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Target Filters...

Development Level

Tbio 2,532 | 10,625
Tchem 571 | 1,890
Tdark 401 | 7,003
Tclin 163 | 602

Collection

Eligible Ion Channel Proteins 19 | 117
Eligible Kinase Proteins 12 | 134
Eligible non-olfactory GPCR Proteins 7 | 145

IMPC Term

preweaning lethality, complete... 141 | 633
abnormal behavior 62 | 226
preweaning lethality, incomple... 52 | 260
decreased lean body mass 50 | 195
decreased total body fat amoun... 48 | 186
embryonic lethality prior to t... 47 | 187
decreased grip strength 41 | 123
decreased bone mineral content 39 | 157
increased or absent threshold ... 37 | 128
embryonic lethality prior to o... 34 | 148
increased circulating alkaline... 34 | 119
abnormal bone structure 32 | 131
decreased body weight 32 | 174
abnormal embryo size 30 | 112
enlarged heart 30 | 111
decreased body length 28 | 108
decreased bone mineral density 27 | 126
short tibia 27 | 82
hypoactivity 26 | 89
abnormal retina morphology 24 | 100
hyperactivity 24 | 108
increased mean corpuscular hem... 24 | 93
increased mean corpuscular vol... 24 | 91
abnormal lens morphology 23 | 73
decreased circulating HDL chol... 23 | 77
decreased circulating glucose ... 23 | 121
decreased circulating insulin ... 23 | 75
decreased circulating choleste... 22 | 85
increased lean body mass 21 | 107
impaired glucose tolerance 20 | 52
increased grip strength 20 | 83
increased bone mineral content 19 | 92
decreased circulating serum al... 18 | 79
decreased mean corpuscular vol... 18 | 50
abnormal retinal pigmentation 16 | 61
decreased circulating triglyce... 16 | 83
decreased leukocyte cell numbe... 16 | 54
increased circulating sodium l... 16 | 71
increased fasted circulating g... 16 | 68
abnormal bone mineralization 15 | 55
decreased fasted circulating g... 15 | 49
decreased hemoglobin content 15 | 53
improved glucose tolerance 15 | 56
abnormal seminal vesicle morph... 14 | 47
decreased mean corpuscular hem... 14 | 34
decreased startle reflex 14 | 48
increased blood urea nitrogen ... 14 | 44
increased exploration in new e... 14 | 56
decreased circulating alkaline... 13 | 41
decreased heart weight 13 | 44
decreased prepulse inhibition 13 | 52
increased circulating chloride... 13 | 43
male infertility 13 | 62
prenatal lethality prior to he... 13 | 64
abnormal neural tube closure 12 | 37
cardiovascular system phenotyp... 12 | 35
increased bone mineral density 12 | 52
increased total body fat amoun... 12 | 57
thrombocytopenia 12 | 46
abnormal coat/hair pigmentatio... 11 | 54
abnormal sleep behavior 11 | 63
decreased circulating LDL chol... 11 | 37
decreased circulating alanine ... 11 | 53
decreased eosinophil cell numb... 11 | 41
decreased erythrocyte cell num... 11 | 43
decreased lumbar vertebrae num... 11 | 62
increased sacral vertebrae num... 11 | 62
tremors 11 | 34
abnormal QRS complex 10 | 25
abnormal kidney morphology 10 | 30
cataract 10 | 26
decreased threshold for audito... 10 | 32
enlarged epididymis 10 | 27
increased hematocrit 10 | 36
increased leukocyte cell numbe... 10 | 37
abnormal epididymis morphology 9 | 31
abnormal eye morphology 9 | 38
abnormal heart morphology 9 | 51
decreased caudal vertebrae num... 9 | 49
decreased circulating total pr... 9 | 41
decreased rib number 9 | 59
increased body weight 9 | 42
increased circulating HDL chol... 9 | 63
increased hemoglobin content 9 | 45
abnormal behavioral response t... 8 | 52
abnormal cranium morphology 8 | 32
abnormal skin morphology 8 | 23
corneal opacity 8 | 25
decreased circulating free fat... 8 | 39
decreased circulating fructosa... 8 | 31
increased heart weight 8 | 37
increased red blood cell distr... 8 | 21
small testis 8 | 37
abnormal coat appearance 7 | 25
abnormal cornea morphology 7 | 24
abnormal gait 7 | 51
decreased neutrophil cell numb... 7 | 37
decreased vertical activity 7 | 22
increased circulating potassiu... 7 | 31
increased prepulse inhibition 7 | 21

