Development Level

Tbio 336 | 11,445
Tchem 74 | 1,598
Tdark 51 | 6,588
Tclin 16 | 613

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 35 | 979
embryonic lethality prior to t... 11 | 278
abnormal behavior 10 | 298
preweaning lethality, incomple... 10 | 499
embryonic lethality prior to o... 9 | 239
increased circulating alkaline... 8 | 122
increased lean body mass 8 | 172
short tibia 8 | 97
abnormal heart morphology 7 | 162
decreased body weight 7 | 161
decreased total body fat amoun... 7 | 207
hypoactivity 7 | 132
increased bone mineral content 7 | 108
increased bone mineral density 7 | 72
abnormal bone structure 6 | 187
abnormal embryo size 6 | 220
abnormal seminal vesicle morph... 6 | 114
enlarged heart 6 | 210
increased circulating sodium l... 6 | 71
increased mean corpuscular hem... 6 | 96
small adrenal glands 6 | 16
decreased circulating serum al... 5 | 82
decreased vertical activity 5 | 208
edema 5 | 59
cataract 4 | 92
decreased circulating HDL chol... 4 | 68
decreased mean corpuscular hem... 4 | 50
decreased prepulse inhibition 4 | 82
enlarged lymph nodes 4 | 37
hyperactivity 4 | 148
increased blood urea nitrogen ... 4 | 48
increased circulating potassiu... 4 | 29
increased circulating triglyce... 4 | 42
increased mean corpuscular vol... 4 | 92
abnormal bone mineralization 3 | 38
abnormal coat-hair pigmentatio... 3 | 64
abnormal craniofacial morpholo... 3 | 33
abnormal iris morphology 3 | 13
abnormal pericardium morpholog... 3 | 26
absent pinna reflex 3 | 23
decreased circulating choleste... 3 | 93
decreased circulating insulin ... 3 | 76
decreased mean corpuscular vol... 3 | 79
hemorrhage 3 | 23
increased leukocyte cell numbe... 3 | 47
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
small superior vagus ganglion 3 | 74
thrombocytosis 3 | 27
abnormal behavioral response t... 2 | 66
abnormal cecum morphology 2 | 7
abnormal coat appearance 2 | 31
abnormal eye morphology 2 | 68
abnormal eye size 2 | 7
abnormal head size 2 | 6
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal locomotor activation 2 | 16
abnormal neural tube closure 2 | 46
abnormal response to new envir... 2 | 10
abnormal retina morphology 2 | 71
abnormal skin coloration 2 | 25
abnormal snout morphology 2 | 23
abnormal tail morphology 2 | 25
cardiovascular system phenotyp... 2 | 36
decreased bone mineral density 2 | 126
decreased circulating calcium ... 2 | 36
decreased circulating glucose ... 2 | 126
decreased circulating sodium l... 2 | 22
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
enlarged cecum 2 | 5
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased B cell number 2 | 9
increased body weight 2 | 25
increased circulating HDL chol... 2 | 80
increased circulating bilirubi... 2 | 16
increased circulating creatini... 2 | 38
increased circulating fructosa... 2 | 13
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased grip strength 2 | 41
increased hemoglobin content 2 | 45
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
narrow eye opening 2 | 12
polycystic kidney 2 | 15
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
tremors 2 | 39
trunk curl 2 | 16

