Development Level

Tbio 868 | 10,625
Tchem 193 | 1,890
Tdark 143 | 7,003
Tclin 59 | 602

Collection

Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 2 | 143
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 56 | 633
decreased total body fat amoun... 22 | 186
abnormal behavior 20 | 226
embryonic lethality prior to t... 20 | 187
preweaning lethality, incomple... 18 | 260
increased circulating alkaline... 17 | 119
embryonic lethality prior to o... 15 | 148
decreased grip strength 13 | 123
increased or absent threshold ... 13 | 128
decreased lean body mass 12 | 195
hypoactivity 12 | 89
decreased body length 11 | 108
decreased body weight 11 | 174
decreased bone mineral content 11 | 157
decreased bone mineral density 11 | 126
increased bone mineral content 11 | 92
increased bone mineral density 11 | 52
abnormal bone structure 10 | 131
decreased prepulse inhibition 10 | 52
increased lean body mass 10 | 107
increased mean corpuscular hem... 10 | 93
decreased circulating HDL chol... 9 | 77
decreased circulating glucose ... 9 | 121
decreased mean corpuscular vol... 9 | 50
increased sacral vertebrae num... 9 | 62
abnormal retina morphology 8 | 100
abnormal retinal pigmentation 8 | 61
decreased circulating serum al... 8 | 79
decreased circulating triglyce... 8 | 83
decreased lumbar vertebrae num... 8 | 62
decreased mean corpuscular hem... 8 | 34
decreased rib number 8 | 59
enlarged heart 8 | 111
increased circulating HDL chol... 8 | 63
increased fasted circulating g... 8 | 68
increased mean corpuscular vol... 8 | 91
thrombocytosis 8 | 23
abnormal lens morphology 7 | 73
abnormal sleep behavior 7 | 63
decreased circulating choleste... 7 | 85
decreased leukocyte cell numbe... 7 | 54
decreased monocyte cell number 7 | 28
increased blood urea nitrogen ... 7 | 44
increased circulating choleste... 7 | 53
short tibia 7 | 82
abnormal bone mineralization 6 | 55
cardiovascular system phenotyp... 6 | 35
decreased circulating LDL chol... 6 | 37
decreased hemoglobin content 6 | 53
improved glucose tolerance 6 | 56
increased circulating LDL chol... 6 | 15
increased circulating potassiu... 6 | 31
increased circulating sodium l... 6 | 71
increased grip strength 6 | 83
abnormal kidney morphology 5 | 30
abnormal seminal vesicle morph... 5 | 47
decreased NK T cell number 5 | 28
decreased circulating insulin ... 5 | 75
decreased eosinophil cell numb... 5 | 41
decreased erythrocyte cell num... 5 | 43
hyperactivity 5 | 108
impaired glucose tolerance 5 | 52
increased B cell number 5 | 23
increased circulating serum al... 5 | 25
limb grasping 5 | 35
small adrenal glands 5 | 15
abnormal coat/hair pigmentatio... 4 | 54
abnormal embryo size 4 | 112
abnormal epididymis morphology 4 | 31
abnormal heart morphology 4 | 51
abnormal rib morphology 4 | 28
decreased B cell number 4 | 30
decreased CD8-positive, alpha-... 4 | 26
decreased Ly6C low monocyte nu... 4 | 23
decreased caudal vertebrae num... 4 | 49
decreased circulating alkaline... 4 | 41
decreased circulating bilirubi... 4 | 14
decreased heart weight 4 | 44
decreased total retina thickne... 4 | 20
enlarged lymph nodes 4 | 27
increased NK cell number 4 | 19
increased T cell number 4 | 15
increased body weight 4 | 42
increased circulating calcium ... 4 | 32
increased circulating chloride... 4 | 43
increased leukocyte cell numbe... 4 | 37
abnormal behavioral response t... 3 | 52
abnormal coat appearance 3 | 25
abnormal gait 3 | 51
abnormal vibrissa morphology 3 | 17
decreased T cell number 3 | 31
decreased circulating calcium ... 3 | 33
decreased circulating iron lev... 3 | 25
decreased fasted circulating g... 3 | 49
decreased neutrophil cell numb... 3 | 37
enlarged spleen 3 | 26
increased hematocrit 3 | 36
increased hemoglobin content 3 | 45
prenatal lethality prior to he... 3 | 64
straub tail 3 | 26