Disease

ovarian cancer 1,976 | 8,492
osteosarcoma 1,587 | 7,933
psoriasis 1,553 | 6,685
glioblastoma 1,306 | 5,572
medulloblastoma, large-cell 1,296 | 6,234
lung cancer 1,157 | 4,473
atypical teratoid / rhabdoid tumor 949 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 859 | 3,289
Cancer 838 | 2,346
pilocytic astrocytoma 804 | 3,086
malignant mesothelioma 793 | 3,163
intraductal papillary-mucinous adenoma (IPMA) 783 | 2,956
lung carcinoma 783 | 2,844
invasive ductal carcinoma 780 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 777 | 2,988
Breast cancer 756 | 3,099
pancreatic cancer 741 | 2,300
lung adenocarcinoma 736 | 2,714
non-small cell lung cancer 725 | 2,798
pediatric high grade glioma 656 | 2,712
oligodendroglioma 645 | 2,849
primitive neuroectodermal tumor 621 | 3,031
interstitial cystitis 603 | 2,299
diabetes mellitus 585 | 1,663
ulcerative colitis 583 | 2,087
subependymal giant cell astrocytoma 572 | 2,287
ependymoma 558 | 2,514
pancreatic ductal adenocarcinoma liver metastasis 544 | 1,795
Multiple myeloma 480 | 1,328
Carcinoma 476 | 2,147
cystic fibrosis 472 | 1,670
ductal carcinoma in situ 469 | 1,745
astrocytoma 462 | 1,493
breast carcinoma 458 | 1,614
astrocytic glioma 456 | 2,241
pituitary cancer 450 | 1,972
Pick disease 445 | 1,893
tuberculosis 443 | 1,563
primary pancreatic ductal adenocarcinoma 438 | 1,271
adult high grade glioma 434 | 2,148
colon cancer 411 | 1,475
group 4 medulloblastoma 398 | 1,875
group 3 medulloblastoma 389 | 2,254
posterior fossa group A ependymoma 383 | 1,511
medulloblastoma 331 | 1,524
Rheumatoid Arthritis 327 | 1,171
adrenocortical carcinoma 325 | 1,427
dermatomyositis 322 | 967
juvenile dermatomyositis 322 | 1,189
acute quadriplegic myopathy 320 | 1,157
sonic hedgehog group medulloblastoma 313 | 1,482
cutaneous lupus erythematosus 299 | 1,056
Waldenstrons macroglobulinemia 289 | 765
esophageal adenocarcinoma 288 | 737
posterior fossa group B ependymoma 276 | 1,530
nasopharyngeal carcinoma 273 | 1,056
gastric carcinoma 267 | 832
Duchenne muscular dystrophy 261 | 602
spina bifida 252 | 1,064
Atopic dermatitis 248 | 944
atypical teratoid/rhabdoid tumor 244 | 1,095
active Crohn's disease 234 | 918
Alzheimer's disease 213 | 644
Kidney disease 199 | 397
Obesity 197 | 616
Prostatic Neoplasms 189 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 188 | 499
non primary Sjogren syndrome sicca 186 | 840
primary Sjogren syndrome 185 | 789
Down syndrome 183 | 548
acute myeloid leukemia 180 | 785
mucosa-associated lymphoid tissue lymphoma 174 | 480
aldosterone-producing adenoma 163 | 664
pancreatic carcinoma 163 | 567
fibroadenoma 161 | 557
Multiple Sclerosis 159 | 498
IGA Glomerulonephritis 158 | 454
Hypertension 145 | 293
Schizophrenia 145 | 503
Arthritis 144 | 248
Neurodegenerative disease 142 | 383
active ulcerative colitis 140 | 477
progressive supranuclear palsy 140 | 674
nephrosclerosis 134 | 329
Atherosclerosis 133 | 275
Hypersensitivity reaction type II disease 133 | 235
Endometriosis 131 | 535
Parkinson's disease 131 | 364
Intellectual disability 128 | 573
tuberculosis and treatment for 6 months 128 | 686
hepatocellular carcinoma 126 | 550
non-small cell lung carcinoma 126 | 413
Liver disease 123 | 219
Anemia 122 | 252
Mammary Neoplasms 121 | 410
Amyotrophic Lateral Sclerosis 116 | 432
Asthma 116 | 349
Vascular disease 116 | 281
Epilepsy 115 | 346
Coronary artery disease 113 | 240

Tissue

Nervous System 3,550 | 18,561
Digestive Tract 3,546 | 18,473
Female tissues 3,546 | 18,647
Endocrine System 3,541 | 18,512
Urinary Tract 3,537 | 18,444
Liver and Pancreas 3,535 | 18,136
Blood and immune system 3,522 | 17,995
Cardiovascular System 3,522 | 17,958
Male tissues 3,516 | 17,969
Skin and soft tissues 3,495 | 18,115
Respiratory system 3,493 | 17,484

Target Family

Non-IDG 2,217 | 11,969
Enzyme 1,063 | 4,146
Kinase 123 | 634
Transporter 121 | 473
Ion Channel 68 | 341
GPCR 32 | 408
Transcription Factor 26 | 1,400
Epigenetic 14 | 242
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38
oGPCR 1 | 421

Compartment GO Term

Vesicle 3,667 | 3,667
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
Protein BRICK1 BRK1 Tbio Non-IDG -1.42109 29.2 53
Cullin-associated NEDD8-dissociated protein 1 CAND1 Tbio Non-IDG -1.85520 69.1 156
SH3 domain-binding glutamic acid-rich-like protein 2 SH3BGRL2 Tbio Non-IDG 0.08 0.71 6
Ubiquitin-associated domain-containing protein 1 UBAC1 Tbio Non-IDG -2.56341 358.4 116
Syncollin SYCN Tdark Non-IDG -2.12341 132.9 35