1. Home
  2. Targets
Target Filters...

Development Level

Tbio 1,673 | 11,445
Tchem 313 | 1,598
Tdark 222 | 6,588
Tclin 134 | 613

Collection

RFA-RM-18-021 25 | 328
Ion Channel: IDG Consortium (T... 10 | 99
GPCR: IDG Consortium (Targets) 8 | 126
Kinase: IDG Consortium (Target... 7 | 125
GPCR: IDG Consortium (Complete... 5 | 25
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 136 | 979
preweaning lethality, incomple... 71 | 499
abnormal behavior 47 | 298
embryonic lethality prior to t... 47 | 278
embryonic lethality prior to o... 37 | 239
decreased total body fat amoun... 32 | 207
abnormal embryo size 31 | 220
decreased vertical activity 28 | 208
hypoactivity 27 | 132
decreased grip strength 25 | 116
decreased bone mineral content 24 | 151
increased circulating alkaline... 24 | 122
increased lean body mass 24 | 172
short tibia 24 | 97
abnormal bone structure 23 | 187
increased total body fat amoun... 23 | 134
enlarged heart 22 | 210
abnormal seminal vesicle morph... 21 | 114
increased startle reflex 20 | 112
decreased body weight 19 | 161
decreased circulating choleste... 19 | 93
hyperactivity 18 | 148
decreased bone mineral density 17 | 126
edema 17 | 59
abnormal retina morphology 16 | 71
decreased circulating HDL chol... 16 | 68
impaired glucose tolerance 16 | 75
increased bone mineral content 16 | 108
decreased circulating insulin ... 15 | 76
decreased circulating serum al... 15 | 82
decreased mean corpuscular hem... 15 | 50
embryonic growth retardation 15 | 106
increased circulating sodium l... 15 | 71
increased mean corpuscular vol... 15 | 92
abnormal heart morphology 14 | 162
abnormal sleep behavior 14 | 70
cataract 14 | 92
decreased circulating glucose ... 14 | 126
decreased lean body mass 14 | 135
increased heart weight 14 | 62
increased or absent threshold ... 14 | 101
improved glucose tolerance 13 | 79
increased bone mineral density 13 | 72
abnormal kidney morphology 12 | 65
abnormal lens morphology 12 | 81
decreased fasted circulating g... 12 | 65
decreased lymphocyte cell numb... 12 | 83
decreased mean corpuscular vol... 12 | 79
decreased prepulse inhibition 12 | 82
increased mean corpuscular hem... 12 | 96
prolonged QT interval 12 | 38
tremors 12 | 39
decreased leukocyte cell numbe... 11 | 73
increased circulating chloride... 11 | 41
abnormal behavioral response t... 10 | 66
abnormal coat-hair pigmentatio... 10 | 64
decreased circulating LDL chol... 10 | 38
decreased startle reflex 10 | 75
enlarged lymph nodes 10 | 37
increased fasted circulating g... 10 | 76
increased leukocyte cell numbe... 10 | 47
prolonged ST segment 10 | 36
abnormal gait 9 | 69
cardiovascular system phenotyp... 9 | 36
decreased circulating alkaline... 9 | 46
increased circulating HDL chol... 9 | 80
increased circulating choleste... 9 | 66
increased hematocrit 9 | 46
limb grasping 9 | 41
abnormal eye morphology 8 | 68
decreased circulating total pr... 8 | 49
decreased circulating triglyce... 8 | 79
decreased hemoglobin content 8 | 68
increased circulating triglyce... 8 | 42
increased neutrophil cell numb... 8 | 46
prenatal lethality prior to he... 8 | 87
small superior vagus ganglion 8 | 74
decreased body length 7 | 101
decreased caudal vertebrae num... 7 | 53
increased body weight 7 | 25
increased monocyte cell number 7 | 63
pallor 7 | 34
prenatal lethality 7 | 28
small testis 7 | 58
thrombocytosis 7 | 27
abnormal craniofacial morpholo... 6 | 33
abnormal neural tube closure 6 | 46
decreased circulating bilirubi... 6 | 19
decreased circulating sodium l... 6 | 22
decreased mean corpuscular hem... 6 | 31
enlarged spleen 6 | 41
increased circulating amylase ... 6 | 25
increased circulating calcium ... 6 | 34
increased circulating free fat... 6 | 20
increased circulating iron lev... 6 | 30
increased circulating total pr... 6 | 28
increased hemoglobin content 6 | 45
increased prepulse inhibition 6 | 32
increased red blood cell distr... 6 | 34
male infertility 6 | 123

