Development Level

Tbio 1,590 | 11,178
Tchem 342 | 1,885
Tdark 218 | 6,569
Tclin 130 | 612

Collection

Ion Channel: IDG Consortium (T... 10 | 99
GPCR: IDG Consortium (Targets) 8 | 126
Kinase: IDG Consortium (Target... 6 | 125
GPCR: IDG Consortium (Complete... 5 | 25
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 131 | 979
preweaning lethality, incomple... 69 | 499
abnormal behavior 46 | 298
embryonic lethality prior to t... 45 | 278
embryonic lethality prior to o... 37 | 239
decreased total body fat amoun... 32 | 207
abnormal embryo size 29 | 220
decreased vertical activity 27 | 208
hypoactivity 25 | 132
decreased bone mineral content 24 | 151
decreased grip strength 24 | 116
increased lean body mass 24 | 172
abnormal bone structure 23 | 187
increased circulating alkaline... 23 | 122
increased total body fat amoun... 23 | 134
enlarged heart 22 | 210
short tibia 22 | 97
abnormal seminal vesicle morph... 20 | 114
decreased body weight 19 | 161
increased startle reflex 19 | 112
hyperactivity 18 | 148
decreased circulating choleste... 17 | 93
edema 17 | 59
abnormal retina morphology 16 | 71
decreased bone mineral density 16 | 126
impaired glucose tolerance 16 | 75
increased bone mineral content 16 | 108
decreased circulating insulin ... 15 | 76
decreased circulating serum al... 15 | 82
decreased mean corpuscular hem... 15 | 50
increased mean corpuscular vol... 15 | 92
abnormal heart morphology 14 | 162
abnormal sleep behavior 14 | 70
cataract 14 | 92
decreased circulating HDL chol... 14 | 68
decreased circulating glucose ... 14 | 126
decreased lean body mass 14 | 135
increased circulating sodium l... 14 | 71
increased heart weight 14 | 62
embryonic growth retardation 13 | 106
improved glucose tolerance 13 | 79
increased bone mineral density 13 | 72
increased or absent threshold ... 13 | 101
abnormal kidney morphology 12 | 65
abnormal lens morphology 12 | 81
decreased lymphocyte cell numb... 12 | 83
decreased mean corpuscular vol... 12 | 79
decreased prepulse inhibition 12 | 82
decreased fasted circulating g... 11 | 65
decreased leukocyte cell numbe... 11 | 73
increased circulating chloride... 11 | 41
increased mean corpuscular hem... 11 | 96
prolonged QT interval 11 | 38
tremors 11 | 39
abnormal behavioral response t... 10 | 66
abnormal coat-hair pigmentatio... 10 | 64
decreased circulating LDL chol... 10 | 38
decreased startle reflex 10 | 75
enlarged lymph nodes 10 | 37
increased fasted circulating g... 10 | 76
increased leukocyte cell numbe... 10 | 47
cardiovascular system phenotyp... 9 | 36
decreased circulating alkaline... 9 | 46
increased circulating HDL chol... 9 | 80
increased circulating choleste... 9 | 66
limb grasping 9 | 41
abnormal eye morphology 8 | 68
abnormal gait 8 | 69
decreased circulating total pr... 8 | 49
decreased circulating triglyce... 8 | 79
decreased hemoglobin content 8 | 68
increased circulating triglyce... 8 | 42
increased hematocrit 8 | 46
increased neutrophil cell numb... 8 | 46
prenatal lethality prior to he... 8 | 87
prolonged ST segment 8 | 36
small superior vagus ganglion 8 | 74
decreased body length 7 | 101
decreased caudal vertebrae num... 7 | 53
increased body weight 7 | 25
increased monocyte cell number 7 | 63
pallor 7 | 34
prenatal lethality 7 | 28
small testis 7 | 58
thrombocytosis 7 | 27
abnormal coat appearance 6 | 31
abnormal craniofacial morpholo... 6 | 33
decreased blood urea nitrogen ... 6 | 51
decreased circulating sodium l... 6 | 22
decreased mean corpuscular hem... 6 | 31
enlarged spleen 6 | 41
increased circulating LDL chol... 6 | 13
increased circulating amylase ... 6 | 25
increased circulating calcium ... 6 | 34
increased circulating free fat... 6 | 20
increased circulating total pr... 6 | 28
increased hemoglobin content 6 | 45
increased prepulse inhibition 6 | 32
increased red blood cell distr... 6 | 34
male infertility 6 | 123

