Development Level

Tbio 513 | 11,445
Tchem 116 | 1,598
Tdark 65 | 6,588
Tclin 38 | 613

Collection

RFA-RM-18-021 3 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 52 | 979
preweaning lethality, incomple... 21 | 499
embryonic lethality prior to t... 19 | 278
embryonic lethality prior to o... 17 | 239
abnormal behavior 15 | 298
increased circulating alkaline... 11 | 122
abnormal seminal vesicle morph... 10 | 114
decreased total body fat amoun... 10 | 207
increased lean body mass 10 | 172
hypoactivity 9 | 132
short tibia 9 | 97
abnormal bone structure 8 | 187
abnormal embryo size 8 | 220
abnormal heart morphology 8 | 162
decreased body weight 8 | 161
decreased vertical activity 8 | 208
enlarged heart 8 | 210
increased bone mineral content 7 | 108
increased bone mineral density 7 | 72
increased circulating sodium l... 7 | 71
increased mean corpuscular hem... 7 | 96
abnormal retina morphology 6 | 71
decreased circulating HDL chol... 6 | 68
decreased circulating serum al... 6 | 82
decreased mean corpuscular hem... 6 | 50
decreased prepulse inhibition 6 | 82
increased total body fat amoun... 6 | 134
small adrenal glands 6 | 16
decreased circulating bilirubi... 5 | 19
decreased circulating glucose ... 5 | 126
decreased circulating insulin ... 5 | 76
edema 5 | 59
increased blood urea nitrogen ... 5 | 48
increased circulating potassiu... 5 | 29
increased circulating triglyce... 5 | 42
increased mean corpuscular vol... 5 | 92
prenatal lethality 5 | 28
small superior vagus ganglion 5 | 74
abnormal coat appearance 4 | 31
abnormal coat-hair pigmentatio... 4 | 64
abnormal iris morphology 4 | 13
cataract 4 | 92
decreased circulating LDL chol... 4 | 38
decreased circulating choleste... 4 | 93
decreased grip strength 4 | 116
decreased heart weight 4 | 27
decreased leukocyte cell numbe... 4 | 73
enlarged lymph nodes 4 | 37
hyperactivity 4 | 148
impaired glucose tolerance 4 | 75
improved glucose tolerance 4 | 79
increased neutrophil cell numb... 4 | 46
increased startle reflex 4 | 112
prolonged ST segment 4 | 36
thrombocytosis 4 | 27
abnormal bone mineralization 3 | 38
abnormal cecum morphology 3 | 7
abnormal craniofacial morpholo... 3 | 33
abnormal kidney morphology 3 | 65
abnormal pericardium morpholog... 3 | 26
absent pinna reflex 3 | 23
decreased blood urea nitrogen ... 3 | 51
decreased bone mineral density 3 | 126
decreased circulating aspartat... 3 | 34
decreased circulating calcium ... 3 | 36
decreased circulating sodium l... 3 | 22
decreased circulating triglyce... 3 | 79
decreased erythrocyte cell num... 3 | 62
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular vol... 3 | 79
embryonic growth retardation 3 | 106
enlarged cecum 3 | 5
hemorrhage 3 | 23
increased circulating HDL chol... 3 | 80
increased circulating bilirubi... 3 | 16
increased circulating choleste... 3 | 66
increased circulating creatini... 3 | 38
increased circulating total pr... 3 | 28
increased fasted circulating g... 3 | 76
increased grip strength 3 | 41
increased leukocyte cell numbe... 3 | 47
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular hem... 3 | 36
increased or absent threshold ... 3 | 101
prenatal lethality prior to he... 3 | 87
prolonged QT interval 3 | 38
abnormal epididymis morphology 2 | 42
abnormal skin coloration 2 | 25
abnormal sleep behavior 2 | 70
abnormal vibrissa morphology 2 | 25
absent startle reflex 2 | 24
cardiovascular system phenotyp... 2 | 36
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
increased circulating calcium ... 2 | 34
increased circulating serum al... 2 | 22
increased hemoglobin content 2 | 45

