Development Level

Tbio 223 | 11,178
Tdark 41 | 6,569
Tchem 38 | 1,885
Tclin 7 | 612

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 27 | 979
abnormal behavior 9 | 298
embryonic lethality prior to t... 9 | 278
embryonic lethality prior to o... 8 | 239
preweaning lethality, incomple... 8 | 499
decreased body weight 7 | 161
abnormal embryo size 6 | 220
decreased total body fat amoun... 6 | 207
increased bone mineral density 6 | 72
increased lean body mass 6 | 172
abnormal bone structure 5 | 187
edema 5 | 59
hypoactivity 5 | 132
increased bone mineral content 5 | 108
increased circulating alkaline... 5 | 122
increased circulating sodium l... 5 | 71
increased mean corpuscular hem... 5 | 96
short tibia 5 | 97
abnormal heart morphology 4 | 162
abnormal seminal vesicle morph... 4 | 114
decreased vertical activity 4 | 208
abnormal bone mineralization 3 | 38
abnormal craniofacial morpholo... 3 | 33
abnormal iris morphology 3 | 13
abnormal pericardium morpholog... 3 | 26
absent pinna reflex 3 | 23
decreased circulating serum al... 3 | 82
decreased mean corpuscular hem... 3 | 50
decreased prepulse inhibition 3 | 82
enlarged lymph nodes 3 | 37
hemorrhage 3 | 23
increased blood urea nitrogen ... 3 | 48
increased circulating potassiu... 3 | 29
increased circulating triglyce... 3 | 42
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular vol... 3 | 92
increased startle reflex 3 | 112
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
abnormal behavioral response t... 2 | 66
abnormal cecum morphology 2 | 7
abnormal coat-hair pigmentatio... 2 | 64
abnormal eye morphology 2 | 68
abnormal eye size 2 | 7
abnormal head size 2 | 6
abnormal kidney morphology 2 | 65
abnormal locomotor activation 2 | 16
abnormal neural tube closure 2 | 46
abnormal response to new envir... 2 | 10
abnormal retina morphology 2 | 71
abnormal skin coloration 2 | 25
cardiovascular system phenotyp... 2 | 36
decreased bone mineral density 2 | 126
decreased circulating calcium ... 2 | 36
decreased circulating insulin ... 2 | 76
decreased circulating sodium l... 2 | 22
decreased erythrocyte cell num... 2 | 62
decreased mean corpuscular vol... 2 | 79
enlarged cecum 2 | 5
enlarged heart 2 | 210
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased B cell number 2 | 9
increased body weight 2 | 25
increased circulating HDL chol... 2 | 80
increased circulating creatini... 2 | 38
increased circulating fructosa... 2 | 13
increased circulating iron lev... 2 | 30
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased hemoglobin content 2 | 45
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
narrow eye opening 2 | 12
polycystic kidney 2 | 15
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
small adrenal glands 2 | 16
thrombocytosis 2 | 27
tremors 2 | 39
trunk curl 2 | 16
abnormal body wall morphology 1 | 9
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal optic disc morphology 1 | 10
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
convulsive seizures 1 | 13
decreased T cell number 1 | 15
decreased circulating amylase ... 1 | 28
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
enlarged spleen 1 | 41
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased circulating choleste... 1 | 66
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
persistence of hyaloid vascula... 1 | 33

