Development Level

Tbio 20 | 11,445
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal coat-hair pigmentatio... 1 | 64
cataract 1 | 92
decreased circulating LDL chol... 1 | 38
decreased total body fat amoun... 1 | 207
impaired righting response 1 | 26
increased lean body mass 1 | 172
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 13 | 11,493
ovarian cancer 13 | 8,520
Autosomal recessive predisposition 11 | 1,442
Acidosis, Lactic 9 | 97
Cerebellar Ataxia 9 | 304
Lactic acidemia 9 | 95
Muscle hypotonia 9 | 571
medulloblastoma, large-cell 9 | 6,241
psoriasis 9 | 6,694
Cognitive delay 8 | 608
Epilepsy 8 | 792
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Seizures 8 | 596
glioblastoma 8 | 5,792
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
astrocytic glioma 7 | 2,597
lung cancer 7 | 4,740
osteosarcoma 7 | 7,950
Pick disease 6 | 1,894
Small head 6 | 374
adult high grade glioma 6 | 3,801
ependymoma 6 | 4,679
group 3 medulloblastoma 6 | 4,104
Dull intelligence 5 | 645
Hypoglycemia 5 | 152
Intellectual disability 5 | 1,016
Lactic acidosis 5 | 51
Leigh disease 5 | 100
Low intelligence 5 | 645
Maple syrup urine disease 5 | 24
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
atypical teratoid / rhabdoid tumor 5 | 5,112
Feeding difficulties in infancy 4 | 175
Lethargy 4 | 77
Metabolic acidosis 4 | 90
Multiple myeloma 4 | 1,332
Muscle Hypertonia 4 | 88
Neurogenic Muscular Atrophy 4 | 139
Neurogenic muscle atrophy, especially in the lower limbs 4 | 139
Skeletal muscle atrophy 4 | 139
lung carcinoma 4 | 2,843
malignant mesothelioma 4 | 3,232
muscle degeneration 4 | 139
oligodendroglioma 4 | 2,850
ulcerative colitis 4 | 1,819
Abnormal urinary amino-acid findings 3 | 38
Aminoaciduria 3 | 38
Astrocytoma, Pilocytic 3 | 3,081
Brain Edema 3 | 50
Breast cancer 3 | 3,578
Cerebral Edema 3 | 30
Cerebral atrophy 3 | 178
Classic Maple Syrup Urine Disease 3 | 3
Comatose 3 | 56
Degenerative brain disorder 3 | 100
Dystonia 3 | 164
Dystonic disease 3 | 106
Elevated plasma branched chain amino acids 3 | 3
Failure to gain weight 3 | 365
Hallucinations 3 | 34
Hallucinations, Sensory 3 | 33
Infantile onset 3 | 238
Intermediate Maple Syrup Urine Disease 3 | 4
Intermittent Maple Syrup Urine Disease 3 | 3
Ketonemia 3 | 11
Ketosis 3 | 11
Liver Cirrhosis, Experimental 3 | 769
Maple Syrup Urine Disease, Thiamine Responsive 3 | 3
Pancreatitis 3 | 123
Pediatric failure to thrive 3 | 365
Primary biliary cirrhosis 3 | 51
Supratentorial atrophy 3 | 94
Vomiting 3 | 116
abnormal growth 3 | 26
hereditary spastic paraplegia 3 | 318
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
non-small cell lung cancer 3 | 2,890
primitive neuroectodermal tumor 3 | 3,035
Byzanthine arch palate 2 | 194
Cancer 2 | 2,499
Crohn's disease 2 | 321
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hypertension 2 | 396
Kidney cancer 2 | 2,613
Methylmalonic acidemia 2 | 37
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Phenotypic variability 2 | 150
aldosterone-producing adenoma 2 | 665
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
lung adenocarcinoma 2 | 2,716
medulloblastoma 2 | 720

Tissue

Blood and immune system 21 | 16,909
Cardiovascular System 21 | 15,192
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678

Target Family

Enzyme 16 | 4,145
Non-IDG 3 | 12,091
Kinase 1 | 634
Transcription Factor 1 | 1,400

Compartment GO Term

Tricarboxylic acid cycle enzym... 21 | 21
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,237 | 12,237
Intracellular organelle 12,023 | 12,023
membrane-bounded organelle 11,130 | 11,130
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,340 | 10,340
Cytoplasmic part 9,247 | 9,247
Organelle part 8,976 | 8,976
Intracellular organelle part 8,784 | 8,784
Membrane 8,531 | 8,531
Nucleus 7,561 | 7,561
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,476 | 5,476
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,972 | 3,972
non-membrane-bounded organelle 3,972 | 3,972
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,955 | 1,955
Golgi apparatus 1,932 | 1,932
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,641 | 1,641
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,547 | 1,547
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
GO:0031975 1,150 | 1,150
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,123 | 1,123
Nuclear outer membrane-endopla... 1,121 | 1,121
Nucleoplasm part 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,040 | 1,040
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 949 | 949
Nucleoli 942 | 942
Endosome 931 | 931
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 864 | 864
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 849 | 849
Transferase complex 848 | 848
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 662 | 662
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

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