Development Level

Tbio 217 | 11,178
Tdark 76 | 6,569
Tchem 28 | 1,885
Tclin 4 | 612

Collection

GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 27 | 979
preweaning lethality, incomple... 16 | 499
abnormal embryo size 11 | 220
embryonic lethality prior to t... 10 | 278
abnormal behavior 8 | 298
abnormal heart morphology 8 | 162
embryonic lethality prior to o... 8 | 239
enlarged heart 7 | 210
embryonic growth retardation 6 | 106
increased mean corpuscular vol... 6 | 92
decreased hemoglobin content 5 | 68
decreased lean body mass 5 | 135
increased circulating HDL chol... 5 | 80
increased mean corpuscular hem... 5 | 96
short tibia 5 | 97
abnormal bone structure 4 | 187
decreased body weight 4 | 161
decreased bone mineral content 4 | 151
decreased circulating chloride... 4 | 30
decreased circulating creatini... 4 | 39
decreased circulating glucose ... 4 | 126
decreased grip strength 4 | 116
decreased startle reflex 4 | 75
decreased vertical activity 4 | 208
hypoactivity 4 | 132
impaired glucose tolerance 4 | 75
increased grip strength 4 | 41
increased hematocrit 4 | 46
increased lean body mass 4 | 172
male infertility 4 | 123
prenatal lethality prior to he... 4 | 87
abnormal bone mineralization 3 | 38
abnormal gait 3 | 69
anophthalmia 3 | 33
decreased basophil cell number 3 | 16
decreased blood urea nitrogen ... 3 | 51
decreased circulating iron lev... 3 | 32
decreased erythrocyte cell num... 3 | 62
decreased leukocyte cell numbe... 3 | 73
decreased red blood cell distr... 3 | 41
decreased total body fat amoun... 3 | 207
enlarged spleen 3 | 41
female infertility 3 | 60
increased circulating creatini... 3 | 38
increased circulating triglyce... 3 | 42
increased heart weight 3 | 62
increased mean platelet volume 3 | 45
increased or absent threshold ... 3 | 101
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
thrombocytopenia 3 | 56
abnormal craniofacial morpholo... 2 | 33
abnormal heart left ventricle ... 2 | 16
abnormal joint morphology 2 | 23
abnormal neural tube closure 2 | 46
abnormal placenta size 2 | 20
abnormal seminal vesicle morph... 2 | 114
abnormal skin coloration 2 | 25
abnormal sleep behavior 2 | 70
abnormal spleen morphology 2 | 55
abnormal vocalization 2 | 21
brachydactyly 2 | 19
corneal opacity 2 | 32
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating alanine ... 2 | 47
decreased circulating alkaline... 2 | 46
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased heart left ventricle... 2 | 28
decreased hematocrit 2 | 46
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased prepulse inhibition 2 | 82
dilated heart left ventricle 2 | 11
edema 2 | 59
hyperactivity 2 | 148
increased blood urea nitrogen ... 2 | 48
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased circulating glucose ... 2 | 24
increased fasted circulating g... 2 | 76
increased neutrophil cell numb... 2 | 46
limb grasping 2 | 41
microphthalmia 2 | 26
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
prolonged QT interval 2 | 38
small adrenal glands 2 | 16
small spleen 2 | 19
small testis 2 | 58
syndactyly 2 | 23
thrombocytosis 2 | 27
vertebral fusion 2 | 23
decreased circulating serum al... 1 | 82
increased cardiac muscle contr... 1 | 8