Disease

ovarian cancer 187 | 8,297
Carcinoma 182 | 11,192
osteosarcoma 151 | 7,766
medulloblastoma, large-cell 116 | 6,086
glioblastoma 115 | 5,635
psoriasis 92 | 6,514
atypical teratoid / rhabdoid tumor 82 | 4,971
lung cancer 79 | 4,607
ependymoma 76 | 4,559
lung carcinoma 72 | 2,755
adult high grade glioma 66 | 3,701
invasive ductal carcinoma 63 | 2,867
Astrocytoma, Pilocytic 62 | 3,006
Breast cancer 62 | 3,469
malignant mesothelioma 60 | 3,135
tuberculosis 58 | 1,963
intraductal papillary-mucinous neoplasm (IPMN) 57 | 3,204
intraductal papillary-mucinous carcinoma (IPMC) 55 | 2,902
subependymal giant cell astrocytoma 53 | 2,230
intraductal papillary-mucinous adenoma (IPMA) 52 | 2,872
group 3 medulloblastoma 51 | 4,002
pancreatic cancer 51 | 2,322
Cancer 49 | 2,388
diabetes mellitus 46 | 1,683
non-small cell lung cancer 46 | 2,799
pancreatic ductal adenocarcinoma liver metastasis 46 | 1,911
Multiple myeloma 44 | 1,296
lung adenocarcinoma 43 | 2,627
astrocytic glioma 41 | 2,530
interstitial cystitis 41 | 2,237
oligodendroglioma 41 | 2,768
Kidney cancer 40 | 2,548
Pick disease 40 | 1,856
breast carcinoma 40 | 1,589
Autosomal recessive predisposition 38 | 1,407
primitive neuroectodermal tumor 38 | 2,957
acute quadriplegic myopathy 36 | 1,133
astrocytoma 36 | 1,113
Rheumatoid arthritis 34 | 1,156
dermatomyositis 32 | 941
ductal carcinoma in situ 32 | 1,686
ulcerative colitis 32 | 1,765
juvenile dermatomyositis 30 | 1,147
active Crohn's disease 29 | 882
cystic fibrosis 29 | 1,629
pediatric high grade glioma 29 | 1,035
group 4 medulloblastoma 28 | 1,806
pituitary cancer 28 | 1,915
cutaneous lupus erythematosus 27 | 1,016
primary pancreatic ductal adenocarcinoma 27 | 1,071
adrenocortical carcinoma 26 | 1,385
Waldenstrons macroglobulinemia 23 | 742
esophageal adenocarcinoma 23 | 696
mucosa-associated lymphoid tissue lymphoma 23 | 473
Alzheimer's disease 22 | 640
Muscle hypotonia 22 | 562
colon cancer 21 | 1,428
spina bifida 21 | 1,053
Intellectual disability 20 | 998
primary Sjogren syndrome 20 | 710
Epilepsy 19 | 775
Down syndrome 18 | 480
Liver Cirrhosis, Experimental 18 | 733
active ulcerative colitis 18 | 736
Duchenne muscular dystrophy 17 | 587
Multiple Sclerosis 17 | 527
Cognitive delay 16 | 596
Dull intelligence 16 | 634
Global developmental delay 16 | 596
Low intelligence 16 | 634
Mental Retardation 16 | 634
Mental and motor retardation 16 | 596
Mental deficiency 16 | 634
Neurodegenerative disease 16 | 402
Poor school performance 16 | 634
Schizophrenia 16 | 1,136
gastric carcinoma 16 | 781
Anemia 14 | 353
non primary Sjogren syndrome sicca 14 | 861
Seizures 13 | 584
medulloblastoma 13 | 702
pancreatic carcinoma 13 | 555
progressive supranuclear palsy 13 | 656
Melanoma 12 | 689
Splenomegaly 12 | 186
head and neck cancer and chronic obstructive pulmonary disease 12 | 226
hepatocellular carcinoma 12 | 536
nasopharyngeal carcinoma 12 | 1,024
posterior fossa group A ependymoma 12 | 456
sarcoidosis 12 | 357
Crohn's disease 11 | 311
Hepatomegaly 11 | 280
Hypersensitivity reaction type II disease 11 | 245
aldosterone-producing adenoma 11 | 646
Asthma 10 | 370
Atopic dermatitis 10 | 915
Cerebellar Ataxia 10 | 302
Failure to gain weight 10 | 359
Pediatric failure to thrive 10 | 359
sonic hedgehog group medulloblastoma 10 | 459

Tissue

Endocrine System 301 | 18,159
Blood and immune system 300 | 16,909
Digestive Tract 300 | 17,369
Female tissues 299 | 17,400
Male tissues 299 | 17,142
Respiratory system 299 | 16,393
Skin and soft tissues 299 | 17,230
Urinary Tract 298 | 16,678
Liver and Pancreas 296 | 16,750
Nervous System 294 | 16,725
Cardiovascular System 286 | 15,192

Target Family

Non-IDG 194 | 12,091
Enzyme 70 | 4,145
Transporter 28 | 473
Ion Channel 8 | 344
GPCR 4 | 408
Kinase 3 | 634
Transcription Factor 2 | 1,400

Compartment GO Term

Vacuolar membrane 309 | 309
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Serine/threonine-protein kinase D1 PRKD1 Tchem Kinase -2.88440 775.2 667
E3 ubiquitin-protein ligase MARCH1 MARCH1 Tbio Enzyme -2.08811 122.3 133
BLOC-1-related complex subunit 8 BORCS8 Tdark Non-IDG 0.26 0.55 31
Inorganic pyrophosphatase PPA1 Tbio Enzyme -2.82678 691.2 169
P protein OCA2 Tbio Non-IDG -2.47946 286.8 125
E3 ubiquitin-protein ligase MARCH2 MARCH2 Tbio Enzyme -2.03161 106.7 150
Ras-related protein Rab-12 RAB12 Tbio Enzyme -1.21868 13.9 73
Vacuole membrane protein 1 VMP1 Tbio Non-IDG -2.49755 302.1 137
Protein LTV1 homolog LTV1 Tdark Non-IDG -1.50402 31.8 46