Development Level

Tbio 505 | 10,625
Tdark 77 | 7,003
Tchem 71 | 1,890
Tclin 14 | 602

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 34 | 633
abnormal behavior 12 | 226
embryonic lethality prior to t... 12 | 187
decreased total body fat amoun... 11 | 186
embryonic lethality prior to o... 11 | 148
hypoactivity 10 | 89
decreased mean corpuscular vol... 9 | 50
preweaning lethality, incomple... 9 | 260
decreased body weight 8 | 174
increased mean corpuscular hem... 8 | 93
abnormal retinal pigmentation 7 | 61
abnormal sleep behavior 6 | 63
decreased body length 6 | 108
decreased grip strength 6 | 123
decreased mean corpuscular hem... 6 | 34
decreased prepulse inhibition 6 | 52
increased bone mineral content 6 | 92
increased bone mineral density 6 | 52
increased circulating alkaline... 6 | 119
increased or absent threshold ... 6 | 128
abnormal bone structure 5 | 131
abnormal retina morphology 5 | 100
cardiovascular system phenotyp... 5 | 35
decreased bone mineral density 5 | 126
decreased lean body mass 5 | 195
decreased rib number 5 | 59
improved glucose tolerance 5 | 56
increased circulating sodium l... 5 | 71
increased lean body mass 5 | 107
thrombocytosis 5 | 23
abnormal bone mineralization 4 | 55
abnormal epididymis morphology 4 | 31
decreased circulating HDL chol... 4 | 77
decreased circulating serum al... 4 | 79
decreased hemoglobin content 4 | 53
increased circulating chloride... 4 | 43
increased circulating choleste... 4 | 53
increased circulating potassiu... 4 | 31
increased circulating serum al... 4 | 25
increased fasted circulating g... 4 | 68
increased leukocyte cell numbe... 4 | 37
increased mean corpuscular vol... 4 | 91
short tibia 4 | 82
abnormal kidney morphology 3 | 30
abnormal skin morphology 3 | 23
absent pinna reflex 3 | 21
decreased bone mineral content 3 | 157
decreased circulating LDL chol... 3 | 37
decreased circulating choleste... 3 | 85
decreased circulating triglyce... 3 | 83
decreased eosinophil cell numb... 3 | 41
decreased erythrocyte cell num... 3 | 43
decreased hematocrit 3 | 25
decreased leukocyte cell numbe... 3 | 54
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 19
enlarged epididymis 3 | 27
enlarged heart 3 | 111
hyperactivity 3 | 108
impaired glucose tolerance 3 | 52
increased B cell number 3 | 23
increased blood urea nitrogen ... 3 | 44
increased body weight 3 | 42
increased circulating HDL chol... 3 | 63
increased circulating LDL chol... 3 | 15
increased rib number 3 | 41
increased sacral vertebrae num... 3 | 62
prenatal lethality prior to he... 3 | 64
abnormal QRS complex 2 | 25
abnormal body wall morphology 2 | 7
abnormal coat/hair pigmentatio... 2 | 54
abnormal embryo size 2 | 112
abnormal eye size 2 | 11
abnormal lens morphology 2 | 73
abnormal limb bud morphology 2 | 15
abnormal lung morphology 2 | 15
abnormal testis morphology 2 | 30
abnormal vertebrae morphology 2 | 14
absent vibrissae 2 | 14
decreased CD4-positive, alpha ... 2 | 19
decreased CD8-positive, alpha-... 2 | 26
decreased NK T cell number 2 | 28
decreased T cell number 2 | 31
decreased blood urea nitrogen ... 2 | 31
decreased circulating alkaline... 2 | 41
decreased circulating free fat... 2 | 39
decreased circulating insulin ... 2 | 75
decreased circulating phosphat... 2 | 15
decreased fasted circulating g... 2 | 49
decreased heart rate 2 | 10
enlarged lymph nodes 2 | 27
enlarged spleen 2 | 26
hemorrhage 2 | 12
increased NK T cell number 2 | 11
increased NK cell number 2 | 19
increased circulating calcium ... 2 | 32
increased exploration in new e... 2 | 56
limb grasping 2 | 35
straub tail 2 | 26
trunk curl 2 | 15

