 573

Tissue

Nervous System 1,241 | 18,561
Digestive Tract 1,239 | 18,473
Liver and Pancreas 1,238 | 18,136
Endocrine System 1,237 | 18,512
Female tissues 1,237 | 18,647
Urinary Tract 1,236 | 18,444
Cardiovascular System 1,233 | 17,958
Blood and immune system 1,230 | 17,995
Male tissues 1,229 | 17,969
Respiratory system 1,222 | 17,484
Skin and soft tissues 1,220 | 18,115

Target Family

Non-IDG 846 | 11,969
Enzyme 268 | 4,146
Kinase 68 | 634
Transporter 67 | 473
Ion Channel 40 | 341
GPCR 17 | 408
Transcription Factor 8 | 1,400
Epigenetic 5 | 242
Nuclear Receptor 1 | 48

Compartment GO Term

Whole membrane 1,320 | 1,320
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
MARVEL domain-containing protein 1 MARVELD1 Tbio Non-IDG -1.56013 36.2 57
Syncollin SYCN Tdark Non-IDG -2.12341 132.9 35
Vasorin VASN Tbio Non-IDG -1.19472 15.7 108
Lipopolysaccharide-induced tumor necrosis factor-alpha factor LITAF Tbio Transcription Factor -2.00894 100.6 155
AP-5 complex subunit sigma-1 AP5S1 Tdark Non-IDG 0.00000 2
Lateral signaling target protein 2 homolog ZFYVE28 Tbio Non-IDG 0.38 0.33 63