Disease

Carcinoma 213 | 11,192
ovarian cancer 196 | 8,297
osteosarcoma 159 | 7,766
medulloblastoma, large-cell 138 | 6,086
glioblastoma 126 | 5,635
psoriasis 120 | 6,514
atypical teratoid / rhabdoid tumor 113 | 4,971
ependymoma 85 | 4,559
adult high grade glioma 84 | 3,701
lung cancer 83 | 4,607
Breast cancer 76 | 3,469
group 3 medulloblastoma 76 | 4,002
primitive neuroectodermal tumor 72 | 2,957
oligodendroglioma 69 | 2,768
Cancer 66 | 2,388
malignant mesothelioma 66 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 57 | 3,204
invasive ductal carcinoma 55 | 2,867
astrocytic glioma 54 | 2,530
Astrocytoma, Pilocytic 53 | 3,006
non-small cell lung cancer 51 | 2,799
Kidney cancer 47 | 2,548
group 4 medulloblastoma 45 | 1,806
intraductal papillary-mucinous carcinoma (IPMC) 45 | 2,902
subependymal giant cell astrocytoma 45 | 2,230
Multiple myeloma 44 | 1,296
pancreatic cancer 42 | 2,322
adrenocortical carcinoma 39 | 1,385
breast carcinoma 37 | 1,589
lung adenocarcinoma 37 | 2,627
tuberculosis 36 | 1,963
ductal carcinoma in situ 34 | 1,686
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,872
lung carcinoma 33 | 2,755
pituitary cancer 33 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,911
ulcerative colitis 31 | 1,765
Pick disease 30 | 1,856
interstitial cystitis 29 | 2,237
acute quadriplegic myopathy 27 | 1,133
Rheumatoid arthritis 26 | 1,156
Intellectual disability 25 | 998
colon cancer 23 | 1,428
diabetes mellitus 23 | 1,683
juvenile dermatomyositis 23 | 1,147
spina bifida 23 | 1,053
astrocytoma 22 | 1,113
dermatomyositis 20 | 941
pediatric high grade glioma 19 | 1,035
Autosomal recessive predisposition 18 | 1,407
Waldenstrons macroglobulinemia 18 | 742
Atopic dermatitis 17 | 915
aldosterone-producing adenoma 17 | 646
medulloblastoma 17 | 702
nasopharyngeal carcinoma 17 | 1,024
primary Sjogren syndrome 17 | 710
Dull intelligence 16 | 634
Low intelligence 16 | 634
Mental Retardation 16 | 634
Mental deficiency 16 | 634
Parkinson's disease 16 | 378
Poor school performance 16 | 634
Schizophrenia 16 | 1,136
Endometriosis 15 | 521
Epilepsy 15 | 775
hepatocellular carcinoma 14 | 536
non primary Sjogren syndrome sicca 14 | 861
tuberculosis and treatment for 6 months 14 | 399
Alzheimer's disease 13 | 640
Amyotrophic lateral sclerosis 13 | 437
Small head 13 | 366
cystic fibrosis 13 | 1,629
primary pancreatic ductal adenocarcinoma 13 | 1,071
Seizures 12 | 584
Short stature 12 | 514
posterior fossa group A ependymoma 12 | 456
Bipolar Disorder 11 | 646
Cognitive delay 11 | 596
Global developmental delay 11 | 596
Mental and motor retardation 11 | 596
active Crohn's disease 11 | 882
cutaneous lupus erythematosus 11 | 1,016
gastric carcinoma 11 | 781
Acquired metabolic disease 10 | 329
Breast Neoplasms 10 | 423
Liver cancer 10 | 589
Mammary Neoplasms 10 | 403
acute myeloid leukemia 10 | 760
gastric cancer 10 | 445
sonic hedgehog group medulloblastoma 10 | 459
Cryptorchidism 9 | 287
Glaucoma 9 | 232
Prostatic Neoplasms 9 | 472
Cataract 8 | 290
Duchenne muscular dystrophy 8 | 587
Hypertensive disease 8 | 278
Lens Opacities 8 | 227
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 492
esophageal adenocarcinoma 8 | 696
pancreatic carcinoma 8 | 555

Tissue

Endocrine System 324 | 18,159
Male tissues 320 | 17,142
Digestive Tract 319 | 17,369
Skin and soft tissues 319 | 17,230
Female tissues 316 | 17,400
Nervous System 316 | 16,725
Blood and immune system 315 | 16,909
Liver and Pancreas 311 | 16,750
Urinary Tract 311 | 16,678
Respiratory system 310 | 16,393
Cardiovascular System 303 | 15,192

Target Family

Non-IDG 241 | 12,091
Enzyme 59 | 4,145
Kinase 9 | 634
Epigenetic 8 | 242
Transcription Factor 6 | 1,400
GPCR 1 | 408
Nuclear Receptor 1 | 48

Compartment GO Term

Ubiquitin ligase complex 325 | 325
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
E3 ubiquitin-protein ligase MARCH6 MARCH6 Tbio Enzyme -1.67925 45.8 121
DNA damage-binding protein 1 DDB1 Tchem Non-IDG -2.34719 202.5 353
Speckle-type POZ protein-like SPOPL Tdark Non-IDG -0.40512 2.41 91
E3 ubiquitin-protein ligase NEDD4 NEDD4 Tchem Enzyme -2.44046 259.8 167
DCN1-like protein 1 DCUN1D1 Tbio Non-IDG -1.35710 26.1 224
E3 ubiquitin-protein ligase RNF14 RNF14 Tbio Enzyme -1.12199 12.5 194
Ubiquitin-conjugating enzyme E2 S UBE2S Tbio Non-IDG -2.36597 158.3 384
Ubiquitin-conjugating enzyme E2 J2 UBE2J2 Tbio Non-IDG -0.52612 2.75 84