Development Level

Tbio 320 | 11,178
Tchem 79 | 1,885
Tdark 51 | 6,569
Tclin 15 | 612

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 35 | 979
embryonic lethality prior to t... 11 | 278
abnormal behavior 10 | 298
preweaning lethality, incomple... 10 | 499
embryonic lethality prior to o... 9 | 239
increased lean body mass 8 | 172
short tibia 8 | 97
abnormal heart morphology 7 | 162
decreased body weight 7 | 161
decreased total body fat amoun... 7 | 207
hypoactivity 7 | 132
increased bone mineral content 7 | 108
increased bone mineral density 7 | 72
increased circulating alkaline... 7 | 122
abnormal bone structure 6 | 187
abnormal embryo size 6 | 220
abnormal seminal vesicle morph... 6 | 114
enlarged heart 6 | 210
increased circulating sodium l... 6 | 71
increased mean corpuscular hem... 6 | 96
small adrenal glands 6 | 16
decreased circulating serum al... 5 | 82
decreased vertical activity 5 | 208
edema 5 | 59
cataract 4 | 92
decreased mean corpuscular hem... 4 | 50
decreased prepulse inhibition 4 | 82
enlarged lymph nodes 4 | 37
hyperactivity 4 | 148
increased blood urea nitrogen ... 4 | 48
increased circulating potassiu... 4 | 29
increased circulating triglyce... 4 | 42
increased mean corpuscular vol... 4 | 92
abnormal bone mineralization 3 | 38
abnormal coat-hair pigmentatio... 3 | 64
abnormal craniofacial morpholo... 3 | 33
abnormal iris morphology 3 | 13
abnormal pericardium morpholog... 3 | 26
absent pinna reflex 3 | 23
decreased circulating HDL chol... 3 | 68
decreased mean corpuscular vol... 3 | 79
hemorrhage 3 | 23
increased leukocyte cell numbe... 3 | 47
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
small superior vagus ganglion 3 | 74
thrombocytosis 3 | 27
abnormal behavioral response t... 2 | 66
abnormal cecum morphology 2 | 7
abnormal coat appearance 2 | 31
abnormal eye morphology 2 | 68
abnormal eye size 2 | 7
abnormal head size 2 | 6
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal locomotor activation 2 | 16
abnormal neural tube closure 2 | 46
abnormal response to new envir... 2 | 10
abnormal retina morphology 2 | 71
abnormal skin coloration 2 | 25
abnormal snout morphology 2 | 23
abnormal tail morphology 2 | 25
cardiovascular system phenotyp... 2 | 36
decreased bone mineral density 2 | 126
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating sodium l... 2 | 22
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
enlarged cecum 2 | 5
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased B cell number 2 | 9
increased body weight 2 | 25
increased circulating HDL chol... 2 | 80
increased circulating bilirubi... 2 | 16
increased circulating creatini... 2 | 38
increased circulating fructosa... 2 | 13
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased grip strength 2 | 41
increased hemoglobin content 2 | 45
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
narrow eye opening 2 | 12
polycystic kidney 2 | 15
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
tremors 2 | 39
trunk curl 2 | 16