Disease

ovarian cancer 365 | 8,484
osteosarcoma 286 | 7,933
psoriasis 253 | 6,685
medulloblastoma, large-cell 244 | 6,234
glioblastoma 230 | 5,572
Cancer 167 | 2,346
atypical teratoid / rhabdoid tumor 161 | 4,369
lung cancer 154 | 4,466
diabetes mellitus 129 | 1,663
invasive ductal carcinoma 118 | 2,950
pilocytic astrocytoma 118 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 116 | 3,289
pediatric high grade glioma 112 | 2,712
lung carcinoma 110 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 106 | 2,956
subependymal giant cell astrocytoma 106 | 2,287
Breast cancer 102 | 3,094
oligodendroglioma 100 | 2,849
ependymoma 99 | 2,514
malignant mesothelioma 99 | 3,162
Rheumatoid Arthritis 98 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 98 | 2,988
pancreatic cancer 95 | 2,300
non-small cell lung cancer 94 | 2,798
Pick disease 87 | 1,893
astrocytic glioma 86 | 2,241
primitive neuroectodermal tumor 83 | 3,031
lung adenocarcinoma 80 | 2,713
astrocytoma 79 | 1,493
adult high grade glioma 78 | 2,148
tuberculosis 78 | 1,557
Multiple myeloma 76 | 1,327
interstitial cystitis 76 | 2,299
ulcerative colitis 75 | 2,087
Ankylosing spondylitis 74 | 138
juvenile dermatomyositis 74 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 73 | 1,795
Hypersensitivity reaction type II disease 72 | 235
Arthritis 68 | 248
Carcinoma 68 | 2,147
breast carcinoma 65 | 1,614
group 4 medulloblastoma 65 | 1,875
primary pancreatic ductal adenocarcinoma 65 | 1,271
Juvenile rheumatoid arthritis 61 | 104
dermatomyositis 61 | 933
ductal carcinoma in situ 61 | 1,745
cystic fibrosis 60 | 1,665
Acquired immunodeficiency syndrome 59 | 164
Uveitis 58 | 103
medulloblastoma 57 | 1,524
Behcet's disease 56 | 74
pituitary cancer 56 | 1,972
acute quadriplegic myopathy 55 | 1,157
Psoriatic arthritis 52 | 83
posterior fossa group A ependymoma 51 | 1,511
group 3 medulloblastoma 48 | 2,254
adrenocortical carcinoma 46 | 1,427
cutaneous lupus erythematosus 46 | 1,056
spina bifida 45 | 1,064
Multiple Sclerosis 44 | 498
colon cancer 43 | 1,475
posterior fossa group B ependymoma 43 | 1,530
Alzheimer's disease 42 | 644
esophageal adenocarcinoma 42 | 737
primary Sjogren syndrome 42 | 789
sonic hedgehog group medulloblastoma 42 | 1,482
Stevens-Johnson syndrome 41 | 78
Kidney disease 40 | 396
active Crohn's disease 40 | 918
atypical teratoid/rhabdoid tumor 39 | 1,095
Liver disease 36 | 219
Neurodegenerative disease 36 | 383
Waldenstrons macroglobulinemia 36 | 765
Anemia 35 | 252
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
gastric carcinoma 33 | 832
Down syndrome 32 | 548
Duchenne muscular dystrophy 32 | 602
progressive supranuclear palsy 32 | 674
mucosa-associated lymphoid tissue lymphoma 31 | 480
Hepatitis B 29 | 103
acute myeloid leukemia 29 | 780
non primary Sjogren syndrome sicca 28 | 840
Leprosy 27 | 77
fibroadenoma 27 | 557
Hemochromatosis 26 | 55
IGA Glomerulonephritis 26 | 454
aldosterone-producing adenoma 25 | 664
pancreatic carcinoma 24 | 567
Skin disease 23 | 65
tuberculosis and treatment for 6 months 23 | 686
Primary immunodeficiency disease 22 | 52
active ulcerative colitis 22 | 477
Parkinson's disease 21 | 364
Schizophrenia 21 | 501
Atopic dermatitis 20 | 944
sarcoidosis 20 | 358
Obesity 19 | 616

Tissue

Nervous System 594 | 18,561
Digestive Tract 593 | 18,473
Female tissues 593 | 18,647
Urinary Tract 593 | 18,444
Endocrine System 592 | 18,512
Liver and Pancreas 592 | 18,136
Male tissues 592 | 17,969
Cardiovascular System 590 | 17,958
Respiratory system 588 | 17,484
Blood and immune system 587 | 17,995
Skin and soft tissues 582 | 18,115

Target Family

Non-IDG 460 | 11,971
Enzyme 127 | 4,146
Transporter 39 | 473
Kinase 23 | 634
Ion Channel 12 | 341
GPCR 4 | 406
Transcription Factor 2 | 1,400

Compartment GO Term

Vacuolar membrane 667 | 667
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

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