Disease

Carcinoma 1,476 | 11,493
ovarian cancer 1,227 | 8,520
osteosarcoma 1,125 | 7,950
psoriasis 968 | 6,694
glioblastoma 907 | 5,792
medulloblastoma, large-cell 847 | 6,241
lung cancer 722 | 4,740
atypical teratoid / rhabdoid tumor 717 | 5,112
ependymoma 667 | 4,679
Cancer 623 | 2,499
adult high grade glioma 561 | 3,801
Astrocytoma, Pilocytic 548 | 3,081
lung carcinoma 515 | 2,843
malignant mesothelioma 513 | 3,232
Breast cancer 500 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 494 | 3,291
invasive ductal carcinoma 464 | 2,951
group 3 medulloblastoma 461 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 458 | 2,955
non-small cell lung cancer 456 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 445 | 2,989
diabetes mellitus 436 | 1,728
lung adenocarcinoma 435 | 2,716
oligodendroglioma 431 | 2,850
tuberculosis 425 | 2,010
pancreatic cancer 412 | 2,398
interstitial cystitis 396 | 2,312
astrocytic glioma 393 | 2,597
subependymal giant cell astrocytoma 388 | 2,287
Kidney cancer 377 | 2,613
primitive neuroectodermal tumor 376 | 3,035
ulcerative colitis 334 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 323 | 1,962
Pick disease 295 | 1,894
Autosomal recessive predisposition 285 | 1,442
Schizophrenia 271 | 1,160
cystic fibrosis 271 | 1,696
Multiple myeloma 265 | 1,332
pituitary cancer 264 | 1,972
group 4 medulloblastoma 259 | 1,855
ductal carcinoma in situ 257 | 1,745
Rheumatoid arthritis 255 | 1,191
breast carcinoma 247 | 1,638
juvenile dermatomyositis 233 | 1,187
cutaneous lupus erythematosus 232 | 1,057
dermatomyositis 232 | 966
astrocytoma 215 | 1,146
colon cancer 213 | 1,478
primary pancreatic ductal adenocarcinoma 208 | 1,109
acute quadriplegic myopathy 205 | 1,158
Liver Cirrhosis, Experimental 195 | 769
adrenocortical carcinoma 194 | 1,428
Alzheimer's disease 184 | 658
Intellectual disability 182 | 1,016
Kidney disease 178 | 430
Epilepsy 169 | 792
pediatric high grade glioma 168 | 1,064
Bipolar Disorder 166 | 666
Waldenstrons macroglobulinemia 166 | 765
esophageal adenocarcinoma 162 | 737
Arthritis 161 | 290
gastric carcinoma 159 | 807
active Crohn's disease 156 | 922
Obesity 155 | 678
mucosa-associated lymphoid tissue lymphoma 154 | 484
spina bifida 153 | 1,074
Multiple Sclerosis 146 | 540
nasopharyngeal carcinoma 146 | 1,058
Duchenne muscular dystrophy 143 | 601
Hypersensitivity reaction type II disease 141 | 253
Hypertension 141 | 396
primary Sjogren syndrome 141 | 735
Atopic dermatitis 136 | 952
Neurodegenerative disease 136 | 414
Seizures 134 | 596
non primary Sjogren syndrome sicca 130 | 891
active ulcerative colitis 128 | 764
Melanoma 121 | 711
Anemia 119 | 365
Dull intelligence 119 | 645
Low intelligence 119 | 645
Mental Retardation 119 | 645
Mental deficiency 119 | 645
Poor school performance 119 | 645
Atherosclerosis 118 | 291
Prostatic Neoplasms 118 | 495
Down syndrome 116 | 499
Depressive disorder 113 | 409
Liver disease 110 | 237
Parkinson's disease 109 | 392
Asthma 107 | 385
Vascular disease 106 | 319
acute myeloid leukemia 105 | 783
pancreatic carcinoma 104 | 562
Cognitive delay 100 | 608
Global developmental delay 100 | 608
Mental and motor retardation 100 | 608
autosomal dominant Emery-Dreifuss muscular dystrophy 100 | 510
Liver cancer 99 | 604
Short stature 97 | 531

Tissue

Endocrine System 2,209 | 18,159
Digestive Tract 2,185 | 17,369
Female tissues 2,174 | 17,400
Skin and soft tissues 2,168 | 17,230
Liver and Pancreas 2,152 | 16,750
Male tissues 2,149 | 17,142
Blood and immune system 2,137 | 16,909
Urinary Tract 2,131 | 16,678
Nervous System 2,117 | 16,725
Respiratory system 2,106 | 16,393
Cardiovascular System 1,965 | 15,192

Target Family

Non-IDG 1,508 | 12,091
Enzyme 516 | 4,145
Kinase 95 | 634
Transporter 86 | 473
GPCR 59 | 408
Ion Channel 56 | 344
Transcription Factor 13 | 1,400
oGPCR 5 | 421
Epigenetic 3 | 242
TF/Epigenetic 1 | 38

Compartment GO Term

Vesicle 2,342 | 2,342
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Serpin B12 SERPINB12 Tbio Non-IDG -0.56624 4.27 155
Zona pellucida-binding protein 1 ZPBP Tdark Non-IDG -1.44041 27.1 43
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
MAGE-like protein 2 MAGEL2 Tbio Non-IDG -1.95242 83.8 86
CAP-Gly domain-containing linker protein 1 CLIP1 Tbio Non-IDG -2.54943 343.7 221
Sorcin SRI Tbio Non-IDG -2.69915 481.5 119
Synaptotagmin-like protein 2 SYTL2 Tbio Non-IDG -1.27949 19.5 60