Disease

Carcinoma 282 | 11,192
ovarian cancer 270 | 8,297
osteosarcoma 225 | 7,766
glioblastoma 170 | 5,635
psoriasis 166 | 6,514
medulloblastoma, large-cell 165 | 6,086
lung cancer 128 | 4,607
atypical teratoid / rhabdoid tumor 123 | 4,971
ependymoma 114 | 4,559
Breast cancer 102 | 3,469
lung carcinoma 100 | 2,755
Astrocytoma, Pilocytic 99 | 3,006
malignant mesothelioma 97 | 3,135
invasive ductal carcinoma 95 | 2,867
adult high grade glioma 91 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 91 | 3,204
Cancer 90 | 2,388
tuberculosis 88 | 1,963
intraductal papillary-mucinous adenoma (IPMA) 86 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 85 | 2,902
diabetes mellitus 83 | 1,683
group 3 medulloblastoma 82 | 4,002
Autosomal recessive predisposition 81 | 1,407
subependymal giant cell astrocytoma 81 | 2,230
pancreatic cancer 78 | 2,322
non-small cell lung cancer 71 | 2,799
lung adenocarcinoma 70 | 2,627
Multiple myeloma 68 | 1,296
pancreatic ductal adenocarcinoma liver metastasis 67 | 1,911
interstitial cystitis 64 | 2,237
oligodendroglioma 63 | 2,768
primitive neuroectodermal tumor 62 | 2,957
breast carcinoma 61 | 1,589
Kidney cancer 59 | 2,548
Pick disease 58 | 1,856
astrocytic glioma 58 | 2,530
astrocytoma 58 | 1,113
ulcerative colitis 57 | 1,765
ductal carcinoma in situ 55 | 1,686
acute quadriplegic myopathy 52 | 1,133
Rheumatoid arthritis 51 | 1,156
juvenile dermatomyositis 51 | 1,147
cystic fibrosis 49 | 1,629
dermatomyositis 49 | 941
pituitary cancer 49 | 1,915
Waldenstrons macroglobulinemia 48 | 742
cutaneous lupus erythematosus 48 | 1,016
primary pancreatic ductal adenocarcinoma 47 | 1,071
group 4 medulloblastoma 45 | 1,806
adrenocortical carcinoma 42 | 1,385
Epilepsy 41 | 775
Intellectual disability 40 | 998
pediatric high grade glioma 40 | 1,035
Duchenne muscular dystrophy 38 | 587
esophageal adenocarcinoma 38 | 696
Muscle hypotonia 37 | 562
Seizures 36 | 584
active Crohn's disease 36 | 882
colon cancer 36 | 1,428
Dull intelligence 35 | 634
Low intelligence 35 | 634
Mental Retardation 35 | 634
Mental deficiency 35 | 634
Neurodegenerative disease 35 | 402
Poor school performance 35 | 634
Alzheimer's disease 33 | 640
Hepatomegaly 33 | 280
primary Sjogren syndrome 33 | 710
spina bifida 32 | 1,053
Schizophrenia 31 | 1,136
Splenomegaly 31 | 186
Atopic dermatitis 30 | 915
Liver Cirrhosis, Experimental 30 | 733
Cognitive delay 28 | 596
Global developmental delay 28 | 596
Mental and motor retardation 28 | 596
mucosa-associated lymphoid tissue lymphoma 27 | 473
Down syndrome 26 | 480
gastric carcinoma 26 | 781
Multiple Sclerosis 25 | 527
active ulcerative colitis 25 | 736
non primary Sjogren syndrome sicca 25 | 861
Cerebellar Ataxia 24 | 302
Anemia 22 | 353
nasopharyngeal carcinoma 22 | 1,024
Congenital deafness 21 | 180
Deafness 21 | 193
Dementia 21 | 172
Hearing Loss, Partial 21 | 180
Short stature 21 | 514
hearing impairment 21 | 194
sonic hedgehog group medulloblastoma 21 | 459
Coarse facial features 20 | 103
Kidney disease 20 | 411
Thickened facial skin with coarse facial features 20 | 103
aldosterone-producing adenoma 20 | 646
autosomal dominant Emery-Dreifuss muscular dystrophy 20 | 492
progressive supranuclear palsy 20 | 656
Vascular disease 19 | 294
pancreatic carcinoma 19 | 555

Tissue

Endocrine System 450 | 18,159
Digestive Tract 448 | 17,369
Blood and immune system 447 | 16,909
Female tissues 447 | 17,400
Skin and soft tissues 447 | 17,230
Urinary Tract 445 | 16,678
Male tissues 444 | 17,142
Liver and Pancreas 443 | 16,750
Respiratory system 441 | 16,393
Nervous System 436 | 16,725
Cardiovascular System 424 | 15,192

Target Family

Non-IDG 277 | 12,091
Enzyme 137 | 4,145
Transporter 28 | 473
Ion Channel 8 | 344
Kinase 8 | 634
GPCR 4 | 408
Transcription Factor 3 | 1,400

Compartment GO Term

Vacuolar part 465 | 465
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Serine/threonine-protein kinase D1 PRKD1 Tchem Kinase -2.88440 775.2 667
E3 ubiquitin-protein ligase MARCH1 MARCH1 Tbio Enzyme -2.08811 122.3 133
BLOC-1-related complex subunit 8 BORCS8 Tdark Non-IDG 0.26 0.55 31
Inorganic pyrophosphatase PPA1 Tbio Enzyme -2.82678 691.2 169
P protein OCA2 Tbio Non-IDG -2.47946 286.8 125
E3 ubiquitin-protein ligase MARCH2 MARCH2 Tbio Enzyme -2.03161 106.7 150
Tubulin beta-4B chain TUBB4B Tclin Non-IDG -0.95954 8.09 107
Ras-related protein Rab-12 RAB12 Tbio Enzyme -1.21868 13.9 73
Vacuole membrane protein 1 VMP1 Tbio Non-IDG -2.49755 302.1 137