Disease

Carcinoma 447 | 11,493
ovarian cancer 415 | 8,520
osteosarcoma 361 | 7,950
psoriasis 277 | 6,694
glioblastoma 273 | 5,792
medulloblastoma, large-cell 273 | 6,241
lung cancer 226 | 4,740
atypical teratoid / rhabdoid tumor 205 | 5,112
ependymoma 185 | 4,679
Cancer 176 | 2,499
malignant mesothelioma 168 | 3,232
lung carcinoma 157 | 2,843
Astrocytoma, Pilocytic 155 | 3,081
invasive ductal carcinoma 154 | 2,951
adult high grade glioma 150 | 3,801
Breast cancer 148 | 3,578
diabetes mellitus 148 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 144 | 3,291
tuberculosis 144 | 2,010
intraductal papillary-mucinous adenoma (IPMA) 139 | 2,955
non-small cell lung cancer 136 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 131 | 2,989
subependymal giant cell astrocytoma 126 | 2,287
Autosomal recessive predisposition 125 | 1,442
group 3 medulloblastoma 124 | 4,104
pancreatic cancer 123 | 2,398
lung adenocarcinoma 122 | 2,716
oligodendroglioma 114 | 2,850
interstitial cystitis 107 | 2,312
Multiple myeloma 104 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 104 | 1,962
ulcerative colitis 103 | 1,819
primitive neuroectodermal tumor 102 | 3,035
Kidney cancer 98 | 2,613
Pick disease 98 | 1,894
astrocytic glioma 96 | 2,597
breast carcinoma 86 | 1,638
Rheumatoid arthritis 84 | 1,191
ductal carcinoma in situ 81 | 1,745
group 4 medulloblastoma 81 | 1,855
acute quadriplegic myopathy 80 | 1,158
astrocytoma 80 | 1,146
cystic fibrosis 79 | 1,696
dermatomyositis 76 | 966
juvenile dermatomyositis 76 | 1,187
pituitary cancer 75 | 1,972
cutaneous lupus erythematosus 74 | 1,057
Schizophrenia 72 | 1,160
Epilepsy 71 | 792
Alzheimer's disease 70 | 658
Waldenstrons macroglobulinemia 70 | 765
Neurodegenerative disease 69 | 414
primary pancreatic ductal adenocarcinoma 66 | 1,109
adrenocortical carcinoma 63 | 1,428
colon cancer 63 | 1,478
Seizures 60 | 596
Intellectual disability 59 | 1,016
pediatric high grade glioma 59 | 1,064
Kidney disease 58 | 430
esophageal adenocarcinoma 58 | 737
active Crohn's disease 56 | 922
Liver Cirrhosis, Experimental 54 | 769
Hepatomegaly 52 | 285
Dull intelligence 50 | 645
Low intelligence 50 | 645
Mental Retardation 50 | 645
Mental deficiency 50 | 645
Poor school performance 50 | 645
primary Sjogren syndrome 49 | 735
Duchenne muscular dystrophy 48 | 601
Multiple Sclerosis 48 | 540
Anemia 47 | 365
Atopic dermatitis 47 | 952
Obesity 47 | 678
spina bifida 47 | 1,074
Muscle hypotonia 46 | 571
Hypertension 45 | 396
Dementia 44 | 175
Splenomegaly 44 | 190
gastric carcinoma 44 | 807
Bipolar Disorder 43 | 666
Heart disease 43 | 306
active ulcerative colitis 43 | 764
Arthritis 42 | 290
Cognitive delay 42 | 608
Global developmental delay 42 | 608
Mental and motor retardation 42 | 608
mucosa-associated lymphoid tissue lymphoma 42 | 484
Vascular disease 41 | 319
Down syndrome 39 | 499
nasopharyngeal carcinoma 39 | 1,058
non primary Sjogren syndrome sicca 38 | 891
Hypersensitivity reaction type II disease 37 | 253
Parkinson's disease 37 | 392
Atherosclerosis 36 | 291
Liver disease 35 | 237
Melanoma 35 | 711
Asthma 34 | 385
Depressive disorder 34 | 409
pancreatic carcinoma 34 | 562

Tissue

Endocrine System 711 | 18,159
Digestive Tract 707 | 17,369
Female tissues 707 | 17,400
Skin and soft tissues 707 | 17,230
Blood and immune system 702 | 16,909
Liver and Pancreas 702 | 16,750
Urinary Tract 700 | 16,678
Male tissues 699 | 17,142
Respiratory system 696 | 16,393
Nervous System 688 | 16,725
Cardiovascular System 669 | 15,192

Target Family

Non-IDG 427 | 12,091
Enzyme 228 | 4,145
Transporter 30 | 473
Kinase 23 | 634
Ion Channel 11 | 344
GPCR 8 | 408
Transcription Factor 5 | 1,400

Compartment GO Term

Vacuole 732 | 732
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Transient receptor potential cation channel subfamily M member 2 TRPM2 Tchem Ion Channel -1.34318 25.1 209
Proton-coupled amino acid transporter 2 SLC36A2 Tchem Transporter -1.78507 61.5 88
Ras-related protein Rab-39A RAB39A Tdark Enzyme -0.57787 3.49 68
Sorting nexin-14 SNX14 Tbio Non-IDG -0.86091 6.82 56
CKLF-like MARVEL transmembrane domain-containing protein 6 CMTM6 Tdark Non-IDG -0.56950 2.80 85
Carboxypeptidase Q CPQ Tbio Enzyme -2.51783 330.9 81
Ceroid-lipofuscinosis neuronal protein 6 CLN6 Tbio Non-IDG -1.87357 0.00000 103