Disease

Carcinoma 1,433 | 11,192
ovarian cancer 1,194 | 8,297
osteosarcoma 1,100 | 7,766
psoriasis 939 | 6,514
glioblastoma 888 | 5,635
medulloblastoma, large-cell 835 | 6,086
atypical teratoid / rhabdoid tumor 699 | 4,971
lung cancer 699 | 4,607
ependymoma 646 | 4,559
Cancer 597 | 2,388
adult high grade glioma 550 | 3,701
Astrocytoma, Pilocytic 535 | 3,006
lung carcinoma 501 | 2,755
malignant mesothelioma 497 | 3,135
Breast cancer 481 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 475 | 3,204
group 3 medulloblastoma 452 | 4,002
invasive ductal carcinoma 449 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 445 | 2,872
non-small cell lung cancer 439 | 2,799
intraductal papillary-mucinous carcinoma (IPMC) 430 | 2,902
diabetes mellitus 422 | 1,683
oligodendroglioma 419 | 2,768
lung adenocarcinoma 418 | 2,627
tuberculosis 418 | 1,963
pancreatic cancer 397 | 2,322
interstitial cystitis 389 | 2,237
astrocytic glioma 380 | 2,530
subependymal giant cell astrocytoma 378 | 2,230
Kidney cancer 368 | 2,548
primitive neuroectodermal tumor 367 | 2,957
ulcerative colitis 323 | 1,765
pancreatic ductal adenocarcinoma liver metastasis 310 | 1,911
Pick disease 285 | 1,856
Autosomal recessive predisposition 276 | 1,407
Schizophrenia 265 | 1,136
cystic fibrosis 263 | 1,629
Multiple myeloma 260 | 1,296
pituitary cancer 257 | 1,915
group 4 medulloblastoma 252 | 1,806
Rheumatoid arthritis 249 | 1,156
ductal carcinoma in situ 246 | 1,686
breast carcinoma 238 | 1,589
dermatomyositis 228 | 941
cutaneous lupus erythematosus 226 | 1,016
juvenile dermatomyositis 225 | 1,147
astrocytoma 209 | 1,113
colon cancer 204 | 1,428
primary pancreatic ductal adenocarcinoma 199 | 1,071
acute quadriplegic myopathy 198 | 1,133
adrenocortical carcinoma 190 | 1,385
Liver Cirrhosis, Experimental 182 | 733
Intellectual disability 178 | 998
Alzheimer's disease 174 | 640
Kidney disease 168 | 411
Epilepsy 165 | 775
pediatric high grade glioma 163 | 1,035
Bipolar Disorder 162 | 646
Waldenstrons macroglobulinemia 160 | 742
esophageal adenocarcinoma 155 | 696
Arthritis 153 | 276
gastric carcinoma 152 | 781
active Crohn's disease 150 | 882
mucosa-associated lymphoid tissue lymphoma 150 | 473
spina bifida 150 | 1,053
Obesity 146 | 655
nasopharyngeal carcinoma 143 | 1,024
Multiple Sclerosis 142 | 527
primary Sjogren syndrome 138 | 710
Duchenne muscular dystrophy 137 | 587
Hypersensitivity reaction type II disease 137 | 245
Hypertension 132 | 372
Seizures 131 | 584
Neurodegenerative disease 130 | 402
Atopic dermatitis 129 | 915
non primary Sjogren syndrome sicca 126 | 861
active ulcerative colitis 124 | 736
Melanoma 116 | 689
Dull intelligence 115 | 634
Low intelligence 115 | 634
Mental Retardation 115 | 634
Mental deficiency 115 | 634
Poor school performance 115 | 634
Anemia 113 | 353
Prostatic Neoplasms 113 | 472
Depressive disorder 111 | 401
Down syndrome 111 | 480
Atherosclerosis 110 | 276
Parkinson's disease 105 | 378
Liver disease 104 | 227
pancreatic carcinoma 104 | 555
acute myeloid leukemia 102 | 760
Asthma 101 | 370
Cognitive delay 97 | 596
Global developmental delay 97 | 596
Liver cancer 97 | 589
Mental and motor retardation 97 | 596
Vascular disease 97 | 294
aldosterone-producing adenoma 95 | 646
hepatocellular carcinoma 95 | 536

Tissue

Endocrine System 2,148 | 18,159
Digestive Tract 2,129 | 17,369
Female tissues 2,117 | 17,400
Skin and soft tissues 2,110 | 17,230
Liver and Pancreas 2,096 | 16,750
Male tissues 2,095 | 17,142
Blood and immune system 2,081 | 16,909
Urinary Tract 2,077 | 16,678
Nervous System 2,063 | 16,725
Respiratory system 2,054 | 16,393
Cardiovascular System 1,922 | 15,192

Target Family

Non-IDG 1,497 | 12,091
Enzyme 469 | 4,145
Kinase 94 | 634
Transporter 84 | 473
GPCR 59 | 408
Ion Channel 56 | 344
Transcription Factor 12 | 1,400
oGPCR 5 | 421
Epigenetic 3 | 242
TF/Epigenetic 1 | 38

Compartment GO Term

Vesicle 2,280 | 2,280
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Protocadherin-7 PCDH7 Tbio Non-IDG -1.42056 26.3 248
T-lymphocyte activation antigen CD80 CD80 Tclin Non-IDG -3.39216 2405.6 1323
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Prominin-2 PROM2 Tbio Non-IDG -1.12562 11.0 199
Bone sialoprotein 2 IBSP Tbio Non-IDG -2.95483 756.8 261
HLA class I histocompatibility antigen, B-67 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 362
Cytosolic phospholipase A2 beta JMJD7-PLA2G4B Tchem Enzyme -0.60640 3.75 104