Disease

ovarian cancer 690 | 8,484
osteosarcoma 584 | 7,933
psoriasis 506 | 6,685
medulloblastoma, large-cell 460 | 6,234
glioblastoma 444 | 5,572
lung cancer 353 | 4,466
Cancer 329 | 2,346
atypical teratoid / rhabdoid tumor 308 | 4,369
malignant mesothelioma 255 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 251 | 3,289
diabetes mellitus 249 | 1,663
invasive ductal carcinoma 248 | 2,950
pilocytic astrocytoma 247 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 228 | 2,956
lung carcinoma 227 | 2,844
subependymal giant cell astrocytoma 214 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 211 | 2,988
pediatric high grade glioma 207 | 2,712
non-small cell lung cancer 204 | 2,798
Breast cancer 201 | 3,094
oligodendroglioma 200 | 2,849
lung adenocarcinoma 198 | 2,713
pancreatic cancer 194 | 2,300
ulcerative colitis 189 | 2,087
primitive neuroectodermal tumor 177 | 3,031
ependymoma 175 | 2,514
tuberculosis 170 | 1,557
Pick disease 165 | 1,893
Rheumatoid Arthritis 165 | 1,160
interstitial cystitis 165 | 2,299
adult high grade glioma 159 | 2,148
astrocytic glioma 152 | 2,241
Multiple myeloma 151 | 1,327
astrocytoma 150 | 1,493
Carcinoma 149 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 141 | 1,795
group 4 medulloblastoma 138 | 1,875
cystic fibrosis 135 | 1,665
juvenile dermatomyositis 133 | 1,189
pituitary cancer 131 | 1,972
ductal carcinoma in situ 130 | 1,745
primary pancreatic ductal adenocarcinoma 123 | 1,271
breast carcinoma 121 | 1,614
posterior fossa group A ependymoma 114 | 1,511
dermatomyositis 112 | 933
Arthritis 109 | 248
cutaneous lupus erythematosus 109 | 1,056
medulloblastoma 108 | 1,524
Hypersensitivity reaction type II disease 103 | 235
colon cancer 103 | 1,475
Alzheimer's disease 101 | 644
sonic hedgehog group medulloblastoma 100 | 1,482
Kidney disease 99 | 396
acute quadriplegic myopathy 98 | 1,157
posterior fossa group B ependymoma 98 | 1,530
Neurodegenerative disease 96 | 383
group 3 medulloblastoma 96 | 2,254
adrenocortical carcinoma 93 | 1,427
Multiple Sclerosis 84 | 498
esophageal adenocarcinoma 84 | 737
primary Sjogren syndrome 83 | 789
spina bifida 83 | 1,064
Ankylosing spondylitis 80 | 138
gastric carcinoma 80 | 832
atypical teratoid/rhabdoid tumor 77 | 1,095
Waldenstrons macroglobulinemia 75 | 765
active Crohn's disease 71 | 918
Acquired immunodeficiency syndrome 70 | 164
Down syndrome 69 | 548
Obesity 69 | 616
Duchenne muscular dystrophy 67 | 602
Juvenile rheumatoid arthritis 66 | 104
Uveitis 66 | 103
Liver disease 65 | 219
non primary Sjogren syndrome sicca 65 | 840
Anemia 62 | 252
acute myeloid leukemia 60 | 780
Atherosclerosis 58 | 275
Hypertension 58 | 287
Atopic dermatitis 57 | 944
Behcet's disease 57 | 74
nasopharyngeal carcinoma 57 | 1,056
Psoriatic arthritis 56 | 83
mucosa-associated lymphoid tissue lymphoma 56 | 480
Heart disease 54 | 279
tuberculosis and treatment for 6 months 54 | 686
IGA Glomerulonephritis 53 | 454
progressive supranuclear palsy 53 | 674
Amyotrophic Lateral Sclerosis 52 | 431
Asthma 52 | 349
pancreatic carcinoma 52 | 567
aldosterone-producing adenoma 51 | 664
Coronary artery disease 50 | 240
Prostatic Neoplasms 50 | 471
Schizophrenia 50 | 501
Parkinson's disease 49 | 364
Cerebrovascular disease 47 | 231
Intellectual disability 47 | 573
Vascular disease 47 | 281
fibroadenoma 47 | 557

Tissue

Nervous System 1,182 | 18,561
Endocrine System 1,180 | 18,512
Female tissues 1,180 | 18,647
Urinary Tract 1,180 | 18,444
Liver and Pancreas 1,179 | 18,136
Digestive Tract 1,178 | 18,473
Male tissues 1,176 | 17,969
Cardiovascular System 1,172 | 17,958
Blood and immune system 1,171 | 17,995
Respiratory system 1,166 | 17,484
Skin and soft tissues 1,164 | 18,115

Target Family

Non-IDG 806 | 11,971
Enzyme 299 | 4,146
Kinase 59 | 634
Transporter 44 | 473
GPCR 28 | 406
Ion Channel 19 | 341
Transcription Factor 6 | 1,400
Epigenetic 1 | 242
oGPCR 1 | 421

Compartment GO Term

Vacuole 1,263 | 1,263
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523