Development Level

Tbio 210 | 10,625
Tdark 76 | 7,003
Tchem 30 | 1,890
Tclin 4 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 23 | 633
preweaning lethality, incomple... 10 | 260
decreased grip strength 8 | 123
decreased lean body mass 8 | 195
increased mean corpuscular vol... 7 | 91
abnormal embryo size 6 | 112
decreased bone mineral density 6 | 126
embryonic lethality prior to o... 6 | 148
abnormal behavior 5 | 226
decreased circulating triglyce... 5 | 83
embryonic lethality prior to t... 5 | 187
abnormal bone mineralization 4 | 55
decreased body weight 4 | 174
decreased bone mineral content 4 | 157
decreased leukocyte cell numbe... 4 | 54
increased circulating HDL chol... 4 | 63
increased grip strength 4 | 83
increased lean body mass 4 | 107
increased mean corpuscular hem... 4 | 93
increased monocyte cell number 4 | 27
decreased circulating alanine ... 3 | 53
decreased circulating glucose ... 3 | 121
decreased hemoglobin content 3 | 53
decreased lymphocyte cell numb... 3 | 9
decreased rib number 3 | 59
decreased total body fat amoun... 3 | 186
embryonic growth retardation 3 | 28
enlarged spleen 3 | 26
increased bone mineral density 3 | 52
increased circulating alkaline... 3 | 119
increased circulating choleste... 3 | 53
increased circulating glucose ... 3 | 16
increased circulating triglyce... 3 | 24
increased effector memory CD8-... 3 | 14
increased fasted circulating g... 3 | 68
increased neutrophil cell numb... 3 | 15
thrombocytopenia 3 | 46
abnormal QRS complex 2 | 25
abnormal bone structure 2 | 131
abnormal gait 2 | 51
abnormal heart left ventricle ... 2 | 20
abnormal neural tube closure 2 | 37
abnormal skin coloration 2 | 18
abnormal spleen morphology 2 | 36
abnormal vocalization 2 | 21
anophthalmia 2 | 20
decreased CD4-positive, alpha ... 2 | 19
decreased blood urea nitrogen ... 2 | 31
decreased circulating HDL chol... 2 | 77
decreased circulating alkaline... 2 | 41
decreased circulating aspartat... 2 | 27
decreased circulating fructosa... 2 | 31
decreased circulating insulin ... 2 | 75
decreased circulating iron lev... 2 | 25
decreased circulating serum al... 2 | 79
decreased erythrocyte cell num... 2 | 43
decreased heart weight 2 | 44
decreased startle reflex 2 | 48
enlarged heart 2 | 111
hyperactivity 2 | 108
hypoactivity 2 | 89
increased NK cell number 2 | 19
increased circulating bilirubi... 2 | 16
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased effector memory CD4-... 2 | 15
increased exploration in new e... 2 | 56
increased hematocrit 2 | 36
increased or absent threshold ... 2 | 128
increased rib number 2 | 41
increased sacral vertebrae num... 2 | 62
limb grasping 2 | 35
male infertility 2 | 62
persistence of hyaloid vascula... 2 | 22
short tibia 2 | 82
small adrenal glands 2 | 15
thrombocytosis 2 | 23
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 52
abnormal defecation 1 | 1
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal rib morphology 1 | 28
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
corneal opacity 1 | 25
decreased cervical vertebrae n... 1 | 12
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased effector memory CD8-... 1 | 24
decreased gamma-delta T cell n... 1 | 18
increased CD4-positive, CD25-p... 1 | 18
increased blood urea nitrogen ... 1 | 44
increased circulating alanine ... 1 | 11
increased eosinophil cell numb... 1 | 9
increased mean platelet volume 1 | 19
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
small thymus 1 | 11