Disease

Carcinoma 287 | 11,493
ovarian cancer 277 | 8,520
osteosarcoma 231 | 7,950
glioblastoma 174 | 5,792
psoriasis 171 | 6,694
medulloblastoma, large-cell 166 | 6,241
lung cancer 134 | 4,740
atypical teratoid / rhabdoid tumor 125 | 5,112
ependymoma 118 | 4,679
Breast cancer 103 | 3,578
lung carcinoma 103 | 2,843
Astrocytoma, Pilocytic 102 | 3,081
malignant mesothelioma 101 | 3,232
invasive ductal carcinoma 96 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 94 | 3,291
adult high grade glioma 93 | 3,801
Cancer 92 | 2,499
tuberculosis 89 | 2,010
intraductal papillary-mucinous adenoma (IPMA) 87 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 86 | 2,989
diabetes mellitus 85 | 1,728
subependymal giant cell astrocytoma 85 | 2,287
Autosomal recessive predisposition 83 | 1,442
group 3 medulloblastoma 82 | 4,104
pancreatic cancer 78 | 2,398
non-small cell lung cancer 74 | 2,890
lung adenocarcinoma 73 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 71 | 1,962
Multiple myeloma 69 | 1,332
interstitial cystitis 66 | 2,312
oligodendroglioma 64 | 2,850
primitive neuroectodermal tumor 63 | 3,035
Kidney cancer 61 | 2,613
breast carcinoma 61 | 1,638
astrocytoma 60 | 1,146
Pick disease 59 | 1,894
astrocytic glioma 59 | 2,597
ulcerative colitis 58 | 1,819
ductal carcinoma in situ 55 | 1,745
Rheumatoid arthritis 54 | 1,191
juvenile dermatomyositis 54 | 1,187
acute quadriplegic myopathy 52 | 1,158
pituitary cancer 52 | 1,972
dermatomyositis 50 | 966
Waldenstrons macroglobulinemia 49 | 765
cystic fibrosis 49 | 1,696
cutaneous lupus erythematosus 48 | 1,057
group 4 medulloblastoma 48 | 1,855
primary pancreatic ductal adenocarcinoma 48 | 1,109
Epilepsy 43 | 792
adrenocortical carcinoma 43 | 1,428
Intellectual disability 42 | 1,016
pediatric high grade glioma 41 | 1,064
Duchenne muscular dystrophy 39 | 601
active Crohn's disease 39 | 922
esophageal adenocarcinoma 39 | 737
Muscle hypotonia 38 | 571
Dull intelligence 37 | 645
Low intelligence 37 | 645
Mental Retardation 37 | 645
Mental deficiency 37 | 645
Poor school performance 37 | 645
Seizures 37 | 596
colon cancer 37 | 1,478
Neurodegenerative disease 36 | 414
Hepatomegaly 35 | 285
primary Sjogren syndrome 35 | 735
Alzheimer's disease 33 | 658
Schizophrenia 33 | 1,160
Liver Cirrhosis, Experimental 32 | 769
Splenomegaly 32 | 190
spina bifida 32 | 1,074
Atopic dermatitis 31 | 952
Cognitive delay 28 | 608
Global developmental delay 28 | 608
Mental and motor retardation 28 | 608
mucosa-associated lymphoid tissue lymphoma 28 | 484
Down syndrome 27 | 499
active ulcerative colitis 27 | 764
gastric carcinoma 27 | 807
non primary Sjogren syndrome sicca 27 | 891
Multiple Sclerosis 26 | 540
Cerebellar Ataxia 24 | 304
Anemia 23 | 365
Short stature 23 | 531
Dementia 22 | 175
nasopharyngeal carcinoma 22 | 1,058
Coarse facial features 21 | 108
Congenital deafness 21 | 185
Deafness 21 | 198
Hearing Loss, Partial 21 | 185
Thickened facial skin with coarse facial features 21 | 108
aldosterone-producing adenoma 21 | 665
hearing impairment 21 | 199
progressive supranuclear palsy 21 | 676
sonic hedgehog group medulloblastoma 21 | 467
Kidney disease 20 | 430
autosomal dominant Emery-Dreifuss muscular dystrophy 20 | 510
Vascular disease 19 | 319
limb girdle muscular dystrophy 2A 19 | 213

Tissue

Endocrine System 462 | 18,159
Blood and immune system 458 | 16,909
Digestive Tract 458 | 17,369
Female tissues 458 | 17,400
Skin and soft tissues 458 | 17,230
Liver and Pancreas 454 | 16,750
Urinary Tract 454 | 16,678
Male tissues 453 | 17,142
Respiratory system 452 | 16,393
Nervous System 446 | 16,725
Cardiovascular System 432 | 15,192

Target Family

Non-IDG 278 | 12,091
Enzyme 147 | 4,145
Transporter 29 | 473
Ion Channel 8 | 344
Kinase 8 | 634
GPCR 4 | 408
Transcription Factor 3 | 1,400

Compartment GO Term

Vacuolar part 477 | 477
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
Transient receptor potential cation channel subfamily M member 2 TRPM2 Tchem Ion Channel -1.34318 25.1 209
Proton-coupled amino acid transporter 2 SLC36A2 Tchem Transporter -1.78507 61.5 88
Sorting nexin-14 SNX14 Tbio Non-IDG -0.86091 6.82 56
CKLF-like MARVEL transmembrane domain-containing protein 6 CMTM6 Tdark Non-IDG -0.56950 2.80 85
GATOR complex protein WDR24 WDR24 Tdark Non-IDG 0.16 1.02 28
Beta-1,4-galactosyltransferase 1 B4GALT1 Tbio Enzyme -2.34454 211.1 130
Heme-binding protein 2 HEBP2 Tbio Non-IDG -1.05941 10.8 114
Carcinoembryonic antigen-related cell adhesion molecule 6 CEACAM6 Tbio Non-IDG -2.41947 255.1 325