Disease

ovarian cancer 192 | 8,484
osteosarcoma 156 | 7,933
medulloblastoma, large-cell 137 | 6,234
glioblastoma 119 | 5,572
psoriasis 115 | 6,685
atypical teratoid / rhabdoid tumor 94 | 4,369
lung cancer 80 | 4,466
primitive neuroectodermal tumor 72 | 3,031
Breast cancer 67 | 3,094
oligodendroglioma 66 | 2,849
Cancer 64 | 2,346
malignant mesothelioma 62 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 58 | 3,289
pediatric high grade glioma 57 | 2,712
invasive ductal carcinoma 54 | 2,950
ependymoma 53 | 2,514
non-small cell lung cancer 50 | 2,798
pilocytic astrocytoma 48 | 3,086
group 3 medulloblastoma 45 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 45 | 2,988
subependymal giant cell astrocytoma 45 | 2,287
Multiple myeloma 44 | 1,327
astrocytic glioma 42 | 2,241
adult high grade glioma 41 | 2,148
adrenocortical carcinoma 38 | 1,427
lung adenocarcinoma 38 | 2,713
medulloblastoma 37 | 1,524
pancreatic cancer 37 | 2,300
Carcinoma 34 | 2,147
breast carcinoma 34 | 1,614
group 4 medulloblastoma 34 | 1,875
ductal carcinoma in situ 33 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,956
pituitary cancer 33 | 1,972
ulcerative colitis 32 | 2,087
lung carcinoma 31 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,795
astrocytoma 29 | 1,493
interstitial cystitis 29 | 2,299
posterior fossa group A ependymoma 29 | 1,511
sonic hedgehog group medulloblastoma 29 | 1,482
Pick disease 28 | 1,893
Rheumatoid Arthritis 25 | 1,160
acute quadriplegic myopathy 25 | 1,157
tuberculosis 25 | 1,557
tuberculosis and treatment for 6 months 24 | 686
colon cancer 23 | 1,475
juvenile dermatomyositis 22 | 1,189
spina bifida 22 | 1,064
diabetes mellitus 21 | 1,663
dermatomyositis 20 | 933
Waldenstrons macroglobulinemia 18 | 765
atypical teratoid/rhabdoid tumor 18 | 1,095
nasopharyngeal carcinoma 18 | 1,056
Atopic dermatitis 17 | 944
aldosterone-producing adenoma 17 | 664
primary Sjogren syndrome 17 | 789
Parkinson's disease 16 | 364
Intellectual disability 15 | 573
posterior fossa group B ependymoma 15 | 1,530
cystic fibrosis 14 | 1,665
primary pancreatic ductal adenocarcinoma 14 | 1,271
Endometriosis 13 | 535
IGA Glomerulonephritis 13 | 454
hepatocellular carcinoma 13 | 532
non primary Sjogren syndrome sicca 13 | 840
Amyotrophic Lateral Sclerosis 12 | 431
Alzheimer's disease 11 | 644
Mammary Neoplasms 11 | 410
active Crohn's disease 11 | 918
cutaneous lupus erythematosus 11 | 1,056
Prostatic Neoplasms 10 | 471
acute myeloid leukemia 10 | 780
gastric cancer 10 | 430
gastric carcinoma 10 | 832
esophageal adenocarcinoma 9 | 737
pancreatic carcinoma 9 | 567
Epilepsy 8 | 346
Brain Ischemia 7 | 87
Down syndrome 7 | 548
Duchenne muscular dystrophy 7 | 602
Multiple Sclerosis 7 | 498
Neurodegenerative disease 7 | 383
Schizophrenia 7 | 501
sarcoidosis 7 | 358
Acquired metabolic disease 6 | 267
Asthma 6 | 349
Autistic Disorder 6 | 320
Cockayne syndrome 6 | 54
Crohn's disease 6 | 304
Gaucher disease type 1 6 | 171
Hemangioma 6 | 35
Lung Neoplasms 6 | 171
Microcephaly 6 | 149
Prostate cancer 6 | 172
Renal Cell Carcinoma 6 | 199
Stevens-Johnson syndrome 6 | 78
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
inflammatory breast cancer 6 | 404
tuberculosis and treatment for 3 months 6 | 327

Tissue

Digestive Tract 319 | 18,473
Female tissues 319 | 18,647
Nervous System 319 | 18,561
Endocrine System 318 | 18,512
Liver and Pancreas 318 | 18,136
Blood and immune system 317 | 17,995
Male tissues 317 | 17,969
Skin and soft tissues 317 | 18,115
Urinary Tract 317 | 18,444
Cardiovascular System 316 | 17,958
Respiratory system 313 | 17,484

Target Family

Non-IDG 235 | 11,971
Enzyme 60 | 4,146
Epigenetic 8 | 242
Kinase 8 | 634
Transcription Factor 7 | 1,400
GPCR 1 | 406
Nuclear Receptor 1 | 48

Compartment GO Term

Ubiquitin ligase complex 320 | 320
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,611 | 13,611
Intracellular part 13,474 | 13,474
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,352 | 10,352
Membrane 8,872 | 8,872
Organelle part 8,170 | 8,170
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,830 | 7,830
Nucleus 6,897 | 6,897
Membrane part 6,469 | 6,469
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,172 | 5,172
Cell periphery 5,145 | 5,145
Plasma membrane 5,059 | 5,059
Extracellular region 4,606 | 4,606
Protein complex 4,438 | 4,438
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,873 | 3,873
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Cytosol 3,352 | 3,352
Nucleoplasm 2,938 | 2,938
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,593 | 2,593
Plasma membrane part 2,563 | 2,563
Cytoskeleton 2,045 | 2,045
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Integral component of plasma m... 1,723 | 1,723
Endoplasmic reticulum 1,663 | 1,663
Cytoskeletal part 1,567 | 1,567
Mitochondrion 1,530 | 1,530
Cell projection 1,426 | 1,426
Golgi apparatus 1,402 | 1,402
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,233 | 1,233
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,093 | 1,093
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,085 | 1,085
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Chromosome 999 | 999
Mitochondrial part 989 | 989
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 816 | 816
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 780 | 780
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 738 | 738
Plasma membrane protein comple... 720 | 720
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 657 | 657
Extracellular matrix 633 | 633
Microtubule organizing center 617 | 617
Synapse 594 | 594
Lysosome 571 | 571
Lytic vacuole 571 | 571
Vesicle membrane 559 | 559
cell-cell junction 557 | 557
Cytoplasmic vesicle membrane 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Kelch-like protein 23 KLHL23 Tdark Non-IDG -0.01424 1.64 48
Kelch-like protein 10 KLHL10 Tdark Non-IDG -0.62839 4.48 35
Ubiquitin-conjugating enzyme E2 R1 CDC34 Tbio Non-IDG -2.08055 124.6 194
Kelch-like protein 26 KLHL26 Tdark Non-IDG 0.60 0.08 76
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.50248 30.7 117
DCN1-like protein 3 DCUN1D3 Tdark Non-IDG -0.34242 2.58 44
Polyhomeotic-like protein 3 PHC3 Tbio Non-IDG -2.68637 475.4 59
Cullin-5 CUL5 Tbio Non-IDG -1.93258 89.1 172